Funded Graduate Student Positions at the University of Manitoba

Multiple graduate student positions (M.Sc., Ph.D.) are available in the laboratory of Dr. Tabrez Siddiqui at the University of Manitoba. The Siddiqui lab’s multidisciplinary research program encompasses the molecular, systems and behavioural branches of neuroscience to investigate neuronal circuit organization, plasticity and network integration. Our goals are to generate transformative knowledge on the molecular mechanisms of synapse development and function in both the developing and mature brain, provide conceptual advances in understanding the mechanisms governing enduring changes in synaptic properties (plasticity) that underlie cognitive function and associative learning, and determine how synapses are specified in the mammalian brain to provide the framework for understanding the molecular logic of circuit organization and associated behaviours. The Siddiqui lab is also actively pursuing translational goals in uncovering synaptic regulatory mechanisms and targets in neurodevelopmental and psychiatric disorders such as autism and schizophrenia.

Eligibility Requirements

  1. Excellent academic standing
  2. Strong work ethic and interest in discovery science
  3. Experience or interest in using animal models
  4. Research experience is an asset
  5. Excellent written and oral communication skills

The positions are fully funded with standard stipends commensurate with the University of Manitoba guidelines and Departmental bylaws. Successful students will be admitted to the Physiology graduate program, but may be considered for the Biomedical Engineering program.

This search will close on January 20, 2023.

Please send the following the documents to Dr. Siddiqui by email

  1. Cover letter explaining your background, interests, and training, and why you will be a good fit for the Siddiqui lab research program.
  2. CV
  3. Transcripts

We thank all applicants for their interest. However, however only those candidates selected for interviews will be contacted.

Rady Faculty of Health Sciences
Max Rady College of Medicine
Department of Physiology and Pathophysiology
Neuroscience Research Program
Kleysen Institute for Advanced Medicine
Health Sciences Centre
SR422-710 William Avenue
Winnipeg, MB R3E 0Z3
Phone: 1.204.318.2564

 

Email: tabrez.siddiqui@umanitoba.ca

https://umanitoba.ca

Siddiqui Lab Publications can be accessed here.

https://pubmed.ncbi.nlm.nih.gov/?term=Tabrez+j+siddiqui&sort=date

Some of our recent published studies are listed below

  1. Dhume S.H., Karimi B., Roppongi R.T. Connor, S.A., Mills, F., Tari, P.K., Oku, S., Bamji, S.X., Wang, Y.T., Brose, N., and Craig, A.M., Siddiqui, T.J., Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits, Elife. (2022) Jun 6;11:e64742. doi: 10.7554/eLife.64742.0: 0.
  2. Karimi B, Silwal P, Booth S, Padmanabhan N, Dhume S, Zhang D, Zahra N, Jackson MF, Kirouac GJ, Ko JH, and Siddiqui T.J.*, Schizophrenia-associated LRRTM1 regulates cognitive function through controlling synaptic activity in the mediodorsal thalamus, Molecular Psychiatry, 2021May 12. doi: 10.1038/s41380-021-01146-6
  3. Roppongi RT#, Dhume S#, Padmanabhan N#, Silwal P, Zahra N, Bomkamp C, Pati Cl, Karimi B, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MJ, and Siddiqui TJ, LRRTMs organize synapses through differential engagement of neurexin and PTPσ, Neuron (2020), Apr 8; 106 (1):108-125.e12. doi: 10.1016/j.neuron.2020.01.003 (# co-first authors)
  4. Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Fred Rieke, Craig AM, Wong RO, and Hoon M, LRRTM4: a novel regulator of presynaptic inhibitory and dyad output synapses of retinal bipolar neurons, Neuron (2020), Mar 18;105(6):1007- 1017.e5. doi: 10.1016/j.neuron.2019.12.028.
  5. Zhang Z, Pines MK, Oku S, Ge Y, Siddiqui TJ, Wu W, Archer-Hartmann S, Azadi P, Gordon MD, and Craig AM. (2018). Heparan Sulfate Organizes Neuronal Synapses Through Neurexin Partnerships. Cell 174(6): 1450-1464.

tabrez.siddiqui@umanitoba.ca

Tabrez J. Siddiqui, PhD

Associate Professor of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba.

Principal Investigator, Children’s Hospital Research Institute of Manitoba.

Principal Investigator, Neuroscience Research Program,

Kleysen Institute for Advanced Medicine, Health Sciences Centre.
SR422-710 William Avenue, Winnipeg R3E 0Z3, Manitoba, Canada.
Phone: 1. 204.318.2564

https://umanitoba.ca/medicine/faculty-staff/tabrez-siddiqui

Twitter: @siddiquilab

The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota and Dene peoples, and on the homeland of the Métis Nation. We respect the Treaties that were made on these territories, we acknowledge the harms and mistakes of the past, and we dedicate ourselves to move forward in partnership with Indigenous communities in a spirit of reconciliation and collaboration.

Graduate student position – University of Lethbridge

Description: We are looking for graduate students (Master’s and/or Ph.D. levels) to help build UHF-based Internet of Things (IoT) system that will be used as a Brain-Machine Interface device. Projects will be related to our recent work:

 

Challenges of a small world analysis for the continuous monitoring of behaviour in mice. Neuroscience and Behavioral Reviews 2022 https://www.sciencedirect.com/science/article/pii/S0149763422001105

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice. Nature Methods 2021 https://www.nature.com/articles/s41592-021-01104-8

The project is a collaborative effort between the research groups of Majid Mohajerani (http://lethbridgebraindynamics.com/majid-mohajerani/) and Dr. Robert Sutherland. Successful candidates will join the highly collaborative and interdisciplinary Canadian Centre for Neuroengineering Solutions and Brain Dynamics Group. We are located close to the Rocky Mountains, Lethbridge has the largest number of sunny days in Canada, and it is the most affordable city for young people in Canada (https://dailyhive.com/calgary/alberta-city-most-affordable-young-people ).

Requirements: Only applicants with previous experience working in UHF-based antenna design and software-defined radio systems are encouraged to apply.

The applications review will start on Oct 1st till the positions are filled. Interested applicants must send an email to Dr. Mohajerani (mohajerani@uleth.ca) and include a cover letter, curriculum vitae, a brief statement of research interests, and the contact information of three references.

ERC-funded project: neural control of locomotion before and after spinal cord injury in salamanders – Graduate student position

PROJECT: Salamanders can swim underwater and walk on ground. Their spinal cord regenerates after a full transection and the animal recovers voluntary locomotion after a few weeks. How this occurs is largely unknown. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualization of genetically-defined cells. Such approaches can be combined with patch-clamp electrophysiology, calcium imaging, optogenetics, tracing and movement analysis (Ryczko et al. 2020 Trends in Neurosciences, https://doi.org/10.1016/j.tins.2020.08.006). The candidate will use electrophysiology (patch-clamp recordings), calcium imaging and movement analysis based on deep learning and neuroanatomy to study salamander locomotor circuits. This project is funded by a synergy grant of the ERC. The work will be carried out in collaboration with a team of modelers and roboticists (Pr. Ijspeert, EPFL, Switzerland) and experts in genomics (Pr. Simon, Karolinska Institute, Sweden).

REQUIREMENTS: The candidate should have completed a MSc in neuroscience. The ideal candidate would have experience in electrophysiology, calcium imaging, optogenetics, virus injections, deep learning-based movement analysis, matlab scripting, and a keen interest in motor control.

HOST LABORATORY: The lab of Dr. Ryczko has expertise in the neural control of locomotion and publishes in excellent journals (PNAS, Science, Science Robotics, Journal of Neuroscience…). The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC. We are equipped for patch-clamp recordings, confocal and two photon calcium imaging, optogenetics, viral injections, deep learning-based movement analysis, and microscopy (confocal, light-sheet, two-photon, STED).

APPLY: Candidates should send a letter of interest explaining how they would fit, a CV, a record of their academic results and three references at: dimitri.ryczko@usherbrooke.ca. Please specify where you found the job post.

Postdoc and graduate students (Master’s and/or Ph.D. levels) positions at intersection of AI and Neuroscience – University of Lethbridge

Description: We are looking for postdocs and graduate students (Master’s and/or Ph.D. levels) to use inspirations from neuroscience to make better AI and conversely to apply AI to better understand brain function and behaviour. Projects will be related to our recent work:

Neurons learn by predicting future activity. Nature Machine Intelligence 2022 https://www.nature.com/articles/s42256-021-00430-y

Predictive neuronal adaptation as a basis for consciousness. Front in Sys Neurosci 2022 https://www.frontiersin.org/articles/10.3389/fnsys.2021.767461/full

Miniaturized head-mounted microscope for whole-cortex mesoscale imaging in freely behaving mice. Nature Methods 2021 https://www.nature.com/articles/s41592-021-01104-8

A Matlab-based toolbox for characterizing behavior of rodents engaged in string-pulling. Elife 2020 https://elifesciences.org/articles/54540

Challenges of a small world analysis for the continuous monitoring of behavior in mice. Neuroscience and Behavioral Reviews 2022 https://www.sciencedirect.com/science/article/pii/S0149763422001105

Data-driven analyses of motor impairments in animal models of neurological disorders. PLoS Biology 2019 https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000516

The project is a collaborative effort between the research groups of Majid Mohajerani (http://lethbridgebraindynamics.com/majid-mohajerani/) and Artur Luczak (http://lethbridgebraindynamics.com/artur-luczak/). Successful candidates will join the highly collaborative and interdisciplinary Canadian Centre for Behavioural Neuroscience and Brain Dynamics group. We are located close to Rocky Mountains, Lethbridge has the largest number of sunny days in Canada, and it is the most affordable city for young people in Canada (https://dailyhive.com/calgary/alberta-city-most-affordable-young-people ).

The applications review will start on Aug 15th till the positions are filled. Interested applicants must send an email to Dr Mohajerani (mohajerani@uleth.ca) and Dr. Luczak (luczak@uleth.ca) and include a cover letter, curriculum vitae, a brief statement of research interests, and contact information of three references.

Neurophysiology graduate student position at the University of Victoria, BC

We are inviting applications for a Master’s or PhD student position to study synaptic neurophysiology at the University of Victoria, in Victoria, British Columbia, Canada. The selected candidate will join the team of Dr. Raad Nashmi’s laboratory.

Our lab is interested in understanding how cholinergic neurons affect the excitability and plasticity of neural circuits in the brain. To achieve this our lab employs a variety of techniques including whole-cell patch-clamp recordings of mouse brain slice tissue, optogenetics, UV uncaging of neurotransmitters and the study of mouse behaviours. Ultimately, we are interested in how specific neural circuit activity in the brain control or modulate specific behaviours. The Master’s or PhD candidate will examine how different neurotransmitter systems, including the cholinergic system, modifies the function of substantia nigral neurons in a spatial and temporal manner.

Applicants should have taken courses at the undergraduate or graduate level in physiology and/or neuroscience. Experience with electrophysiology would be an asset but is not necessary.

The University of Victoria is a research intensive university located on Vancouver Island in the city of Victoria, the capital of British Columbia. Greater Victoria region has a population of 397,000 and has all the amenities common to major Canadian cities. Victoria and its surrounding local areas boast breathtaking natural scenery and a mild climate, making it one of the most desirable destinations in Canada.

Please contact Raad Nashmi, raad@uvic.ca, with a resume or CV, a copy of your university transcripts and a brief explanation of your research interests.

Contact information
Raad Nashmi

raad@uvic.ca

Synaptic physiology/brain plasticity positions in Victoria B.C. – graduate students

Fully funded positions are available for graduate (MSc or PhD) trainees to study cellular and synaptic neurophysiology. We are looking for energetic, self-motivated individuals with an interest in basic neuroscience questions that can be applied for our research on transmitter release, synaptic plasticity. September or January start dates are possible.

Our research uses a variety of model system combining electrophysiology with fluorescence imaging to study nervous system in vivo or in blocks/slices of tissue maintained in vitro. We aim to understand how cell and synaptic physiology affect the performance of neural networks with an emphasis on the role of short-term activity dependent plasticity or neuromodulators.

Two programs are currently funded and looking for new students. Our work on olfactory bulb and related structures use this as a model system for studies of synaptic plasticity and dendritic processing (NSERC). Our research funded by CIHR and International Rett Syndrome Foundation examines the physiological consequences of mutation in an X-linked transcription factor, MeCP2 for thalamo-cortical connectivity and neuromodulation by nicotinic acetylcholine receptors. These studies are performed using transgenic mice that are a model for the human disorder combined with fluorescence markers that allow targeted recording from mutant and non-mutant neurons in mosaic female mouse brains to determine cell autonomous vs. non-autonomous effects of the mutation.

Successful applicants should have training through coursework and/or undergraduate research experiences that includes physiology and neuroscience. Experience with electrophysiology or fluorescence microscopy is advantageous but not necessary. Trainees will join a highly collaborative group of active researchers who are directly engaged in student training: https://www.uvic.ca/science/biology/research/researchareas/index.php#neurobiology

Victoria offers an exceptional quality of life for those with an interest in outdoor activities such as hiking, kayaking, sailing, climbing and simply getting out into nature. https://www.hellobc.com/places-to-go/victoria/

Contact information

Kerry Delaney
kdelaney@uvic.ca

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Master’s or PhD position in Neurosciences – Laval University, in Quebec City, Canada

We are inviting applications for a Master’s or PhD student position at the Faculty of Medicine, Laval University, in Quebec City, Canada. The selected candidate will join the team of Dr. Aurelie de Rus Jacquet and Dr. Abid Oueslati.

 

Our research:

We specialize in the study of Parkinson’s disease, with the objective to describe molecular mechanisms regulating pathogenesis. Dr. de Rus Jacquet focuses on the study of glial cells, their role in the pathogenesis of Parkinson’s disease, and mechanisms by which they modulate blood-brain interactions at the blood-brain barrier. We use patient-derived induced pluripotent cells and microfluidic technologies to model cell-cell interactions and elucidate disease mechanisms.

 

The project:

The Master’s or PhD project will focus on understanding how plasma proteins affect the function and survival of neuronal and glial cells in the context of Parkinson’s disease. The objective of this novel and exciting work is to discover new drug targets and propose innovative therapeutic approaches to slow or stop the progression of the disease. Technical approaches will include cell culture, immunofluorescence, imaging, biochemistry, cell biology and mass spectrometry.

 

Your profile:

  • Obtained a Bachelor’s or a Master’s degree in Neurosciences, Cell Biology, Biomedical Sciences or related area
  • Strong academic record
  • Ability to work independently and as part of a team
  • Highly motivated and dedicated to improving human health

 

The work environment:

We are located in a dynamic and fast-paced work environment. We thrive to offer an inclusive workplace where each team member can grow and explore their scientific creativity. We welcome applications from all interested candidates and greatly encourage those from groups traditionally underrepresented in the sciences. The work languages are English and French. Laval University is a French-speaking University (https://www.ulaval.ca/). Québec City is a UNESCO world heritage destination and offers a rich student experience in one of the most beautiful cities in Canada (https://www.quebec-cite.com/en ).

 

Apply:

For more information, please contact Dr. Aurelie de Rus Jacquet: aurelie.jacquet@crchudequebec.ulaval.ca. Applications will be reviewed until the position is filled. The candidates selected for an interview will be contacted directly.

 

Interested applicants should send the following PDF documents to Dr. Aurelie de Rus Jacquet:

  • Your CV detailing education, research experience, skills, awards and publications
  • A cover letter discussing your previous experiences, career goals and research interests
  • Academic transcripts
  • Names and emails of three references who can provide letters of recommendation

Contact information

For more information, please contact Dr. Aurelie de Rus Jacquet: aurelie.jacquet@crchudequebec.ulaval.ca.

Master’s Position Available – Investigating the Molecular Regulators of Brain Development – University of Manitoba

Description of the position:

This project aims to investigate the molecular regulators of neural stem cell lineage progression and their role in determining cell types and states in the developing central nervous system. The successful candidate will be directly supervised by Dr. Robert Beattie (expert in studying neural development using mouse models) and apply state-of-the-art single cell and molecular biology techniques such as Mosaic Analysis with Double Markers (MADM). The successful candidate will be admitted to the Department of Biochemistry and Medical Genetics graduate program, where they will be expected to complete coursework in addition to their thesis-based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the annual competitive stipend provided by Dr. Beattie.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, brain development, molecular biology and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 15, 2022; Start Date: September 1, 2022

Please send your CV and cover letter directly to Dr. Beattie, highlighting your reasons for doing research and specifically why this position in the Beattie lab is interesting for you. We thank all applicants for their interest, however only those candidates selected for interviews will be contacted.

Contact information

Robert.beattie@umanitoba.ca

Robert Beattie, Ph.D. Assistant Professor

Department of Biochemistry and Medical Genetics

Rady Faculty of Health Sciences

University of Manitoba

www.beattiescience.com

 

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Posting end date:  2022/06/30

Master’s Position Available to Study the Effect of Neural Stem Cell Senescence on Brain Repair – Lindsey Lab, University of Manitoba

Description of the position:

This project uniquely examines the role of cellular senescence in regulating the regenerative capacity of neural stem cells in the aging brain using the adult zebrafish model. The objective of the proposed study is to define which zebrafish neural stem cell populations undergo aging, how this is regulated by changes in cell signaling and gene expression, and how neural stem cell senescence effects timely brain repair following injury. The successful candidate will be directly supervised by Dr. Benjamin Lindsey (expert in neural stem cells and repair in the zebrafish model) and learn cutting edge cell biology, injury models, microscopy and molecular biology techniques. The successful candidate will be admitted to the Human Anatomy and Cell Science graduate program where they will be expected to complete coursework in addition to their thesis based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the annual stipend provided by Lindsey.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, brain repair, and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 1, 2022; Start Date: September 1, 2022

Contact information

benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,
Department of Human Anatomy & Cell Science
Rady Faculty of Health Sciences
University of Manitoba
www.lindseylab.ca

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Master’s Position Available to Study the Role of the Unfolded Protein Response (UPR) during Spinal Cord Injury – Lindsey/Logue Labs, University of Manitoba

Description of the position:

This project uniquely investigates the role of the unfolded protein response (UPR) in regulating the regenerative ability of neural stem cells following spinal cord injury (SCI) using the zebrafish model. The objective of the proposed study is to identify the temporal dynamics of UPR signaling during the repair process, characterize the cell types in which the UPR is activated, and ask if modulating UPR signaling can impact upon repair after SCI. The successful candidate will be jointly supervised by Dr. Benjamin Lindsey (expert in neural stem cells and repair in the zebrafish model) and Dr. Susan Logue (Canada Research Chair in Cell Stress and Inflammation) and learn cutting edge cell biology, microscopy and molecular biology techniques. The successful candidate will be admitted to the Human Anatomy and Cell Science graduate program where they will be expected to complete coursework in addition to their thesis based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the stipend provided by Lindsey/Logue.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, cell signaling, and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 1, 2022; Start Date: September 1, 2022

Contact information

benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,
Department of Human Anatomy & Cell Science
Rady Faculty of Health Sciences
University of Manitoba
www.lindseylab.ca

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