Tag: mendeley

Assistant Professor – Biological Psychiatry – University of Saskatchewan

Posted on | by Julie

University of Saskatchewan logoApplications are invited from qualified individuals for a tenure-track position at the level of Assistant Professor with the Department of Psychiatry, in the area of Biological Psychiatry. We are searching for individuals with exceptional promise to develop a vibrant, externally funded research program. While we encourage applications from candidates studying any aspect of Biological Psychiatry, we are particularly interested in applicants who will build a research program focused on platforms capable of screening for microglial mechanisms and pro-inflammatory processes across a range of disease models as they relate to neuropsychiatry. The research program is expected to underpin unique translational studies in personalized medicine. A competitive start-up package is available to facilitate this. The successful candidate will also show a strong commitment to undergraduate and graduate teaching, as well as Psychiatry residency training.

The successful applicant will join a department that is undergoing significant renewal, particularly in the areas of Biological Psychiatry. The department has several areas of research strength encompassing cellular and molecular biological as well as bioinformatics investigator-led programs focused Alzheimer disease, depression, suicidality, mood instability, forensics, and alternative treatment modalities, all of which offer many opportunities for interdisciplinary collaboration. Specific research areas of our faculty can be viewed here: (https://medicine.usask.ca/department/clinical/psychiatry.php#Research). The department benefits from having the Canadian Light Source situated on our campus, and the department has affiliations with the Department of Anatomy, Physiology and Pharmacology, the School of Public Health, and the Centre for Forensic Behavioural Science and Justice Studies.

The University of Saskatchewan’s main campus is situated on Treaty 6 Territory and the Homeland of the Métis. The University of Saskatchewan is located in Saskatoon, Saskatchewan, a family friendly city with a diverse and thriving economic base, a vibrant arts community and a full range of leisure opportunities. The University has a reputation for excellence in teaching, research and scholarly activities and offers a full range of undergraduate, graduate, and professional programs to a student population of over 25,000.

Qualifications

Applicants must have a PhD degree and post-doctoral experience in a biomedical discipline relevant to the position and a demonstrated ability to conduct original, innovative research. Applicants must also provide evidence of teaching at multiple levels as well as demonstrate a track record of research awards. The ideal candidate will have excellent interpersonal and communication skills, and show an interest in fostering collaborations with faculty members in the department and elsewhere on campus.

Salary band for this position at the rank of Assistant Professor for the 2022-2023 academic year is $98,178 to $117,978. This position includes a comprehensive benefits package which includes a dental, health and extended vision care plan; pension plan, life insurance (compulsory and voluntary), academic long term disability, sick leave, travel insurance, death benefits, an employee assistance program, a professional expense allowance, and a flexible health and wellness spending program.

Interested candidates must submit via email a cover letter, a detailed curriculum vitae, a brief statement of research interests and 5-year research plan (max. 3 pages), a teaching statement (1 page), an equity, diversity and inclusion (EDI) statement (1 page or less), and contact information for three references. In your EDI statement please reflect on your lived experiences, attitudes, beliefs and practices then discuss how you will consider EDI in your role as a colleague, teacher, researcher, and in building your research team. For more information related to equity, diversity and inclusion please see our webpage: https://medicine.usask.ca/about-us/edi.php. Due to federal immigration requirements, we also ask candidates to indicate in the cover letter whether they are Canadian citizens, permanent residents, or are otherwise already authorized to work at this position for the duration of the appointment, with an explanation if this last category is indicated. All qualified candidates are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadian citizens and permanent residents will be given priority.

Review of applications will begin in February of 2023; however, applications will be accepted and evaluated until the position is filled. The anticipated start date is July 1, 2023.

 

Contact information

 

Dr. AG Ahmed

Chair of Search Committee

103 Hospital Drive, Ellis Hall Rm 119

University of Saskatchewan

Saskatoon, SK S7N 0W8

Telephone: (306) 844-1310

Email: psychiatry@usask.ca

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Master’s and PhD graduate student positions (Neuroscience) – University of Saskatchewan

Posted on | by Julie

We are inviting applications for Master’s and PhD students in behavioural and systems neuroscience at the University of Saskatchewan (Saskatoon, Saskatchewan).

Our Research:
The Botterill laboratory has two major research pillars, including a basic science pillar focused on studying the cells and circuits that support learning, memory, and affective behaviours and a health sciences pillar focused on studying the neurobiological mechanisms of temporal lobe epilepsy and its treatment. Our research programs primarily focus on the dentate gyrus subfield of the hippocampus to study how hilar mossy cells, dentate granule cells (including adult-born neurons), and GABAergic interneurons influence hippocampal function in health and disease.

Methods:

  1. Mouse stereotaxic surgery for injections of adeno-associated viruses (AAV), electrode recording assemblies, optic fibers, and cannulae for drug infusions, etc.
  2. Gain- and loss-of function manipulations via optogenetics and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)
  3. Mouse models of epilepsy (pilocarpine, kainic acid)
  4. 24/7 video electroencephalography (EEG) recordings in freely behaving mice
  5. Slice electrophysiology (whole cell patch clamp & extracellular field recordings)
  6. Mouse behavioural testing
  7. Behavioural pharmacology
  8. Biochemistry
  9. Epifluorescence and confocal microscopy

Eligibility requirements:

  • Strong academic record
  • Interest in behavioural neuroscience and/or epilepsy research
  • Excellent written and oral communication skills
  • Experience in rodent handling / behavioural neuroscience is preferred.
  • The ideal candidate will have experience with AAV injections, in vivo optogenetics, slice electrophysiology, and/or video EEG data collection & analysis.

Funding:
Successful candidates will receive graduate student stipends commensurate with the standard stipend amounts for graduate students in the Department of Anatomy, Physiology, and Pharmacology in the College of Medicine. Candidates will be expected to apply to the College of Medicine’s Graduate Student Award (CoMGrad) and Tri-council competitions (e.g., NSERC or CIHR).

Important dates:
Deadline: June 1, 2023. Start date: September 1, 2023

Additional information:
Google Scholar Publications: https://scholar.google.ca/citations?hl=en&user=VL_1ODIAAAAJ
Botterill Laboratory Website: https://research-groups.usask.ca/botterillneurolab/index.php
Anatomy, Physiology, & Pharmacology website (for program details and tuition costs):
https://grad.usask.ca/programs/anatomy-physiology-pharmacology.php

Contact information

Contact information:

We welcome applications from qualified candidates and strongly encourage applications from individuals belonging to groups that have been traditionally underrepresented in the sciences. Applications will be reviewed until the positions are filled.

Please contact Justin Botterill (j.botterill@usask.ca) with the following information:

  1. A brief statement of research interests and goals
  2. A copy of your curriculum vitae (CV) with at least 2 references.
  3. A copy of your unofficial transcripts.
  4. Please indicate whether you are a Canadian Citizen or a permanent resident of Canada.

Posting end date

2023/06/01

 

Postdoctoral Researcher in Translational Rodent to Human Pain Models

Posted on | by Julie

About the position:

Position: Postdoctoral researcher for a two year term, with the possibility of extension

Field of Specialization: Spinal cord nociceptive processing; translational pain models

Academic Group: Hildebrand Pain Lab, Department of Neuroscience, Carleton University

Sources of Funds: 2023-2028 CIHR Project Grant, potential future industrial R&D fellowship

Start Date: May 1, 2023 (or earlier/later depending on applicant’s availability)

Closing Date: March 30, 2023

The Hildebrand Pain Lab (HildebrandPainLab.com) at Carleton University (and affiliated with the Ottawa Hospital Research Institute) invites applications for a postdoctoral research position investigating spinal mechanisms of nociceptive processing in rodent and human tissue models. This translational project involves combining cutting-edge high density multi-electrode array (MEA) recordings with the Hildebrand lab’s unique ability to collect highly viable tissue from human organ donors. Using this powerful combination, the applicant will investigate how molecular and cellular mechanisms of spinal excitability and pain processing are conserved and/or diverge across sex and species. Beyond these physiological questions, the applicant will test how targeting specific molecular players with current and potential future therapeutic compounds impacts excitability in spinal nociceptive circuits of both rodents and humans.

The skills, networks, and mentorship gained through this translational pain project will equip the candidate for potential careers in academic, industrial, and/or healthcare-related fields. Along with direct supervision and mentorship by Dr. Hildebrand, the applicant will be working alongside a neurosurgeon/clinical research scientist collaborator at the Ottawa Hospital, Dr. Eve Tsai (https://www.ohri.ca/profile/etsai), with the opportunity to participate in the surgical collection of spinal cord tissue from neurologic determination of death organ donors. Because of the high translational value of these rodent-to-human spinal cord physiology and pharmacology experiments, the applicant will also have the opportunity to work with and be mentored by pharmaceutical researchers that have ongoing collaborative research partnerships with the Hildebrand Pain Lab.

Qualifications:

Candidates must have a Ph.D. in a relevant field, with neuroscience-related research experience including performing electrophysiological, pharmacological, and/or biochemical experiments on ex vivo nervous system tissue. Expertise in analysis of large datasets and coding is also an asset. The position is full time, and salary will be commensurate with experience. The postdoc will be considered unionized, as a member of PSAC Local 77000. Information on this bargaining unit can be found here: https://psac77000.ca/. Optional extended health and dental benefit plans are available with this position.

The Hildebrand Pain Lab and Carleton University are strongly committed to fostering diversity within their communities as a source of excellence, cultural enrichment, and social strength. We welcome those who would contribute to the further diversification of our team, including, but not limited to: women; visible minorities; First Nations, Inuit and Métis peoples; persons with disabilities; and persons of any sexual orientation or gender identity and expressions. We understand that career paths vary. Legitimate career interruptions will in no way prejudice the assessment process and their impact will be taken into careful consideration.

Application instructions:

Completed applications should be sent as one single PDF document to Dr. Hildebrand (mike.hildebrand@carleton.ca) and should include a cover letter highlighting relevant research experiences and how this position fits with your career goals, as well as a curriculum vitae that includes the names and contact information of three referees familiar with your past work and experiences. Please indicate in your application if you are a Canadian citizen or permanent resident of Canada.

About Carleton University:

The Neuroscience department (https://carleton.ca/neuroscience/) is a dynamic and growing academic/research unit at Carleton University that includes a diverse range of research interests, outreach activities, and networking/mentorship opportunities. To learn more about our University and the City of Ottawa, please visit https://carleton.ca/provost/reports/.

Contact information

Michael Hildebrand, mike.hildebrand@carleton.ca
Associate Professor and Graduate Chair, Carleton University
Affiliate Investigator, Ottawa Hospital Research Institute
1125 Colonel By Drive
6310 Health Sciences Building
Ottawa, ON K1S 5B6 CANADA

 

Posting end date

2023/06/01

Download – PDF

 

Assistant/Associate Professor, Department of Pharmacology and Therapeutics – University of Manitoba

Posted on | by Julie

U manitoba logoAssistant/Associate Professor, Department of Pharmacology and Therapeutics
Max Rady College of Medicine, Rady Faculty of Health Sciences
University of Manitoba
Position #32314

The Department of Pharmacology and Therapeutics (DPT), Rady Faculty of Health Sciences (https://umanitoba.ca/health-sciences/) at the University of Manitoba (https://umanitoba.ca) invites applications for a full-time, Probationary (Tenure-track) or Tenured position at the rank of Assistant Professor or Associate Professor within the Max Rady College of Medicine, commencing on July 1, 2023, or on a date mutually agreed upon. Salary and rank will be commensurate with experience and qualifications

The Rady Faculty of Health Sciences is a major center of interdisciplinary health sciences education and research in Canada, offering a full range of undergraduate and postgraduate programs in biomedical sciences and health professions. The DPT has a rich history of excellence in research and high-quality education in biomedical and clinical pharmacology at the graduate and undergraduate levels across all Rady Faculty of Health Sciences constituent Colleges of Medicine, Pharmacy, Rehabilitation Sciences, Dentistry and Nursing. The DPT also contributes heavily to undergraduate programming in the Faculty of Science (BSc) and the Interdisciplinary Health Program Bachelor of Health Sciences (BHSc) curriculum.

DPT faculty members maintain robust, internationally recognized research programs maintained by extramural operating and infrastructure grants from local, national and international sources. Foundational DPT research themes include cancer biology, clinical pharmacology, neurosciences, and cardiovascular and metabolic sciences. Research strengths are cultivated by leveraging partnerships between DPT and partner research institutes in Manitoba, including the Kleysen Institute for Advanced Medicine, St. Boniface Hospital Research, Children’s Hospital Research Institute of Manitoba and the CancerCare Manitoba Research Institute.

The successful candidate will have an MD and/or PhD, postdoctoral training experience with a highly productive track-record of impactful scholarly activity, inspire learning and a strong commitment to excellence in pharmacology and therapeutics education. Evidence of teaching experience is considered an asset. The appointed candidate will be expected to teach throughout the DPT program to support the educational advancement of undergraduate and graduate students in the core theoretical knowledge of drug action, including relevant methodological concepts. They will also have a prominent role in developing and executing the DPT strategic educational plan, which is likely to encompass activities such as development of new courses, market-driven micro-credentials, career development initiatives for trainees, and national training programs. The appointed candidate will also be expected to develop a rigorous well-funded research program. Applicants with research expertise across all pharmacology disciplines are encouraged to apply but preferred areas of research will align with departmental themes of strength and institute partner priorities in child health, cancer, clinical pharmacology, cardiovascular sciences and neurosciences.

At the Assistant Professor rank, candidates must display a promising research agenda and have demonstrated potential and a commitment to teaching. At the Associate Professor rank, candidates must have a strong research orientation, a demonstrated record of high-quality publications and successful experience in academic teaching.

A generous startup package will be available to establish a world-class research program. Additionally, the University of Manitoba has a long track-record of reserving institutional infrastructure funding opportunities (e.g. Canada Foundation for Innovation John R. Evans Leadership fund) for early career investigators.

The City of Winnipeg (www.tourismwinnipeg.com), located where the Red and Assiniboine Rivers meet, is recognized for its vibrant, multicultural community and diverse culture. The city, with a growing population of more than 766,000, is home to internationally renowned festivals, galleries and museums, the historic Exchange District and The Forks, and ever-expanding research, education, and business sectors. From the Hudson Bay waters, across the farmland fields, to the pulse of the cities and towns, The Province of Manitoba’s (www.travelmanitoba.com) people and places – its 100,000 lakes, 92 provincial parks, winding river valleys and storied prairie skies – inspire.

The University of Manitoba is a driving force of innovation, discovery and advancement. Our momentum is propelled by our campus community – UM faculty, staff and students whose determination and curiosity shape our world for the better. Our teaching, learning and work environment is uniquely strengthened and enriched by Indigenous perspectives. With two main campuses in Winnipeg, satellite campuses throughout Manitoba, and world-wide research, UM’s impact is global.

Discover outstanding employee benefits, experience world-class facilities and join a dynamic community that values reconciliation, sustainability, diversity, and inclusion. We are one of Manitoba’s Top Employers and one of Canada’s Best Diversity Employers. At the University of Manitoba, what inspires you can change everything.

Applicants are requested to submit the following materials, preferably via email as a single PDF file:

  1. Cover letter concisely describing suitability for the position
  2. Curriculum Vitae
  3. Statement of teaching philosophy documenting experience and approach to training and mentoring students from different types of educational backgrounds and using a variety of teaching strategies for diverse learners, including undergraduates and graduate students.
  4. A one page personal statement describing previous contributions to equity, diversity and inclusion and the incorporation into the teaching philosophy, research program and service activities.
  5. Five-year research plan (max 5 pages) outlining background, rationale, aims and experiments
  6. Names of three referees in confidence (contacted only if short-listed)

 

Submit all materials to:

 

Vernon Dolinsky

Professor and Associate Head, Department of Pharmacology & Therapeutics

Chair of Department of Pharmacology & Therapeutics Search Committee

Rady Faculty of Health Sciences

University of Manitoba

A205 Chown Building, 753 McDermot Avenue

Winnipeg, MB, Canada R3E OT6

Tel:      (204) 789-3405

Email: Karen.Donald@umanitoba.ca

 

Review of applications will commence starting December 1, 2022 and will continue until the position has been filled. Materials may be shared with participating members of the search process.  All materials, including reference letters, will be handled in accordance with the Freedom of Information and Protection of Privacy Act (Manitoba).

The University of Manitoba is committed to the principles of equity, diversity & inclusion and to promoting opportunities in hiring, promotion and tenure (where applicable) for systemically marginalized groups who have been excluded from full participation at the University and the larger community including Indigenous Peoples, women, racialized persons, persons with disabilities and those who identify as 2SLGBTQIA+ (Two Spirit, lesbian, gay, bisexual, trans, questioning, intersex, asexual and other diverse sexual identities). All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

 An inclusive, open and diverse community is essential to excellence and fosters voices that have been ignored or discouraged. To address the Rady Faculty of Health Sciences commitment to equity, diversity and inclusion, and in recognition of the underrepresentation of members of historically and currently excluded groups, we take proactive measures including implicit bias training for all hiring panels. We strive for diversity and cultural safety throughout the hiring process (hiring panels, short-list of candidates, interviews). We encourage you to self-identify any aspect of diversity in your cover letter. 

 If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

Download a PDF version of this advertisement

 

Postdoc in Neuroimmunology – Macauley lab, University of Alberta

Posted on | by Julie

The Macauley lab is accepting applications for a Postdoctoral fellow in the area of neuroimmunology. Research in the lab focuses on the role of Siglec family of immunomodulatory glycan-binding receptors in human health and disease. The lab is located in the Gunning/Lemieux Chemistry center at University of Alberta and is part of the Neuroscience and Mental Health Institute (NHMI) and Alberta Glycomics Institute (GIA). Additionally, we are strongly connected to the Canadian Glycomics Network (GlycoNet), and collaborate closely with several other UAlberta investigators studying microglia (e.g. Drs. Plemel, Voronova, Sipione)

Working within a highly interdisciplinary environment, the fellow will lead projects related to the role of an Alzheimer’s disease susceptibility factor, CD33, in disease pathogenesis, as well as development of novel CD33-based therapeutics in this context (PMID:35940942). Genetic models (PMID:33766097 and PMID:31815204) and biochemical tools (PMID:34517042) are readily available in our laboratory for working on this exciting project that is closely connected to human disease. Funding through multiple sources (CIHR, Alzheimer Society of Canada, Weston Brain Institute, GlycoNet, and NIH) are in place to advance our goal of understanding the cellular and molecular mechanisms by which Siglecs impact the function of microglia in the brain.

The position requires a Ph.D. in one of the following disciplines: neurobiology, immunology, chemical biology, biochemistry, or other related fields. Candidates should have a record of completed graduate research that can be directly applied to the field of interest described above. Prior experience with transgenic models of neurodegeneration, cell culture, microscopy (including immunohistochemical techniques) and biochemical techniques are highly desirable. The ideal candidate must demonstrate excellent laboratory skills, independence, and resourcefulness. Candidates must possess strong communication and organizational skills manifested with proven track records including peer-reviewed publications.

Please email a cover letter, CV, and the name of 3 potential references to Dr. Macauley.

Matthew Macauley
macauley@ualberta.ca

Posting end date: 2022/12/31

Imaging Specialist Position at University of Manitoba

Posted on | by Julie

Position Title: Imaging Specialist

Employer: University of Manitoba, Department of Pharmacology & Therapeutics

Salary: $60,000-70,000; salary will be commensurate with qualifications and experience.

Expected Start: December 1st, 2022 or earliest availability.

 

Job Description

The Live-Cell Imaging Facility (LCIF) is a Rady Faculty of Health Sciences (RFHS) supported core platform located within the Neuroscience Research Program on the 4th floor of the Kleysen Institute for Advanced Medicine. The LCIF includes state-of-the-art facilities for intravital multiphoton imaging from behaving small animals, in vitro multiphoton imaging, imaging with laser-capture/microdissection, confocal and super-resolution imaging. LCIF facilities are routinely accessed for day-to-day research activities of highly successful and established RFHS members probing the molecular, genetic and cellular basis of disease.

The LCIF seeks to hire a full-time Research Associate with a strong background in advanced optical microscopy who will oversee day-to-day operations of the LCIF and provide expert-level technical expertise and user support.

Responsibilities:

  • Facilitate facility access and promote increased adoption of advanced imaging and analysis techniques.
  • Offer in depth training, assistance with experimental design and advanced analysis procedures.
  • Consolidate and share collective expertise and best practices among our user base by organizing instructional seminars, tutorials and workshops.
  • Assist in the development of post-processing algorithms and software tools, including commercially available and in-house software.
  • Promote open access to imaging expertise and tools locally, nationally and internationally by networking with other facilities, curating content hosted on the LCIF website, and by further promoting discoveries and capabilities (e.g. via social media).
  • Ensure optimal operation and longevity of imaging facilities by troubleshooting system problems, undertaking routine maintenance and liaising with system manufacturers for scheduled maintenance or repairs.
  • Manage bookings, track and report system usage (number of users and hours logged), assist in billing based on usage and maintain training records (number of new users and hours of training provided).

Qualifications, skills and abilities:

  • Doctoral degree or equivalent qualifications and experience.
  • Experience with advanced optical microscopy (e.g. widefield, confocal or multiphoton imaging) including experimental design, sample preparation, image processing and analysis.
  • Experience in training and supervising trainees and staff.
  • Ability to troubleshoot and resolve technical problems with imaging equipment or software.
  • Ability and willingness to learn new techniques and skills, and to keep abreast of developments in the areas of expertise.
  • Effective communication skills, both written and verbal, and enthusiasm for sharing knowledge and expertise with others.
  • Demonstrated organizational skills and ability to prioritize tasks to meet objectives.
  • Ability to work both independently and as a member of a team is essential.

Interested Candidates should send their CV and cover letter, including a summary of their experience and qualifications for the position described, as well as the names and contact information for academic/research references, to Dr. Michael Jackson (michael.jackson@umanitoba.ca).

Additional information:

The University of Manitoba is committed to the principles of equity, diversity & inclusion and to promoting opportunities in hiring, promotion and tenure (where applicable) for systemically marginalized groups who have been excluded from full participation at the University and the larger community including Indigenous Peoples, women, racialized persons, persons with disabilities and those who identify as 2SLGBTQIA+ (Two Spirit, lesbian, gay, bisexual, trans, questioning, intersex, asexual and other diverse sexual identities). All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

An inclusive, open and diverse community is essential to excellence and fosters voices that have been ignored or discouraged. To address the Rady Faculty of Health Sciences commitment to equity, diversity and inclusion, and in recognition of the underrepresentation of members of historically and currently excluded groups, we take proactive measures including implicit bias training for all hiring panels. We strive for diversity and cultural safety throughout the hiring process (hiring panels, short-list of candidates, interviews). We encourage you to self-identify any aspect of diversity in your cover letter.

Application materials, including letters of reference, will be handled in accordance with the protection of privacy provision of The Freedom of Information and Protection of Privacy Act (Manitoba). Please note that curriculum vitae may be provided to participating members of the search process.

Contact information

Dr. Michael Jackson

LCIF Director

Associate Professor, Department of Pharmacology & Therapeutics

University of Manitoba

michael.jackson@umanitoba.ca

Doctoral students with an Interest in Healthy Brain, Aging and Dementia Prevention

Posted on | by Julie

University of Calgary logoOpportunities: The Brain in Motion research program is looking for doctoral students with an interest in healthy brain aging and dementia prevention who wish to join a large interdisciplinary and diverse research team of over 35 scientists from Calgary, Canada and other parts of the World. There are opportunities currently available for doctoral students in neurosciences, physiological sciences, psychology and kinesiology in several areas related to this research program. Four-year doctoral stipend support is available via matching funding models, through application in March 2023, at the University of Calgary. Below you will find the thematic areas, the Brain in Motion protocol, the timeline for this opportunity, and contact information for more details.

Thematic areas within the program of research

  • Cognitive function (executive function, complex attention, processing speed, verbal memory, overall cognition), exercise and aging
  • Biomarkers (vascular, neuroendocrine, inflammation)
  • Proteomics, lipidomics, metabolomics
  • Genetics (genetic variants related to ADRD, neuronal integrity, growth factors and clearance enzymes, lipid and vascular function modulators)
  • Neuroimaging
  • Sleep and novel biomarkers of cognitive decline
  • Maintenance of health behavior
  • Role of lifestyle factors on cognitive function
  • Machine learning and artificial intelligence
  • Healthcare system costs and quality of life measures
  • Exercise physiology
  • Sex and gender differences

Summary of Brain in Motion

Background: There remains no effective intervention capable of reversing most cases of dementia. Current research is focused on prevention by addressing risk factors that are shared between cardiovascular disease and dementia (e.g., hypertension) before the cognitive, functional, and behavioural symptoms of dementia manifest. A promising preventive treatment is exercise. This study describes the methods of a randomized controlled trial (RCT) that assesses the effects of aerobic exercise and behavioural support interventions in older adults at increased risk of dementia due to genetic and/or cardiovascular risk factors. The specific aims are to determine the effect of aerobic exercise on cognitive performance, explore the biological mechanisms that influence cognitive performance after exercise training, and determine if changes in cerebrovascular physiology and function persist one year after a 6-month aerobic exercise intervention followed by a 1-year behavioural support program (at 18 months).

Methods: We will recruit 264 participants (aged 50-80 years) at elevated risk of dementia. Participants will be randomly allocated into one of four treatment arms: (1) aerobic exercise and health behaviour support, (2) aerobic exercise and no health behaviour support, (3) stretching-toning and health behaviour support, and (4) stretching-toning and no health behaviour support. The aerobic exercise intervention will consist of three supervised walking/jogging sessions per week for 6 months, whereas the stretching-toning control intervention will consist of three supervised stretching-toning sessions per week also for 6 months. Following the exercise interventions, participants will receive either one year of ongoing telephone behavioural support or no telephone support. The primary aim is to determine the independent effect of aerobic exercise on a cognitive composite score in participants allocated to this intervention compared to participants allocated to the stretching-toning group. Secondary aims are to examine the effects of aerobic exercise on a number of secondary outcomes and determine whether aerobic exercise-related changes persist after a one-year behavioural support program (at 18 months).

Significance: This study will address knowledge gaps regarding the underlying mechanisms of the pro-cognitive effects of exercise by examining potential mediating factors, including cerebrovascular/physiological, neuroimaging, sleep, and genetic factors that will provide novel biologic evidence on how aerobic exercise can prevent declines in cognition with aging. Trial Registration: ClinicalTrials.gov (NCT03035851); protocol paper published (Kruger et al., 2021).

Timeline for these opportunities:

By December 15, 2022– Deadline for prospective students to submit i) a letter of interest, ii) a curriculum vitae, iii) a list of publications and awards, and iv) the names of 3 referees who have agreed to be contacted to bimstudy@ucalgary.ca. Prospective supervisors, co-supervisors and doctoral students will complete the application process for matching funds with support from the Brain in Motion team. The start date for the doctoral program will be between May – September 2023.

Contact information

For more details please contact:

Dr. Marc Poulin, Lead Investigator for the Brain in Motion team
Department of Physiology & Pharmacology
Cumming School of Medicine
University of Calgary
Calgary, Alberta

Email: poulin@ucalgary.ca
Email: bimstudy@ucalgary.ca

Post Doc Position-Neurotrophic mechanisms in brain diseases – Centre for Addiction and Mental Health, Toronto

Posted on | by Julie

Reduced brain cell structure and function contributes to cognitive symptoms in depression, Alzheimer’s disease and other brain disorders, and during aging. Current efforts aimed at developing therapeutic agents to reverse these deficits focus on excitatory or neurotrophic mechanisms, but have had limited translation to effective therapeutics potential, identifying a world-leading unmet clinical need with significant impact on patients, family, society and healthcare.

The Neurobiology of Depression and Aging program (www.NDA-sibille.ca) is seeking a postdoctoral fellow to investigate the cellular mechanisms of novel neurotrophic approaches, using cell-based and rodent models. The NDA program investigates the molecular bases of psychiatric disorders and develop novel therapeutic avenues. It is located at the Centre for Addiction and Mental Health (CAMH), Canada’s largest mental health and addiction teaching hospital. CAMH is fully affiliated with the University of Toronto.

Qualifications:

The candidate will have a PhD in Neuroscience, Neuropharmacology or a related discipline, with demonstrated expertise in molecular neuroscience, including primary neuron culture and in vivo rodent models. Experience with methods related to molecular biology (plasmid DNA handling, qPCR, Western blot, proteome analysis, recombinant virus handling etc.), pharmacology, immunohistochemistry and imaging (confocal microscopy, morphometric analysis) is preferred.
The successful candidate will have a track record that demonstrates competence in publishing in high impact peer reviewed journals, disseminating research at formal scientific meetings, writing grant proposals and participation in the education of students and trainees. The successful candidate will also possess strong interpersonal, organizational and communication skill, and the ability to work both independently and in a team. The ability to interact with populations of diverse ethno-racial and cultural backgrounds is also required.

Please note: This full-time position is NOT part of any bargaining unit.

Salary Range: Competitive Salary

Contact information

Send your application with cover letter and CV to: Etienne.sibille@camh.ca

Download a PDF version of this advertisement

Posting end date: 2022/10/21

Research Associate 1 – University of Guelph – Khokhar lab

Posted on | by Julie

Position Title:                 Research Associate 1, (Grant & Trust Professional)
Employer:                         University of Guelph (Biomedical Sciences, Ontario Veterinary College)
Term:                                  Temporary full time (15 month contract to start as soon as possible)
Hours:                               Full-time (35 Hours/Week)
Number of Positions:  1
Hiring Ref. Number:   2022-0604

N.B.:    Please read the Application Instructions before applying: https://www.uoguelph.ca/hr/careers-guelph/how-apply

The Khokhar Lab researches the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The Research Associate is responsible for the following main duties:

  • conducts behavioural experiments assessing the effects of cannabinoids in a variety of animal models of addiction (e.g., withdrawal, conditioned place preference and self-administration/free-access intake) and serious mental illness (e.g., prepulse inhibition, latent inhibition);
  • provides input with respect to appropriate methodology, procedures, equipment and standards to produce required research data;
  • applies specialized knowledge and principles to review, appraise and interpret published literature, summarize research findings, and draft scientific/technical reports, manuscripts, grant proposals;
  • establishes and maintains effective relationships with external partners, which may include coordinating of project plans, presenting research findings (may include presenting findings at conferences).

Education, Skills, Work Experience and other Requirements:

  • Master’s degree in relevant discipline combined with at least 3-5 years of relevant research experience with behavioural paradigms including: withdrawal, conditioned place preference, self-administration/free-access intake, prepulse inhibition, latent inhibition;
  • Experience coding with behavioural control software (e.g., Med Associates or equivalent), and using behavioural assessment software (e.g., Noldus Ethovision or equivalent) and statistical analysis software packages (e.g., SPSS or R);
  • Proven ability in methodology, procedures, equipment and standards to produce required research data;
  • Proficiency in summarizing research findings, reviewing, appraising and interpreting published literature;
  • Strong attention to detail;
  • Self-motivated and able to work collaboratively within a team environment;
  • Experience with in vivo electrophysiology is considered an asset.

Salary: $54,107 – $62,168

Vacation Pay: accrual rate of 1.25-1.83 days/month

Benefits: Extended Health, Basic Life Insurance (up to specified maximums), Dental coverage subject to minimum employment contract and minimum workload thresholds being met and Long Term Disability subject to minimum employment contract and minimum workload thresholds being met (payable to a maximum of 5 years).

Location of Employer: 50 Stone Road, Guelph, ON N1G2W1

Location of Work: Guelph, ON                    

Language of Work: English

All Canadian citizens or permanent residents who qualify are invited to apply by sending their Cover Letter and CV (including list of publications demonstrating relevant experience), quoting hiring number 2022-0604, by email to careers@uoguelph.ca or by mail to the following address: 50 Stone Rd E, Guelph ON N1G 2W1 (Attention: Human Resources).

At the University of Guelph, fostering a culture of inclusion is an institutional imperative. The University invites and encourages applications from all qualified individuals, including from groups that are traditionally underrepresented in employment, who may contribute to further diversification of our Institution.

ERC-funded project: neural control of locomotion before and after spinal cord injury in salamanders – Research Staff

Posted on | by Julie

The Université de Sherbrooke is inviting applications at the rank of Research professional responsible at the Faculty of Medicine and Health Sciences, with an association with the Department of pharmacology – physiology. The position is in the Ryczko team. This is a renewable full-time position for one year.
The Ryczko lab uses electrophysiology, calcium imaging and neuroanatomy to identify the mechanisms through which the brain and spinal cord control locomotion in salamanders.
The candidate will work in a dynamic team with a strong collaborative spirit. She or he will be responsible for overall lab management and organization, student training, in vivo and in vitro experiments. The position includes execution of patch-clamp, calcium imaging, neuroanatomy and behavioral experiments (training can be provided), training student, maintenance of salamander colonies, maintenance of setups, ordering of reagents, ensuring the implementation of health and safety standards in the lab.

PRINCIPAL CHALLENGES AND DUTIES
– Patch-clamp electrophysiology, calcium imaging (epifluorescent, confocal, two photon) and behavioral experiments in salamanders
– Help to analyze data and communicate results
– Participate in operational activities of the lab (general lab management, maintenance of equipment, purchasing, safety)
– Train students in electrophysiology, calcium imaging, neuroanatomy and behavioral techniques

QUALIFICATIONS
– Master degree in Life sciences or equivalent
– Hands-on experience in electrophysiology or calcium imaging or movement analysis
– Experience in laboratory organization & maintenance
– Fluency in English

APPLY
Candidates should send a letter of interest explaining how they would fit, a CV, a record of their academic results and three references at dimitri.ryczko@usherbrooke.ca. Please specify where you found the job post.