Post Doctoral Scholar – experimental detection of ultra-weak photon emission from biological systems

PRIMARY PURPOSE OF POSITION

The postdoctoral researcher is responsible for performing experimental research on detecting ultra- weak photon emission from biological samples. The candidate will plan, perform, and analyze experiments on biological samples using single-photon detection and imaging systems. The position has a 2-year term; the candidate will initially work at UCalgary, and then will transition to the National Research Council of Canada in Ottawa. These two sites are home to teams of experts in biophoton detection/theory and neuroscience applications. The candidate is expected to support the development of funding and attracting graduate students to ensure continued growth in the area of quantum biology. The incumbent will be expected to also present research accomplishments and findings in internal and external meetings, conferences, reports, and publications.

QUALIFICATIONS/EXPERTISE REQUIRED

  • A PhD in neuroscience, biology or related fields is required.
  • Experience in operating optical spectroscopy imaging equipment and image analysis softwaretools and software.
  • Experience in preparing and maintaining in vitro biological cell preparations (ideally dissociated cultures and brain slices).
  • Position requires flexibility to be on-site at U Calgary for up to 6 months, followed by being on-site at National Research Council (NRC) in Ottawa for up to 1.5 years.
  • An asset would be experience in assessing effect of pharmacological agents on cells and tissues, preferably neuronal in origin.
  • An asset would be experience in theoretical and experimental aspects of light emission from biological systems.
  • An asset would be knowledge of quantum mechanics.
  • Ability to communicate effectively with internal and external stakeholders.
  • Capable of assisting expansion and development of research projects in biophoton research.
  • A high level of effective time and project management, personal initiative, communications skills and teamwork.
  • Ability to travel nationally and internationally.
  • Knowledge of university policies and procedures is an asset.

ACCOUNTABILITIES/TASKS AND DUTIES

Technical:

The candidate will primarily be responsible for operation of an experimental setup designed to detect single photons (biophotons) from biological samples. Biological samples to be investigated will include living tadpoles and various neuron culture assemblies. Biophoton emission will be investigated using pharmacological and possibly electrophysiological approaches. The incumbent will also be responsible for the analysis and interpretation of the data, working with the teams at uCalgary and National Research Council. The incumbent will design, implement, and consult with the Principal Investigator on projects and programs. The candidate will be expected to identify and pursue new research opportunities aligned with the overall vision of the project.

Mentorship/Coaching:

  • The candidate will provide training of undergraduate and graduate students in experimental and theoretical research techniques, as well as presentation skills (written and oral).
  • Publishing/Presenting Research:
  • Publish/present research accomplishments at both the national and international level, including in high impact/selective academic journals.
  • Prepare manuscripts describing findings for submission for publication, and lead process of responding to referees/editors during the peer review process.
  • Occupational Health & Safety:
  • Understands and complies with the requirements of the University’s Occupational Health and Safety Policy.
  • Has knowledge of and understands the expectations of the University’s Occupational Health and Safety Management System (OHSMS) and applicable Faculty/Departmental/Unit specific health and safety policies and procedures.
  • Ensures that all work conducted is in accordance with the Alberta Occupational Health and Safety Act, Regulation and Code and other health and safety legislation as applicable.

 

ABOUT THE UNIVERSITY OF CALGARY

The University of Calgary is Canada’s leading next-generation university – a living, growing and youthful institution that embraces change and opportunity with a can-do attitude. Located in the nation’s most enterprising city, the university is making tremendous progress on its Eyes High journey to be recognized as one of Canada’s top five research universities, grounded in innovative learning and teaching and fully integrated with the community it both serves and leads. The University of Calgary inspires and supports discovery, creativity and innovation across all disciplines. For more information, visit ucalgary.ca.

To succeed as one of Canada’s top universities, where new ideas are created, tested and applied through first-class teaching and research, the University of Calgary needs more of the best minds in our classrooms and labs. We’re increasing our scholarly capacity by investing in people who want to change the world, bringing the best and brightest to Calgary to form a global intellectual hub and achieve advances that matter to everyone. For more information visit research.ucalgary.ca/postdocs.

 

ABOUT CALGARY, ALBERTA

Calgary is one of the world’s cleanest cities and has been named one of the world’s most livable cities for years. Calgary is a city of leaders – in business, community, philanthropy and volunteerism. Calgarians benefit from the strongest economy in the nation and enjoy more days of sunshine per year than any other major Canadian city. Calgary is less than an hour’s drive from the Rocky Mountains and boasts the most extensive urban pathway and bikeway network in North America.

The University of Calgary has launched an institution-wide Indigenous Strategy in line with the foundational goals of Eyes High, committing to creating a rich, vibrant, and culturally competent campus that welcomes and supports Indigenous Peoples, encourages Indigenous community partnerships, is inclusive of Indigenous perspectives in all that we do.

As an equitable and inclusive employer, the University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their academic and professional success while they are here. In particular, we encourage members of the designated groups (women, Indigenous peoples, persons with disabilities, members of visible/racialized minorities, and diverse sexual orientation and gender identities) to apply. To ensure a fair and equitable assessment, we offer accommodation at any stage during the recruitment process to applicants with disabilities. Questions regarding [diversity] EDI at UCalgary can be sent to the Office of Equity, Diversity and Inclusion (equity@ucalgary.ca) and requests for accommodations can be sent to Human Resources (hrhire@ucalgary.ca).

 

Contact information

LINK TO JOB-POSTING

https://science.careers.ucalgary.ca/jobs/10577986-post-doctoral-scholar-physics-and-astronomy-faculty-of-science

QUESTIONS

For questions specific to the role contact Prof. Daniel Oblak doblak@ucalgary.ca

Posting end date

2023/01/31

Post-doctoral Fellow in Neuropsychopharmacology – Khokhar lab – Western University

The Khokhar Lab (www.khokharlab.com) researches the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The Post-doctoral Fellow will conduct brain imaging and behavioural experiments assessing the effects of alcohol/cannabis use and chemogenetic or pharmacologic manipulation in a rat model of schizophrenia or during development (CRC and CIHR-funded grant).

Previous training and experience with pre-clinical MRI imaging (e.g., fMRI, DTI, MRS) is preferred. In addition, any experience with schizophrenia (e.g., pre-pulse inhibition) and addiction-like behaviours (e.g., self-administration) would be beneficial. The Post-doctoral fellow will also provide input with respect to appropriate methodology, procedures, equipment and standards to produce required research data and apply specialized knowledge and principles to review, appraise and interpret published literature, summarize research findings, and draft scientific/technical reports, manuscripts, grant proposals while establishing and maintaining effective relationships with lab members, and presenting research findings (may include presenting findings at conferences).

Minimum Qualifications: PhD degree in Neuroscience or Medical Biophysics, with related research experience (pre-clinical MRI Imaging and Behavioural methods above).

The successful applicant will be encouraged to apply to extramural funding, but funding is in place for renewal of contract beyond the first year. The expected start date is as soon as possible. The position will remain open until filled. Please indicate in your application if you are a Canadian citizen or a permanent resident of Canada.

How to apply

Please send a cover letter/statement of interest, current CV, and a list of 3 references to Dr. Jibran Khokhar at jkhokha@uwo.ca. We will notify applicants before contacting any references.

 

Postdoc in Neuroimmunology – Macauley lab, University of Alberta

The Macauley lab is accepting applications for a Postdoctoral fellow in the area of neuroimmunology. Research in the lab focuses on the role of Siglec family of immunomodulatory glycan-binding receptors in human health and disease. The lab is located in the Gunning/Lemieux Chemistry center at University of Alberta and is part of the Neuroscience and Mental Health Institute (NHMI) and Alberta Glycomics Institute (GIA). Additionally, we are strongly connected to the Canadian Glycomics Network (GlycoNet), and collaborate closely with several other UAlberta investigators studying microglia (e.g. Drs. Plemel, Voronova, Sipione)

Working within a highly interdisciplinary environment, the fellow will lead projects related to the role of an Alzheimer’s disease susceptibility factor, CD33, in disease pathogenesis, as well as development of novel CD33-based therapeutics in this context (PMID:35940942). Genetic models (PMID:33766097 and PMID:31815204) and biochemical tools (PMID:34517042) are readily available in our laboratory for working on this exciting project that is closely connected to human disease. Funding through multiple sources (CIHR, Alzheimer Society of Canada, Weston Brain Institute, GlycoNet, and NIH) are in place to advance our goal of understanding the cellular and molecular mechanisms by which Siglecs impact the function of microglia in the brain.

The position requires a Ph.D. in one of the following disciplines: neurobiology, immunology, chemical biology, biochemistry, or other related fields. Candidates should have a record of completed graduate research that can be directly applied to the field of interest described above. Prior experience with transgenic models of neurodegeneration, cell culture, microscopy (including immunohistochemical techniques) and biochemical techniques are highly desirable. The ideal candidate must demonstrate excellent laboratory skills, independence, and resourcefulness. Candidates must possess strong communication and organizational skills manifested with proven track records including peer-reviewed publications.

Please email a cover letter, CV, and the name of 3 potential references to Dr. Macauley.

Matthew Macauley
macauley@ualberta.ca

Posting end date: 2022/12/31

Doctoral students with an Interest in Healthy Brain, Aging and Dementia Prevention

University of Calgary logoOpportunities: The Brain in Motion research program is looking for doctoral students with an interest in healthy brain aging and dementia prevention who wish to join a large interdisciplinary and diverse research team of over 35 scientists from Calgary, Canada and other parts of the World. There are opportunities currently available for doctoral students in neurosciences, physiological sciences, psychology and kinesiology in several areas related to this research program. Four-year doctoral stipend support is available via matching funding models, through application in March 2023, at the University of Calgary. Below you will find the thematic areas, the Brain in Motion protocol, the timeline for this opportunity, and contact information for more details.

Thematic areas within the program of research

  • Cognitive function (executive function, complex attention, processing speed, verbal memory, overall cognition), exercise and aging
  • Biomarkers (vascular, neuroendocrine, inflammation)
  • Proteomics, lipidomics, metabolomics
  • Genetics (genetic variants related to ADRD, neuronal integrity, growth factors and clearance enzymes, lipid and vascular function modulators)
  • Neuroimaging
  • Sleep and novel biomarkers of cognitive decline
  • Maintenance of health behavior
  • Role of lifestyle factors on cognitive function
  • Machine learning and artificial intelligence
  • Healthcare system costs and quality of life measures
  • Exercise physiology
  • Sex and gender differences

Summary of Brain in Motion

Background: There remains no effective intervention capable of reversing most cases of dementia. Current research is focused on prevention by addressing risk factors that are shared between cardiovascular disease and dementia (e.g., hypertension) before the cognitive, functional, and behavioural symptoms of dementia manifest. A promising preventive treatment is exercise. This study describes the methods of a randomized controlled trial (RCT) that assesses the effects of aerobic exercise and behavioural support interventions in older adults at increased risk of dementia due to genetic and/or cardiovascular risk factors. The specific aims are to determine the effect of aerobic exercise on cognitive performance, explore the biological mechanisms that influence cognitive performance after exercise training, and determine if changes in cerebrovascular physiology and function persist one year after a 6-month aerobic exercise intervention followed by a 1-year behavioural support program (at 18 months).

Methods: We will recruit 264 participants (aged 50-80 years) at elevated risk of dementia. Participants will be randomly allocated into one of four treatment arms: (1) aerobic exercise and health behaviour support, (2) aerobic exercise and no health behaviour support, (3) stretching-toning and health behaviour support, and (4) stretching-toning and no health behaviour support. The aerobic exercise intervention will consist of three supervised walking/jogging sessions per week for 6 months, whereas the stretching-toning control intervention will consist of three supervised stretching-toning sessions per week also for 6 months. Following the exercise interventions, participants will receive either one year of ongoing telephone behavioural support or no telephone support. The primary aim is to determine the independent effect of aerobic exercise on a cognitive composite score in participants allocated to this intervention compared to participants allocated to the stretching-toning group. Secondary aims are to examine the effects of aerobic exercise on a number of secondary outcomes and determine whether aerobic exercise-related changes persist after a one-year behavioural support program (at 18 months).

Significance: This study will address knowledge gaps regarding the underlying mechanisms of the pro-cognitive effects of exercise by examining potential mediating factors, including cerebrovascular/physiological, neuroimaging, sleep, and genetic factors that will provide novel biologic evidence on how aerobic exercise can prevent declines in cognition with aging. Trial Registration: ClinicalTrials.gov (NCT03035851); protocol paper published (Kruger et al., 2021).

Timeline for these opportunities:

By December 15, 2022– Deadline for prospective students to submit i) a letter of interest, ii) a curriculum vitae, iii) a list of publications and awards, and iv) the names of 3 referees who have agreed to be contacted to bimstudy@ucalgary.ca. Prospective supervisors, co-supervisors and doctoral students will complete the application process for matching funds with support from the Brain in Motion team. The start date for the doctoral program will be between May – September 2023.

Contact information

For more details please contact:

Dr. Marc Poulin, Lead Investigator for the Brain in Motion team
Department of Physiology & Pharmacology
Cumming School of Medicine
University of Calgary
Calgary, Alberta

Email: poulin@ucalgary.ca
Email: bimstudy@ucalgary.ca

Post Doc Position-Neurotrophic mechanisms in brain diseases – Centre for Addiction and Mental Health, Toronto

Reduced brain cell structure and function contributes to cognitive symptoms in depression, Alzheimer’s disease and other brain disorders, and during aging. Current efforts aimed at developing therapeutic agents to reverse these deficits focus on excitatory or neurotrophic mechanisms, but have had limited translation to effective therapeutics potential, identifying a world-leading unmet clinical need with significant impact on patients, family, society and healthcare.

The Neurobiology of Depression and Aging program (www.NDA-sibille.ca) is seeking a postdoctoral fellow to investigate the cellular mechanisms of novel neurotrophic approaches, using cell-based and rodent models. The NDA program investigates the molecular bases of psychiatric disorders and develop novel therapeutic avenues. It is located at the Centre for Addiction and Mental Health (CAMH), Canada’s largest mental health and addiction teaching hospital. CAMH is fully affiliated with the University of Toronto.

Qualifications:

The candidate will have a PhD in Neuroscience, Neuropharmacology or a related discipline, with demonstrated expertise in molecular neuroscience, including primary neuron culture and in vivo rodent models. Experience with methods related to molecular biology (plasmid DNA handling, qPCR, Western blot, proteome analysis, recombinant virus handling etc.), pharmacology, immunohistochemistry and imaging (confocal microscopy, morphometric analysis) is preferred.
The successful candidate will have a track record that demonstrates competence in publishing in high impact peer reviewed journals, disseminating research at formal scientific meetings, writing grant proposals and participation in the education of students and trainees. The successful candidate will also possess strong interpersonal, organizational and communication skill, and the ability to work both independently and in a team. The ability to interact with populations of diverse ethno-racial and cultural backgrounds is also required.

Please note: This full-time position is NOT part of any bargaining unit.

Salary Range: Competitive Salary

Contact information

Send your application with cover letter and CV to: Etienne.sibille@camh.ca

Download a PDF version of this advertisement

Posting end date: 2022/10/21

ERC-funded project: neural control of locomotion before and after spinal cord injury in salamanders – Post-doc position

PROJECT: Salamanders can swim underwater and walk on ground. Their spinal cord regenerates after a full transection and the animal recovers voluntary locomotion after a few weeks. How this occurs is largely unknown. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualization of genetically-defined cells. Such approaches can be combined with patch-clamp electrophysiology, calcium imaging, optogenetics, tracing and movement analysis (Ryczko et al. 2020 Trends in Neurosciences, https://doi.org/10.1016/j.tins.2020.08.006). The candidate will use electrophysiology, calcium imaging and movement analysis based on deep learning and neuroanatomy to study salamander locomotor circuits. This project is funded by a synergy grant of the ERC. The work will be carried out in collaboration with a team of modelers and roboticists (Pr. Ijspeert, EPFL, Switzerland) and experts in genomics (Pr. Simon, Karolinska Institute, Sweden).

REQUIREMENTS: The candidate should have completed a PhD in neuroscience. The ideal candidate would have experience in patch-clamp electrophysiology, calcium imaging, optogenetics, virus injections, deep learning-based movement analysis, or matlab scripting, and a keen interest in motor control.

HOST LABORATORY: The lab of Dr. Ryczko (https://ryczkolab.wordpress.com/) has expertise in the neural control of locomotion and publishes in excellent journals (PNAS, Science Robotics, Journal of Neuroscience…). The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC. We are equipped for patch-clamp recordings, confocal and two photon calcium imaging, optogenetics, viral injections, deep learning-based movement analysis, and microscopy (confocal, light-sheet, two-photon, STED).

APPLY: Candidates should send a letter of interest explaining how they would fit, a CV, a record of their academic results and three references at: dimitri.ryczko@usherbrooke.ca. Please mention where you found the job post.

Postdoctoral positions available in neuroimmunology in Calgary, Canada

The laboratory of Dr. Wee Yong (Pubmed: Yong VW or Wee Yong V) at the University of Calgary is recruiting postdoctoral fellows in neuroimmunology. The successful candidate is recently graduated or about to finish a PhD program. Available are several projects on the roles and mechanisms of neuroimmunology in mediating injury or recovery in multiple sclerosis. Please send your resume to vyong@ucalgary.ca. Calgary offers a world-class neuroscience program and superb indoor/outdoor activities.

https://live-cumming.ucalgary.ca/labs/reparative-neuroinflammation/home

Contact information:

Wee Yong

vyong@ucalgary.ca

Download a PDF version of this advertisement

Post-doctoral fellow positions – Vulnerable Brain Lab at Western University

The Vulnerable Brain Laboratory (www.vulnerablebrain.com), in the Dept. Anatomy and Cell Biology at Western University is a cross-disciplinary, translational lab interested in interrogating the role of microglia activation in aging and disease/injury. We are currently recruiting 1-2 post-doctoral fellows with interests developing assays aimed at using circulating brain extracellular vesicles as a diagnostic tool for measuring brain inflammation and cognitive impairment in cell, experimental animal, and human samples. Additionally, we are searching for candidates with interests in extracellular vesicle trafficking and release, and proteomic/lipidomic analysis of extracellular vesicles and their cargo.

Previous experience some of the following is preferred: rodent based stroke models, cell culture, rodent behaviour, molecular biology, microscopy, histology, and mass spectrometry, including mass spectrometry imaging.

Western University is strongly committed to principles related to equity, diversity, inclusion, and decolonization (EDID). We encourage applications from all qualified candidates, including women, members of visible minorities, Aboriginal persons, members of sexual minorities and persons with disabilities.

Contact information

Please send a cover letter, CV, and a list of 3 references to Dr. Shawn Whitehead (shawn.whitehead@schulich.uwo.ca). We will notify applicants prior to contacting references.

 

Postdoc and graduate students (Master’s and/or Ph.D. levels) positions at intersection of AI and Neuroscience – University of Lethbridge

Description: We are looking for postdocs and graduate students (Master’s and/or Ph.D. levels) to use inspirations from neuroscience to make better AI and conversely to apply AI to better understand brain function and behaviour. Projects will be related to our recent work:

Neurons learn by predicting future activity. Nature Machine Intelligence 2022 https://www.nature.com/articles/s42256-021-00430-y

Predictive neuronal adaptation as a basis for consciousness. Front in Sys Neurosci 2022 https://www.frontiersin.org/articles/10.3389/fnsys.2021.767461/full

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice. Nature Methods 2021 https://www.nature.com/articles/s41592-021-01104-8

A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling. Elife 2020 https://elifesciences.org/articles/54540

Challenges of a small world analysis for the continuous monitoring of behavior in mice. Neuroscience and Behavioral Reviews 2022 https://www.sciencedirect.com/science/article/pii/S0149763422001105

Data-driven analyses of motor impairments in animal models of neurological disorders. PLoS Biology 2019 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000516

The project is a collaborative effort between the research groups of Majid Mohajerani (http://lethbridgebraindynamics.com/majid-mohajerani/) and Artur Luczak (http://lethbridgebraindynamics.com/artur-luczak/). Successful candidates will join the highly collaborative and interdisciplinary Canadian Centre for Behavioural Neuroscience and Brain Dynamics group. We are located close to Rocky Mountains, Lethbridge has the largest number of sunny days in Canada, and it is the most affordable city for young people in Canada (https://dailyhive.com/calgary/alberta-city-most-affordable-young-people ).

The applications review will start on Aug 15th till the positions are filled. Interested applicants must send an email to Dr Mohajerani (mohajerani@uleth.ca) and Dr. Luczak (luczak@uleth.ca) and include a cover letter, curriculum vitae, a brief statement of research interests, and contact information of three references.

Postdoctoral positions in Systems Neuroscience-University of Calgary

The Sargin lab at the University of Calgary is seeking motivated scientists with experience and interest in Neurophysiology and Systems Neuroscience. The goal of our research program is to understand the long-term effects of early life stress on brain function. We have fully-funded two postdoctoral positions available to start immediately. The projects will focus on 1) the activity of neural circuits in mouse models with social deficits and 2) serotonin physiology in mouse models of Alzheimer’s Disease. We use a variety of multidisciplinary techniques including stereotaxic viral delivery, slice electrophysiology, in vivo calcium imaging, optogenetics and behavior.

Ideal candidates will have a PhD in Neuroscience, Physiology or related fields and experience with patch clamp electrophysiology. Strong background in neuroscience or physiology is required. Experience with photometry or optogenetics and mouse behavior is advantageous.

Dr. Sargin’s research group is a part of the Department of Psychology, Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute and the Mathison Centre for Mental Health Research and Education. Our group is in a highly collaborative, interdisciplinary and international research environment that provides opportunities to develop new skills and collaborations. Our lab, department and university are committed to fostering and enhancing diversity, equity and inclusion. We welcome all applicants of diverse backgrounds.

To apply, please send a cover letter describing research background and interests along with a CV to Dr. Derya Sargin at derya.sargin@ucalgary.ca

Contact information

derya.sargin@ucalgary.ca

Posting end date

2022/10/21