Clinician Scientist Fellowships – University of Alberta

The Neuroscience and Mental Health Institute (NMHI) at the University of Alberta is offering two fellowships to attract outstanding clinician scientists in training to the University of Alberta to conduct postdoctoral research in neurology and neuroscience: The Mildred I. Olsen Neurology Fellowship and The University Hospital Foundation Neurology Fellowship.

To apply:

  • Your supervisor must be a member of the NMHI (applicants must identify and contact a potential NMHI supervisor before applying);
  • You must hold an MD and plan to work in an area that falls within the NMHI research areas;

The value of each fellowship is $70,000 to be used towards salary costs; supervisors are responsible for benefits. The awards are tenable at the University of Alberta.

Deadline for Applications: August 31, 2021

About the NMHI: The NMHI is a multi-faculty, interdisciplinary teaching and research institute located at the University of Alberta. It is home to over 150 scientists and clinicians, spanning across all areas of neuroscience and mental health.

Contact information

nmhicoms@ualberta.ca

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Posting end date

2021/08/31

 

Post-Doctoral Fellowship in Experimental Quantum Neuroscience – University of Waterloo

The Quantum Neuroscience research group at the University of Waterloo, Canada is seeking an outstanding applicant for a Post-Doctoral Fellowship with experience in electrophysiology and molecular neuroscience.

Motivated by growing interest in the possibility that quantum effects may be at play in neuroscience, the University of Waterloo Quantum Neuroscience research group is aiming to find experimental evidence of novel quantum effects across established mammalian models used in experimental neuroscience. Specifically, the project will focus on studying the effects lithium isotopes may have on the electrophysiological activity of rodent-derived brain tissue. The demonstration of a lithium isotope effect in brain activity will be of great interest in helping to shed light on its mode of action. Of particular interest, a lithium isotope effect on animal behaviour was previously reported by Sechzer et al. [DOI:10.1016/0006-3223(86)90308-2] and, more recently, by Ettenberg et al. [DOI:10.1016/j.pbb.2020.172875]. In addition, the Waterloo Team recently obtained experimental evidence for a lithium isotope effect on electrical responses of rodent brain tissue. The post-doctoral fellow will extend this work using electrophysiology and other biochemical and biophysical methods.

The Waterloo Quantum Neuroscience research team consists of four faculty members: Zoya Leonenko, Michel Gingras, John Mielke and Michael Beazely and 12 undergraduate and graduate students. The team adopts an interdisciplinary approach that brings together expertise in theoretical physics, experimental biophysics, molecular pharmacology and neuroscience. The Waterloo team is part of the International Quantum Brain Network and works on this project in collaboration with Matthew Fisher at the University of California at Santa Barbara and four other research laboratories and is funded by an industrial pharmaceutical partner.

As a part of this project, we are seeking a post-doctoral level scientist with the following key characteristics and skills:

  • neuroscience-related, or biophysics doctoral degree
  • demonstrated expertise in the recording of field potentials (ideally, using multi-electrode arrays)
  • demonstrated research excellence in publications and presentations
  • well-developed ability to write in English
  • strong ability to work effectively within an inter-disciplinary team (involving biologists, physicists, and trainees at all levels)
  • detail-oriented with strong organizational skills
  • expertise with statistical tools typically used in biophysics and medical science
  • training in basic molecular biology techniques (such as Western blotting) is a plus

Expected duties and responsibilities:

  1. design and execute experiments
  2. work with team members to identify experimental goals and the research plans needed to reach these targets
  3. use a multi-electrode array (MED64) to perform field recording experiments from tissue slices acutely prepared from rodent brain
  4. analyze and present data, prepare written reports, and manuscript drafts
  5. analyze and present data for regular lab meetings
  6. present results (in poster, or oral form) at scientific meetings
  7. mentor junior trainees
  8. serve as a role model for junior-level trainees by providing constructive feedback and maintaining a friendly disposition

The position is initially for a 12-month appointment, with the possibility of renewal for up to three years, depending on performance. Applications will be considered until a suitable applicant is found. The start date can be as early as May 1, 2021.

To apply, please send a cover letter (2 pages maximum), a CV (including your education, scientific skills, your research experience and list of publications) and contact information for at least three senior researchers familiar with your research credentials and expertise who could provide a letter of reference on your behalf.

Contact information

Please send your application by email to: qneuro.uwaterloo@gmail.com with subject line: PDF Applicant QNeuro; Last name, First name.

Posting end date: 2021-10-01

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Postdoc position in neural stem cell biology – University of Toronto

The Yuzwa lab in the Department of Laboratory Medicine and Pathobiology at the University of Toronto is seeking to hire a Post-doctoral Fellow. Work in our lab aims to understand how cell genesis occurs in the developing and mature brain under conditions of healthy physiology and disease. To do so, we are currently studying the role of cell signaling inhibition and developing/applying tools to probe lineage and spatial relationships in the brain. Such studies typically involve the use of traditional neurobiological approaches (immunostaining, primary culture, transgenics, etc.) and tools from systems-biology (single-cell genomics and spatially-resolved transcriptomic approaches).

The successful applicant, working independently with consultation from the Principal Investigator (PI), will apply and advance the aforementioned systems-biology tools to characterize neural stem cell biology and the impacts of disease on these cells. The applicant will also be required to validate and test predictions resulting from these data using biochemical, primary neural culture, small animal surgery or transgenic based approaches.

Primary responsibilities will largely include carrying out an independent research project as described above. However, the applicant may be required (as directed by the PI) to 1) work with and train graduate/undergraduate students; 2) help ensure the smooth functioning of the lab (such as maintaining supplies and equipment) and; 3) collaborate with internal/external research groups.

Qualifications (Minimum):

Education: Applicant must hold a PhD or equivalent degree (within 3 years of being awarded) by the agreed upon start date in neuroscience, molecular biology, molecular genetics, cell biology, biochemistry or a related discipline.

Experience: Applicant must demonstrate a strong record of research achievement as evidenced by the ability to prepare and publish scientific manuscripts in major journals and present research findings at scientific meetings. Familiarity with any one or more of the following: neurobiology, synthetic biology, bioinformatics or single-cell genomics would be an asset.

Skills: Prior training in cell culture and molecular biological techniques is required (at minimum). In addition, the successful applicant must possess a number of the following skills: experience with transcriptomics/next-generation sequencing; experience with experimental design and trouble-shooting; ability to adapt and learn new techniques; strong communicator (both oral and written); excellent analytical and problem-resolution skills; good time management and organization skills with the ability to work on multiple competing tasks. Ability to complete University of Toronto certification in chemical, biosafety and animal care, procedures will be required.

Contact information

Please forward a cover letter, CV and names and contact information for three references to:

Dr. Scott Yuzwa
Department of Laboratory Medicine & Pathobiology
University of Toronto
Medical Sciences Building, 1 King’s College Circle,
Toronto, ON M5S 1A8
yuzwalab.ca
Email: scott.yuzwa@utoronto.ca

Posting end date 2021/04/26

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Two Postdoc positions are available to study the role of primary cilia in neurodevelopment – University of Calgary

Two postdoctoral fellow positions in the field of Neuroscience are immediately available in the research group of Dr. Jiami Guo, Calgary University, Alberta, Canada. The research team focuses on the function of primary cilia, under-appreciated cellular antenna, in brain development and function and how disrupted cilia contribute to neurological disorders such as intellectual disabilities, autism spectrum disorders, and glioblastoma.
Interested applicants must have a Ph.D. and/or M.D. degree in a field related to Neuroscience or Biomedical sciences.

For position 1, previous research experience with neurodevelopment, human/mouse genetics, iPSC, biochemistry, molecular cloning, organoids, single-cell RNAseq, next-generation RNAseq will be considered a plus;

For position 2, 2-photon live imaging, in vitro and in vivo electrophysiology, optogenetic/chemogenetic neural circuit manipulations, rodent behavioral assays, neural surgeries and viral delivery of genes will be considered a strong plus. This position will be co-supervised by another PI who is a leading expert in these techniques.

Successful applicants will be highly motivated and energetic individuals with good communication skills, interest and experience in neuroscience/cell biology /developmental biology /genetics, and will have a proven publication record and the ability to work independently.

The research group of Dr. Jiami Guo is part of the Department of Cell Biology and Anatomy. Dr. Guo is a New York Stem Cell Foundation Robertson Investigator, a member of the Alberta Children’s Hospital Research Institute and Hotchkiss Brain Institute. These institutes provide an international, dynamic and collaborative research environment and stimulate innovative basic and biomedical research.

To apply, please send a cover letter describing research background and interests, plus Curriculum Vitae with a complete list of all your journal publications and the contact information of 3 professional references to Dr. Jiami Guo (email: jiami.guo@ucalgary.ca)

Postdoctoral or Graduate Student Position: Corticothalamic synaptic physiology in a Rett Syndrome mouse model

Corticothalamic synaptic physiology in a Rett Syndrome mouse model

2 year funded Postdoctoral position, University of Victoria, BC Canada – available immediately

Rett syndrome is a neurodevelopmental disorder which manifests postnatally due to loss of function of an X-linked transcription factor MECP2, which controls various aspects of neuronal and synapse maturation. Studies will be performed primarily on female mice heterozygous for Mecp2 in which approximately half of neurons express the wild type and half the mutant allele. By utilizing a GFP-based nuclear marker we identify neurons expressing the wild-type or non-functional (mutated) Mecp2 allele for targeted physiological recordings. Optogenetic stimulation of virally-expressed channel rhodopsin will be used to investigate the relative strength of input from thalamus to cortex and feedback from cortex to thalamus for mutant versus wildtype neurons. Preference will be given to a researcher with experience in whole cell patch clamp recording (current and or voltage clamp) in acute brain slices or in vivo. Funded by the International Rett Syndrome Foundation. Contact Dr. Kerry Delaney, kdelaney@uvic.ca

More information about UVic Neuroscience can be found at https://www.uvic.ca/medsci/neuroscience/

The Delaney lab: https://web.uvic.ca/~neurolab

Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=delaney+rett

Victoria as a place to live:
https://www.tourismvictoria.com

 

Contact information

kdelaney@uvic.ca
250 472 5657

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Postdoctoral position in computational neuroscience | CAMH, University of Toronto

We will study cortical processing in health and depression in pre-clinical animal models using large-scale simulations of rat cortical microcircuits (in collaboration with the Blue Brain Project). The position is for 2 years, with anticipated start time in June 2021.

Interested applicants with publications and experience in computational neuroscience, who have completed their PhD in the last 5 years, are invited to send their CV to Dr. Etay Hay (etay.hay@camh.ca). In support of diversity, women are particularly encouraged to apply.

Hay lab for brain microcircuit modelling is located at Krembil Centre for Neuroinformatics, within the Centre for Addiction and Mental Health (camh). We are fully affiliated with the University of Toronto, and situated at the main campus, downtown Toronto.

Contact information:

Dr. Etay Hay (etay.hay@camh.ca)

IBRO – MBL and CSHL Fellowships

The IBRO (International Brain Research Organization) US-Canada Regional Committee (USCRC) is pleased to announce our 2021 fellowships program that will cover the cost for PhD students and postdoctoral fellows training in neuroscience in Canada to attend advanced neuroscience courses or meetings at the Marine Biological Laboratories (MBL) at Woods Hole, MA., and Cold Spring Harbor Laboratory (CSHL), NY.

For MBL, all trainees are welcomed to apply but preference will be given to trainees belonging to minority groups (Indigenous communities in Canada, visible minorities, persons with disabilities, women, and other minorities) as
well as those in non-U15 Universities (http://u15.ca/). The MBL awards will cover the cost of tuition, room, and board. Fellowships are worth up to $11,000 per trainee depending on the course taken.

For CSHL, reduced registration fees for virtual meetings are available for trainees from non-U15 Universities (http://u15.ca/). If in-person courses resume in the second half of 2021, partial tuition support of up to $8,000 per trainee will be available.

The aim of this program is to increase diversity in neuroscience in Canada, by providing such trainees with access to cutting-edge research training in contemporary neuroscience.

Interested trainees should submit applications directly to the course of interest (see link below). Evaluation of applications and offers of admission to courses are made by the course leaders. Accepted candidates with the backgrounds mentioned above will be automatically considered for IBRO fellowship.

Eligible MBL courses: Neural Systems and Behavior, Neurobiology: Mechanisms & Advanced Approaches, Methods in Computational Neuroscience, Biology of the Inner Ear: Experimental and Analytical Approaches, Brains, Minds and Mechanisms, Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches, and Frontiers in Stem Cells and Regeneration.

Eligible CSHL courses: see link below.

MBL: http://www.mbl.edu/education/courses/
CSHL: https://meetings.cshl.edu/meetingshome.aspx

Please inform us when applying or if you have questions about eligibility.

Contact: sam.david@mcgill.ca

Post-doctoral Research Fellow position in clinical neurophysiology at The Hospital for Sick Children

Post-doctoral Research Fellow position in clinical neurophysiology

Neurological Outcome of Glycemia in Neonatal Encephalopathy

The Neurosciences & Mental Health Program at the Hospital for Sick Children Research Institute is seeking an enthusiastic postdoc researcher to work in close collaboration with neurologists, neurophysiologists, and neuroradiologists in analysing pre-existing continuous glucose, EEG, and clinical data.

With the direction of principal supervisors Drs. Emily Tam and Cecil Hahn, you will work closely with affiliated staff and students who form a group that use neuroimaging and neurophysiology to study newborn brain disorders.

Despite therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE), rates of death and major disability continue to be high. Using continuous glucose monitoring, we have found that hyperglycemia occurs in more than 50% of HIE, associated with brain injury and possibly long-term outcomes. This study uses continuous glucose data paired with continuous electroencephalography (cEEG) and detailed clinical data to determine the temporal relationships between abnormal glycemia and brain function.

This is part of an ongoing project that is funded by the Canadian Institutes of Health Research (CIHR) and the National Institutes of Health (NIH).

A substantial amount of data already exists for this project and the motivated researcher will be able to jump straight into analysis.

Requirements

  • PhD in a relevant area (engineering or computer sciences) required.
  • Must have experience with EEG analyses
  • Well developed skills in data science is required.
  • Computer programming (Matlab, Python, or R) and/or signal processing/time series analyses.
  • Proven experience in research commensurate with your level of experience post-PhD.
  • Experience in analysis of neurophysiological data is preferred.
  • Experience in clinical research would be an asset.
  • Excellent communication skills (oral and written).
  • Be able to work independently and meet deadlines.

We offer

  • Initial contract will be for a period of 1 year, with the possibility of extension for a second year.
  • We offer a competitive salary based on qualifications and experience.
  • In addition, we offer an attractive benefits package, that includes extended health and dental coverage.
  • Toronto is a world-class rated in the top ten cities worldwide for livability that has a large and rich neuroscience community.
  • The Research Institute offers many opportunities for career development and additional training as part of the Research Training Centre.

Additional information

The post is available from 4th January 2021.

Contact Dr. Emily Tam via emily.tam@sickkids.ca for more information.
If you wish to apply directly, please send a CV, a cover letter with research statement/interests, and the names of two references.

Please use the following direct link to the job posting to apply to the position via the SickKids website:

https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=13321&PostingSeq=1&

Postdoctoral position in cellular/computational Neuroscience: Katalin Tóth, uOttawa Brain and Mind Institute

Applications are invited for a postdoctoral fellowship starting immediately at the University of Ottawa to investigate features of synaptic signal integration and microcircuit function using experimental and computational approaches. The researcher will join a collaborative group with expertise in cellular electrophysiology, two-photon imaging, and advanced computational modelling and statistical processing (Drs Katalin Toth and Richard Naud). Expertise in cellular electrophysiology and/or in two-photon cellular imaging is required. This fully funded position with attractive conditions is available immediately. The candidate is expected to be competitive for external fellowships.

The researcher will join uOttawa’s Brain and Mind Research Institute’s Center for Neural Dynamics (Department of Cellular and Molecular Medicine; Faculty of Medicine). uOttawa’s Neuroscience community is fast expanding, highly dynamic and offers a rich array of collaborative opportunities. Ottawa, the capital of Canada, is a green, multi-cultural city that offers the highest standard of living in the country and is second worldwide for quality of life (Numbeo index, 2015). The city has many parks including the Unesco World Heritage Rideau Canal and is surrounded by an extensive greenbelt. This bilingual, culturally-rich city lies along the border between the province of Quebec and Ontario and is within driving distance to Montréal and Toronto.

Employer Profile:

The University of Ottawa is a bilingual research university in Ottawa, Ontario, Canada. The university offers a wide variety of academic programs, administered by ten faculties. It is a member of the U15, a group of research-intensive universities in Canada. In the Maclean’s 2015 Canadian University rankings, the University of Ottawa ranked 2nd for Medical/Science Grants, 2nd for Scholarships & Bursaries and 1st for Student Services in the Medical/Doctoral University category.

Please send CV, statement of research interest and names of three references to: Katalin Toth (ktoth@uottawa.ca).

Three-years funded Postdoctoral Fellow in Multiscale Mechanisms in Alzheimer’s Disease – Montreal Neurological Institute, McGill University

Postdoctoral Researcher in Molecular and Brain Macroscopic Mechanisms in Alzheimer’s Disease

We are looking for a highly motivated postdoctoral researcher, for joining the Neuroinformatics for Personalized Medicine lab (NeuroPM) at the Montreal Neurological Institute (McGill University, Montreal, Canada). The postdoc will be under the primary supervision of Prof. Yasser Iturria-Medina and will collaborate with multiple associated groups, including the McGill Center for Studies in Aging, CERVO – Laval Univ., Lady Davis Research Institute, Yale Child Study Center and Litwin Family Centre in Genetic Medicine. The project, initially funded for 3 years and potentially extendable, includes the analysis of molecular and macroscopic brain alterations in AD, with a particular interest on characterizing disease evolution with novel computational techniques. For examples, see our recent publications: https://doi.org/10.1093/brain/awz400 and doi.org/10.1016/j.neuroimage.2018.06.028

The NeuroPM lab (http://www.neuropm-lab.com/) is affiliated with the Healthy brain for Healthy Lives (HBHL) initiative (https://www.mcgill.ca/hbhl/), the Ludmer Center (http://ludmercentre.ca/), and the McConnell Brain Imaging Center (https://www.mcgill.ca/bic/), involving computationally intensive and interdisciplinary research on the brain. The MNI is an internationally renowned institution, characterized by the integration of research and patient care.

Interested candidates should have a solid background and multiple publications in genetics and brain imaging in neurodegeneration. Experience in brain computational modeling will be an asset. Interested persons should send their CV and two reference contacts.

Contact information

Yasser Iturria Medina, Email: yasser.iturriamedina@mcgill.ca