Postdoctoral Fellow identifying exosomal biomarkers in Multiple Sclerosis – Montreal Neurological Institute, McGill University

We are looking for a highly motivated postdoctoral researcher to join our team at the Montreal Neurological Institute (McGill University, Montreal, Canada). The postdoc will be under the primary supervision of Prof. Alyson Fournier and will collaborate with Dr. Jack Antel’s group and other members of the neuroimmunological diseases group (https://www.mcgill.ca/neuro/people/field_mprofile_research_areas/neuroimmunological_diseases). The project includes the analysis of protein and RNA content of exosomes derived from neurons and oligodendrocytes from human iPSC-derived neurons and oligodendrocytes and from human patient plasma samples. The aims of the project are to identify markers of neuronal and oligodendrocyte damage and repair as diagnostic and prognostic tools in Multiple Sclerosis.

Interested candidates should have a solid background and publications in molecular and biochemical neuroscience techniques with an interest in neuroimmunology and neurological disease. Experience in basic bioinformatics assessments would be an asset. Interested persons should send their CV and two reference contacts.

Contact information

Alyson Fournier

Email: alyson.fournier@mcgill.ca

Neurologists & Locum Neurologists – Windsor Regional Hospital

Our client, Windsor Regional Hospital (WRH), is a multi-faceted health services organization operating from two main sites, the Metropolitan Campus and the Ouellette Campus. With 500 beds and an operating budget of over half a billion dollars, WRH is the regional provider of advanced care in areas that include complex trauma, renal dialysis, cardiac care, stroke and neurosurgery, intensive care, acute mental health, family birthing centre, neonatal intensive care, paediatric services, and regional cancer services. WRH provides a broad range of medical and surgical services required to support these specialized areas for more than 400,000 people in Windsor and Essex County. Windsor Regional Hospital is seeking: Neurologists & Locum Neurologists

With increasing volumes, program development, and growing demands for service, WRH is seeking top tier Neurologists to join their team to contribute to service delivery excellence in the Neuro-Interventional Program. This is an exceptional opportunity to join an innovative, collegial, and mutually respectful team to contribute to neurology service delivery excellence.

There is a need to expand the group of neurologists which would include general neurologists who have interest in supporting inpatient endeavors. Full time, part time, and locum opportunities are available. WRH is also interested in recruiting subspecialty neurologists to bring unique skills to the group and community.

As a designated Enhanced District Stroke Centre, Windsor Regional Hospital provides specialized services for stroke and TIA patients offering timely hyper-acute treatments like tPA and endovascular therapy (Thrombectomy and Coiling), as well as neurosurgical services. The hospital has neurologists, neurosurgeons, and interventional radiologists on staff providing expert care for stroke patients. Following intervention and post procedure recovery and stabilization in the ICU, patients are transferred to the Acute Stroke Unit, a designated 16-bed unit dedicated to the care of Stroke patients. Inpatient and outpatient rehabilitation services for Windsor-Essex are offered locally through Hotel-Dieu Grace Healthcare. Outpatient Rehab options direct from hospital also includes the Intensive Hospital to Home Rehab program and E-Rehab services provided through the Erie St. Clair LHIN.

Physicians at WRH have the opportunity to educate and mentor residents from the Schulich School of Medicine and Dentistry, with professional staff members eligible to hold a University appointment.

Candidates must be certified, or eligible for certification, by the Royal College of Physicians and Surgeons of Canada in Neurology and hold, or be eligible for, licensure with the College of Physicians and Surgeons of Ontario. Offering great flexibility and work/life balance, these positions include an attractive compensation and relocation incentive package.

The Windsor-Essex area is ecologically rich with extensive parkland combined with a southwest location that extends warm weather activities such a golfing, gardening, and water sports. Windsor offers the unique opportunities of a larger metropolitan area and the benefits of a smaller community. Living directly across the border from Detroit, Michigan places you on a cosmopolitan stage where arts, culture, big league sports, and entertainment are just moments away. Best of all, you can enjoy access to all of these big-city advantages while living in the tranquility and beauty of the Windsor region.

Please forward a CV in confidence to:

Robb Callaghan, E-mail: rcallaghan@medfall.com Tel: 289-238-9079

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Post-doctoral fellowship – Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry – Université Laval

Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the impact of chronic stress on the activity of the medial prefrontal cortical (mPFC) excitatory/inhibitory circuitry in males and females. This project builds on results from our group showing that chronic stress interferes with the inhibitory control of principal cells differently in the mPFC of chronically stressed males and females. The aim of this project is to define how stress impacts the transcriptional programs controlling the activity of the different inhibitory interneuron subclasses in the mPFC and dissect their individual contribution on the disruption of the mPFC excitatory/inhibitory balance required for proper emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either behavioral or computational neuroscience with an established record of productivity in these fields of research. The lab models complex emotional responses to chronic stress through different paradigms including social defeat stress, chronic variable stress and prolonged social isolation. The project involves combining different trans-sectional viral approaches with single-cell RNAseq, patch clamp electrophysiology and single-cell Ca2+ imaging in freely behaving animals during stressful and operant tasks to ultimately dissect and confirm the contribution of cell-type specific gene programs on the maintenance/alteration of the excitatory/inhibitory balance in the mPFC of stressed males and females. Of particular interest, our lab owns unique human molecular profiles which provide highly translational findings relevant to clinical populations. This project is fully funded.

The candidate should have proven expertise with the assessment of mouse behavior and stereotaxic delivery of viral vectors. The candidate should also have a have a strong background with either patch clamp electrophysiology and/or Ca2+ imaging. Previous molecular expertise is a plus and proficiency with Matlab, R and Python coding would be ideal. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. The candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

Post-doctoral fellowship – Deciphering the epigenetics code underlying the expression of major depressive disorder in men and women.

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the epigenetic regulation of sex-specific gene networks across brain regions from men and women suffering from Major Depressive Disorder (MDD). This project relies on solid findings published from our lab showing that the transcriptional organization of gene networks across brain regions from men and women with MDD is highly sexually dimorphic and that these sex-specific gene networks control different aspects of emotional stress responses in males and females. The aim of this project is to reveal the epigenetic landscape across brain regions from men and women with MDD and confirm the impact of epigenetic changes on the activity of sex-specific gene networks and their control over emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either molecular or cellular biology, genetics, neuroscience or any other relevant disciplines with an established record of productivity in the respective fields of research. The project implies combining approaches to screen histone modifications, chromatin confirmation/occupancy and DNA base modifications in post-mortem tissue from men and women with MDD. The relationship between the layers of epigenetic complexity and the transcriptional organization of gene networks in men and women with MDD will be assessed by bioinformatically. In the lab, this will be first performed by delivering epigenetic modulators at regions of interest in human NPS cell lines and ultimately in mouse models using conditional viral approaches in transgenic mouse lines. This is a truly translational project with direct clinical implications in human populations. This project is fully funded and in-house bioinformatics expertise is already established.

The candidate should have proven expertise in basic and advanced molecular techniques related to the study of epigenetic, chromatin or DNA base modifications. The candidate should also have a strong experience with cell line maintenance and manipulation. Experience with animal work and stereotaxic viral delivery would be important assets. Proficiency with R or Python coding is a plus. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. By joining the group, the candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers a transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

IBRO – MBL and CSHL Fellowships

The IBRO (International Brain Research Organization) US-Canada Regional Committee (USCRC) is pleased to announce our 2021 fellowships program that will cover the cost for PhD students and postdoctoral fellows training in neuroscience in Canada to attend advanced neuroscience courses or meetings at the Marine Biological Laboratories (MBL) at Woods Hole, MA., and Cold Spring Harbor Laboratory (CSHL), NY.

For MBL, all trainees are welcomed to apply but preference will be given to trainees belonging to minority groups (Indigenous communities in Canada, visible minorities, persons with disabilities, women, and other minorities) as
well as those in non-U15 Universities (http://u15.ca/). The MBL awards will cover the cost of tuition, room, and board. Fellowships are worth up to $11,000 per trainee depending on the course taken.

For CSHL, reduced registration fees for virtual meetings are available for trainees from non-U15 Universities (http://u15.ca/). If in-person courses resume in the second half of 2021, partial tuition support of up to $8,000 per trainee will be available.

The aim of this program is to increase diversity in neuroscience in Canada, by providing such trainees with access to cutting-edge research training in contemporary neuroscience.

Interested trainees should submit applications directly to the course of interest (see link below). Evaluation of applications and offers of admission to courses are made by the course leaders. Accepted candidates with the backgrounds mentioned above will be automatically considered for IBRO fellowship.

Eligible MBL courses: Neural Systems and Behavior, Neurobiology: Mechanisms & Advanced Approaches, Methods in Computational Neuroscience, Biology of the Inner Ear: Experimental and Analytical Approaches, Brains, Minds and Mechanisms, Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches, and Frontiers in Stem Cells and Regeneration.

Eligible CSHL courses: see link below.

MBL: http://www.mbl.edu/education/courses/
CSHL: https://meetings.cshl.edu/meetingshome.aspx

Please inform us when applying or if you have questions about eligibility.

Contact: sam.david@mcgill.ca

Post-doctoral Research Fellow position in clinical neurophysiology at The Hospital for Sick Children

Post-doctoral Research Fellow position in clinical neurophysiology

Neurological Outcome of Glycemia in Neonatal Encephalopathy

The Neurosciences & Mental Health Program at the Hospital for Sick Children Research Institute is seeking an enthusiastic postdoc researcher to work in close collaboration with neurologists, neurophysiologists, and neuroradiologists in analysing pre-existing continuous glucose, EEG, and clinical data.

With the direction of principal supervisors Drs. Emily Tam and Cecil Hahn, you will work closely with affiliated staff and students who form a group that use neuroimaging and neurophysiology to study newborn brain disorders.

Despite therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE), rates of death and major disability continue to be high. Using continuous glucose monitoring, we have found that hyperglycemia occurs in more than 50% of HIE, associated with brain injury and possibly long-term outcomes. This study uses continuous glucose data paired with continuous electroencephalography (cEEG) and detailed clinical data to determine the temporal relationships between abnormal glycemia and brain function.

This is part of an ongoing project that is funded by the Canadian Institutes of Health Research (CIHR) and the National Institutes of Health (NIH).

A substantial amount of data already exists for this project and the motivated researcher will be able to jump straight into analysis.

Requirements

  • PhD in a relevant area (engineering or computer sciences) required.
  • Must have experience with EEG analyses
  • Well developed skills in data science is required.
  • Computer programming (Matlab, Python, or R) and/or signal processing/time series analyses.
  • Proven experience in research commensurate with your level of experience post-PhD.
  • Experience in analysis of neurophysiological data is preferred.
  • Experience in clinical research would be an asset.
  • Excellent communication skills (oral and written).
  • Be able to work independently and meet deadlines.

We offer

  • Initial contract will be for a period of 1 year, with the possibility of extension for a second year.
  • We offer a competitive salary based on qualifications and experience.
  • In addition, we offer an attractive benefits package, that includes extended health and dental coverage.
  • Toronto is a world-class rated in the top ten cities worldwide for livability that has a large and rich neuroscience community.
  • The Research Institute offers many opportunities for career development and additional training as part of the Research Training Centre.

Additional information

The post is available from 4th January 2021.

Contact Dr. Emily Tam via emily.tam@sickkids.ca for more information.
If you wish to apply directly, please send a CV, a cover letter with research statement/interests, and the names of two references.

Please use the following direct link to the job posting to apply to the position via the SickKids website:

https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=13321&PostingSeq=1&

BrainsCAN Graduate Studentship Program at Western University

We are pleased to announce the “Call for Applications” for the BrainsCAN Graduate Studentship Program. This program is part of Western’s $66M BrainsCAN initiative, supported by the Canada First Research Excellence Fund (CFREF). The CFREF investment is intended to enable researchers at the University, along with their national and international academic and commercial partners, to seek answers to fundamental questions regarding how we learn, think, move and communicate.

Recruiting the next generation of neuroscience researchers is a key aim of BrainsCAN. The BrainsCAN Graduate Studentship Program has been developed to attract the world’s most promising prospective master’s and doctoral students in cognitive neuroscience to Western University.

Up to five BrainsCAN Graduate Studentships will be awarded in this competition to highly qualified individuals pursuing a collaborative research project in cognitive neuroscience. This Studentship is open to any prospective graduate student not currently, or recently, enrolled in a graduate program at Western, and will provide a minimum salary of $25,000 for 2 years for master’s students, and $35,000 for 3 years for doctoral students.

Already ranked amongst the best in the world in cognitive neuroscience and neuroimaging, Western researchers employ cognitive, computational, clinical, and translational approaches to understand and intervene in brain function. Our graduate students will have access to BrainsCAN-supported core facilities for neuroimaging; for studying human cognition, behaviour and sensorimotor control; for development and use of computational methods; and for establishing and exploring rodent and nonhuman primate models of cognition and behaviour. Skilled staff within these cores support state-of-the-art technical equipment including research-only MRI systems (3T, 7T, and 9.4T), laboratories for cognitive, behavioural, and electrophysiological testing in humans and animal models, advanced molecular techniques, a sleep laboratory, and access to a variety of neurological patient populations in affiliated teaching hospitals.

Applicants must identify and contact potential advisors at Western before applying. An interdisciplinary, collaborative approach, involving more than one lab is a requirement for application. Lastly, it is strongly recommended that all potential applicants review Western’s Graduate School Admission procedures and academic calendar prior to preparing their application.

The application deadline is January 4th, 2021.

Contact information For more information, please see: https://brainscan.uwo.ca/programs/graduate_studentship_program/index.html

Contact: brainscan@uwo.ca
Posting end date 2021/01/03

Neurology Clinician Scientist Fellowships – Neuroscience and Mental Health Institute – University of Alberta

The Neuroscience and Mental Health Institute (NMHI) at the University of Alberta is offering two fellowships to attract outstanding clinician scientists in training to the University of Alberta to conduct postdoctoral research in neurology and neuroscience: The Mildred I. Olsen Neurology Fellowship and The University Hospital Foundation Neurology Fellowship.

The NMHI is a multi-faculty, interdisciplinary teaching and research institute located at the University of Alberta. It is home to over 150 scientists and clinicians, spanning across all areas of neuroscience and mental health.

Eligibility

To apply for this competition:

  • Your supervisor must be a member of the NMHI (applicants must identify and contact a potential NMHI supervisor before applying);
  • You must hold an MD and plan to work in an area that falls within the NMHI research areas;
  • You must provide a complete application form along with all required accompanying documents.

Award Details

The Mildred I. Olsen Neurology Fellowship and the University Hospital Foundation Neurology Fellowship will be awarded for a term of one year. The value of each fellowship is $70,000 to be used towards salary costs; supervisors are responsible for benefits.

Supervisors are required to provide funding to support trainees beyond the first year. Trainees may hold this award once per eligible training program. Funding is non-transferable. It is the responsibility of the supervisor and/or awardee to inform the NMHI if they receive another award. Awardees are required to accept alternate funding. The awards are tenable at the University of Alberta.

Application

Please visit the NMHI website for details on how to apply.

Contact information

nmhicoms@ualberta.ca

Posting end date

2020/11/29

 

Neuroscience Postdoctoral Fellowships – Neuroscience and Mental Health Institute, University of Alberta

The Neuroscience and Mental Health Institute (NMHI) at the University of Alberta is offering two Dr. Rowland and Muriel Haryett Neuroscience Fellowships to attract outstanding scientists in training to the University of Alberta to conduct postdoctoral research in neuroscience.

The NMHI is a multi-faculty, interdisciplinary teaching and research institute located at the University of Alberta. It is home to over 150 scientists and clinicians, spanning across all areas of neuroscience and mental health.

Eligibility

To apply for this competition:

  •  Your supervisor must be a member of the NMHI (applicants must identify and contact a potential NMHI supervisor before applying);
  • You must hold a PhD and plan to work in an area that falls within the NMHI research areas;
  • You must provide a complete application form along with all required accompanying documents (see Application section below)

Award Details

Two Dr. Rowland and Muriel Haryett Neuroscience Fellowships will be awarded for a term of one year. The value of each fellowship is $50,000 to be used towards salary costs; supervisors are responsible for benefits.

Supervisors are responsible for funding to support trainees beyond the first year. Trainees may hold this award once per eligible training program. Funding is non-transferable. It is the responsibility of the supervisor and/or awardee to inform the NMHI if they receive another award. Awardees are required to accept alternate funding. The award is tenable at the University of Alberta.

Application

Please visit the NMHI website for details on how to apply.

Contact information

nmhicoms@ualberta.ca

Posting end date

2020/11/29

Postdoctoral Fellowships in Cognitive Neuroscience – BrainsCAN at Western University

Western University, home to a large cluster of world-renowned neuroscience researchers, is looking to bring the world’s most promising young cognitive neuroscientists to an outstanding research environment with unparalleled infrastructure. BrainsCAN is a 7-year, $66 million initiative funded by the Government of Canada, that is enabling researchers at the University, along with its national and international academic and commercial partners, to understand and significantly reduce the impact of cognitive disorders across the lifespan.

BrainsCAN is committed to improving representation of marginalized groups in neuroscience through the implementation of best practices of equity and inclusion. We are inviting applications from outstanding neuroscientists who identify with an underrepresented group (including Black, Indigenous, LGBTQ2S+, people with disabilities, and women) for 10 available postdoctoral positions. Applicants will have the opportunity to work with our talented cognitive neuroscientists, and should contact potential advisors based on their research interests before submitting their application.

The Postdoctoral Fellow program offers highly competitive compensation packages with independent research allowances, a brand-new state-of-the-art facility, and opportunities to work with highly esteemed researchers across multiple disciplines. Postdoctoral Fellows will have access to BrainsCAN-supported core facilities for neuroimaging; for studying human cognition, behaviour and sensorimotor control; for development and use of computational methods; and for establishing and exploring rodent and nonhuman primate models of cognition and behaviour. Skilled staff within these cores support state-of-the-art technical equipment including research-only MRI systems (3T, 7T, and 9.4T), laboratories for cognitive, behavioural, and electrophysiological testing in humans and animal models, advanced molecular techniques, a sleep laboratory, and access to a variety of neurological patient populations in affiliated teaching hospitals.

Already ranked amongst the best in the world in cognitive neuroscience and neuroimaging, Western researchers employ cognitive, computational, clinical, and translational approaches to understand and intervene in brain function.

Contact information

For additional information, please visit our website at: https://brainscan.uwo.ca/programs/pdf_special_call/index.html

Contact: brainscan@uwo.ca

Posting end date

2020/12/04