Doctoral student position available in the Sephton laboratory at Université Laval: Investigating lipid metabolism in amyotrophic lateral sclerosis (ALS).

Join our innovative research team at the CERVO Brain Research Centre of Université Laval in Québec City, Canada. The Sephton lab is dedicated to uncovering the mechanisms that cause the fatal motor neuron disease, amyotrophic lateral sclerosis (ALS) and developing targeted therapies based on these discoveries. The Sephton lab is pleased to announce a funded postdoctoral fellowship that will investigate the cause and impact of metabolic dysregulation in ALS and how it impacts disease progression.

Project overview:

An early clinical feature of ALS is an imbalance in energy homeostasis, which leads to an overall energy deficit. Due to the high energy demands and impaired glucose metabolism that occurs in ALS, there is a metabolic switch from glucose to lipids for energy production in the central nervous system. The successful candidate will lead a project investigating the cause and impact of this metabolic switch in the brain and spinal cord using animal models and cell-culture models of ALS/FTD. Utilizing methods like immunohistochemistry, confocal microscopy, neuron-glia co-cultures, western blotting and lipid and protein mass-spectrometry, the project aims to elucidate how the central nervous system manages lipids as an energy source and whether it is impaired in familial models of ALS, contributing further to the pathogenesis of disease.

Requirements:

  • MSc in Neuroscience or a related field with evidence of expertise and productivity
  • Proficiency in one or more of the following: primary cell-culture, immunohistochemistry, western blotting, confocal microscopy, animal handling and data analysis.
  • Independence in research, creative problem-solving skills, and a collaborative mindset.
  • Strong communication skills in English and the ability to work effectively within a team.

Lab Environment:

The Sephton lab cultivates an atmosphere that encourages collaboration and intellectual stimulation, placing a high value on creativity, scientific rigor, and innovative thinking. We create abundant avenues for professional development and promote independence in research endeavors. We are also strongly committed to supporting diversity, equity and inclusion. Our support extends to diverse career paths, encompassing both academia and industry. Situated in Québec City, renowned for its safety, affordability, and family-friendly surroundings, our lab provides an ideal setting for research and personal growth.

Funding:

The project is funded by a 2-year grant from ALS Canada and Brain Canada and a 5-year grant the Canadian Institute of Health Research (CIHR). Additionally, candidates can apply for several other funding opportunities for international students available through the Québec and Canadian funding systems. The lab is supported by Natural Sciences and Engineering Research Council of Canada (NSERC), Brain Canada, Canadian Foundation for Innovation (CFI).

Interested candidates should submit a cover letter describing research interests, relevant experience and university transcripts, along with a curriculum vitae by May 1st, 2024 to Dr. Sephton here:

https://docs.google.com/forms/d/1T4sSrgXMxrFbYByO2drinoqApSksh2VtUAacSyoBw14/viewform?edit_requested=true

Download a PDF version of this advertisement here:

PhD position-Sephton lab-Final

PhD position: Regeneration of locomotor circuits in salamanders

PROJECT: Salamanders can swim underwater and walk on ground. Their spinal cord regenerates after a full transection and the animal recovers voluntary locomotion after a few weeks. How this occurs is largely unknown. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualization of genetically-defined cells. Such approaches can be combined with patch-clamp electrophysiology, calcium imaging, optogenetics, tracing and movement analysis (Ryczko et al. 2020 Trends in Neurosciences). The candidate will use genetic tools, calcium imaging, electrophysiology and movement analysis based on deep learning and neuroanatomy to study salamander locomotor circuits. The work will be carried out in collaboration with a team of modelers and roboticists (Pr. Ijspeert, EPFL, Switzerland) and experts in genomics (Pr. Simon, Karolinska Institute, Sweden).

REQUIREMENTS: The candidate should have completed a MSc in neuroscience or a related field. The ideal candidate would have experience in electrophysiology (patch-clamp), calcium imaging, optogenetics, virus injections, deep learning-based movement analysis, matlab scripting, and a keen interest in motor control.

HOST LABORATORY: The lab of Pr. Ryczko (Sherbrooke, QC, Canada) has expertise in the neural control of locomotion and publishes in excellent journals (PNAS, Journal of Neuroscience, Trends in Neuroscience). The lab receives grant support by the CIHR, NSERC, FRQS, CFI. This project is funded by a synergy grant of the ERC. We are equipped for patch-clamp recordings, confocal and two photon calcium imaging, optogenetics, viral injections, deep learning-based movement analysis, and microscopy (confocal, light-sheet, two-photon, STED).

START: the student could satrt either in May 2024 or September 2024.

APPLY: Candidates should send a letter of interest explaining how they would fit, a CV, a complete record of their academic results and an international scale to interpret these, and three references at: dimitri.ryczko@gmail.com. Please specify where you have found the job post.

Contact :

dimitri.ryczko@gmail.com

PhD position: Brainstem control of locomotion in mice

PROJECT: The locomotor role of dopaminergic cells is classically attributed to their ascending projections to the basal ganglia that project to brainstem locomotor circuits that controls locomotion. However, descending dopaminergic projections to brainstem locomotor circuits were uncovered (Ryczko et al. PNAS 2013, PNAS 2016, J Neurosci 2017, J Neurosci 2020). In lamprey, these descending projections increase locomotor activity. In mammals, their role remains to be determined.

The student will address this issue in mice using in vivo optogenetics and chemogenetics, movement analysis, patch-clamp electrophysiology or calcium imaging in brain slices, viral injections or neuroanatomy. The new knowledge will provide a better understanding of the relation between dopaminergic and locomotor neurons and help identify new clinical strategies to improve locomotor function in Parkinson’s disease.

REQUIREMENTS: The candidate should have completed a MSc in neuroscience or a close field. The ideal candidate would have experience in patch-clamp electrophysiology, optogenetics or calcium imaging in slices, in vivo optogenetics or chemogenetics, virus injections, matlab scripting, and a keen interest in motor control.

HOST LABORATORY: Pr. Ryczko has expertise in the neural control of locomotion and published his research in excellent journals (PNAS, Science, Science Robotics, Journal of Neuroscience…). The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC. We are equipped for optogenetics, viral injections, patch-clamp recordings, confocal and two photon calcium imaging, high-resolution movement analysis based on deep learning, and microscopy (confocal, light-sheet, two-photon, STED).

START: The student could start either in May 2024 or September 2024.

APPLY: Candidates should send a letter of interest, a CV, a complete record of their academic results and three references at: dimitri.ryczko@gmail.com. Please specify where you found the job post.

Contact information : dimitri.ryczko@gmail.com

M.Sc. & Ph.D. Positions at McGill University in Computational Analysis of Behavior and Brain dynamics with Computer Vision/Machine Learning

Positions Overview:

The Mohajerani lab (https://douglas.research.mcgill.ca/majid-mohajerani/) at McGill University is seeking prospective M.Sc. or Ph.D. to join our lab for Winter 2025 semester. The focus of student’s project will be on analysis of animal behaviour and brain activity using deep learning tools. To be qualified for this position, ideal candidates must have a solid background in computer vision and be familiar with neuroscience. As part of this role, students also must complete coursework for neuroscience program at McGill (www.mcgill.ca/ipn/), a university known for its world-class research and academic excellence, providing them an intellectually stimulating and inspiring environment for their career growth. We are searching for dedicated researchers to join our lab, so if you like tackling challenges, you are welcome to apply! Lastly, the successful candidate must have a collaborative spirit, as this role involves cooperation with multiple institutions and investigators.

Deadline: March 31st, 2024

Key qualifications:

  • Academic Background: M.Sc. or B.Sc. in computer science, computer engineering, neuroscience, or related fields. Solid foundation in machine learning , and knowledge of experimental neuroscience (e.g., optical imaging/ontogenetic, electrophysiology, behavioural assessment) will be a bonus.
  • Technical Knowledge: Familiarity with deep learning libraries (TensorFlow, PyTorch), and image processing in Python.
  • Soft Skills: Individuals who are driven by curiosity, practical problem-solvers, and team players.
  • Passionate About Neuroscience: A genuine interest in computational, and/or behavioural neuroscience and a commitment to contributing to the field.

What we offer:

  • A Focus on Behavioural Neuroscience: Dive deep into research that aims to unravel the complexities of behaviour and brain dynamics through AI. Our projects span various aspects of the field, offering a rich environment for academic and personal growth.
  • Collaborative Environment: Work alongside leading scientists in a supportive, interdisciplinary team where your ideas and contributions are valued.
  • Resources: Access to cutting-edge technology and resources to facilitate your research, experimentation, and learning.
  • Real-World Impact: Engage in projects that aim to translate scientific discoveries into practical applications, making a tangible difference in the field and beyond.
  • Academic Excellence: As part of McGill University, you’ll be immersed in an environment known for its high standards of research and education.

How to Apply:

If you’re passionate about machine learning and want to work in a dynamic and exciting environment, please apply with your resume and a cover letter describing your relevant experience and why you’re the right fit for this role. We strive to ensure that our team is diverse, equitable, and inclusive. All qualified applicants, including women and members of visible minority groups, are welcome to apply. If you meet all the requirements, please fill out the following form:

https://docs.google.com/forms/d/1TK_TfBSzkqNcR_DYt82HGb0MImX_1mthtegbxbkJtbI/edit

Chief Research and Program Officer – Brain Canada Foundation

Brain Canada logoPosition: Chief Research and Program Officer

Status: Permanent, full-time

Location: Flexible-work remote position

SUMMARY OF THE POSITION

The Chief Research and Program Officer (CRPO) is a key member of the Executive Leadership Team, and a strategic member of the Management Team. Reporting directly to the President and CEO, the CRPO contributes actively to the organization’s strategic plan by providing leadership and expertise for the development of long-term strategic research and program priorities and goals.

Overseeing a team of dedicated research and program staff, the CRPO leads and directs the development, design, conception and implementation of all Brain Canada’s research activities and funding programs. They engage regularly with the Canadian brain research community and assist with managing relationships at the scientific level with key stakeholders including Brain Canada’s Board of Directors, the Government of Canada, partners and research funders, universities, private or philanthropic donors, and the international brain research community. They act as a key spokesperson and an ambassador for Brain Canada on the national and international stage.

They work in close collaboration with the Evaluation and Special Projects Team on evaluation, impact assessment and other initiatives.

RESPONSIBILITIES:

Positions reporting directly to this role:

  • Program Operational Lead
  • Senior Program Manager, Knowledge Mobilization
  • Research and Program Analyst

Key Accountabilities:

Leadership and Relationship Management:

  • As a key mission ambassador for Brain Canada, lead and inspire Brain Canada’s team in championing and advocating the organization’s ambitious future directions.
  • Develop, grow, and broaden relationships with the federal government and key stakeholders to identify and achieve exciting and transformational research priorities and goals, and promote funding opportunities.
  • Liaise and oversee the presentation of information to the federal government at a strategic level.
  • Develop and maintain active participation and strong relationships with the brain research community and key institutional and organizational research partners, such as universities, partner organizations, research centers and hospitals, researchers, philanthropic donors, etc.
  • Present regularly at Brain Canada Board meetings and represent the Research and Program Team on the Research Committee.
  • Align Brain Canada’s Research and Program activities with the Research Committee recommendations.
  • Participate in the development and stewarding of key donor relationships, assist the President and CEO and the National Director of Philanthropy with discussions, presentations, and meetings with prospective donors and funding partners to develop and implement new agreements which will be mutually beneficial and meet both research and philanthropic objectives.
  • Target and develop new strategic partnerships: initiate discussions with new strategic partners, develop agreements and terms of initial contracts, allocate funds to a specific research domain, etc.

Strategic Planning and Business Management:

  • Lead the Research and Program Team in the development of the organization’s strategic and operational plans (aligned with Brain Canada’s long-term strategic plan). This includes:
    • Overseeing the development, design and conception of all research activities and funding programs, including the peer review process.
    • Preparing and overseeing the execution of the annual budget of the Research and Program Team.
    • Reporting KPIs related to Research and Program to the Board of Directors.
    • Overseeing the selection and implementation of IT systems to increase the Research and Program Team efficiency.
    • Working closely with the CFO and Director of Legal Affairs and Governance to ensure compliance with the federal government’s contribution agreement.
  • Lead the implementation of the long-term strategic plan through annually-developed business plans (with aligned resources, identified reporting, and accountability).
  • Contribute and participate as a member of the executive team supporting the President and CEO to ensure the effective management of the organization including the integration of evidence-based research in the Mission and Vision, Research, Fund Development, and Marketing/Communications plans.
  • Support the Evaluation and Special Projects team to set priorities for evaluation initiatives (e.g., program evaluation, bibliometric analysis).
  • Collaborate closely with the Evaluation and Special Projects Lead on special projects such as strategic planning and stakeholder engagement for Indigenous initiatives and developing concept papers to support program development and philanthropy.

Human Resource Management:

  • Lead, inspire, and engage a highly effective Research and Program Team, ensuring high standards of delivery, competence, performance, and values are maintained and that staff is well supported in fulfilling their duties, developing their skills, and achieving their career potential. Specifically:
  • Ensure a clear understanding of organizational goals and priorities; ensure optimal deployment of resources to achieve business goals.
  • Establish team contribution plan; manage a strong team and develop effective lateral relationships cross-functionally.
  • Establish contribution plans and objectives and review on an ongoing basis.
  • Onboard and integrate direct reports, provide coaching and feedback, assess their contribution, nurture talent, and support their growth to help them realize their potential and engagement.
  • As required, recruit skilled talent in support of current and future needs.
  • Be familiar and comply with Brain Canada policies.
  • Provide coaching and development to team members and implement initiatives that effectively inspire loyalty and philanthropy amongst our supporters.
  • Be a visible leader in living the values throughout the organization.

Policy development:

  • In close collaboration with the Research Committee and Director, Legal Affairs and Governance, develop and update Brain Canada policies that relate to conflict of interest, research integrity, ethical conduct of research, privacy & security, data protection, publication, data access and sharing, intellectual property, and other aspects of the research process.

Other duties:

  • As assigned.

QUALIFICATIONS:

  • Graduate degree in neuroscience or a related discipline; Ph.D is a plus.
  • Proven success as a strategic transformational leader in a mission-driven health care, research or science organization (8-10 years leadership experience).
  • Extensive knowledge in the design, implementation, and delivery of scientific funding competitions, as well as best practices in the management of funded projects, research, and training programs through experience working in a research-funding organization or in an administrative capacity in a research-performing organization.
  • A demonstrated understanding or a desire/ability to acquire knowledge of the scientific and research issues associated with the brain; experience in inspiring, connecting, and engaging with researchers.
  • Excellent relationship-building skills with a proven ability to engage others and establish strong partnerships.
  • Success in advocacy, policy, and program development, working with government officials, research partners, volunteers, and internal teams.
  • Demonstrated ability to communicate and inspire audiences with varying levels of knowledge regarding brain research.
  • Success in rallying a talented staff around a shared vision and plan, delivering planned results.
  • Evidence of strong strategy development and implementation success.
  • Experience in leading change with and through others.
  • Passion for the cause: demonstrated ability to gain partners and donors and raise funds for a cause.

TALENTS:

  • Inspiring and Engaging leadership – inspires, motivates, develops, and manages a high-performing service-oriented team.
  • Excellent relationship-building skills, with people at all levels of organization (internally and externally); a passionate champion and ambassador.
  • Healthy self-confidence, authenticity, and humility.
  • Political savvy/acuity.
  • Superb negotiation, mediation, and persuasive abilities.
  • Ability to work under pressure, balance multiple tasks and projects at once, considering priorities appropriately, meet tight deadlines and cope with rapidly changing scenarios.
  • Excellent written and verbal communications and writing skills in English. Fluency in French is a plus.
  • Available for travel across Canada on a regular basis, and internationally on an occasional basis.
  • Comfort and ease in dealing with volunteers, donors, being visible internally and externally.
  • Agile and flexible leadership style and approach; comfort in leading in a matrix leadership model.
  • Commitment to Equity, Diversity and Inclusion.

Work environment:

Brain Canada Foundation is committed to providing an excellent work environment for team members. We offer:

  • A competitive compensation package including a complete benefits plan.
  • A flexibility to work from home, in accordance with our Work-from-Home Policy.
  • A healthy, flexible, and dynamic work environment that values teamwork, creativity, innovation and work-life balance.
  • Access to professional development and training as available.

About Brain Canada

Brain Canada Foundation (Brain Canada) is a national registered charity headquartered in Montréal, Quebec. We play a unique and invaluable role as a national convenor of those who support and advance brain research. A greater understanding of how the brain works contributes to the prevention, diagnosis, treatment, and cure of disorders of the brain, ultimately improving the health outcomes of people in Canada and around the world.

Our Commitment to equity, diversity, and inclusion (EDI)

Brain Canada is committed to improving and expanding brain science to benefit all people, including groups historically under-researched and underrepresented. We know that increasing the diversity of the research workforce and integrating sex and gender in brain research leads to innovation and greater impact.

Our commitment to EDI is reflected in actions we are taking to diversify our workforce and to foster inclusive environments through our advertising, interviewing, hiring, training, mentoring, and performance review practices. We actively welcome members of underrepresented groups such as women, Indigenous Peoples, persons with disabilities, visible minorities, immigrants, and LGBTQ2+ communities.

Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien’kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues (Calls to Action numbers 19 to 24)

 

To apply:

careers@braincanada.ca

General Neurologists & Stroke Neurologists – Windsor Regional Hospital

Our client, Windsor Regional Hospital (WRH), is a multi-faceted health services organization operating from two main sites, the Metropolitan Campus and the Ouellette Campus. With 500 beds and an operating budget of over half a billion dollars, WRH is the regional provider of advanced care in areas that include complex trauma, renal dialysis, cardiac care, stroke and neurosurgery, intensive care, acute mental health, family birthing centre, neonatal intensive care, paediatric services, and regional cancer services. WRH provides a broad range of medical and surgical services required to support these specialized areas for more than 400,000 people in Windsor and Essex County.

With increasing volumes, program development, and growing demands for service, WRH is seeking top tier General Neurologists and Stroke Neurologists to join their team. This is an exceptional opportunity to join an innovative, collegial, and mutually respectful team to contribute to neurology service delivery excellence.

Full time and part time opportunities are available. WRH is also interested in recruiting subspecialty neurologists to bring unique skills to the group and community.

As a designated Enhanced District Stroke Centre, Windsor Regional Hospital provides specialized services for stroke and TIA patients offering timely hyper-acute treatments like tPA and endovascular therapy (Thrombectomy and Coiling), as well as neurosurgical services. The hospital has neurologists, neurosurgeons, and interventional radiologists on staff providing expert care for stroke patients. Following intervention and post procedure recovery and stabilization in the ICU, patients are transferred to the Acute Stroke Unit, a designated 16-bed unit dedicated to the care of Stroke patients. Inpatient and outpatient rehabilitation services for Windsor-Essex are offered locally through Hôtel-Dieu Grace Healthcare. Outpatient Rehab options direct from hospital also includes the Intensive Hospital to Home Rehab program and E-Rehab services provided through the Erie St. Clair LHIN.

Physicians at WRH have the opportunity to educate and mentor residents from the Schulich School of Medicine and Dentistry, with professional staff members eligible to hold a University appointment.

Candidates must be certified, or eligible for certification, by the Royal College of Physicians and Surgeons of Canada in Neurology and hold, or be eligible for, licensure with the College of Physicians and Surgeons of Ontario. Offering great flexibility and work/life balance, these positions include an attractive compensation and relocation incentive package.

The Windsor-Essex area is ecologically rich with extensive parkland combined with a southwest location that extends warm weather activities such a golfing, gardening, and water sports. Windsor offers the unique opportunities of a larger metropolitan area and the benefits of a smaller community. Living directly across the border from Detroit, Michigan places you on a cosmopolitan stage where arts, culture, big league sports, and entertainment are just moments away. Best of all, you can enjoy access to all of these big-city advantages while living in the tranquility and beauty of the Windsor region.

Please forward a CV in confidence to:

Robb Callaghan, E-mail: rcallaghan@medfall.com

Download a PDF version of this advertisement:    Ad-WRH-General-and-Stroke-Neurologists-Canada.pdf

Master’s and PhD positions available in visual neuroscience at Université de Montréal.

The Neurophotonics lab of the School of Optometry of the University of Montreal is looking for students interested to start a MSc or a PhD in Vision Sciences, Neuroscience or Biomedical Engineering. Our projects focus on the plasticity of cortical maps and functional connectivity in different models of blindness and stroke affecting visual functions. We are also interested in the spatial coding of information in the context of Brain/Machine interfaces and the development of neuroprosthesis to restore vision.
We use a platform for measuring and manipulating brain functions in mice performing visual cognitive tasks in combination with neurophotonic approaches such as calcium imaging (macroscopic or multi-photon) or optogenetics.
We are also interested in the development of technologies applied to neuroscience, in collaboration with companies.

The support of the lab (CIHR, NSERC) will guarantee a scholarship for students who do not yet have the support of funding organizations.

To apply:

  1. You will need to have training or lab experience in at least one of the disciplines below:
    – Neurophysiology (including calcium imaging, electrophysiology, …)
    – Computational Neuroscience
    – Behavioral measurement in animals
    – Biomedical Engineering
  2. You must have a preliminary experience in data analysis (with Matlab or Python ideally)

Contact information Send your CV and cover letter (and any other documents you think could be relevant: transcript, achievement, etc.) to Matthieu Vanni: matthieu.vanni@umontreal.ca

Master’s and PhD graduate student positions (Neuroscience) – University of Saskatchewan

We are inviting applications for Master’s and PhD students in behavioural and systems neuroscience at the University of Saskatchewan (Saskatoon, Saskatchewan).

Our Research:
The Botterill laboratory has two major research pillars, including a basic science pillar focused on studying the cells and circuits that support learning, memory, and affective behaviours and a health sciences pillar focused on studying the neurobiological mechanisms of temporal lobe epilepsy and its treatment. Our research programs primarily focus on the dentate gyrus subfield of the hippocampus to study how hilar mossy cells, dentate granule cells (including adult-born neurons), and GABAergic interneurons influence hippocampal function in health and disease.

Methods:

  1. Mouse stereotaxic surgery for injections of adeno-associated viruses (AAV), electrode recording assemblies, optic fibers, and cannulae for drug infusions, etc.
  2. Gain- and loss-of function manipulations via optogenetics and Designer Receptors Exclusively Activated by Designer Drugs (DREADDs)
  3. Mouse models of epilepsy (pilocarpine, kainic acid)
  4. 24/7 video electroencephalography (EEG) recordings in freely behaving mice
  5. Slice electrophysiology (whole cell patch clamp & extracellular field recordings)
  6. Mouse behavioural testing
  7. Behavioural pharmacology
  8. Biochemistry
  9. Epifluorescence and confocal microscopy

Eligibility requirements:

  • Strong academic record
  • Interest in behavioural neuroscience and/or epilepsy research
  • Excellent written and oral communication skills
  • Experience in rodent handling / behavioural neuroscience is preferred.
  • The ideal candidate will have experience with AAV injections, in vivo optogenetics, slice electrophysiology, and/or video EEG data collection & analysis.

Funding:
Successful candidates will receive graduate student stipends commensurate with the standard stipend amounts for graduate students in the Department of Anatomy, Physiology, and Pharmacology in the College of Medicine. Candidates will be expected to apply to the College of Medicine’s Graduate Student Award (CoMGrad) and Tri-council competitions (e.g., NSERC or CIHR).

Important dates:
Deadline: June 1, 2023. Start date: September 1, 2023

Additional information:
Google Scholar Publications: https://scholar.google.ca/citations?hl=en&user=VL_1ODIAAAAJ
Botterill Laboratory Website: https://research-groups.usask.ca/botterillneurolab/index.php
Anatomy, Physiology, & Pharmacology website (for program details and tuition costs):
https://grad.usask.ca/programs/anatomy-physiology-pharmacology.php

Contact information

Contact information:

We welcome applications from qualified candidates and strongly encourage applications from individuals belonging to groups that have been traditionally underrepresented in the sciences. Applications will be reviewed until the positions are filled.

Please contact Justin Botterill (j.botterill@usask.ca) with the following information:

  1. A brief statement of research interests and goals
  2. A copy of your curriculum vitae (CV) with at least 2 references.
  3. A copy of your unofficial transcripts.
  4. Please indicate whether you are a Canadian Citizen or a permanent resident of Canada.

Posting end date

2023/06/01

 

Funded Graduate Student Positions at the University of Manitoba

Multiple graduate student positions (M.Sc., Ph.D.) are available in the laboratory of Dr. Tabrez Siddiqui at the University of Manitoba. The Siddiqui lab’s multidisciplinary research program encompasses the molecular, systems and behavioural branches of neuroscience to investigate neuronal circuit organization, plasticity and network integration. Our goals are to generate transformative knowledge on the molecular mechanisms of synapse development and function in both the developing and mature brain, provide conceptual advances in understanding the mechanisms governing enduring changes in synaptic properties (plasticity) that underlie cognitive function and associative learning, and determine how synapses are specified in the mammalian brain to provide the framework for understanding the molecular logic of circuit organization and associated behaviours. The Siddiqui lab is also actively pursuing translational goals in uncovering synaptic regulatory mechanisms and targets in neurodevelopmental and psychiatric disorders such as autism and schizophrenia.

Eligibility Requirements

  1. Excellent academic standing
  2. Strong work ethic and interest in discovery science
  3. Experience or interest in using animal models
  4. Research experience is an asset
  5. Excellent written and oral communication skills

The positions are fully funded with standard stipends commensurate with the University of Manitoba guidelines and Departmental bylaws. Successful students will be admitted to the Physiology graduate program, but may be considered for the Biomedical Engineering program.

This search will close on January 20, 2023.

Please send the following the documents to Dr. Siddiqui by email

  1. Cover letter explaining your background, interests, and training, and why you will be a good fit for the Siddiqui lab research program.
  2. CV
  3. Transcripts

We thank all applicants for their interest. However, however only those candidates selected for interviews will be contacted.

Rady Faculty of Health Sciences
Max Rady College of Medicine
Department of Physiology and Pathophysiology
Neuroscience Research Program
Kleysen Institute for Advanced Medicine
Health Sciences Centre
SR422-710 William Avenue
Winnipeg, MB R3E 0Z3
Phone: 1.204.318.2564

 

Email: tabrez.siddiqui@umanitoba.ca

https://umanitoba.ca

Siddiqui Lab Publications can be accessed here.

https://pubmed.ncbi.nlm.nih.gov/?term=Tabrez+j+siddiqui&sort=date

Some of our recent published studies are listed below

  1. Dhume S.H., Karimi B., Roppongi R.T. Connor, S.A., Mills, F., Tari, P.K., Oku, S., Bamji, S.X., Wang, Y.T., Brose, N., and Craig, A.M., Siddiqui, T.J., Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits, Elife. (2022) Jun 6;11:e64742. doi: 10.7554/eLife.64742.0: 0.
  2. Karimi B, Silwal P, Booth S, Padmanabhan N, Dhume S, Zhang D, Zahra N, Jackson MF, Kirouac GJ, Ko JH, and Siddiqui T.J.*, Schizophrenia-associated LRRTM1 regulates cognitive function through controlling synaptic activity in the mediodorsal thalamus, Molecular Psychiatry, 2021May 12. doi: 10.1038/s41380-021-01146-6
  3. Roppongi RT#, Dhume S#, Padmanabhan N#, Silwal P, Zahra N, Bomkamp C, Pati Cl, Karimi B, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MJ, and Siddiqui TJ, LRRTMs organize synapses through differential engagement of neurexin and PTPσ, Neuron (2020), Apr 8; 106 (1):108-125.e12. doi: 10.1016/j.neuron.2020.01.003 (# co-first authors)
  4. Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Fred Rieke, Craig AM, Wong RO, and Hoon M, LRRTM4: a novel regulator of presynaptic inhibitory and dyad output synapses of retinal bipolar neurons, Neuron (2020), Mar 18;105(6):1007- 1017.e5. doi: 10.1016/j.neuron.2019.12.028.
  5. Zhang Z, Pines MK, Oku S, Ge Y, Siddiqui TJ, Wu W, Archer-Hartmann S, Azadi P, Gordon MD, and Craig AM. (2018). Heparan Sulfate Organizes Neuronal Synapses Through Neurexin Partnerships. Cell 174(6): 1450-1464.

tabrez.siddiqui@umanitoba.ca

Tabrez J. Siddiqui, PhD

Associate Professor of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba.

Principal Investigator, Children’s Hospital Research Institute of Manitoba.

Principal Investigator, Neuroscience Research Program,

Kleysen Institute for Advanced Medicine, Health Sciences Centre.
SR422-710 William Avenue, Winnipeg R3E 0Z3, Manitoba, Canada.
Phone: 1. 204.318.2564

https://umanitoba.ca/medicine/faculty-staff/tabrez-siddiqui

Twitter: @siddiquilab

The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota and Dene peoples, and on the homeland of the Métis Nation. We respect the Treaties that were made on these territories, we acknowledge the harms and mistakes of the past, and we dedicate ourselves to move forward in partnership with Indigenous communities in a spirit of reconciliation and collaboration.

Graduate student position – University of Lethbridge

Description: We are looking for graduate students (Master’s and/or Ph.D. levels) to help build UHF-based Internet of Things (IoT) system that will be used as a Brain-Machine Interface device. Projects will be related to our recent work:

 

Challenges of a small world analysis for the continuous monitoring of behaviour in mice. Neuroscience and Behavioral Reviews 2022 https://www.sciencedirect.com/science/article/pii/S0149763422001105

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice. Nature Methods 2021 https://www.nature.com/articles/s41592-021-01104-8

The project is a collaborative effort between the research groups of Majid Mohajerani (http://lethbridgebraindynamics.com/majid-mohajerani/) and Dr. Robert Sutherland. Successful candidates will join the highly collaborative and interdisciplinary Canadian Centre for Neuroengineering Solutions and Brain Dynamics Group. We are located close to the Rocky Mountains, Lethbridge has the largest number of sunny days in Canada, and it is the most affordable city for young people in Canada (https://dailyhive.com/calgary/alberta-city-most-affordable-young-people ).

Requirements: Only applicants with previous experience working in UHF-based antenna design and software-defined radio systems are encouraged to apply.

The applications review will start on Oct 1st till the positions are filled. Interested applicants must send an email to Dr. Mohajerani (mohajerani@uleth.ca) and include a cover letter, curriculum vitae, a brief statement of research interests, and the contact information of three references.