Category: Graduate Student Opportunities

PROJECT: Salamanders can swim underwater and walk on ground. Their spinal cord regenerates after a full transection and the animal recovers voluntary locomotion after a few weeks. How this occurs is largely unknown. Genetic dissection of salamander neural circuits is now feasible with methods for manipulation, elimination, and visualization of genetically-defined cells. Such approaches can be combined with patch-clamp electrophysiology, calcium imaging, optogenetics, tracing and movement analysis (Ryczko et al. 2020 Trends in Neurosciences, https://doi.org/10.1016/j.tins.2020.08.006). The candidate will use electrophysiology (patch-clamp recordings), calcium imaging and movement analysis based on deep learning and neuroanatomy to study salamander locomotor circuits. This project is funded by a synergy grant of the ERC. The work will be carried out in collaboration with a team of modelers and roboticists (Pr. Ijspeert, EPFL, Switzerland) and experts in genomics (Pr. Simon, Karolinska Institute, Sweden).

REQUIREMENTS: The candidate should have completed a MSc in neuroscience. The ideal candidate would have experience in electrophysiology, calcium imaging, optogenetics, virus injections, deep learning-based movement analysis, matlab scripting, and a keen interest in motor control.

HOST LABORATORY: The lab of Dr. Ryczko has expertise in the neural control of locomotion and publishes in excellent journals (PNAS, Science, Science Robotics, Journal of Neuroscience…). The lab receives grant support by the CIHR, NSERC, FRQS, CFI and ERC. We are equipped for patch-clamp recordings, confocal and two photon calcium imaging, optogenetics, viral injections, deep learning-based movement analysis, and microscopy (confocal, light-sheet, two-photon, STED).

APPLY: Candidates should send a letter of interest explaining how they would fit, a CV, a record of their academic results and three references at: dimitri.ryczko@usherbrooke.ca. Please specify where you found the job post.

We are inviting applications for a Master’s or PhD student position to study synaptic neurophysiology at the University of Victoria, in Victoria, British Columbia, Canada. The selected candidate will join the team of Dr. Raad Nashmi’s laboratory.

Our lab is interested in understanding how cholinergic neurons affect the excitability and plasticity of neural circuits in the brain. To achieve this our lab employs a variety of techniques including whole-cell patch-clamp recordings of mouse brain slice tissue, optogenetics, UV uncaging of neurotransmitters and the study of mouse behaviours. Ultimately, we are interested in how specific neural circuit activity in the brain control or modulate specific behaviours. The Master’s or PhD candidate will examine how different neurotransmitter systems, including the cholinergic system, modifies the function of substantia nigral neurons in a spatial and temporal manner.

Applicants should have taken courses at the undergraduate or graduate level in physiology and/or neuroscience. Experience with electrophysiology would be an asset but is not necessary.

The University of Victoria is a research intensive university located on Vancouver Island in the city of Victoria, the capital of British Columbia. Greater Victoria region has a population of 397,000 and has all the amenities common to major Canadian cities. Victoria and its surrounding local areas boast breathtaking natural scenery and a mild climate, making it one of the most desirable destinations in Canada.

Please contact Raad Nashmi, raad@uvic.ca, with a resume or CV, a copy of your university transcripts and a brief explanation of your research interests.

Contact information
Raad Nashmi

raad@uvic.ca