BRAIN CREATE | Interdisciplinary Training Program for New Neurotechnologies

BRAIN CREATE program

Want to develop and commercialize the neurotechnology of the future?

Professors Marc Poulin and Richard Wilson from the University of Calgary are pleased to announce new cutting-
edge training opportunities with full scholarships for MSc and PhD students and Postdoctoral Fellows. Training draws heavily on elective workshops and is focused in labs developing drugs, devices and protocols that improve
nervous system function and monitoring. Funding will be provided for up to 100 trainees over the next 5 years.

Highlights:

  • Training in both neurosciences and integrated physiology
  • Training in technology transfer, patenting, and commercialization
  • Fully-funded scholarships
  • Opportunities for international travel
  • World-class supervisors

Find out more:

Web: cumming.ucalgary.ca/braincreate

Email: braincreate@ucalgary.ca

The Canadian-IBRO School Offers Two Teaching Internships on Neuroscience Education and Research in Africa and Latin America.

COVID-19 UPDATE: Due to uncertainties related to the evolution of the COVID-19 pandemic, the Canadian IBRO School has been postponed to 2021.  New opportunities will be posted next year.

 

Deadline for applications: March 30, 2020

A unique opportunity for 2 senior neuroscience graduate students or postdocs, registered at a Canadian university, interested in helping to promote neuroscience education and research capacity in Africa and Latin America.

This internship program builds on the rich scientific and cultural diversity that the Canadian-IBRO School program has accumulated since its inception in 2006. Successful applicants will spend 3 ½-weeks in Montreal, from May 14 – June 7, 2020 at the 14th Canadian-IBRO School.

Who should apply?
A unique opportunity for 2 senior neuroscience Graduate Students or Postdoctoral Fellows, registered at a Canadian university, interested in helping to promote neuroscience education and research capacity in Africa and Latin America.

Description
The two Canadian IBRO Trainee Interns will contribute to the teaching of graduate trainees from Latin America and Africa, and gain valuable insights into the challenges and opportunities of conducting research in countries with limited resources. The Interns will be advised on how to coordinate discussions and interact with talented students from diverse backgrounds who have English as a second language. In addition, the Interns will gain a deeper knowledge of Canada’s role in international development and in lessening the burden of neurological diseases in low- and middle-income countries.
For more details consult the following page.

Where & When
The internship will take place in Montreal from May 14 – June 7, 2020, and include participation in the annual meeting of the Canadian Association for Neuroscience (CAN). This program covers travel costs, meals, and accommodation.

How to apply
Applicants should complete the online application. Instructions are provided on this page:
http://www.can-ibroschools.info/Pub/Pub_Main_Display.asp?LC_Docs_ID=4938

OR
Submit a brief (200 words) statement of how their interests align with this internship, an updated CV, and a letter of reference from their supervisor before March 30, 2020 to:

Dr. Ellis Cooper: Ellis.Cooper@McGill.ca

For further details, see www.can-ibroschools.info

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell regulation and function, Lindsey Lab at the Rady Faculty of Health Sciences, University of Manitoba

Description of the position:

Our research focuses on uncovering the function and regulation of neural stem cell populations during brain development, behaviour, and following neurotrauma. The overarching goal of our lab is to define conserved themes in vertebrate neural stem cell regulation at the molecular and cellular levels. To address this goal, our lab takes advantage of the lifelong proliferative, neurogenic, and regenerative capacity of the zebrafish model. We currently use a number of transgenic zebrafish lines to study the response of neural stem cells to brain and spinal cord injury, stem cell niche maturation, and animal behaviour. A variety of models of neurotrauma are used in the lab along with contemporary molecular, cellular, imaging, and behavioral techniques, including primary cell culture, 2-D and 3-D imaging, correlative EM, RNA-sequencing approaches, fluorescence in situ hybridization, immunohistochemistry, etc.

Eligibility Requirements:

  • Experience in Imaging (2-D/3-D, confocal, EM, clearing methods)
  • Experience in Molecular Biology (cloning, PCR, CRISPR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry)
  • Experience using animal models of study
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

Benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,

Department of Human Anatomy & Cell Science

Rady Faculty of Health Sciences

University of Manitoba

 

130 Basic Medical Science Building

745 Bannatyne Avenue,

Winnipeg, Manitoba, R3E 0J9, CANADA

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell reprogramming and differentiation, Wang lab at Ottawa Hospital Research Institute

Description of the position:

Our research focuses on delineating molecular mechanisms that regulate neural stem cell reprograming and differentiation, with the ultimate goal of defining ways to recruit the stem cells that are resident in the brains or are derived from non-neuronal cells, and to thereby potentially promote neural repair. We are currently using stroke, Alzheimer’s disease, multiple sclerosis and autism as brain disease models to explore underlying molecular mechanisms. A variety of molecular, cellular, biochemical and behavioral techniques are used in the laboratory, including transgenic mouse models, in vivo neurodegenerative disease model, primary cell culture, co-IP and ChIP, and RNA-seq approaches and etc.

Eligibility Requirements:

  • Experience in Molecular Biology (cloning, mutagenesis, PCR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry) or in vivo animal model study.
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

jiwang@ohri.ca
Dr. Jing Wang, Ph.D.
Senior Scientist, Sprott Centre for Stem Cell Research
Ottawa Hospital Research Institute
Assistant Professor Department of Cellular & Molecular Medicine

University of Ottawa
Ottawa Hospital, 501 Smyth Rd, Box 511
Ottawa, ON K1H 8L6 CANADA

PhD position in Visual Neuroscience and Neurophotonics at the Université de Montréal

Funded PhD positions in Neurophotonics and Visual Neuroscience at the Université de Montréal (www.opto.umontreal.ca/cortex). We use a range of behavioral and neurophysiological techniques including calcium imaging and optogenetics on mice to study brain circuits underlying vision. We also focus on exploring plasticity after a stroke in the visual system and developing innovative neuroprosthesis devices to restore vision.
Candidates with a strong background in in vivo Neurophysiology AND/OR Behavioral Neuroscience AND/OR Engineering in Neuroscience are encouraged to apply.

Please contact Pr. Matthieu Vanni (matthieu.vanni@umontreal.ca) with

  1. a full CV,
  2. motivations for joining the lab and
  3. contact information of two referees.

Qualifications:

  • MSc or equivalent degree in natural, medical sciences, bioengineering or related fields.
  • Good English AND/OR French communication skills, both oral and written.
  • Be eligible to join a PhD Program of Vision Science or Biomedical engineering at the Université de Montréal.https://admission.umontreal.ca/programmes/doctorat-en-sciences-de-la-vision/
  • Proficiency with Data analysis using Matlab or Python

Contact information matthieu.vanni@umontreal.ca

Learning mechanisms of pain – PhD or post-doctoral position, Martin lab, University of Toronto

The ability to predict pain or other unpleasant events by learning from prior experience is an important adaptive behavior in healthy organisms and can cause disabling fear and avoidance in patients with chronic pain. While there is no single ‘pain processing area of the brain’, our recent efforts have focused on the role of the anterior cingulate cortex (ACC), due to its capacity to modulate pain and emotion based on prior experience.

The Martin Lab (www.martinpainlab.com) at the University of Toronto is currently seeking an independent, highly motivated and enthusiastic individual to study the molecular and synaptic basis of pain memory. Specifically, the candidate will be tasked with developing novel behavioural models of pain memory and should have a strong interest in neural circuits, in vivo imaging and electrophysiology.

Qualified postdoctoral candidates should have extensive experience with in vitro (patch-clamp) electrophysiological techniques, in vivo optogenetics or fiber photometry. Experience with molecular biology and/or immunohistochemistry are strong assets for both positions.

The postdoctoral position is available to start July 2020 (or later) and the deadline for graduate student applications is December 1, 2019 (Department of Psychology) or February 15, 2020 (Cell, Systems & Biology).

To apply, please send a brief statement of research interests, CV, and contact information for 3 references to lj.martin@utoronto.ca.

Contact information

Loren J. Martin, Ph.D.
Assistant Professor, University of Toronto Mississauga
Tier II Canada Research Chair in Translational Pain Research
Department of Psychology, CCT Building, Room 4061
3359 Mississauga Rd, Mississauga, ON, L5L 1C6

Exploring inhibitory neuron-secreted chemokines as a novel remyelination therapy – Post-doc or student position, Voronova lab, U Alberta

Neural precursor cells in adult mammalian brain, such as subventricular zone (SVZ) neural stem cells and oligodendrocyte precursors in brain parenchyma, form oligodendrocytes throughout life. The purpose of oligodendrocytes is to produce myelin, an insulating material that performs vital functions in efficient neural information transmission and constitutes the brain white matter. Demyelinating disorders occur when myelin, a protective substance that coats nerve projections and ensures efficient neuronal signalling, is damaged. This leads to nerve dysfunction and neurological impairments. Demyelination occurs in neurological disorders such as multiple sclerosis (MS), in which myelin is attacked and damaged by the body’s own immune cells. Current MS treatments only target inflammation but not central nervous system (CNS) remyelination, which could be achieved by stimulating the production of new oligodendrocytes.

Postdoctoral fellow or Ph.D. candidate will investigate how developmentally important neuronal chemokines (Voronova et al. 2017 Neuron) affect precursor-microglia cell-to-cell interactions for enhanced remyelination. The production of oligodendrocyte lineage cells and/or new myelin will be investigated using transgenic animals. Other techniques will include live imaging, flow cytometry, phagocytosis assays, brain slice and primary cell culture, intracerebroventricular injections (live animal surgery), RNA-sequencing and in situ hybridization, cytokine analysis, immunohistochemistry as well as confocal and electron microscopy.

An ideal candidate will be highly motivated and can work as a team player and a leader. Preference will be given to applicants with previous rodent experience and/or extensive cell or developmental biology expertise. Highly motivated Ph.D. and postdoctoral fellow candidates ready to learn live animal surgeries and work collaboratively and responsibly are encouraged to apply. Salary for potential postdoctoral fellow with commensurate with experience. Position will be open until filled.

Candidates should submit:
i) cover letter including research interests including a brief summary of previous graduate thesis and/or post-doctoral research (if applicable);
ii) complete CV;
iii) transcripts (unofficial is suitable); and
iv) the names and contact information of at least two academic referees.

E-mail applications to voronova@ualberta.ca. Only applicants selected for an interview will be contacted.

Download a PDF version of this advertisement: 20190522-Voronova

Graduate Student/Postdoctoral Positions in Cellular Neuroscience – Bowie lab, McGill University

Two CIHR-funded positions are available immediately for enthusiastic graduate students/postdoctoral fellows with a keen interest in using electrophysiology and imaging techniques to study ligand-gated ion-channels and their role in neuronal circuit behavior.

The first project will focus on an ongoing theme to understand the structure-function properties of ionotropic glutamate receptors. The successful applicant will use single-channel and macroscopic patch clamp techniques to tease apart the mechanism of channel activation in wildtype and mutant receptors. This work will be part of a multilab collaboration with researchers using computational chemistry and structural biology.

The second project will examine the signaling defects associated with Fragile X syndrome, a prominent neurodevelopmental disorder. The successful applicant will study neuronal circuit connectivity using single and multi-electrode recordings from acutely isolated brain tissue. Imaging and functional experiments will be collected simultaneously using a multiphoton microscope equipped with an electrophysiology rig.

Related Publications
Dawe et al (2016) Distinct structural pathways coordinate the activation of AMPA receptor-auxiliary subunit complexes. Neuron.

Accardi et al (2014) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun.

*Student stipends will be based on the policy recommendations of individual McGill Graduate Programs. Postdoctoral salaries will be based on CIHR recommendations and level of experience*

Applicants should send a cover letter, cv and the names of 2-3 referees to:

Dr. Derek Bowie,
Department of Pharmacology & Therapeutics
McGill University, Faculty of Medicine
3649 Promenade Sir-William Osler, Rm 164
Montreal, QC, Canada, H3G 0B1

Tele: 514-398-1581 Email: derek.bowie@mcgill.ca
Webpage: http://www.medicine.mcgill.ca/pharma/dbowielab

Connect on LinkedIn: https://www.linkedin.com/in/derek-bowie-177a7855/

Download a pdf version of this advertisement: Bowie-Advertisement-PDF

Study the Basic Mechanisms of Multiple Sclerosis: Graduate Student & Postdoctoral Fellow Positions Available (University of Saskatchewan)

Join a dynamic, world-class, generously funded basic and translation science team. Located in state-of-the-art laboratory facilities in the Saskatoon City Hospital, basic scientists are able to work hand-in-hand with clinicians from the Saskatoon MS Clinic (also located in Saskatoon City Hospital). Graduate Student and Postdoctoral Fellow positions in the Office of the Saskatchewan MS Clinical Research Chair are offered highly competitive compensation, personalized mentorship with in vitro, in vivo, genetic, and human projects available.

Contact information Ms. Colleen Cochran, colleen.cochran@usask.ca

Graduate Student positions (PDF)

Postdoctoral Fellow positions (PDF)

TWO Graduate student positions in Neural Stem Cell Biology & Neural Stem Cell Regeneration – LINDSEY LAB – University of Manitoba

Graduate student position in Neural Stem Cell Regeneration

The Lindsey Lab is looking for a highly motivated student to fill an open funded graduate student position for September 2019. The focus of the project will be on the cellular and molecular regulation of neural stem cells during the regenerative process following CNS injury in the zebrafish model. The Lindsey Lab is the first laboratory at the University of Manitoba to establish the zebrafish model, and one of the only laboratories in Canada investigating CNS neural stem cell repair using this experimental system. Unlike in mammals, the zebrafish brain remains highly regenerative throughout life. This is made possible by distinct populations of neural stem cells with the potential to generate newborn neurons. The exceptional regenerative capacity of the zebrafish has made it a mainstream vertebrate model to uncover fundamental mechanisms of neural repair for the development of novel approaches to regenerative medicine. To date however, the interplay between the innate molecular programs of regenerative neural stem cells, the niche micro-environment, and the immune response, that together promote successful adult CNS regeneration is poorly understood. We are interested in characterizing the cellular and molecular regulators of neural stem cell populations post-injury to better understand how we may harness the regenerative potential of zebrafish neural stem cells for human therapies related to neurotrauma and neurodegenerative disease.

Graduate student position in Neural Stem Cell Biology

The Lindsey Lab is looking for a highly motivated student to fill an open funded graduate student position for September 2019. The focus of the project will be on neural stem cell niche development in the zebrafish model. The Lindsey Lab is the first laboratory at the University of Manitoba to establish the zebrafish model, and one of few laboratories in Canada investigating CNS neural stem cell development and plasticity using this experimental system. In recent years, the zebrafish has become a leading model for examining neural stem cell behavior and plasticity. The transparency of zebrafish larvae along with the abundance of lifelong stem cell compartments makes this model highly amenable to tracking stem cell niche growth, maintenance, and senescence.

The vertebrate adult neurogenic niche is composed of heterogeneous stem cell populations that receive cues from the vasculature, adjacent neurons, and ventricular cerebral spinal fluid. How adult neural stem cell niches of the vertebrate brain are constructed over development however, currently remains poorly understood. We are interested in defining how diverse stem cell niches are established from the larval to adult brain, and the cellular (i.e. cell cycle changes, differentiation, apoptosis, senescence) and molecular (i.e. signaling pathways, genes, growth factors) drivers involved in this process.

About the Lindsey Lab

The overarching research focus of the Lindsey Lab is to understand context-dependent behavior and control of distinct neural stem cell populations during development, with environmental interactions and learning, and repair. We use a combination of modern cellular and molecular approaches, such as proliferation and senescence assays, lineage tracing, in situ hybridization, transgenic animals, immunohistochemistry, RNA-sequencing, and injury models. These techniques are coupled with advanced 2-dimensional (live or fixed fluorescence confocal microscopy, electron microscopy and correlative electron microscopy) and 3-dimensional (optical projection tomography, confocal/light-sheet microscopy, tissue clearing) imaging. Finally, we use specialized behavioural software to understand the relationship between animal behavior/neurotrauma – stem cell dynamics – and neurogenesis/neuro-regeneration.

Students joining the Lindsey Lab can expect high quality research training and mentorship in a supportive and collaborative learning environment. Trainees will have the opportunity to present their work at local, national, and international scientific meetings and collaborate with diverse researchers within the Rady Faculty of Health Sciences. A highly competitive graduate student stipend is available for the successful candidate. However, all students will be expected to apply for local and national level graduate student scholarships during tenure of the position.

The Lindsey Lab is located within the Department of Human Anatomy and Cell Science in the Rady Faculty of Health Sciences at the University of Manitoba in Winnipeg. http://umanitoba.ca/faculties/health_sciences/medicine/units/anatomy/12818.html

How to apply

Interested candidates should send a brief statement of research interests, a copy of their most recent transcript, and their CV to Dr. Benjamin Lindsey at Benjamin.lindsey@umanitoba.ca. If shortlisted, potential candidates will be asked to provide contact information for three references. Students with an interest in fundamental neural stem cell behavior are highly encouraged to apply.