Graduate student position: Influence of dopaminergic signals on motor plasticity and recovery – EthierLab – Université Laval

The laboratory of Dr. Christian Ethier is currently recruiting graduate students at the masters or PhD levels for a research project in the field of motor neuroscience to begin during the fall 2020 or winter 2021 semesters.

The goal of this project is to investigate the potential of dopaminergic signals to drive neuronal plasticity and promote motor recovery in rat models of stroke. The project will involve behavioural training, surgical injections and implants, optogenetics and immunohistochemistry, and will take place in the dynamic CERVO Brain Research Center.

Applicants from diverse scientific background will be considered, including engineering, biology and neurosciences. Priority will be given to students with knowledge or skills in:

  • Systems neuroscience
  • Motor system (cortex, basal ganglia, spinal cord function and anatomy)
  • Programming (Matlab, Python, C/C++)
  • Neural plasticity
  • Rodent behavioral tests
  • Dopaminergic systems and function
  • Chronic implants, rodent surgical skills
  • Electrical, optogenetic stimulation
  • Immunohistochemistry, RNAscope, Fluorescence imaging

Contact information

To apply or obtain further information, please send your CV, a motivation letter, and the name of 3 references to Christian Ethier directly: christian.ethier@fmed.ulaval.ca.

Posting end date

2020/09/25

Doctoral and Postdoctoral Researcher Position – Brouillette lab, Montreal

The Brouillette Lab at the Hôpital du Sacré-Coeur de Montréal (CIUSSS-NIM) invites applicants for a doctoral and postdoctoral researcher position in the field of Alzheimer’s disease and age-related memory deficits. Specific research topics include the effect of Aβ oligomers on sleep during aging, the impact of Aβ oligomers on different cell types in the hippocampus, the role of the phosphatase STEP on social memory, and blood biomarkers for early AD. We are using state-of-the-art equipment to perform laser microdissection, optogenetic, molecular/cellular biology, and behavioural testing with various animal models. These full-time positions and projects are supported by the Canadian Institutes of Health Research (CIHR) and the Weston Brain Institute. Funding is available for three to five years. The start date is immediate but flexible. Applications will be considered until the positions are filled. The annual stipend is consistent with CIHR funding levels.

Requirements

Candidates should have a degree in neuroscience, biochemistry, molecular/cellular biology, pharmacology, genetic, or a related field. Ideal applicants will have experience in molecular/cellular biology, animal behavioural testing, and knowledge of statistics. Additional preferred qualifications include experience with laser microdissection and optogenetic.

Contact information

Interested applicants should send their CV, a brief cover letter describing research experience and interests, university transcript, and contact information for 2-3 references by e-mail to Jonathan Brouillette (e-mail: jonathan.brouillette@umontreal.ca)

Principal Investigator
Dr. Jonathan Brouillette, Ph.D.
Assistant Professor
Department of Pharmacology and Physiology
Université de Montréal

Lab website:
https://pharmacologie-physiologie.umontreal.ca/recherche/chercheurs/jonathan-brouillette/
https://rechercheciusssnim.ca/profil/jonathan-brouillette/
https://recherche.umontreal.ca/nos-chercheurs/repertoire-des-professeurs/chercheur/is/in17687/

Graduate student position studying astrocyte-neuron interactions – Stobart laboratory, University of Manitoba

We are seeking a motivated graduate student with an interest in glial biology to work on an exciting project related to astrocyte ionotropic signaling and synaptic modulation. We have developed cutting-edge in vivo calcium imaging techniques to simultaneously monitor astrocyte and neuron activity and we will combine this with novel mouse models to probe astrocyte signaling in the tripartite synapse. There will be opportunities to learn animal handling, stereotaxic injection of AAVs, in vivo two-photon calcium microscopy, intrinsic optical imaging, histological techniques, behaviour testing, image analysis (with MATLAB), and statistics (with R). Please see our lab website for more information (www.stobartlab.com).
This work is funded by NSERC.

Eligibility:

  • Excellent academic standing
  • Strong written and oral communication skills
  • Good problem solving skills and the ability to think independently
  • Related lab experience is preferred (but not mandatory)

Successful candidates will be admitted to the graduate program through the College of Pharmacy, where they are expected to complete some course work in addition to research experiments. All students will be paid a stipend to cover tuition and living expenses.

Please submit a letter with statement of research interests, CV including research experience, a copy of recent transcripts and contact details for 2 references by email.

Contact information

Dr. Jill Stobart
Assistant Professor
College of Pharmacy
University of Manitoba
Apotex Centre
750 McDermot Ave.
Winnipeg, Manitoba
Canada

jillian.stobart@umanitoba.ca

BRAIN CREATE | Interdisciplinary Training Program for New Neurotechnologies

BRAIN CREATE program

Want to develop and commercialize the neurotechnology of the future?

Professors Marc Poulin and Richard Wilson from the University of Calgary are pleased to announce new cutting-
edge training opportunities with full scholarships for MSc and PhD students and Postdoctoral Fellows. Training draws heavily on elective workshops and is focused in labs developing drugs, devices and protocols that improve
nervous system function and monitoring. Funding will be provided for up to 100 trainees over the next 5 years.

Highlights:

  • Training in both neurosciences and integrated physiology
  • Training in technology transfer, patenting, and commercialization
  • Fully-funded scholarships
  • Opportunities for international travel
  • World-class supervisors

Find out more:

Web: cumming.ucalgary.ca/braincreate

Email: braincreate@ucalgary.ca

The Canadian-IBRO School Offers Two Teaching Internships on Neuroscience Education and Research in Africa and Latin America.

COVID-19 UPDATE: Due to uncertainties related to the evolution of the COVID-19 pandemic, the Canadian IBRO School has been postponed to 2021.  New opportunities will be posted next year.

 

Deadline for applications: March 30, 2020

A unique opportunity for 2 senior neuroscience graduate students or postdocs, registered at a Canadian university, interested in helping to promote neuroscience education and research capacity in Africa and Latin America.

This internship program builds on the rich scientific and cultural diversity that the Canadian-IBRO School program has accumulated since its inception in 2006. Successful applicants will spend 3 ½-weeks in Montreal, from May 14 – June 7, 2020 at the 14th Canadian-IBRO School.

Who should apply?
A unique opportunity for 2 senior neuroscience Graduate Students or Postdoctoral Fellows, registered at a Canadian university, interested in helping to promote neuroscience education and research capacity in Africa and Latin America.

Description
The two Canadian IBRO Trainee Interns will contribute to the teaching of graduate trainees from Latin America and Africa, and gain valuable insights into the challenges and opportunities of conducting research in countries with limited resources. The Interns will be advised on how to coordinate discussions and interact with talented students from diverse backgrounds who have English as a second language. In addition, the Interns will gain a deeper knowledge of Canada’s role in international development and in lessening the burden of neurological diseases in low- and middle-income countries.
For more details consult the following page.

Where & When
The internship will take place in Montreal from May 14 – June 7, 2020, and include participation in the annual meeting of the Canadian Association for Neuroscience (CAN). This program covers travel costs, meals, and accommodation.

How to apply
Applicants should complete the online application. Instructions are provided on this page:
http://www.can-ibroschools.info/Pub/Pub_Main_Display.asp?LC_Docs_ID=4938

OR
Submit a brief (200 words) statement of how their interests align with this internship, an updated CV, and a letter of reference from their supervisor before March 30, 2020 to:

Dr. Ellis Cooper: Ellis.Cooper@McGill.ca

For further details, see www.can-ibroschools.info

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell regulation and function, Lindsey Lab at the Rady Faculty of Health Sciences, University of Manitoba

Description of the position:

Our research focuses on uncovering the function and regulation of neural stem cell populations during brain development, behaviour, and following neurotrauma. The overarching goal of our lab is to define conserved themes in vertebrate neural stem cell regulation at the molecular and cellular levels. To address this goal, our lab takes advantage of the lifelong proliferative, neurogenic, and regenerative capacity of the zebrafish model. We currently use a number of transgenic zebrafish lines to study the response of neural stem cells to brain and spinal cord injury, stem cell niche maturation, and animal behaviour. A variety of models of neurotrauma are used in the lab along with contemporary molecular, cellular, imaging, and behavioral techniques, including primary cell culture, 2-D and 3-D imaging, correlative EM, RNA-sequencing approaches, fluorescence in situ hybridization, immunohistochemistry, etc.

Eligibility Requirements:

  • Experience in Imaging (2-D/3-D, confocal, EM, clearing methods)
  • Experience in Molecular Biology (cloning, PCR, CRISPR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry)
  • Experience using animal models of study
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

Benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,

Department of Human Anatomy & Cell Science

Rady Faculty of Health Sciences

University of Manitoba

 

130 Basic Medical Science Building

745 Bannatyne Avenue,

Winnipeg, Manitoba, R3E 0J9, CANADA

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell reprogramming and differentiation, Wang lab at Ottawa Hospital Research Institute

Description of the position:

Our research focuses on delineating molecular mechanisms that regulate neural stem cell reprograming and differentiation, with the ultimate goal of defining ways to recruit the stem cells that are resident in the brains or are derived from non-neuronal cells, and to thereby potentially promote neural repair. We are currently using stroke, Alzheimer’s disease, multiple sclerosis and autism as brain disease models to explore underlying molecular mechanisms. A variety of molecular, cellular, biochemical and behavioral techniques are used in the laboratory, including transgenic mouse models, in vivo neurodegenerative disease model, primary cell culture, co-IP and ChIP, and RNA-seq approaches and etc.

Eligibility Requirements:

  • Experience in Molecular Biology (cloning, mutagenesis, PCR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry) or in vivo animal model study.
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

jiwang@ohri.ca
Dr. Jing Wang, Ph.D.
Senior Scientist, Sprott Centre for Stem Cell Research
Ottawa Hospital Research Institute
Assistant Professor Department of Cellular & Molecular Medicine

University of Ottawa
Ottawa Hospital, 501 Smyth Rd, Box 511
Ottawa, ON K1H 8L6 CANADA

PhD position in Visual Neuroscience and Neurophotonics at the Université de Montréal

Funded PhD positions in Neurophotonics and Visual Neuroscience at the Université de Montréal (www.opto.umontreal.ca/cortex). We use a range of behavioral and neurophysiological techniques including calcium imaging and optogenetics on mice to study brain circuits underlying vision. We also focus on exploring plasticity after a stroke in the visual system and developing innovative neuroprosthesis devices to restore vision.
Candidates with a strong background in in vivo Neurophysiology AND/OR Behavioral Neuroscience AND/OR Engineering in Neuroscience are encouraged to apply.

Please contact Pr. Matthieu Vanni (matthieu.vanni@umontreal.ca) with

  1. a full CV,
  2. motivations for joining the lab and
  3. contact information of two referees.

Qualifications:

  • MSc or equivalent degree in natural, medical sciences, bioengineering or related fields.
  • Good English AND/OR French communication skills, both oral and written.
  • Be eligible to join a PhD Program of Vision Science or Biomedical engineering at the Université de Montréal.https://admission.umontreal.ca/programmes/doctorat-en-sciences-de-la-vision/
  • Proficiency with Data analysis using Matlab or Python

Contact information matthieu.vanni@umontreal.ca

Learning mechanisms of pain – PhD or post-doctoral position, Martin lab, University of Toronto

The ability to predict pain or other unpleasant events by learning from prior experience is an important adaptive behavior in healthy organisms and can cause disabling fear and avoidance in patients with chronic pain. While there is no single ‘pain processing area of the brain’, our recent efforts have focused on the role of the anterior cingulate cortex (ACC), due to its capacity to modulate pain and emotion based on prior experience.

The Martin Lab (www.martinpainlab.com) at the University of Toronto is currently seeking an independent, highly motivated and enthusiastic individual to study the molecular and synaptic basis of pain memory. Specifically, the candidate will be tasked with developing novel behavioural models of pain memory and should have a strong interest in neural circuits, in vivo imaging and electrophysiology.

Qualified postdoctoral candidates should have extensive experience with in vitro (patch-clamp) electrophysiological techniques, in vivo optogenetics or fiber photometry. Experience with molecular biology and/or immunohistochemistry are strong assets for both positions.

The postdoctoral position is available to start July 2020 (or later) and the deadline for graduate student applications is December 1, 2019 (Department of Psychology) or February 15, 2020 (Cell, Systems & Biology).

To apply, please send a brief statement of research interests, CV, and contact information for 3 references to lj.martin@utoronto.ca.

Contact information

Loren J. Martin, Ph.D.
Assistant Professor, University of Toronto Mississauga
Tier II Canada Research Chair in Translational Pain Research
Department of Psychology, CCT Building, Room 4061
3359 Mississauga Rd, Mississauga, ON, L5L 1C6

Exploring inhibitory neuron-secreted chemokines as a novel remyelination therapy – Post-doc or student position, Voronova lab, U Alberta

Neural precursor cells in adult mammalian brain, such as subventricular zone (SVZ) neural stem cells and oligodendrocyte precursors in brain parenchyma, form oligodendrocytes throughout life. The purpose of oligodendrocytes is to produce myelin, an insulating material that performs vital functions in efficient neural information transmission and constitutes the brain white matter. Demyelinating disorders occur when myelin, a protective substance that coats nerve projections and ensures efficient neuronal signalling, is damaged. This leads to nerve dysfunction and neurological impairments. Demyelination occurs in neurological disorders such as multiple sclerosis (MS), in which myelin is attacked and damaged by the body’s own immune cells. Current MS treatments only target inflammation but not central nervous system (CNS) remyelination, which could be achieved by stimulating the production of new oligodendrocytes.

Postdoctoral fellow or Ph.D. candidate will investigate how developmentally important neuronal chemokines (Voronova et al. 2017 Neuron) affect precursor-microglia cell-to-cell interactions for enhanced remyelination. The production of oligodendrocyte lineage cells and/or new myelin will be investigated using transgenic animals. Other techniques will include live imaging, flow cytometry, phagocytosis assays, brain slice and primary cell culture, intracerebroventricular injections (live animal surgery), RNA-sequencing and in situ hybridization, cytokine analysis, immunohistochemistry as well as confocal and electron microscopy.

An ideal candidate will be highly motivated and can work as a team player and a leader. Preference will be given to applicants with previous rodent experience and/or extensive cell or developmental biology expertise. Highly motivated Ph.D. and postdoctoral fellow candidates ready to learn live animal surgeries and work collaboratively and responsibly are encouraged to apply. Salary for potential postdoctoral fellow with commensurate with experience. Position will be open until filled.

Candidates should submit:
i) cover letter including research interests including a brief summary of previous graduate thesis and/or post-doctoral research (if applicable);
ii) complete CV;
iii) transcripts (unofficial is suitable); and
iv) the names and contact information of at least two academic referees.

E-mail applications to voronova@ualberta.ca. Only applicants selected for an interview will be contacted.

Download a PDF version of this advertisement: 20190522-Voronova