Multiple graduate student positions (M.Sc., Ph.D.) are available in the laboratory of Dr. Tabrez Siddiqui at the University of Manitoba. The Siddiqui lab’s multidisciplinary research program encompasses the molecular, systems and behavioural branches of neuroscience to investigate neuronal circuit organization, plasticity and network integration. Our goals are to generate transformative knowledge on the molecular mechanisms of synapse development and function in both the developing and mature brain, provide conceptual advances in understanding the mechanisms governing enduring changes in synaptic properties (plasticity) that underlie cognitive function and associative learning, and determine how synapses are specified in the mammalian brain to provide the framework for understanding the molecular logic of circuit organization and associated behaviours. The Siddiqui lab is also actively pursuing translational goals in uncovering synaptic regulatory mechanisms and targets in neurodevelopmental and psychiatric disorders such as autism and schizophrenia.
- Excellent academic standing
- Strong work ethic and interest in discovery science
- Experience or interest in using animal models
- Research experience is an asset
- Excellent written and oral communication skills
The positions are fully funded with standard stipends commensurate with the University of Manitoba guidelines and Departmental bylaws. Successful students will be admitted to the Physiology graduate program, but may be considered for the Biomedical Engineering program.
This search will close on January 20, 2023.
Please send the following the documents to Dr. Siddiqui by email
- Cover letter explaining your background, interests, and training, and why you will be a good fit for the Siddiqui lab research program.
We thank all applicants for their interest. However, however only those candidates selected for interviews will be contacted.
Rady Faculty of Health Sciences
Max Rady College of Medicine
Department of Physiology and Pathophysiology
Neuroscience Research Program
Kleysen Institute for Advanced Medicine
Health Sciences Centre
SR422-710 William Avenue
Winnipeg, MB R3E 0Z3
Siddiqui Lab Publications can be accessed here.
Some of our recent published studies are listed below
- Dhume S.H., Karimi B., Roppongi R.T. Connor, S.A., Mills, F., Tari, P.K., Oku, S., Bamji, S.X., Wang, Y.T., Brose, N., and Craig, A.M., Siddiqui, T.J., Distinct but overlapping roles of LRRTM1 and LRRTM2 in developing and mature hippocampal circuits, Elife. (2022) Jun 6;11:e64742. doi: 10.7554/eLife.64742.0: 0.
- Karimi B, Silwal P, Booth S, Padmanabhan N, Dhume S, Zhang D, Zahra N, Jackson MF, Kirouac GJ, Ko JH, and Siddiqui T.J.*, Schizophrenia-associated LRRTM1 regulates cognitive function through controlling synaptic activity in the mediodorsal thalamus, Molecular Psychiatry, 2021May 12. doi: 10.1038/s41380-021-01146-6
- Roppongi RT#, Dhume S#, Padmanabhan N#, Silwal P, Zahra N, Bomkamp C, Pati Cl, Karimi B, Champagne-Jorgensen K, Twilley RE, Zhang P, Jackson MJ, and Siddiqui TJ, LRRTMs organize synapses through differential engagement of neurexin and PTPσ, Neuron (2020), Apr 8; 106 (1):108-125.e12. doi: 10.1016/j.neuron.2020.01.003 (# co-first authors)
- Sinha R, Siddiqui TJ, Padmanabhan N, Wallin J, Zhang C, Karimi B, Fred Rieke, Craig AM, Wong RO, and Hoon M, LRRTM4: a novel regulator of presynaptic inhibitory and dyad output synapses of retinal bipolar neurons, Neuron (2020), Mar 18;105(6):1007- 1017.e5. doi: 10.1016/j.neuron.2019.12.028.
- Zhang Z, Pines MK, Oku S, Ge Y, Siddiqui TJ, Wu W, Archer-Hartmann S, Azadi P, Gordon MD, and Craig AM. (2018). Heparan Sulfate Organizes Neuronal Synapses Through Neurexin Partnerships. Cell 174(6): 1450-1464.
Tabrez J. Siddiqui, PhD
Associate Professor of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba.
Principal Investigator, Children’s Hospital Research Institute of Manitoba.
Principal Investigator, Neuroscience Research Program,
Kleysen Institute for Advanced Medicine, Health Sciences Centre.
SR422-710 William Avenue, Winnipeg R3E 0Z3, Manitoba, Canada.
Phone: 1. 204.318.2564
The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota and Dene peoples, and on the homeland of the Métis Nation. We respect the Treaties that were made on these territories, we acknowledge the harms and mistakes of the past, and we dedicate ourselves to move forward in partnership with Indigenous communities in a spirit of reconciliation and collaboration.