Doctoral and Postdoctoral Researcher Position – Brouillette lab, Montreal

The Brouillette Lab at the Hôpital du Sacré-Coeur de Montréal (CIUSSS-NIM) invites applicants for a doctoral and postdoctoral researcher position in the field of Alzheimer’s disease and age-related memory deficits. Specific research topics include the effect of Aβ oligomers on sleep during aging, the impact of Aβ oligomers on different cell types in the hippocampus, the role of the phosphatase STEP on social memory, and blood biomarkers for early AD. We are using state-of-the-art equipment to perform laser microdissection, optogenetic, molecular/cellular biology, and behavioural testing with various animal models. These full-time positions and projects are supported by the Canadian Institutes of Health Research (CIHR) and the Weston Brain Institute. Funding is available for three to five years. The start date is immediate but flexible. Applications will be considered until the positions are filled. The annual stipend is consistent with CIHR funding levels.

Requirements

Candidates should have a degree in neuroscience, biochemistry, molecular/cellular biology, pharmacology, genetic, or a related field. Ideal applicants will have experience in molecular/cellular biology, animal behavioural testing, and knowledge of statistics. Additional preferred qualifications include experience with laser microdissection and optogenetic.

Contact information

Interested applicants should send their CV, a brief cover letter describing research experience and interests, university transcript, and contact information for 2-3 references by e-mail to Jonathan Brouillette (e-mail: jonathan.brouillette@umontreal.ca)

Principal Investigator
Dr. Jonathan Brouillette, Ph.D.
Assistant Professor
Department of Pharmacology and Physiology
Université de Montréal

Lab website:
https://pharmacologie-physiologie.umontreal.ca/recherche/chercheurs/jonathan-brouillette/
https://rechercheciusssnim.ca/profil/jonathan-brouillette/
https://recherche.umontreal.ca/nos-chercheurs/repertoire-des-professeurs/chercheur/is/in17687/

Postdoctoral position in Montreal on immune mechanisms in Parkinson’s disease – Trudeau laboratory

Dr. Louis-Eric Trudeau’s laboratory at the Université de Montréal (University of Montreal) (www.labotrudeau.org) is looking for a post-doctoral fellow to join a team of scientists working on the connectivity and vulnerability of dopamine neurons. The ideal candidate will have previous training in cellular and molecular neuroscience, including physiological approaches, in neuroimmunology and interest in the immune mechanisms implicated in Parkinson’s disease. Preference will be given to candidates that have a track record including publications as first author and that are already in Canada or who can easily travel to Canada.

Interested individuals should email the lab principal investigator at: louis-eric.trudeau@umontreal.ca
Posting end date:  2020/12/31

Post-doctoral fellow position on the behavioural neuroscience of reward- Samaha laboratory – Universite de Montreal

Dr Anne-Noel Samaha’s laboratory at the Université de Montréal is looking for a post-doctoral fellow. I will hire someone whose primary expertise is in the behavioural neuroscience of reward.

Training in complementary techniques such as in vivo optogenetics, DREADDs, and in molecular biology assays is also important. The research work involves characterizing the neurobehavioural effects of different intravenous cocaine self-administration procedures in the rat.

If you have this expertise and are interested, please email anna.samaha@umontreal.ca

See also
https://pubmed.ncbi.nlm.nih.gov/?term=samaha+AN+montreal&sort=date

Candidates in Canada or who can easily travel to Canada will be given preference.

Contact information:

anna.samaha@umontreal.ca

Post-doc position – Neurodegenerative Disease Research – Clark lab at the University at Buffalo

The Clark Lab at the State University of New York at Buffalo is looking to build a team to investigate a second-generation preclinical model of Progressive Supranuclear Palsy (PSP). PSP is a devastating neurodegenerative disease, which shares attributes with Alzheimer’s Disease; tau protein aggregates, cognitive and motor deficits. Our goal is to identify neurons that are perturbed early in the disease process and that contribute to key aspects of the behavioral deficits and underlying pathology. This knowledge will allow for improved diagnosis and the initiation of pharmacotherapeutic discovery programs. We are seeking a Post-Doctoral Fellow to work with a team of graduate students and technical staff. The research duties will include surgical manipulation in rats followed by behavioral, biochemical, histological and MRI analysis.

If interested, please contact Dr. Stewart Clark directly (stewartc@buffalo.edu)

Post-doctoral Position Available in the Translational Cognitive Neuroscience Lab (Dr. Tim Bussey & Dr. Lisa Saksida) studying molecular and cellular mechanisms of information storage and neurogenesis in the hippocampus using cutting-edge neurotechnology (e.g., miniscopes, fiber photometry and touchscreen technology).

A postdoctoral position is available immediately under the supervision of Dr. Lisa Saksida and Dr. Tim Bussey at the Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario (www.tcnlab.uwo.ca), in collaboration with the Dr. Mark Brandon and colleagues at McGill University (www.m3platform.org), to work on questions relating to molecular and cellular mechanisms of information storage and neurogenesis in the hippocampus. The work will involve recording and analyzing neuronal activity using miniscopes and fibre photometry, in combination with advanced cognitive testing using touchscreens (www.touchscreencognition.org).

Qualified applicants should have a PhD degree in Neuroscience or related disciplines with significant expertise in studying mouse models and advanced mathematical and analytical skills. Prior experience in miniscope data analysis, mouse surgery, fibre photometry, in vivo electrophysiology, or data analysis using MatLab, Python and R, documented in peer-reviewed publications will be an asset. Salary will be paid commensurate with experience.

Robarts is one of the premier research institutes in Canada with a vibrant research community and many opportunities for collaborations. The University of Western Ontario (www.uwo.ca) is a major educational and research centre in Ontario with over 25,000 undergraduate and 5,000 graduate students. Cognitive neuroscience in health and disease is a major research focus at Western, currently funded by a $66M Canada First Research Excellence Fund program called BrainsCAN. London, also known as the Forest City, is an affordable and lively community close to the Great Lakes and two hours from Toronto. The city offers many options for outdoor and cultural activities.

Western is committed to employment equity and diversity in the workplace and welcomes applications from women, members of racialized groups/visible minorities, Aboriginal persons, persons with disabilities, persons of any sexual orientation, and persons of any gender identity or gender expression.

Please send a statement of interest, Curriculum Vitae, and the names of at least two references to:

Dr. Lisa Saksida, Robarts Research Institute, University of Western Ontario Email: lsaksida@robarts.ca

Posting end date: 2020/12/31

Two year funded Postdoctoral position, University of Victoria – Kerry Delaney lab

Electrophysiology of mutant versus wildtype neurons in a mouse model of Rett Syndrome.

Researcher with experience in whole cell patch clamp recording from neurons in acute brain slices is required to undertake recording from neurons in neocortex and thalamus of mice lacking functional MeCP2. Mecp2 is an X-linked transcription factor controlling various aspects of neuronal and synapse maturation. Studies will be performed primarily on female heterozygous mice utilizing a GFP-based nuclear marker to differentiate neurons expressing wild-type Mecp2 from those expressing a non-functional (mutated) allele. Optogenetic stimulation of virally-expressed channel rhodopsin will be used to investigate the relative strength of thalamo-cortical connections and cortico-thalamic feedback pathways to wild-type versus mutant neurons. Funded by the International Rett Syndrome Foundation.

Contact Dr. Kerry Delaney, kdelaney@uvic.ca

More information about UVic Neuroscience can be found at https://www.uvic.ca/medsci/neuroscience/

The Delaney lab: https://web.uvic.ca/~neurolab

Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=delaney+rett

Contact information

Dr. Kerry Delaney.
Professor, Biology Department, University of Victoria
email: kdelaney@uvic.ca
Phone: 250-472-5657
The Delaney lab: https://web.uvic.ca/~neurolab

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Posting end date: 2020-08-31

Post-Doctoral Fellow – SOAR Project (UBCO)

A Postdoctoral Fellow position is available to work on the SOAR (Supporting Survivors of Abuse and Brain Injury through Research) Project in the School of Health and Exercise Sciences at UBC-Okanagan

Research Program Overview A post-doctoral position is available in the Brain Injury Lab led by Dr. Paul van Donkelaar in the School of Health and Exercise Sciences at the University of British Columbia’s Okanagan campus. The successful candidate will be a key member of the SOAR project team investigating the cerebrovascular, neurocognitive, and sensorimotor effects of traumatic brain injury (TBI) in women who have experienced intimate partner violence (IPV). Our well-funded multidisciplinary program integrates researchers in clinical neuroscience, cerebrovascular physiology, psychopathology, social work, sociology, knowledge translation, and implementation science, with the goal of better understanding IPV-related TBI. As part of this, we are working with the Kelowna Women’s Shelter and other community partners to co-create, implement, and evaluate tools and resources to better support the women they serve. The incumbent would be expected to take a leadership role in the lab-based assessment of brain function in IPV-caused TBI and contribute to broader project goals in collaboration with other team members.

Qualifications PhD required. Experience with, or the capacity to acquire the necessary skills to undertake, the assessment of cerebrovascular, neurocognitive, and/or sensorimotor function following TBI. An understanding and/or knowledge of gender-based violence and its effects would be an asset. Seeking a creative individual who can integrate cerebrovascular, neurocognitive and sensorimotor measures of brain dysfunction following IPV-related TBI. The ability to further contribute to related projects in the lab on sports concussion and post-concussion syndrome is desirable.

Individuals must also:

  • Work well in a goal-oriented team environment
  • Have a proven track record of research accomplishments (i.e. publication record)
  • Possess excellent communication skills – both verbal and written
  • Have the ability to work independently and organize own workload
  • Have the ability to design and analyze experiments, keep meticulous records of experiments and data, report on research progress and outcomes openly, and review methodologies in response to feedback &
  • Have the ability to update knowledge in their specialized area and implement relevant technologies to advance the project.

Other considerations

This position is available from September 1st, 2020 and will be a based on a one-year renewable contract, extendable depending on funding availability. Salary will be commensurate with qualifications and experience. Candidates are strongly encouraged to apply for competitive fellowship awards.

A letter of application, accompanied by a detailed curriculum vitae including a list of publications, and contact details for 3 references, should be sent by email to:

Professor Paul van Donkelaar paul.vandonkelaar@ubc.ca

Please include “SOAR Project PDF search” in the e-mail subject line. Applications will remain open until the position is filled. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Contact information

Dr. Paul van Donkelaar
School of Health and Exercise Sciences
University of British Columbia – Okanagan Campus
Kelowna, B.C.
phone: 250-863-3230
email: paul.vandonkelaar@ubc.ca

Posting end date

2020/11/01

Postdoctoral Position on Astrocyte-Inhibitory Interneuron Interactions – Robitaille & Lacaille laboratories, Université de Montréal

Postdoctoral position
Dept Neurosciences
Université de Montréal
Montreal, Canada

A postdoctoral position is immediately available in the laboratory of Dr Richard Robitaille at Université de Montréal to study the role of astrocytes in the regulation of inhibitory synaptic circuits and hippocampal function. The project is funded by a NSERC Discovery grant and involves a collaboration with the laboratory of Dr Jean-Claude Lacaille.

The research focuses on the mechanisms of astrocyte regulation of inhibitory interneurons and their impact on hippocampus-dependent learning and memory. Our multidisciplinary approach uses brain slices and in vivo transgenic mice, and combines state-of-the-art molecular biology, synaptic physiology, 2-photon imaging, opto- and chemogenetics and behavioral assays.

Requirements are PhD in Neuroscience or related discipline, with expertise in single cell electrophysiology. Experience is also desirable with any of the following techniques: patch-clamp, optogenetics and calcium imaging. Successful candidates will be highly motivated, have strong work ethics, and ability to work independently as well as part of a team.

Interested applicants should submit a statement of research experience and career goals, a current CV and the names of three references to:

Contact information

Dr Richard Robitaille
richard.robitaille@umontreal.ca

Postdoctoral Researcher in the laboratory of Dr. Beverley Orser, University of Toronto

A Postdoctoral Researcher position funded by the Canadian Institutes of Health Research is available in the laboratory of Dr. Beverley Orser (www.orserlab.com). The lab is located in the Department of Physiology at the downtown campus of the University of Toronto.

The goal of the research is to understand physiologic and pathological processes underlying learning and memory, and to identify the mechanisms that contribute to a decline in brain function after anesthesia and surgery. Studies will focus on neurons and glia in the hippocampus and cortex. The long-term goal is to develop novel treatments that target subtypes of inhibitory receptors for cognitive disorders after anesthesia and surgery, as well as for inflammation-induced cognitive dysfunction and mood disorders.

Qualifications:
We are looking for a highly motivated and enthusiastic scientist with the following skills and experience:

  • Ph.D. in Chemistry/Biochemistry/Biophysics/Molecular Cell Biology.
  • Strong background in molecular biology, protein chemistry, and biochemistry.
  • Highly experienced in DNA, RNA and protein handling and analysis techniques.
  • Technical proficiency in the areas of protein biochemistry, including: protein expression, purification and characterization using SDS-PAGE, HPLC/FPLC; characterizing protein-ligand and protein-protein interactions using affinity chromatography.
  • Ability to work independently with strong problem-solving skills.
  • Must demonstrate a good understanding of scientific principles, experimental design, and proper laboratory techniques.

Desirable experience and skills:

  • Carry out assays such as Bradford, ELISA’s and cell-based assays.
  • Knowledge in protein biophysical analysis.
  • Basic knowledge in structural biology (X-ray crystallography/Cryo-EM/NMR spectroscopy).
  • Basic knowledge of bioinformatics tools and site-directed mutagenesis.
  • Knowledge in basic tissues culture techniques is a plus.
  • Prior experiences with animal behavioral assays, electrophysiology, and optogenetics are assets.
  • Design and execute experiments to support research activities and projects in the lab.

The laboratory provides an excellent training environment and we are strongly committed to training high-quality researchers who are interested in advancing translational neuroscience. The laboratory is also strongly committed to diversity within the communities and especially welcomes applications from racialized persons/persons of color, women, indigenous/Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

Contact information

Please send your application (a Cover Letter, a CV and the names of three references) to Dr. Dianshi Wang (dianshi.wang@utoronto.ca).

Postdoctoral Position in Neural Circuits – Topolnik Lab, Université Laval

Laboratory of Lisa Topolnik, Neuroscience Axis, CRCHU-CHUL, Laval University, Quebec-city, Canada

A postdoctoral position is available in the lab of Dr. Lisa Topolnik to work on the functional organization of hippocampal inhibitory and disinhibitory circuits. The laboratory conducts both basic and translational neuroscience research in the areas of neural circuits, synaptic plasticity, and intracellular signalling. Our current research program is focusing on the cellular diversity and function of cortical disinhibitory circuits formed by the vasoactive intestinal peptide (VIP) and somatostatin-expressing interneurons as well as interneuron dendritic integration and synaptic plasticity. Our research strategy is based on combination of transcriptomic, physiological, optogenetic, pharmacogenetic and imaging approaches applied to in vitro and in vivo animal models.

A current PDF project will be focusing on exploring the molecular and cellular basis of dendritic integration in GABAergic neurons. We will study the role of inhibition in dendritic input integration in specific types of interneurons in brain slices obtained from transgenic mice in vitro. A novel optogenetic approach based on a combinatorial targeting of specific cell types for selective manipulations will be developed. The data obtained in vitro will then be integrated for in vivo investigation of the network-state dependent recruitment of specific cell types and their functional role in behaving animals. For this part, we will use cognitive and behavioral animal models in combination with calcium imaging and optogenetic cell type-specific interventions.
Candidates should have a PhD in Neurobiology or a related discipline (with a graduation date within the last 4 years), and at least two first-author papers (published or accepted). Prior experience with patch clamp electrophysiology, optogenetics or 2ph imaging in vitro or in behaving animals will be an asset. Full funding provided by the Canadian Institutes of Health Research and the Natural Sciences and Engineering Research Council of Canada is available for up to 4 years. Salary will be commensurate with experience and will include standard benefits as per Laval University regulations.

Contact information To apply: email your CV and cover letter to Prof. Lisa Topolnik. Lisa.Topolnik@bcm.ulaval.ca

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