Master’s or PhD position in Neurosciences – Laval University, in Quebec City, Canada

We are inviting applications for a Master’s or PhD student position at the Faculty of Medicine, Laval University, in Quebec City, Canada. The selected candidate will join the team of Dr. Aurelie de Rus Jacquet and Dr. Abid Oueslati.

 

Our research:

We specialize in the study of Parkinson’s disease, with the objective to describe molecular mechanisms regulating pathogenesis. Dr. de Rus Jacquet focuses on the study of glial cells, their role in the pathogenesis of Parkinson’s disease, and mechanisms by which they modulate blood-brain interactions at the blood-brain barrier. We use patient-derived induced pluripotent cells and microfluidic technologies to model cell-cell interactions and elucidate disease mechanisms.

 

The project:

The Master’s or PhD project will focus on understanding how plasma proteins affect the function and survival of neuronal and glial cells in the context of Parkinson’s disease. The objective of this novel and exciting work is to discover new drug targets and propose innovative therapeutic approaches to slow or stop the progression of the disease. Technical approaches will include cell culture, immunofluorescence, imaging, biochemistry, cell biology and mass spectrometry.

 

Your profile:

  • Obtained a Bachelor’s or a Master’s degree in Neurosciences, Cell Biology, Biomedical Sciences or related area
  • Strong academic record
  • Ability to work independently and as part of a team
  • Highly motivated and dedicated to improving human health

 

The work environment:

We are located in a dynamic and fast-paced work environment. We thrive to offer an inclusive workplace where each team member can grow and explore their scientific creativity. We welcome applications from all interested candidates and greatly encourage those from groups traditionally underrepresented in the sciences. The work languages are English and French. Laval University is a French-speaking University (https://www.ulaval.ca/). Québec City is a UNESCO world heritage destination and offers a rich student experience in one of the most beautiful cities in Canada (https://www.quebec-cite.com/en ).

 

Apply:

For more information, please contact Dr. Aurelie de Rus Jacquet: aurelie.jacquet@crchudequebec.ulaval.ca. Applications will be reviewed until the position is filled. The candidates selected for an interview will be contacted directly.

 

Interested applicants should send the following PDF documents to Dr. Aurelie de Rus Jacquet:

  • Your CV detailing education, research experience, skills, awards and publications
  • A cover letter discussing your previous experiences, career goals and research interests
  • Academic transcripts
  • Names and emails of three references who can provide letters of recommendation

Contact information

For more information, please contact Dr. Aurelie de Rus Jacquet: aurelie.jacquet@crchudequebec.ulaval.ca.

Master’s Position Available – Investigating the Molecular Regulators of Brain Development – University of Manitoba

Description of the position:

This project aims to investigate the molecular regulators of neural stem cell lineage progression and their role in determining cell types and states in the developing central nervous system. The successful candidate will be directly supervised by Dr. Robert Beattie (expert in studying neural development using mouse models) and apply state-of-the-art single cell and molecular biology techniques such as Mosaic Analysis with Double Markers (MADM). The successful candidate will be admitted to the Department of Biochemistry and Medical Genetics graduate program, where they will be expected to complete coursework in addition to their thesis-based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the annual competitive stipend provided by Dr. Beattie.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, brain development, molecular biology and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 15, 2022; Start Date: September 1, 2022

Please send your CV and cover letter directly to Dr. Beattie, highlighting your reasons for doing research and specifically why this position in the Beattie lab is interesting for you. We thank all applicants for their interest, however only those candidates selected for interviews will be contacted.

Contact information

Robert.beattie@umanitoba.ca

Robert Beattie, Ph.D. Assistant Professor

Department of Biochemistry and Medical Genetics

Rady Faculty of Health Sciences

University of Manitoba

www.beattiescience.com

 

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Posting end date:  2022/06/30

Master’s Position Available to Study the Effect of Neural Stem Cell Senescence on Brain Repair – Lindsey Lab, University of Manitoba

Description of the position:

This project uniquely examines the role of cellular senescence in regulating the regenerative capacity of neural stem cells in the aging brain using the adult zebrafish model. The objective of the proposed study is to define which zebrafish neural stem cell populations undergo aging, how this is regulated by changes in cell signaling and gene expression, and how neural stem cell senescence effects timely brain repair following injury. The successful candidate will be directly supervised by Dr. Benjamin Lindsey (expert in neural stem cells and repair in the zebrafish model) and learn cutting edge cell biology, injury models, microscopy and molecular biology techniques. The successful candidate will be admitted to the Human Anatomy and Cell Science graduate program where they will be expected to complete coursework in addition to their thesis based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the annual stipend provided by Lindsey.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, brain repair, and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 1, 2022; Start Date: September 1, 2022

Contact information

benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,
Department of Human Anatomy & Cell Science
Rady Faculty of Health Sciences
University of Manitoba
www.lindseylab.ca

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Master’s Position Available to Study the Role of the Unfolded Protein Response (UPR) during Spinal Cord Injury – Lindsey/Logue Labs, University of Manitoba

Description of the position:

This project uniquely investigates the role of the unfolded protein response (UPR) in regulating the regenerative ability of neural stem cells following spinal cord injury (SCI) using the zebrafish model. The objective of the proposed study is to identify the temporal dynamics of UPR signaling during the repair process, characterize the cell types in which the UPR is activated, and ask if modulating UPR signaling can impact upon repair after SCI. The successful candidate will be jointly supervised by Dr. Benjamin Lindsey (expert in neural stem cells and repair in the zebrafish model) and Dr. Susan Logue (Canada Research Chair in Cell Stress and Inflammation) and learn cutting edge cell biology, microscopy and molecular biology techniques. The successful candidate will be admitted to the Human Anatomy and Cell Science graduate program where they will be expected to complete coursework in addition to their thesis based research. Additionally, the successful candidate will be expected to apply for scholarships to contribute to the stipend provided by Lindsey/Logue.

Eligibility Requirements:

  • Excellent academic standing
  • Strong work ethic and passion for discovery
  • Interest in neuroscience, cell signaling, and microscopy
  • Experience or interest in using animal models
  • Excellent written and oral communication skills

Deadline: June 1, 2022; Start Date: September 1, 2022

Contact information

benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,
Department of Human Anatomy & Cell Science
Rady Faculty of Health Sciences
University of Manitoba
www.lindseylab.ca

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Multiple positions available at the Canadian Brain Research Strategy

The Canadian Brain Research Strategy (CBRS) is a community-led initiative uniting to advance Canada as a world leader in collaborative, transdisciplinary, open, and ethical brain research. Our objective is to make brain research a national priority by establishing a Canadian Brain Research Initiative.

We are looking to fill three roles but are flexible on the job descriptions and number of personnel:

  • Science Writer/Communicator to engage with our varied stakeholders and the public as we work to advance brain research as a national priority.
  • Program Assistant/Associate to help us coordinate a series of meetings and focus groups, and to synthesize these findings as we build a collective nation-wide strategy for brain research.
  • Program Manager to manage and facilitate the work of various multistakeholder teams to make advances in a series of strategic initiatives within our organization’s larger mission.

We welcome enthusiastic applicants with a passion for brain science who embrace a startup mentality and are looking to expand their professional skill set and for opportunities for growth. This job might be for you if you have a research background and are looking to develop a career path outside of academia.

You’ll get to work closely with top leaders in neuroscience and mental health research across the country and expand your network as we bring together the diverse neuroscience ecosystem – brain research initiatives and projects, public and private funders, health charities, as well as communities and patient organizations across the country – in a uniquely collaborative effort that will push the frontiers of brain science, for the benefit of all Canadians.

These positions are fully remote and the candidate can be located anywhere in Canada.

 

Download the full job descriptions here.

Email for more information on how to apply: info@canadianbrain.ca

We are looking to fill these positions immediately. Applications will be reviewed starting April 11th, 2022.

Closing date: Posting remains open until filled.

General Neurologists & Stroke Neurologists – Windsor General Hospital

Our client, Windsor Regional Hospital (WRH), is a multi-faceted health services organization operating from two main sites, the Metropolitan Campus and the Ouellette Campus. With 500 beds and an operating budget of over half a billion dollars, WRH is the regional provider of advanced care in areas that include complex trauma, renal dialysis, cardiac care, stroke and neurosurgery, intensive care, acute mental health, family birthing centre, neonatal intensive care, paediatric services, and regional cancer services. WRH provides a broad range of medical and surgical services required to support these specialized areas for more than 400,000 people in Windsor and Essex County. Windsor Regional Hospital is seeking: General Neurologists & Stroke Neurologists.

With increasing volumes, program development, and growing demands for service, WRH is seeking top tier General Neurologists and Stroke Neurologists to join their team. This is an exceptional opportunity to join an innovative, collegial, and mutually respectful team to contribute to neurology service delivery excellence.

Full time, part time, and locum opportunities are available. WRH is also interested in recruiting subspecialty neurologists to bring unique skills to the group and community.

As a designated Enhanced District Stroke Centre, Windsor Regional Hospital provides specialized services for stroke and TIA patients offering timely hyper-acute treatments like tPA and endovascular therapy (Thrombectomy and Coiling), as well as neurosurgical services. The hospital has neurologists, neurosurgeons, and interventional radiologists on staff providing expert care for stroke patients. Following intervention and post procedure recovery and stabilization in the ICU, patients are transferred to the Acute Stroke Unit, a designated 16-bed unit dedicated to the care of Stroke patients. Inpatient and outpatient rehabilitation services for Windsor-Essex are offered locally through Hotel-Dieu Grace Healthcare. Outpatient Rehab options direct from hospital also includes the Intensive Hospital to Home Rehab program and E-Rehab services provided through the Erie St. Clair LHIN.

Physicians at WRH have the opportunity to educate and mentor residents from the Schulich School of Medicine and Dentistry, with professional staff members eligible to hold a University appointment.

Candidates must be certified, or eligible for certification, by the Royal College of Physicians and Surgeons of Canada in Neurology and hold, or be eligible for, licensure with the College of Physicians and Surgeons of Ontario. Offering great flexibility and work/life balance, these positions include an attractive compensation and relocation incentive package.

The Windsor-Essex area is ecologically rich with extensive parkland combined with a southwest location that extends warm weather activities such a golfing, gardening, and water sports. Windsor offers the unique opportunities of a larger metropolitan area and the benefits of a smaller community. Living directly across the border from Detroit, Michigan places you on a cosmopolitan stage where arts, culture, big league sports, and entertainment are just moments away. Best of all, you can enjoy access to all of these big-city advantages while living in the tranquility and beauty of the Windsor region.

Please forward a CV in confidence to:
Robb Callaghan,
E-mail: rcallaghan@medfall.com
Tel: 289-238-9079

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Healthy Brain Aging and Dementia Prevention Research – Doctoral student opportunities at University of Calgary

University of CalgaryOpportunities: The Brain in Motion research program is looking for doctoral students with an interest in healthy brain aging and dementia prevention who wish to join a large interdisciplinary and diverse research team of over 35 scientists from Calgary, Canada and other parts of the World. There are opportunities currently available for doctoral students in neurosciences, physiological sciences, psychology and kinesiology in several areas related to this research program. Four-year doctoral stipend support is available via matching funding models, available by application, in March 2022 at the University of Calgary. Below you will find the thematic areas, the Brain in Motion protocol, the timeline for this opportunity, and contact information for more details.

Thematic areas within the program of research

  • Cognitive function (executive function, complex attention, processing speed, verbal memory, overall cognition), exercise and aging
  • Biomarkers (vascular, neuroendocrine, inflammation)
  • Proteomics, lipidomics, metabolomics
  • Genetics (genetic variants related to ADRD, neuronal integrity, growth factors and clearance enzymes, lipid and vascular function modulators)
  • Neuroimaging
  • Sleep and novel biomarkers of cognitive decline
  • Maintenance of health behavior
  • Role of lifestyle factors on cognitive function
  • Machine learning and artificial intelligence
  • Healthcare system costs and quality of life measures
  • Exercise physiology
  • Sex and gender differences

Summary of Brain in Motion

Background: There remains no effective intervention capable of reversing most cases of dementia. Current research is focused on prevention by addressing risk factors that are shared between cardiovascular disease and dementia (e.g., hypertension) before the cognitive, functional, and behavioural symptoms of dementia manifest. A promising preventive treatment is exercise. This study describes the methods of a randomized controlled trial (RCT) that assesses the effects of aerobic exercise and behavioural support interventions in older adults at increased risk of dementia due to genetic and/or cardiovascular risk factors. The specific aims are to determine the effect of aerobic exercise on cognitive performance, explore the biological mechanisms that influence cognitive performance after exercise training, and determine if changes in cerebrovascular physiology and function persist one year after a 6-month aerobic exercise intervention followed by a 1-year behavioural support program (at 18 months).

Methods: We will recruit 264 participants (aged 50-80 years) at elevated risk of dementia. Participants will be randomly allocated into one of four treatment arms: (1) aerobic exercise and health behaviour support, (2) aerobic exercise and no health behaviour support, (3) stretching-toning and health behaviour support, and (4) stretching-toning and no health behaviour support. The aerobic exercise intervention will consist of three supervised walking/jogging sessions per week for 6 months, whereas the stretching-toning control intervention will consist of three supervised stretching-toning sessions per week also for 6 months. Following the exercise interventions, participants will receive either one year of ongoing telephone behavioural support or no telephone support. The primary aim is to determine the independent effect of aerobic exercise on a cognitive composite score in participants allocated to this intervention compared to participants allocated to the stretching-toning group. Secondary aims are to examine the effects of aerobic exercise on a number of secondary outcomes and determine whether aerobic exercise-related changes persist after a one-year behavioural support program (at 18 months).

Significance: This study will address knowledge gaps regarding the underlying mechanisms of the pro-cognitive effects of exercise by examining potential mediating factors, including cerebrovascular/physiological, neuroimaging, sleep, and genetic factors that will provide novel biologic evidence on how aerobic exercise can prevent declines in cognition with aging. Trial Registration: ClinicalTrials.gov (NCT03035851); protocol paper published (Kruger et al., 2021).

Timeline for these opportunities:

By February 1st 2022 – Deadline for prospective students to submit i) a letter of interest, ii) a curriculum vitae, iii) a list of publications and awards, and iv) the names of 3 referees who have agreed to be contacted to bimstudy@ucalgary.ca. Prospective supervisors, co-supervisors and doctoral students will complete the application process for matching funds with support from the Brain in Motion team. The start date for the doctoral program will be between May – September 2022.

For more details please contact:
Dr. Marc Poulin, Lead Investigator for the Brain in Motion team
Department of Physiology & Pharmacology
Cumming School of Medicine
University of Calgary
Calgary, Alberta
Email: poulin@ucalgary.ca
Email: bimstudy@ucalgary.ca

Brain in motion logo

Doctoral and Postdoctoral Researcher Position in Alzheimer’s disease – Université de Montréal

Description

The Brouillette Lab at the Hôpital du Sacré-Coeur de Montréal (CIUSSS-NIM) invites applicants for a doctoral and postdoctoral researcher position in the field of Alzheimer’s disease (AD) and age-related memory deficits. Specific research topics include the effect of Aβ oligomers on sleep during aging, the impact of Aβ oligomers on different cell types in the hippocampus, the role of the phosphatase STEP on social memory, and blood biomarkers for early AD. We are using state-of-the-art equipment to perform laser microdissection, optogenetic, molecular/cellular biology, and behavioural testing with various animal models. These full-time positions and projects are supported by the Canadian Institutes of Health Research (CIHR), Natural Sciences and Engineering Research Council of Canada (NSERC), and the Weston Brain Institute. Funding is available for three to four years. The start date is immediate but flexible. Applications will be considered until the positions are filled. The annual stipend is consistent with CIHR funding levels.

Requirements

Candidates should have a degree in neuroscience, biochemistry, molecular/cellular biology, pharmacology, genetic, or a related field. Ideal applicants will have experience in molecular/cellular biology, animal behavioural testing, and knowledge of statistics. Additional preferred qualifications include experience with laser microdissection and optogenetic.

Contact

Interested applicants should send their CV, a brief cover letter describing research experience and interests, university transcript, and contact information for 2-3 references by e-mail to Jonathan Brouillette (e-mail: jonathan.brouillette@umontreal.ca)

Principal Investigator
Dr. Jonathan Brouillette, Ph.D.
Assistant Professor
Department of Pharmacology and Physiology
Université de Montréal

Lab website:
https://pharmacologie-physiologie.umontreal.ca/recherche/chercheurs/jonathan-brouillette/

https://rechercheciusssnim.ca/profil/jonathan-brouillette/

https://recherche.umontreal.ca/nos-chercheurs/repertoire-des-professeurs/chercheur/is/in17687/

Lab Location

Hôpital du Sacré-Coeur de Montréal (CIUSSS-NIM) – Affiliated to Université de Montréal
Montréal, Québec, Canada

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PhD student position: neural circuits of anxiety – CHU Sainte-Justine Research Center, Montréal

PhD student position is available in the laboratory of Dr Bénédicte Amilhon at the CHU Sainte-Justine Research Center, Montréal (QC) Canada (https://research.chusj.org/en/Research/Research-Axes/Brain-and-Child-Development-Axis). The proposed PhD project aims to investigate modulation of hippocampus brain rhythms and associated behaviors by serotonergic inputs from the raphe nuclei. Our laboratory uses multidisciplinary approaches including optogenetics, in vivo electrophysiology, fiber photometry and calcium imaging.

Highly motivated applicants must hold a MSc degree in Neuroscience or related fields. Skills in mouse brain surgery, in vivo electrophysiology recordings and MATLAB programming/analysis is an advantage but are not required.

Contact information

Applicants are required to send a letter of interest, a CV, 2-3 reference contacts and past degree transcripts to the following address: benedicte.amilhon@umontreal.ca

New Graduate Student Positions Now Available to Study the Basic Mechanisms of Multiple Sclerosis

Join a dynamic, world-class, generously funded basic and translational science team. The laboratory of Dr. Michael Levin offers personalized mentorship, state of the art laboratory facilities, customized coursework, highly competitive compensation, and the opportunity for basic scientists to work hand-in-hand with clinicians in Saskatoon City Hospital and the University of Saskatchewan. The laboratory of Dr. Michael Levin in the Department of Anatomy, Physiology, and Pharmacology at the University of Saskatchewan has positions currently available for graduate students to study the role of abnormalities in the immune and nervous systems and how these abnormalities contribute to the pathogenesis of Multiple Sclerosis (MS). The laboratory is located in Saskatoon City Hospital, as part of the Cameco MS Neuroscience Research Centre. For more information about the lab and Dr. Levin, please visit http://research-groups.usask.ca/skms-office/.

The long-term goal of research in the Levin Lab is to better understand the cause of neurodegeneration, a salient feature and cause of permanent disability in progressive multiple sclerosis (MS) patients. For more than 20 years, we have studied the function of the RNA binding protein heterogeneous nuclear ribonuclear protein A1 (hnRNP A1 – ‘A1’), with a focus on ‘M9.’ M9 is A1’s nucleocytoplasmic transport domain and is required for transport of A1 between the nucleus and cytoplasm. Our lab has discovered that MS patients make antibodies to M9 and the brains and lymphocytes of MS patients contain somatic DNA mutations within M9. Using a number of molecular, in vitro and in vivo techniques, our data indicate that DNA mutations within M9 and autoimmunity to M9 result in A1 dysfunction and subsequent neuronal and axonal degeneration. Using this model, we examine potential mechanisms of neurodegeneration in MS resulting from A1 dysfunction.

The applicant should have an undergraduate or Master’s degree in molecular cellular biology, biochemistry, neurology, neuroscience or a related field. Familiarity in research using one or more of the following will be considered an asset; mouse models, imaging techniques (immunocytochemistry and immunohistochemistry), protein analyses, molecular biology techniques (PCR, cloning, etc.) and human tissue analyses. Knowledge of data analysis and interpretation using statistical software is required.

The individual should be independent, self-motivated and should be able to perform tasks with modest supervision after receiving appropriate training. Applicants must have the ability to adhere to tight deadlines, be detail oriented, possess organizational skills, and keep meticulous records. As the laboratory is a shared space, strong interpersonal skills are necessary. Successful applicants will be encouraged to apply for external funding opportunities.

Applicants should send the following documents to the Office of the Saskatchewan MS Clinical Research Chair via email to Ms. Catherine Hutchinson, c.hutchinson@usask.ca:

  1. Current CV with list of laboratory experience
  2. Transcripts (unofficial, accepted)
  3. Names and detailed contact information of three referees, one of whom should be your undergraduate research supervisor

Applicants are required to apply and be admitted to the Anatomy, Physiology, and Pharmacology graduate program at the University of Saskatchewan in order to fill the position. Candidates whose first language is not English may be required to provide a certificate of English proficiency. The English language requirements for a foreign candidate can be found at the CGPS website (www.usask.ca/cgps/).

Contact information

Catherine Hutchinson
Research Executive Assistant to Michael C. Levin, MD
c.hutchinson@usask.ca