New Graduate Student Positions Now Available to Study the Basic Mechanisms of Multiple Sclerosis

Join a dynamic, world-class, generously funded basic and translational science team. The laboratory of Dr. Michael Levin offers personalized mentorship, state of the art laboratory facilities, customized coursework, highly competitive compensation, and the opportunity for basic scientists to work hand-in-hand with clinicians in Saskatoon City Hospital and the University of Saskatchewan. The laboratory of Dr. Michael Levin in the Department of Anatomy, Physiology, and Pharmacology at the University of Saskatchewan has positions currently available for graduate students to study the role of abnormalities in the immune and nervous systems and how these abnormalities contribute to the pathogenesis of Multiple Sclerosis (MS). The laboratory is located in Saskatoon City Hospital, as part of the Cameco MS Neuroscience Research Centre. For more information about the lab and Dr. Levin, please visit http://research-groups.usask.ca/skms-office/.

The long-term goal of research in the Levin Lab is to better understand the cause of neurodegeneration, a salient feature and cause of permanent disability in progressive multiple sclerosis (MS) patients. For more than 20 years, we have studied the function of the RNA binding protein heterogeneous nuclear ribonuclear protein A1 (hnRNP A1 – ‘A1’), with a focus on ‘M9.’ M9 is A1’s nucleocytoplasmic transport domain and is required for transport of A1 between the nucleus and cytoplasm. Our lab has discovered that MS patients make antibodies to M9 and the brains and lymphocytes of MS patients contain somatic DNA mutations within M9. Using a number of molecular, in vitro and in vivo techniques, our data indicate that DNA mutations within M9 and autoimmunity to M9 result in A1 dysfunction and subsequent neuronal and axonal degeneration. Using this model, we examine potential mechanisms of neurodegeneration in MS resulting from A1 dysfunction.

The applicant should have an undergraduate or Master’s degree in molecular cellular biology, biochemistry, neurology, neuroscience or a related field. Familiarity in research using one or more of the following will be considered an asset; mouse models, imaging techniques (immunocytochemistry and immunohistochemistry), protein analyses, molecular biology techniques (PCR, cloning, etc.) and human tissue analyses. Knowledge of data analysis and interpretation using statistical software is required.

The individual should be independent, self-motivated and should be able to perform tasks with modest supervision after receiving appropriate training. Applicants must have the ability to adhere to tight deadlines, be detail oriented, possess organizational skills, and keep meticulous records. As the laboratory is a shared space, strong interpersonal skills are necessary. Successful applicants will be encouraged to apply for external funding opportunities.

Applicants should send the following documents to the Office of the Saskatchewan MS Clinical Research Chair via email to Ms. Catherine Hutchinson, c.hutchinson@usask.ca:

  1. Current CV with list of laboratory experience
  2. Transcripts (unofficial, accepted)
  3. Names and detailed contact information of three referees, one of whom should be your undergraduate research supervisor

Applicants are required to apply and be admitted to the Anatomy, Physiology, and Pharmacology graduate program at the University of Saskatchewan in order to fill the position. Candidates whose first language is not English may be required to provide a certificate of English proficiency. The English language requirements for a foreign candidate can be found at the CGPS website (www.usask.ca/cgps/).

Contact information

Catherine Hutchinson
Research Executive Assistant to Michael C. Levin, MD
c.hutchinson@usask.ca

 

Neurologists & Locum Neurologists – Windsor Regional Hospital

Our client, Windsor Regional Hospital (WRH), is a multi-faceted health services organization operating from two main sites, the Metropolitan Campus and the Ouellette Campus. With 500 beds and an operating budget of over half a billion dollars, WRH is the regional provider of advanced care in areas that include complex trauma, renal dialysis, cardiac care, stroke and neurosurgery, intensive care, acute mental health, family birthing centre, neonatal intensive care, paediatric services, and regional cancer services. WRH provides a broad range of medical and surgical services required to support these specialized areas for more than 400,000 people in Windsor and Essex County. Windsor Regional Hospital is seeking: Neurologists & Locum Neurologists

With increasing volumes, program development, and growing demands for service, WRH is seeking top tier Neurologists to join their team to contribute to service delivery excellence in the Neuro-Interventional Program. This is an exceptional opportunity to join an innovative, collegial, and mutually respectful team to contribute to neurology service delivery excellence.

There is a need to expand the group of neurologists which would include general neurologists who have interest in supporting inpatient endeavors. Full time, part time, and locum opportunities are available. WRH is also interested in recruiting subspecialty neurologists to bring unique skills to the group and community.

As a designated Enhanced District Stroke Centre, Windsor Regional Hospital provides specialized services for stroke and TIA patients offering timely hyper-acute treatments like tPA and endovascular therapy (Thrombectomy and Coiling), as well as neurosurgical services. The hospital has neurologists, neurosurgeons, and interventional radiologists on staff providing expert care for stroke patients. Following intervention and post procedure recovery and stabilization in the ICU, patients are transferred to the Acute Stroke Unit, a designated 16-bed unit dedicated to the care of Stroke patients. Inpatient and outpatient rehabilitation services for Windsor-Essex are offered locally through Hotel-Dieu Grace Healthcare. Outpatient Rehab options direct from hospital also includes the Intensive Hospital to Home Rehab program and E-Rehab services provided through the Erie St. Clair LHIN.

Physicians at WRH have the opportunity to educate and mentor residents from the Schulich School of Medicine and Dentistry, with professional staff members eligible to hold a University appointment.

Candidates must be certified, or eligible for certification, by the Royal College of Physicians and Surgeons of Canada in Neurology and hold, or be eligible for, licensure with the College of Physicians and Surgeons of Ontario. Offering great flexibility and work/life balance, these positions include an attractive compensation and relocation incentive package.

The Windsor-Essex area is ecologically rich with extensive parkland combined with a southwest location that extends warm weather activities such a golfing, gardening, and water sports. Windsor offers the unique opportunities of a larger metropolitan area and the benefits of a smaller community. Living directly across the border from Detroit, Michigan places you on a cosmopolitan stage where arts, culture, big league sports, and entertainment are just moments away. Best of all, you can enjoy access to all of these big-city advantages while living in the tranquility and beauty of the Windsor region.

Please forward a CV in confidence to:

Robb Callaghan, E-mail: rcallaghan@medfall.com Tel: 289-238-9079

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Graduate student positions imaging brain repair available in the Brown laboratory in beautiful Victoria

Dr. Craig Brown’s laboratory in the Division of Medical Sciences at the University of Victoria in beautiful British Columbia has 1-2 openings for graduate students. Dr. Brown’s research program is primarily interested on the cellular and molecular mechanisms of brain plasticity and repair. Specific themes the lab is currently exploring are: a) understanding the effects of stroke on excitatory and inhibitory neural circuit function; using optogenetic or chemogenetic approaches to manipulate these circuits to maximize functional recovery, b) elucidating endothelial and immune cell based repair of microvascular networks in the brain. To address these questions, the lab employs a multi-disciplinary approach, imaging the structure and function of neurons, microglial and endothelial cells in the living mouse brain in tandem with genetic, biochemical, pharmacological and behavioural approaches. Dr. Brown’s basic science and health related research program is supported by the Canadian Institute for Health Research (CIHR) and the Natural Sciences and Engineering Research Council (NSERC).

Qualifications: The ideal candidate will be curious, motivated, mature, adept at problem solving and passionate about neuroscience research. No specific expertise is required although candidates with experience in handling large data sets, microscopy, electrophysiology, molecular biology, and/or rodent behavior are highly encouraged to apply for this position.

For more information, please contact Dr. Brown (brownc@uvic.ca), his website: http://www.uvic.ca/medsci/people/faculty/browncraig.php

For more information on the Neuroscience Graduate Program at the University of Victoria, please see: https://www.uvic.ca/medsci/neuroscience/

Post doctoral and graduate student positions in neuroscience – Thompson laboratory, University of Calgary

Postdoctoral and Graduate Student (PhD) positions in neuroscience

The lab of Dr. Roger Thompson at the University of Calgary, Hotchkiss Brain Institute is seeking applications for 2 postdoctoral fellows in 2-year funded positions. Appointment extension may be possible after successful performance reviews. Highly qualified candidates for graduate studies at the PhD level may also be considered.
The lab focusses on cellular and molecular mechanisms of neuronal death and altered synaptic / cellular function caused by stroke and Alzheimer’s related dementias. Opportunity exists for research studies using state-of-the-art technologies including molecular biology, protein biochemistry, electrophysiology, optogenetics, in vitro and in vivo multiphoton / confocal imaging and rodent behaviour.

Current CIHR funded research projects could be (but are not limited to):

  • Identify cellular and neural circuit pathways of neuronal death and dysfunction.
  • Discovery of molecular / cellular links between stroke and cognitive decline (i.e., Alzheimer’s disease).
  • Characterize novel forms of synaptic plasticity or cellular excitability related to the pannexin-1 ion / metabolite channel
  • Opportunities may also exist for self-directed research projects that fit within the overall mandate of the lab.

The Thompson lab (www.pannexinexus.com) is a dynamic research group, committed to optimizing success in an inclusive, equitable and diverse environment. Successful candidates will be expected to thrive and contribute to our collaborative environment while producing high quality neuroscience research results that accelerate understanding of stroke, dementia and their linkages.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.

Review of applications will begin immediately and continue until successful candidates are identified.
Contact information
Dr. Roger Thompson
Professor
Hotchkiss Brain Institute
University of Calgary
rj.thompson@ucalgary.ca

 

Post-doctoral fellowship – Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry – Université Laval

Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the impact of chronic stress on the activity of the medial prefrontal cortical (mPFC) excitatory/inhibitory circuitry in males and females. This project builds on results from our group showing that chronic stress interferes with the inhibitory control of principal cells differently in the mPFC of chronically stressed males and females. The aim of this project is to define how stress impacts the transcriptional programs controlling the activity of the different inhibitory interneuron subclasses in the mPFC and dissect their individual contribution on the disruption of the mPFC excitatory/inhibitory balance required for proper emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either behavioral or computational neuroscience with an established record of productivity in these fields of research. The lab models complex emotional responses to chronic stress through different paradigms including social defeat stress, chronic variable stress and prolonged social isolation. The project involves combining different trans-sectional viral approaches with single-cell RNAseq, patch clamp electrophysiology and single-cell Ca2+ imaging in freely behaving animals during stressful and operant tasks to ultimately dissect and confirm the contribution of cell-type specific gene programs on the maintenance/alteration of the excitatory/inhibitory balance in the mPFC of stressed males and females. Of particular interest, our lab owns unique human molecular profiles which provide highly translational findings relevant to clinical populations. This project is fully funded.

The candidate should have proven expertise with the assessment of mouse behavior and stereotaxic delivery of viral vectors. The candidate should also have a have a strong background with either patch clamp electrophysiology and/or Ca2+ imaging. Previous molecular expertise is a plus and proficiency with Matlab, R and Python coding would be ideal. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. The candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

Post-doctoral fellowship – Deciphering the epigenetics code underlying the expression of major depressive disorder in men and women.

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the epigenetic regulation of sex-specific gene networks across brain regions from men and women suffering from Major Depressive Disorder (MDD). This project relies on solid findings published from our lab showing that the transcriptional organization of gene networks across brain regions from men and women with MDD is highly sexually dimorphic and that these sex-specific gene networks control different aspects of emotional stress responses in males and females. The aim of this project is to reveal the epigenetic landscape across brain regions from men and women with MDD and confirm the impact of epigenetic changes on the activity of sex-specific gene networks and their control over emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either molecular or cellular biology, genetics, neuroscience or any other relevant disciplines with an established record of productivity in the respective fields of research. The project implies combining approaches to screen histone modifications, chromatin confirmation/occupancy and DNA base modifications in post-mortem tissue from men and women with MDD. The relationship between the layers of epigenetic complexity and the transcriptional organization of gene networks in men and women with MDD will be assessed by bioinformatically. In the lab, this will be first performed by delivering epigenetic modulators at regions of interest in human NPS cell lines and ultimately in mouse models using conditional viral approaches in transgenic mouse lines. This is a truly translational project with direct clinical implications in human populations. This project is fully funded and in-house bioinformatics expertise is already established.

The candidate should have proven expertise in basic and advanced molecular techniques related to the study of epigenetic, chromatin or DNA base modifications. The candidate should also have a strong experience with cell line maintenance and manipulation. Experience with animal work and stereotaxic viral delivery would be important assets. Proficiency with R or Python coding is a plus. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. By joining the group, the candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers a transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

Master’s Position Available to Study the Role of the Unfolded Protein Response (UPR) during Traumatic Brain Injury – Lindsey/Logue Labs, University of Manitoba

This project uniquely investigates the role of the unfolded protein response (UPR) in regulating the regenerative ability of neural stem cells following traumatic brain injury (TBI) using the zebrafish model. The objective of the proposed study is to identify the temporal dynamics of UPR signaling during the repair process, characterize the cell types in which the UPR is activated, and ask if modulating UPR signaling can impact upon repair after TBI. The successful candidate will be jointly supervised by Dr. Benjamin Lindsey (expert in neural stem cells and repair in the zebrafish model) and Dr. Susan Logue (Canada Research Chair in Cell Stress and Inflammation) and learn cutting edge cell biology, microscopy and molecular biology techniques. The successful candidate will be admitted to the Human Anatomy and Cell Science graduate program where they will be expected to complete coursework in addition to their lab based research.

Eligibility Requirements:

• Excellent academic standing
• Strong work ethic and passion for discovery
• Interest in neuroscience, cell signaling, and microscopy
• Experience or interest in using animal models
• Excellent written and oral communication skills

Deadline: June 1, 2021; Start Date: September 1, 2021
Contact information:

benjamin.lindsey@umanitoba.ca

Download a PDF version of this advertisement: Graduate-Student-Posting-UPR-TBI-Lindsey-Logue-Team.pdf

Posting end date 2021/08/31

Postdoctoral or Graduate Student Position: Corticothalamic synaptic physiology in a Rett Syndrome mouse model

Corticothalamic synaptic physiology in a Rett Syndrome mouse model

2 year funded Postdoctoral position, University of Victoria, BC Canada – available immediately

Rett syndrome is a neurodevelopmental disorder which manifests postnatally due to loss of function of an X-linked transcription factor MECP2, which controls various aspects of neuronal and synapse maturation. Studies will be performed primarily on female mice heterozygous for Mecp2 in which approximately half of neurons express the wild type and half the mutant allele. By utilizing a GFP-based nuclear marker we identify neurons expressing the wild-type or non-functional (mutated) Mecp2 allele for targeted physiological recordings. Optogenetic stimulation of virally-expressed channel rhodopsin will be used to investigate the relative strength of input from thalamus to cortex and feedback from cortex to thalamus for mutant versus wildtype neurons. Preference will be given to a researcher with experience in whole cell patch clamp recording (current and or voltage clamp) in acute brain slices or in vivo. Funded by the International Rett Syndrome Foundation. Contact Dr. Kerry Delaney, kdelaney@uvic.ca

More information about UVic Neuroscience can be found at https://www.uvic.ca/medsci/neuroscience/

The Delaney lab: https://web.uvic.ca/~neurolab

Publications:
https://pubmed.ncbi.nlm.nih.gov/?term=delaney+rett

Victoria as a place to live:
https://www.tourismvictoria.com

 

Contact information

kdelaney@uvic.ca
250 472 5657

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IBRO – MBL and CSHL Fellowships

The IBRO (International Brain Research Organization) US-Canada Regional Committee (USCRC) is pleased to announce our 2021 fellowships program that will cover the cost for PhD students and postdoctoral fellows training in neuroscience in Canada to attend advanced neuroscience courses or meetings at the Marine Biological Laboratories (MBL) at Woods Hole, MA., and Cold Spring Harbor Laboratory (CSHL), NY.

For MBL, all trainees are welcomed to apply but preference will be given to trainees belonging to minority groups (Indigenous communities in Canada, visible minorities, persons with disabilities, women, and other minorities) as
well as those in non-U15 Universities (http://u15.ca/). The MBL awards will cover the cost of tuition, room, and board. Fellowships are worth up to $11,000 per trainee depending on the course taken.

For CSHL, reduced registration fees for virtual meetings are available for trainees from non-U15 Universities (http://u15.ca/). If in-person courses resume in the second half of 2021, partial tuition support of up to $8,000 per trainee will be available.

The aim of this program is to increase diversity in neuroscience in Canada, by providing such trainees with access to cutting-edge research training in contemporary neuroscience.

Interested trainees should submit applications directly to the course of interest (see link below). Evaluation of applications and offers of admission to courses are made by the course leaders. Accepted candidates with the backgrounds mentioned above will be automatically considered for IBRO fellowship.

Eligible MBL courses: Neural Systems and Behavior, Neurobiology: Mechanisms & Advanced Approaches, Methods in Computational Neuroscience, Biology of the Inner Ear: Experimental and Analytical Approaches, Brains, Minds and Mechanisms, Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches, and Frontiers in Stem Cells and Regeneration.

Eligible CSHL courses: see link below.

MBL: http://www.mbl.edu/education/courses/
CSHL: https://meetings.cshl.edu/meetingshome.aspx

Please inform us when applying or if you have questions about eligibility.

Contact: sam.david@mcgill.ca

Graduate student position studying sensory learning and adult neurogenesis – Lindsey laboratory – University of Manitoba

We are seeking an outstanding graduate student with an interest in adult neurogenesis, and learning and memory to lead an exciting new project focusing on the role of adult neural stem cells for learning in response to changes in the sensory environment. To address this question our lab takes advantage of the zebrafish model that houses adult neurogenic zones in brain structures that process both sensory and cognitive input. We have established numerous transgenic lines to address this question and have recently setup a new Noldus DanioVision Behavioral System for experimental design and behavioral analysis. This position will provide trainees the opportunity to learn zebrafish animal husbandry, innovate new behavioral and sensory learning paradigms, perform advanced imaging including confocal microscopy, correlative electron microscopy, and 3-D brain imaging methods, as well as transgenic design. Please visit our laboratory website for more information (www.lindseylab.ca). This project is funded by NSERC.

Eligibility:

  • Excellent academic standing
  • Strong written and oral communication skills
  • Good problem solving skills and the ability to think independently
  • Ability to innovate new research methods
  • Related lab experience is preferred (but not mandatory)

The successful candidate will be admitted to the graduate program through the Department of Human Anatomy and Cell Science at the University of Manitoba, where they are expected to fulfill course work in addition to thesis based research. The candidate will be paid an annual stipend to cover tuition and living expenses.

 

Interested candidates are asked to submit a letter outlining their research interests, a CV including research experience and publications, a copy of recent transcripts and contact details for at least two references by email. Position start date is September 2021.

Contact information:

Dr. Benjamin Lindsey
Assistant Professor
Department of Human Anatomy and Cell Science
University of Manitoba
130 Basic Medical Science Building
745 Bannatyne Avenue
Winnipeg, Manitoba

Canada

 

Benjamin.lindsey@umanitoba.ca

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Posting end date: 2021/06/30