Assistant Professor, Innate Immunity, University of Guelph

The Department of Molecular and Cellular Biology at the University of Guelph invites applications for a tenure-track position, at the rank of Assistant Professor, in the area of Innate Immunity.

We are seeking outstanding candidates whose research interests are at the interface of microbes (bacterial, fungal and/or viral) and the human innate immune system. Individuals investigating the interactions between commensal or pathogenic microorganisms and the physical barriers and cellular responses of the innate immune system are particularly encouraged to apply. The successful candidate may have expertise in a wide range of experimental approaches, including immunological, microbiological, biochemical, -omics technologies and other relevant strategies. The successful applicant is expected to establish an innovative and sustainable research program that will integrate with, and expand, the research strengths of the Department, and offer new avenues for collaboration.

Qualifications include a Ph.D., a preferred minimum of two years of relevant post-doctoral experience, a proven record of research excellence evident in high-quality publications and demonstrated potential to establish a competitive independent research program and secure research funding. The successful candidate must also demonstrate the potential to provide effective and innovative teaching to a diverse population of graduate and undergraduate students, and will be committed to promoting diversity, inclusion, and multicultural competence in an educational and work environment.

A culture of inclusion is an institutional imperative at the University of Guelph as this is vital to advancing innovation, critical thinking, solving complex problems, and creating a modern academic community. Willingness to work collaboratively with faculty and to mentor students from a wide range of disciplines, cultures, and academic backgrounds is essential. Therefore, we invite and encourage applications from all qualified individuals, especially from groups that are underrepresented in higher education. The Department is a collegial, inclusive, and welcoming environment that values diversity, and wellness among our members as key ingredients in our collective success.

The successful candidate will join a dynamic, multidisciplinary, research-intensive department with 44 faculty members who study diverse biological systems at levels from molecules to cells. The Department is the home of undergraduate programs in Biochemistry, Microbiology, Molecular Biology & Genetics, Neuroscience, and contributes to programs in Biological Science, Biomedical Science, and Plant Science. Graduate training activities include programs offering M.Sc. and Ph.D. degrees in Molecular and Cellular Biology, and a Master of Biotechnology degree. Faculty members also participate in cross-department programs, including Bioinformatics, Biophysics, Neuroscience, Plant Science, and Toxicology. The successful applicant will be expected to develop a creative and independent research program, sustained by external funding from national/provincial agencies, and contribute to graduate and undergraduate training.

The University of Guelph is the second largest employer in Guelph, a city of approximately 130,000 people, located about an hour drive west of Toronto, Ontario. The University of Guelph is a top-ranked comprehensive university in Canada with an enrolment of about 30,000 undergraduate and graduate students across over 40 academic units. The University is known for its commitment to student learning, innovative research, and collaboration with world-class partners. It is a unique place, with transformative research and teaching and a distinctive campus culture. People who learn and work here are shaped and inspired by a shared purpose: To Improve Life. Reflecting that shared purpose in every experience connected to our University positions us to create positive change, here, and around the world. Our University community shares a profound sense of social responsibility, a drive for international development, and an obligation to address global issues.

Application Process:

Interested candidates should submit the following materials as a single PDF file: (1) a cover letter indicating area(s) of research focus; (2) a curriculum vitae; (3) an overview of proposed research program (max. 1500 words; see below for additional details); (4) a teaching statement (max. 500 words); (5) a separate statement describing the strategies you will use to promote inclusion and support a diverse community in your research lab and classrooms (max. 500 words); and (6) contact information of three references. Assessment of applications will begin on October 31, 2020 and will continue until the position is filled.

Applications should be sent by email to the attention of:

Dr. Cezar Khursigara

Search Committee Chair

Department of Molecular and Cellular Biology

College of Biological Science

University of Guelph

Guelph, ON, Canada N1G 2W1

Email: mcbchair@uoguelph.ca

The overview of proposed research statement should be a maximum length of 1500 words (~ 3 pages) of 12pt font. This statement should:

  1. Detail the candidate’s specific area of expertise, with a description of their contributions to the field.
  2. Provide a detailed plan of their future independent research program, and how this program might be leveraged to obtain extramural funding.
  3. Indicate how the candidate’s research program will synergize with the Department’s research environment.

All qualified applicants are encouraged to apply; however, Canadians and permanent residents will be given priority.

The University of Guelph recognizes that applicants may have had obligations outside of work that have negatively impacted their record of achievements (e.g., parental, elder care, and/or medical). You are not required to disclose these obligations in the hiring process. If you choose to do so, the University will ensure that these obligations do not negatively impact the assessment of your qualifications for the position.

The University of Guelph resides on the ancestral lands of the Attawandaron people and the treaty lands and territory of the Mississaugas of the Credit and we offer our respect to our Anishinaabe, Haudenosaunee, and Métis neighbours as we strive to strengthen our relationships with them.

At the University of Guelph, fostering a culture of inclusion is an institutional imperative. The University invites and encourages applications from all qualified individuals, including from groups that are traditionally underrepresented in employment, who may contribute to further diversification of our Institution.

If you require a medical accommodation during the recruitment or selection process, please contact the University of Guelph Occupational Health and Wellness at 519-824-4120 x52674.

Contact information

Applications should be sent by email to the attention of:

Dr. Cezar Khursigara

Search Committee Chair

Department of Molecular and Cellular Biology

College of Biological Science

University of Guelph

Guelph, ON, Canada N1G 2W1

Email: mcbchair@uoguelph.ca

Posting end date

2020/10/31

Graduate student position: Influence of dopaminergic signals on motor plasticity and recovery – EthierLab – Université Laval

The laboratory of Dr. Christian Ethier is currently recruiting graduate students at the masters or PhD levels for a research project in the field of motor neuroscience to begin during the fall 2020 or winter 2021 semesters.

The goal of this project is to investigate the potential of dopaminergic signals to drive neuronal plasticity and promote motor recovery in rat models of stroke. The project will involve behavioural training, surgical injections and implants, optogenetics and immunohistochemistry, and will take place in the dynamic CERVO Brain Research Center.

Applicants from diverse scientific background will be considered, including engineering, biology and neurosciences. Priority will be given to students with knowledge or skills in:

  • Systems neuroscience
  • Motor system (cortex, basal ganglia, spinal cord function and anatomy)
  • Programming (Matlab, Python, C/C++)
  • Neural plasticity
  • Rodent behavioral tests
  • Dopaminergic systems and function
  • Chronic implants, rodent surgical skills
  • Electrical, optogenetic stimulation
  • Immunohistochemistry, RNAscope, Fluorescence imaging

Contact information

To apply or obtain further information, please send your CV, a motivation letter, and the name of 3 references to Christian Ethier directly: christian.ethier@fmed.ulaval.ca.

Posting end date

2020/09/25

Doctoral and Postdoctoral Researcher Position – Brouillette lab, Montreal

The Brouillette Lab at the Hôpital du Sacré-Coeur de Montréal (CIUSSS-NIM) invites applicants for a doctoral and postdoctoral researcher position in the field of Alzheimer’s disease and age-related memory deficits. Specific research topics include the effect of Aβ oligomers on sleep during aging, the impact of Aβ oligomers on different cell types in the hippocampus, the role of the phosphatase STEP on social memory, and blood biomarkers for early AD. We are using state-of-the-art equipment to perform laser microdissection, optogenetic, molecular/cellular biology, and behavioural testing with various animal models. These full-time positions and projects are supported by the Canadian Institutes of Health Research (CIHR) and the Weston Brain Institute. Funding is available for three to five years. The start date is immediate but flexible. Applications will be considered until the positions are filled. The annual stipend is consistent with CIHR funding levels.

Requirements

Candidates should have a degree in neuroscience, biochemistry, molecular/cellular biology, pharmacology, genetic, or a related field. Ideal applicants will have experience in molecular/cellular biology, animal behavioural testing, and knowledge of statistics. Additional preferred qualifications include experience with laser microdissection and optogenetic.

Contact information

Interested applicants should send their CV, a brief cover letter describing research experience and interests, university transcript, and contact information for 2-3 references by e-mail to Jonathan Brouillette (e-mail: jonathan.brouillette@umontreal.ca)

Principal Investigator
Dr. Jonathan Brouillette, Ph.D.
Assistant Professor
Department of Pharmacology and Physiology
Université de Montréal

Lab website:
https://pharmacologie-physiologie.umontreal.ca/recherche/chercheurs/jonathan-brouillette/
https://rechercheciusssnim.ca/profil/jonathan-brouillette/
https://recherche.umontreal.ca/nos-chercheurs/repertoire-des-professeurs/chercheur/is/in17687/

Graduate student position studying astrocyte-neuron interactions – Stobart laboratory, University of Manitoba

We are seeking a motivated graduate student with an interest in glial biology to work on an exciting project related to astrocyte ionotropic signaling and synaptic modulation. We have developed cutting-edge in vivo calcium imaging techniques to simultaneously monitor astrocyte and neuron activity and we will combine this with novel mouse models to probe astrocyte signaling in the tripartite synapse. There will be opportunities to learn animal handling, stereotaxic injection of AAVs, in vivo two-photon calcium microscopy, intrinsic optical imaging, histological techniques, behaviour testing, image analysis (with MATLAB), and statistics (with R). Please see our lab website for more information (www.stobartlab.com).
This work is funded by NSERC.

Eligibility:

  • Excellent academic standing
  • Strong written and oral communication skills
  • Good problem solving skills and the ability to think independently
  • Related lab experience is preferred (but not mandatory)

Successful candidates will be admitted to the graduate program through the College of Pharmacy, where they are expected to complete some course work in addition to research experiments. All students will be paid a stipend to cover tuition and living expenses.

Please submit a letter with statement of research interests, CV including research experience, a copy of recent transcripts and contact details for 2 references by email.

Contact information

Dr. Jill Stobart
Assistant Professor
College of Pharmacy
University of Manitoba
Apotex Centre
750 McDermot Ave.
Winnipeg, Manitoba
Canada

jillian.stobart@umanitoba.ca

Post-doctoral fellow position on the behavioural neuroscience of reward- Samaha laboratory – Universite de Montreal

Dr Anne-Noel Samaha’s laboratory at the Université de Montréal is looking for a post-doctoral fellow. I will hire someone whose primary expertise is in the behavioural neuroscience of reward.

Training in complementary techniques such as in vivo optogenetics, DREADDs, and in molecular biology assays is also important. The research work involves characterizing the neurobehavioural effects of different intravenous cocaine self-administration procedures in the rat.

If you have this expertise and are interested, please email anna.samaha@umontreal.ca

See also
https://pubmed.ncbi.nlm.nih.gov/?term=samaha+AN+montreal&sort=date

Candidates in Canada or who can easily travel to Canada will be given preference.

Contact information:

anna.samaha@umontreal.ca

Post-doc position – Neurodegenerative Disease Research – Clark lab at the University at Buffalo

The Clark Lab at the State University of New York at Buffalo is looking to build a team to investigate a second-generation preclinical model of Progressive Supranuclear Palsy (PSP). PSP is a devastating neurodegenerative disease, which shares attributes with Alzheimer’s Disease; tau protein aggregates, cognitive and motor deficits. Our goal is to identify neurons that are perturbed early in the disease process and that contribute to key aspects of the behavioral deficits and underlying pathology. This knowledge will allow for improved diagnosis and the initiation of pharmacotherapeutic discovery programs. We are seeking a Post-Doctoral Fellow to work with a team of graduate students and technical staff. The research duties will include surgical manipulation in rats followed by behavioral, biochemical, histological and MRI analysis.

If interested, please contact Dr. Stewart Clark directly (stewartc@buffalo.edu)

Post-doctoral Position Available in the Translational Cognitive Neuroscience Lab (Dr. Tim Bussey & Dr. Lisa Saksida) studying molecular and cellular mechanisms of information storage and neurogenesis in the hippocampus using cutting-edge neurotechnology (e.g., miniscopes, fiber photometry and touchscreen technology).

A postdoctoral position is available immediately under the supervision of Dr. Lisa Saksida and Dr. Tim Bussey at the Robarts Research Institute, Schulich School of Medicine & Dentistry, The University of Western Ontario (www.tcnlab.uwo.ca), in collaboration with the Dr. Mark Brandon and colleagues at McGill University (www.m3platform.org), to work on questions relating to molecular and cellular mechanisms of information storage and neurogenesis in the hippocampus. The work will involve recording and analyzing neuronal activity using miniscopes and fibre photometry, in combination with advanced cognitive testing using touchscreens (www.touchscreencognition.org).

Qualified applicants should have a PhD degree in Neuroscience or related disciplines with significant expertise in studying mouse models and advanced mathematical and analytical skills. Prior experience in miniscope data analysis, mouse surgery, fibre photometry, in vivo electrophysiology, or data analysis using MatLab, Python and R, documented in peer-reviewed publications will be an asset. Salary will be paid commensurate with experience.

Robarts is one of the premier research institutes in Canada with a vibrant research community and many opportunities for collaborations. The University of Western Ontario (www.uwo.ca) is a major educational and research centre in Ontario with over 25,000 undergraduate and 5,000 graduate students. Cognitive neuroscience in health and disease is a major research focus at Western, currently funded by a $66M Canada First Research Excellence Fund program called BrainsCAN. London, also known as the Forest City, is an affordable and lively community close to the Great Lakes and two hours from Toronto. The city offers many options for outdoor and cultural activities.

Western is committed to employment equity and diversity in the workplace and welcomes applications from women, members of racialized groups/visible minorities, Aboriginal persons, persons with disabilities, persons of any sexual orientation, and persons of any gender identity or gender expression.

Please send a statement of interest, Curriculum Vitae, and the names of at least two references to:

Dr. Lisa Saksida, Robarts Research Institute, University of Western Ontario Email: lsaksida@robarts.ca

Posting end date: 2020/12/31

Two year funded Postdoctoral position, University of Victoria – Kerry Delaney lab

Electrophysiology of mutant versus wildtype neurons in a mouse model of Rett Syndrome.

Researcher with experience in whole cell patch clamp recording from neurons in acute brain slices is required to undertake recording from neurons in neocortex and thalamus of mice lacking functional MeCP2. Mecp2 is an X-linked transcription factor controlling various aspects of neuronal and synapse maturation. Studies will be performed primarily on female heterozygous mice utilizing a GFP-based nuclear marker to differentiate neurons expressing wild-type Mecp2 from those expressing a non-functional (mutated) allele. Optogenetic stimulation of virally-expressed channel rhodopsin will be used to investigate the relative strength of thalamo-cortical connections and cortico-thalamic feedback pathways to wild-type versus mutant neurons. Funded by the International Rett Syndrome Foundation.

Contact Dr. Kerry Delaney, kdelaney@uvic.ca

More information about UVic Neuroscience can be found at https://www.uvic.ca/medsci/neuroscience/

The Delaney lab: https://web.uvic.ca/~neurolab

Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=delaney+rett

Contact information

Dr. Kerry Delaney.
Professor, Biology Department, University of Victoria
email: kdelaney@uvic.ca
Phone: 250-472-5657
The Delaney lab: https://web.uvic.ca/~neurolab

Download a PDF version of this advertisement

Posting end date: 2020-08-31

Post-Doctoral Fellow – SOAR Project (UBCO)

A Postdoctoral Fellow position is available to work on the SOAR (Supporting Survivors of Abuse and Brain Injury through Research) Project in the School of Health and Exercise Sciences at UBC-Okanagan

Research Program Overview A post-doctoral position is available in the Brain Injury Lab led by Dr. Paul van Donkelaar in the School of Health and Exercise Sciences at the University of British Columbia’s Okanagan campus. The successful candidate will be a key member of the SOAR project team investigating the cerebrovascular, neurocognitive, and sensorimotor effects of traumatic brain injury (TBI) in women who have experienced intimate partner violence (IPV). Our well-funded multidisciplinary program integrates researchers in clinical neuroscience, cerebrovascular physiology, psychopathology, social work, sociology, knowledge translation, and implementation science, with the goal of better understanding IPV-related TBI. As part of this, we are working with the Kelowna Women’s Shelter and other community partners to co-create, implement, and evaluate tools and resources to better support the women they serve. The incumbent would be expected to take a leadership role in the lab-based assessment of brain function in IPV-caused TBI and contribute to broader project goals in collaboration with other team members.

Qualifications PhD required. Experience with, or the capacity to acquire the necessary skills to undertake, the assessment of cerebrovascular, neurocognitive, and/or sensorimotor function following TBI. An understanding and/or knowledge of gender-based violence and its effects would be an asset. Seeking a creative individual who can integrate cerebrovascular, neurocognitive and sensorimotor measures of brain dysfunction following IPV-related TBI. The ability to further contribute to related projects in the lab on sports concussion and post-concussion syndrome is desirable.

Individuals must also:

  • Work well in a goal-oriented team environment
  • Have a proven track record of research accomplishments (i.e. publication record)
  • Possess excellent communication skills – both verbal and written
  • Have the ability to work independently and organize own workload
  • Have the ability to design and analyze experiments, keep meticulous records of experiments and data, report on research progress and outcomes openly, and review methodologies in response to feedback &
  • Have the ability to update knowledge in their specialized area and implement relevant technologies to advance the project.

Other considerations

This position is available from September 1st, 2020 and will be a based on a one-year renewable contract, extendable depending on funding availability. Salary will be commensurate with qualifications and experience. Candidates are strongly encouraged to apply for competitive fellowship awards.

A letter of application, accompanied by a detailed curriculum vitae including a list of publications, and contact details for 3 references, should be sent by email to:

Professor Paul van Donkelaar paul.vandonkelaar@ubc.ca

Please include “SOAR Project PDF search” in the e-mail subject line. Applications will remain open until the position is filled. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person. All qualified candidates are encouraged to apply; however Canadians and permanent residents will be given priority.

Contact information

Dr. Paul van Donkelaar
School of Health and Exercise Sciences
University of British Columbia – Okanagan Campus
Kelowna, B.C.
phone: 250-863-3230
email: paul.vandonkelaar@ubc.ca

Posting end date

2020/11/01

Postdoctoral Position on Astrocyte-Inhibitory Interneuron Interactions – Robitaille & Lacaille laboratories, Université de Montréal

Postdoctoral position
Dept Neurosciences
Université de Montréal
Montreal, Canada

A postdoctoral position is immediately available in the laboratory of Dr Richard Robitaille at Université de Montréal to study the role of astrocytes in the regulation of inhibitory synaptic circuits and hippocampal function. The project is funded by a NSERC Discovery grant and involves a collaboration with the laboratory of Dr Jean-Claude Lacaille.

The research focuses on the mechanisms of astrocyte regulation of inhibitory interneurons and their impact on hippocampus-dependent learning and memory. Our multidisciplinary approach uses brain slices and in vivo transgenic mice, and combines state-of-the-art molecular biology, synaptic physiology, 2-photon imaging, opto- and chemogenetics and behavioral assays.

Requirements are PhD in Neuroscience or related discipline, with expertise in single cell electrophysiology. Experience is also desirable with any of the following techniques: patch-clamp, optogenetics and calcium imaging. Successful candidates will be highly motivated, have strong work ethics, and ability to work independently as well as part of a team.

Interested applicants should submit a statement of research experience and career goals, a current CV and the names of three references to:

Contact information

Dr Richard Robitaille
richard.robitaille@umontreal.ca