Post-doc position on the neurobiology of epilepsy – Electrophysiology – E. Rossignol lab, Université de Montréal

Location:             Centre Hospitalier Universitaire Sainte-Justine (CHUSJ)
Affiliation:          Université de Montréal
City:                      Montreal, QC, Canada
Posting date:     April 27th 2022

Deadline:            Open until filled

 

Job Description: Post-doc position on the neurobiology of epilepsy – Electrophysiology

The E. Rossignol lab is looking for a motivated and dynamic post-doctoral candidate to join the Neurobiology of Epilepsy Research program, in the Brain Development and Disease Axis (CHU Sainte-Justine), affiliated with the Neuroscience Department (Université de Montréal).

The Rossignol lab investigates the cellular and network mechanisms of childhood epilepsies and associated neurodevelopmental disorders. Using Next generation Sequencing in patients to identify new genetic causes of the diseases, as well as gene-edited rodent models of these disorders and combinations of genetic, cellular and functional in vitro and in vivo assays, the team addresses how disease mutations in novel candidate genes modify cortical network development and function, in a quest to clarify disease mechanisms and foster new therapeutic development.

With support from the Canadian Institutes of Health Research (CIHR) and recent support from the National Institutes of Health (NIH), the Rossignol lab is expanding its efforts towards translational therapeutic screens and therapeutic development. For this reason, we are seeking a new team member with expertise in patch-clamp electrophysiology/synaptic physiology and/or in vivo recordings to provide important insights on the network perturbations underlying these disorders, while assessing therapeutic outcomes to novel therapies. These studies are the cornerstone of our translational efforts towards future clinical trials.

The CHUSJ is a vibrant academic environment, hosting 210 labs (450 students/trainees) working on various aspects of pediatric diseases and therapeutics. The institution is renowned for its contributions to rare pediatric disorders, personalized medicine, clinical genomics, large–scale studies and translational medicine. The Brain development and disease research group is composed of 50 research labs, including 10 neurobiology labs, with expertise in developmental neurosciences, genetics, electrophysiology, networks and computational neurosciences. The candidate will have the opportunity to interact closely with other labs and will get exposure to an array of techniques relevant to disease modeling and therapeutics. The Neurosciences Department at U. de Montreal is a productive and collaborative milieu, hosting an array of clinical and basic science labs, at the heart of Montreal, a vibrant city, renowned for its long-standing contributions to epilepsy research and Neurosciences.

Minimal requirements: PhD in Neurosciences or Physiology, with training in slice electrophysiology

Application should include: a letter of interest, university transcripts, CV and names of 3 referees

Please send you application to: elsa.rossignol@umontreal.ca

Postdoctoral fellowship – Neural basis of social behaviour – Choe Lab – McMaster University

The Choe Lab (http://choelab.ca) at the Department of Psychology, Neuroscience & Behaviour, McMaster University researches mechanisms underlying social behaviour using a multi-scale approach with a wide array of techniques including in vitro electrophysiology, molecular biology, confocal and lightsheet imaging, optogenetic and chemogenetics, in vivo fiber photometry recordings, mouse fMRI and behaviour assays. The postdoctoral fellow will conduct research projects related to our group’s core interests using any number of above listed approaches.

Previous experience with in vitro slice electrophysiology, confocal microscopy, and/or fMRI (especially using rodent models) is preferred but not necessary. In addition, previous experience with autism neurobiology, developmental neurobiology, and mouse behaviour would be beneficial.

McMaster University is strongly committed to employment equity within its community, and to recruiting a diverse faculty and staff. The University encourages applications from all qualified candidates, including women, members of visible minorities, Aboriginal persons, members of sexual minorities and persons with disabilities.

Please send a cover letter, current CV, and a list of 3 references to Dr. Katrina Choe at choek@mcmaster.ca. We will notify applicants before contacting any references.

Contact information

Dr. Katrina Choe, choek@mcmaster.ca.

Postdoctoral Position in Systems Neuroscience at the University of Toronto Scarborough

The Developmental Systems Neuroscience lab (www.devsneurolab.com) is looking for a postdoc to lead a fully funded project on the intersection of development, synaptic maturation and behavior in mice. Our work spans techniques such as chemo/optogenetics, fiber photometry and slice electrophysiology. We are looking for a highly enthusiastic postdoc to join our team.

Contact information

Please email your CV, statement of interest and the name of three references to m.arrudacarvalho@utoronto.ca

Postdoctoral Fellowship in Computational/Network Neuroscience at Université Laval

The Dynamica Research Lab, led by Antoine Allard and Patrick Desrosiers at Université Laval (Québec, Canada), seeks an exceptional candidate for a postdoctoral research associate to work on an innovative project at the intersection of Neuroscience, Computer Science and Network Science. The initial term of the position is one year, with the possibility of up to three years, and will begin no later than August 1st, 2022. Ideal candidates have:

  • a strong neuroscience and data analysis background;
  • a strong track record of innovative research and publications in selective venues;
  • significant experience in image processing, including cell segmentation in microscopy images;
  • relevant experience in programming and network modeling or graph theory.

The project will be done in close collaboration with Pierre Marquet’s lab at CERVO Brain Research Center and is part of an ambitious scientific partnership called The Neuro-CERVO Alliance for Drug Discovery (NCADD). The research work will focus on acquiring graph-theoretical fingerprints of major psychiatric diseases, including schizophrenia, bipolar disorders, and major depression disorder. The candidate will have to perform, among others, the following tasks:

  • analyze calcium imaging data and digital holographic microscopy data describing the function/structure of cultured neuronal networks obtained from patient-derived iPSCs;
  • implement and optimize computational methods for inferring graph models from functional/structural data;
  • compare the graph models to identify statistically significant variations between cohorts by exploiting the latest approaches in the field of graph comparison;
  • find robust disease-relevant phenotypic signatures;
  • maintain knowledge of current developments in the field, e.g. by attending conferences and workshops;
  • write and edit scientific articles.

Qualifications:

  • a Ph.D. in Neuroscience, Computer Science, Applied Mathematics, or in a similar field, conferred no later than July 2022;
  • education or training in neuroscience and data analysis;
  • significant experience in image processing and cell segmentation;
  • very good programming skills (preferably in Python);
  • strong verbal and written communication and presentation skills;
  • a commitment to working in an interdisciplinary and collaborative environment.

Applicants should submit the following:

  • a one-page cover letter that succinctly describes who you are and specifically mentioning why you want to join the Dynamica Research Lab;
  • a one-page statement of research interests and accomplishments, highlighting their relevance for the project;
  • a full resume or CV detailing your education, employment, research experience, publications and scientific presentations, alongside the contact information for at least two references;
  • an unofficial transcript of your academic record.

Contact information

Applications must be submitted by email to patrick.desrosiers@cervo.ulaval.ca with subject line Graph fingerprinting postdoc. Full consideration will be given to complete applications received before May 15, 2022.

Download this advertisement as a PDF: https://can-acn.org/docs/postdoc_cervo.pdf

Posting end date

2022/05/31

 

Multiple positions available at the Canadian Brain Research Strategy

The Canadian Brain Research Strategy (CBRS) is a community-led initiative uniting to advance Canada as a world leader in collaborative, transdisciplinary, open, and ethical brain research. Our objective is to make brain research a national priority by establishing a Canadian Brain Research Initiative.

We are looking to fill three roles but are flexible on the job descriptions and number of personnel:

  • Science Writer/Communicator to engage with our varied stakeholders and the public as we work to advance brain research as a national priority.
  • Program Assistant/Associate to help us coordinate a series of meetings and focus groups, and to synthesize these findings as we build a collective nation-wide strategy for brain research.
  • Program Manager to manage and facilitate the work of various multistakeholder teams to make advances in a series of strategic initiatives within our organization’s larger mission.

We welcome enthusiastic applicants with a passion for brain science who embrace a startup mentality and are looking to expand their professional skill set and for opportunities for growth. This job might be for you if you have a research background and are looking to develop a career path outside of academia.

You’ll get to work closely with top leaders in neuroscience and mental health research across the country and expand your network as we bring together the diverse neuroscience ecosystem – brain research initiatives and projects, public and private funders, health charities, as well as communities and patient organizations across the country – in a uniquely collaborative effort that will push the frontiers of brain science, for the benefit of all Canadians.

These positions are fully remote and the candidate can be located anywhere in Canada.

 

Download the full job descriptions here.

Email for more information on how to apply: info@canadianbrain.ca

We are looking to fill these positions immediately. Applications will be reviewed starting April 11th, 2022.

Closing date: Posting remains open until filled.

Postdoctoral position in neuroscience and stem cell biology

The Rylett lab at the Robarts Research Institute, Western University is seeking a highly motivated person interested in studying cellular and molecular events regulating chemical neurotransmission by cholinergic neurons and pathology associated with age-related neurodegenerative diseases, such as Alzheimer disease. Projects involve use of neuronal cultures, induced pluripotent stem cells with differentiation to neurons, genetically-modified mouse models, and require a strong background with extensive laboratory experience in molecular and cellular biology, biochemistry, confocal microscopy of fixed tissues and live cells, and/or protein chemistry and proteomics. The responsibilities of the candidate will include leading experimental design, acquisition and analysis of data, manuscript preparation and participation in student training. Successful applicants will have demonstrated excellent oral and written communication skills and ability to work effectively in a team environment. Qualified applicants for this position should have a PhD degree in biomedical sciences or a related discipline, with expertise in cellular and molecular neurobiology, stem cell biology and microscopy. Experience with genetically-modified mouse models of disease would be an asset. Review of applications will start May 1, 2022.
Please send a letter of application including a one-page description of past research experience and interests, CV, and names and contact information for three references.

Contact information
Dr. Jane Rylett
Robarts Research Institute
Western University
Email: jane.rylett@schulich.uwo.ca

Posting end date: 2022/09/01

Post-Doctoral Position in Pain Biology – SUNY-Buffalo

The Bhattacharjee Lab is searching for a postdoc to study basic pain mechanisms. The long-term objectives of our lab are to study and understand the plasticity of pain-sensing dorsal root ganglion neurons. We are especially interested in ion channel trafficking and identifying key protein interactions that are involved in this process. We believe that novel analgesics can be developed through an understanding of how ion channels are scaffolded at the membrane and how chaperones control the movement of these channels in and out of the membrane. Approaches include electrophysiology, neuronal isolation, molecular and biochemical techniques, and pain behavior. We are also seeking ways to develop intellectual property.

Work will extend our recent recent findings: https://www.nature.com/articles/s41467-021-26100-6

Contact information

If interested, please contact Dr. Arin Bhattacharjee directly (ab68@buffalo.edu)

Post-doctoral Fellow in Computational Biology, Bioinformatics and Neurobiology – University of Toronto

The Yuzwa lab in the Department of Laboratory Medicine and Pathobiology (LMP) at the University of Toronto is seeking to hire a Post-doctoral Fellow to work on an exciting project that will unravel lineage and spatial relationships between cells of the mammalian brain and the impacts of disease on these relationships. The primary approaches that will be applied in these studies are single-cell (scRNA-seq) and spatially-resolved transcriptomics (available in-house), the generation of novel DNA constructs (using molecular cloning), primary neural culture and in vivo studies, along with computational biology/bioinformatics to develop and apply tools to analyze the data.

The ideal profile of the successful applicant would be someone who: 1) has a strong training in wet-lab molecular genetics or neurobiology and has a keen interest in learning and applying computational/bioinformatic tools to analyze the data that are generated OR; 2) has a strong background in dry-lab computational biology/bioinformatics and is interested in working closely with individuals in the lab carrying out the wet lab experiments to analyze the data that are produced. The successful applicant will work independently, with consultation from the Principle Investigator (PI), to lead the data collection and analysis. Moreover, the applicant will assist in the dissemination of the data by assisting in the writing of manuscripts and presenting at scientific conferences. In addition, the applicant may be required (as directed by the PI) to work with and train graduate/undergraduate students and collaborate with internal/external research groups as needed.

Qualifications (Minimum)

Education: Applicant must hold a PhD or equivalent degree (within 3 years of being awarded) by the agreed upon start date in bioinformatics, computer science, neurobiology, molecular genetics or a related discipline.

Experience: Applicant must demonstrate a strong record of research achievement as evidenced by the ability to prepare and publish scientific manuscripts in major journals and present research findings at scientific meetings. As described above, applicants must (at minimum) have prior training in neurobiology/molecular genetics OR computational biology/bioinformatics and have a desire to work on an interdisciplinary project which merges these two areas.

Skills: For applicants with prior training in computational biology/bioinformatics: Experience in the analysis of NGS-based transcriptomic data is ideal. Familiarity with the analysis of scRNA-seq/spatially-resolved transcriptomic data is highly desirable. A strong background in the R language and the use of common R packages employed to analyze transcriptomic data would be assets. Some familiarity with Python/MATLAB/Unix/Linux environments and processing NGS data would also be advantageous.

For applicants with prior training in neurobiology/molecular genetics: Experience cloning DNA constructs, synthetic biology, primary neural cell culture, in vivo studies of the brain, immunohistochemistry/immunocytochemistry, and tissue sectioning would be assets.

In addition, regardless of prior training, the applicant must posses a number of the following skills: experience with experimental design and troubleshooting; ability to adapt and learn new techniques; strong communicator (both oral and written); excellent analytical and problem-resolution skills; good time management and organizational skills with the ability to work on multiple competing tasks.

Job Closing: Open until filled.

Available Immediately. Start dates up to September 2022 may be considered.

Salary:

The salary will be in the range of $50,000-$60,000 (CAD), commensurate of research accomplishments and experience. Employment as a Postdoctoral Fellow at the University of Toronto is covered by the terms of the CUPE 3902 Unit 5 Collective Agreement.

The normal hours of work are 40 hours per week for a full-time postdoctoral fellow (pro-rated for those holding a partial appointment) recognizing that the needs of the employee’s research and training and the needs of the supervisor’s research program may require flexibility in the performance of the employee’s duties and hours of work.

Diversity Statement

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

Accessibility Statement

The University strives to be an equitable and inclusive community, and proactively seeks to increase diversity among its community members. Our values regarding equity and diversity are linked with our unwavering commitment to excellence in the pursuit of our academic mission. The University is committed to the principles of the Accessibility for Ontarians with Disabilities Act (AODA). As such, we strive to make our recruitment, assessment and selection processes as accessible as possible and provide accommodations as required for applicants with disabilities. If you require any accommodations at any point during the application and hiring process, please contact lmp.hr@utoronto.ca

 

Contact information

Please forward a cover letter, CV and names and contact information for three references to:

 

Dr. Scott Yuzwa

Department of Laboratory Medicine & Pathobiology

University of Toronto

Medical Sciences Building, 1 King’s College Circle,

Toronto, ON M5S 1A8

Email: scott.yuzwa@utoronto.ca

 

Posting end date

2022/04/29

 

General Neurologists & Stroke Neurologists – Windsor General Hospital

Our client, Windsor Regional Hospital (WRH), is a multi-faceted health services organization operating from two main sites, the Metropolitan Campus and the Ouellette Campus. With 500 beds and an operating budget of over half a billion dollars, WRH is the regional provider of advanced care in areas that include complex trauma, renal dialysis, cardiac care, stroke and neurosurgery, intensive care, acute mental health, family birthing centre, neonatal intensive care, paediatric services, and regional cancer services. WRH provides a broad range of medical and surgical services required to support these specialized areas for more than 400,000 people in Windsor and Essex County. Windsor Regional Hospital is seeking: General Neurologists & Stroke Neurologists.

With increasing volumes, program development, and growing demands for service, WRH is seeking top tier General Neurologists and Stroke Neurologists to join their team. This is an exceptional opportunity to join an innovative, collegial, and mutually respectful team to contribute to neurology service delivery excellence.

Full time, part time, and locum opportunities are available. WRH is also interested in recruiting subspecialty neurologists to bring unique skills to the group and community.

As a designated Enhanced District Stroke Centre, Windsor Regional Hospital provides specialized services for stroke and TIA patients offering timely hyper-acute treatments like tPA and endovascular therapy (Thrombectomy and Coiling), as well as neurosurgical services. The hospital has neurologists, neurosurgeons, and interventional radiologists on staff providing expert care for stroke patients. Following intervention and post procedure recovery and stabilization in the ICU, patients are transferred to the Acute Stroke Unit, a designated 16-bed unit dedicated to the care of Stroke patients. Inpatient and outpatient rehabilitation services for Windsor-Essex are offered locally through Hotel-Dieu Grace Healthcare. Outpatient Rehab options direct from hospital also includes the Intensive Hospital to Home Rehab program and E-Rehab services provided through the Erie St. Clair LHIN.

Physicians at WRH have the opportunity to educate and mentor residents from the Schulich School of Medicine and Dentistry, with professional staff members eligible to hold a University appointment.

Candidates must be certified, or eligible for certification, by the Royal College of Physicians and Surgeons of Canada in Neurology and hold, or be eligible for, licensure with the College of Physicians and Surgeons of Ontario. Offering great flexibility and work/life balance, these positions include an attractive compensation and relocation incentive package.

The Windsor-Essex area is ecologically rich with extensive parkland combined with a southwest location that extends warm weather activities such a golfing, gardening, and water sports. Windsor offers the unique opportunities of a larger metropolitan area and the benefits of a smaller community. Living directly across the border from Detroit, Michigan places you on a cosmopolitan stage where arts, culture, big league sports, and entertainment are just moments away. Best of all, you can enjoy access to all of these big-city advantages while living in the tranquility and beauty of the Windsor region.

Please forward a CV in confidence to:
Robb Callaghan,
E-mail: rcallaghan@medfall.com
Tel: 289-238-9079

View a PDF version of this advertisement

Postdoctoral Fellow in axon regeneration – Montreal Neurological Institute, McGill University

We are looking for a highly motivated postdoctoral researcher to join our team at the Montreal Neurological Institute (McGill University, Montreal, Canada). The postdoc will be under the primary supervision of Prof. Alyson Fournier and will be collaborating with the lab of Molly Shoichet at the University of Toronto to test the effects of pro-regenerative and anti-scarring reagents in axon regeneration.

Interested candidates should have a solid background and publications in molecular neuroscience and some experience in small animal surgeries. Experience in the optic nerve lesion model would be an asset.

Interested persons should send their CV and two reference contacts to alyson.fournier@mcgill.ca.