Category: Research Staff

Research Assistant – University of Saskatchewan

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Research Assistant, Medicine

Join a dynamic, world-class, well-funded basic and translational science team, led by Dr. Michael Levin, the Saskatchewan Multiple Sclerosis Clinical Research Chair. Dr. Levin offers personalized mentorship, state of the art laboratory facilities, and the opportunity for basic scientists to work hand-in-hand with clinicians in Saskatoon City Hospital and the University of Saskatchewan. This university laboratory is physically located in Saskatoon City Hospital, as part of the Cameco MS Neuroscience Research Centre.

Primary Purpose:

Our team studies neurodegeneration – the death and damage to neurons, and the major cause of permanent disability in multiple sclerosis (MS) and other neurological diseases. Using the latest in computer modeling, molecular and imaging technology, we have invented a series of small molecules that inhibit neurodegeneration and promote neuroprotection using both in vitro and small animal in vivo models of disease. We are looking for a research assistant with a strong background in molecular neurobiology that has experience in using primary mouse neurons, human induced pluripotent stem cells (IPSCs), small animal handling/testing as well as molecular biology (RNA/DNA isolation, RNAseq, AAVs, single cell isolation and sequencing, etc.) to test which small molecules can be moved forward in our pipeline to clinical trials in humans. Led by Dr. Michael Levin, the Saskatchewan Multiple Sclerosis Clinical Research Chair, you can learn more about our research by clicking on the following links: our TED Talk, ‘STOP MS IN ITS TRACKS!’ (https://www.youtube.com/watch?v=-ucjHpjlvQo), showing our preliminary small molecule data and the basics of the experiments you will be doing, our lab and dynamic team members (LEVIN LAB, https://research-groups.usask.ca/skms-office/levin-lab.php), our most recent publication in Nature Communications (https://www.nature.com/articles/s41467-023-44658-1 and A1 in MS DISCOVERY, https://www.youtube.com/watch?v=3IbcQAwQC_0). Located in Saskatoon, Saskatchewan, Canada; a diverse college town with plenty to do and like in all of Canada, universal healthcare. If interested, please submit your curriculum vitae/resume and a 1-page summary of how you will contribute to the science in our lab and your ability to collaborate with a team.

Nature of Work:

  • Works independently to design, conduct and support discovery and validation of research in MS and other neurological diseases in a basic science laboratory with a focus on neuroimmunology, neuroscience, immunology, molecular biology, bioinformatics and biostatistics
  • Reports to the SK MS Research Chair regularlyWorks with the SK MS Research Chair to plan and meet research project requirements and deadlines
  • Helps prepare comprehensive documented observations, analyses and interpretations of results, including written technical reports, summaries, protocols and quantitative analyses
  • Assists in publishing activities, findings and conclusions in recognized scientific publications
  • Documents research leading to patent disclosure or technical and/or scientific advancement
  • Acts as a resource, trains and monitors the progress of trainees at all levels (undergraduate/ medical students, MSc and PhD candidates, post-doctoral fellows, and research technicians)
  • Assists in planning, writing, and editing grants and scientific manuscripts
  • Assists in preparing and submitting scientific manuscripts to journals, including formal correspondence with editors and addressing revisions, as necessary

Typical Duties or Accountabilities:

  • Perform, troubleshoot, and optimize in vitro experiments using cell lines of various origins including neuroblastoma, primary neurons derived from mammals and human IPSCs
  • Maintains a meticulous laboratory notebook with detailed documentation of experiments
  • Transfection of cell lines
  • Transduction of primary neurons and cells with AAVs.
  • In vivo experiments using models of MS and naïve controls in mice and rats such as experimental autoimmune encephalomyelitis, Theiler’s Virus induced demyelination, intracranial injections, and oral administration and injections of drugs
  • Perform, troubleshoot, and optimize in situ experiments using human tissue samples
  • Improve upon and/or develop new methods and protocols to address key experimental questions
  • Document, compile, and analyze experimental data
  • Presentations at lab meetings
  • Assists collaboratively with the SK MS Clinical Research Chair to prepare publications and abstracts at international and national scientific meetings
  • Attend scientific meetings at the discretion of the SK MS Clinical Research Chair
  • Train and educate trainees
  • Establish and maintain training SOPs for trainees and staff at all levels.
  • Meet with the SK MS Clinical Research Chair at regular intervals
  • Other duties, tasks and assignments as required by the SK MS Clinical Research Chair

Education: Graduate degree required (PhD preferred, MSc acceptable) in molecular biology, cell biology, biochemistry, immunology, neuroscience or a related field with 3-5 years of work experience.

Licenses: N/A

Experience:

  • -Experience in research using one or more of the following is necessary:
    • Mouse models, including perfusion, dissection of central nervous system and peripheral tissues, blood collection, oral and injectable administration of drugs, intracranial injections and sample processing for downstream analyses
    • Cell culture work, experience in generating and working with cell lines, primary cell lines derived from mice and human IPSCs, transfection of cell lines and transduction of primary neurons and cells with AAVs.
    • Imaging techniques, including fluorescence and brightfield microscopy; live-cell imaging
    • Protein analyses, including recombinant protein expression/purification, western blot
    • PCR and qPCR
    • Molecular cloning
    • DNA/RNA sequencing and library preparation
    • Human tissue analyses, including immunohistochemistry and immunofluorescence
    • Broad computer experience using advanced scientific and statistical software
    • Bioinformatics
  • Knowledge of data analysis and interpretation using statistical software is required
  • Experience in one-on-one mentoring of junior trainees, including graduate and undergraduate students, is required
  • Demonstrated grant writing and publication record
  • Experience working and collaborating in diverse and inclusive settings is required

Skills:

  • Immunohistochemistry, immunofluorescence and immunocytochemistry
  • Fluorescent and brightfield microscopy
  • Computer skills including bioinformatics, advanced scientific and statistical software
  • Intracranial injection, perfusion, and blood sampling of small animals such as mice and rats
  • Oral administration and injections of drugs into mice and rats
  • Tissue dissection, embedding, and sectioning (fresh frozen, fixed frozen, paraffin)
  • Molecular techniques including but not limited to Western blotting, PCR, RT-PCR, qPCR, in situ hybridization, –RNA/DNA extraction from cell lines and tissues, recombinant protein expression and purification
  • Extraction of immune cells from lymphoid organs
  • Isolating primary neurons from mice and rats, cell culture and human IPSC cultures
  • Cell culture: primary neurons, cell lines, transfection and transduction.
  • FACS analyses and cell sorting
  • Knowledge and use of Photoshop and related platforms
  • Strong interpersonal skills, demonstrated leadership abilities, and attention to detail
  • Excellent time management and organizational capabilities
  • Ability to work independently
  • Effective oral and written communication skills

Inquiries regarding this position can be directed to Catherine Hutchinson at c.hutchinson@usask.ca.

Department: Medicine (Department)
Status: Term 1 year
Employment Group: Research Positions – Non-union
Full Time Equivalent (FTE): 1.0
Salary: The salary range, based on 1.0 FTE, is $65,975.00 – 102,024.00 per annum. The starting salary will be commensurate with education and experience.
Salary Phase/Band: Salary Band 8
Posted Date: 4/2/2025
Closing Date: 5/13/2025
Number of Openings: 1
Work Location: On Campus

The University is committed to employment equity, diversity, and inclusion, and are proud to support career opportunities for Indigenous peoples to reflect the community we serve. We are dedicated to recruiting individuals who will enrich our work and learning environments. All qualified candidates are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadian citizens and permanent residents will be given priority. We are committed to providing accommodations to those with a disability or medical necessity. If you require an accommodation to participate in the recruitment process, please notify us and we will work together on the accommodation request. We continue to grow our partnerships with Indigenous communities across the province, nationally, and internationally and value the unique perspective that Indigenous employees provide to strengthen these relationships. Verification of Indigenous Membership/Citizenship at the University of Saskatchewan is led and determined by the deybwewin | taapwaywin | tapwewin: Indigenous Truth policy and Standing Committee in accordance with the processes developed to enact the policy. Successful candidates that assert Indigenous membership/citizenship will be asked to complete the verification process of Indigenous membership/citizenship with documentation. The University of Saskatchewan’s main campus is situated on Treaty 6 Territory and the Homeland of the Métis. We pay our respects to the First Nations and Métis ancestors of this place and reaffirm our relationship with one another. Together, we are uplifting Indigenization to a place of prominence at the University of Saskatchewan.

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Scientist in Neuroimaging and Precision Child Youth Mental Health – Children’s Hospital of Eastern Ontario Research Institute

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JOB DESCRIPTION

Posting # – RI-25-011

POSITION:Scientist in Neuroimaging and Precision Child Youth Mental Health
POSTING PERIODFebruary 18, 2025 to April 30, 2025
TERM:Full-time (1.0 FTE) Three (3) year contract, with possibility of renewal
SALARY:Commensurate with skills & experience
REPORTS TO: Director, Precision Child Youth Mental Health Collaboratory

Children’s Hospital of Eastern Ontario Research Institute (“CHEO RI” https://www.cheoresearch.ca/) is the research arm of the Children’s Hospital of Eastern Ontario – Ottawa Children’s Treatment Centre (“CHEO”) and an affiliated institute of the University of Ottawa. We acknowledge that Ottawa is built on un-ceded Algonquin Anishinabek territory. The Algonquin Anishinabek Nation have lived on this territory for millennia and we honour them and this land. Their culture and presence have nurtured and continue to nurture this land. CHEO RI also honours all First Nations, Inuit and Métis peoples and their valuable past and present contributions to this land. CHEO is a beloved institution and workplace that is widely recognized for being an anchor in our community. CHEO RI works to create new knowledge and evidence to support CHEO in its provision of world-class care to our children. Our mission at CHEO RI is to connect exceptional talent and technology in pursuit of life-changing research for every child, youth, and family in our community and beyond.

We are inviting applications for an early to mid-career Ph.D. full-time Neuroimaging Scientist for the Precision Child Youth Mental Health Collaboratory. The goal of the position is to create an independent research program focused on neuroimaging markers of diagnosis, treatment response, or prognosis to support advancement of precision child and youth mental healthcare.

This will be a three-year, renewable appointment at the rank of Assistant or Associate Professor commensurate with experience and does not confer eligibility for tenure. The successful candidate will be recommended for a faculty appointment in the Department of Cellular and Molecular Medicine and secondary appointments in other departments such as Psychiatry will also be available.

Required Qualifications: A Ph.D., superior research achievements in MRI neuroimaging related to child and youth mental health disorders, treatment response, or prognosis, evidence of interdisciplinary collaborations, experience in teaching and training of students at the graduate level, the ability to obtain external research funds, and excellent communication skills in either English or French. Passive knowledge of the other official language is considered an asset. Training in data analytics is also an asset.

The PCYMH Collaboratory is a ground-breaking research centre with close ties with SickKids in Toronto, ON, providing additional opportunities for networking and scientific development. The Collaboratory’s Strategic Priorities are to 1) Conduct Impactful PCYMH Research; 2) Use Technology to Deepen Understanding of Child and Youth Mental Health; 3) Nurture Teams That Translate Research to Real-Life PCYMH Care; and 4) Advance the Growth of PCYMH At Home and Worldwide. Expanding the extant neuroimaging research at the RI is one of our most important plans.

We are fully integrated within the Children’s Hospital of Eastern Ontario (CHEO) with collaboration opportunities with clinicians and access to patients. CHEO is the home to a vibrant research culture including the leadership of national programs on rare disease gene discovery (http://care4rare.ca/), neuro-muscular disorders (https://neuromuscularnetwork.ca/) and Concussion research (www.transcendentconcussion.ca) CHEO also houses Newborn Screening Ontario (https://www.newbornscreening.on.ca/), one of the largest newborn screening programs in North America.

We are also fully integrated within the Faculty of Medicine at the University of Ottawa, which comprises several research-intensive Departments supporting a vibrant research and educational environment with multiple strong foci in multiple health-related fields. Relevant to this position, the associated Department of the candidate will confer MSc and PhD degrees in respective fields of study (for example, within the uOttawa Department of Cellular and Molecular Medicine). The successful candidate will therefore become an integral member of the University of Ottawa’s core network, with access to a large and broad group of research collaborators as well as state-of-the-art equipment facilities across the University and affiliated Research Institutes, including the Ottawa Hospital Research Institute (OHRI), the University of Ottawa Heart Institute (UOHI), the Royal Ottawa Mental Health Centre (ROMHC), Bruyère Research Institute, and Institut du Savoir Montfort. There are additional opportunities to join intellectual communities of practice with like-mined researchers within the uOttawa Brain Mind Research Institute (uOBMRI).

Join us in Ottawa, Canada’s capital and a cosmopolitan metropolis surpassing one million residents, making it the fourth largest city in Canada. With a vibrant technology sector and high median household income, Ottawa is the best place to live and do collaborative research. The region was first home to Indigenous Peoples who lived, met and traded commodities and knowledge; the city’s name is derived from the Algonquin word “Odawa” which means “traders.” The rich history of Algonquin Anishinaabe, along with that of the Europeans who arrived in the 1600s, is represented throughout the region.

Other Requirements:

  • Valid work permit to work in Canada;
  • Valid police record check;
  • Compliance with the CHEO Research Institute’s Universal COVID-19 Vaccination Policy

To Apply:

The selection process will begin immediately after the closing date and will continue until the position is filled. Please send the application package by e-mail to pcymhi@cheo.on.ca.

We thank all applicants for their interest, but only those invited for an interview will be contacted. Your application package must include:

  • A cover letter;
  • An up-to-date curriculum vitae (please include career interruptions such as parental or sick leaves that may have impacted your record of research. These will be taken into consideration in the selection process);
  • A research plan (2 to 3 pages);
  • Three names of people who may be contacted by the CHEO Research Institute for letters of reference; and
  • Self-identification form (see Preferential Hiring section above).

The CHEO Research Institute values diversity and is an equal opportunity employer who value diverse perspectives and support people to be their authentic selves. We are committed to providing an inclusive and barrier-free work environment, starting with the hiring process and welcome interest from all qualified applicants. Should an applicant require any accommodations during the application process, as per the Accessibility for Ontarians with Disabilities Act, please notify Human Resources at researchhr@cheo.on.ca.

The CHEO Research Institute seeks to increase equity, diversity, and inclusion in all of its activities, including research, education and career development, patient, family and donor partnerships. We value diverse and non-traditional career paths and perspectives, and value skills such as resilience, collaboration, and relationship-building. We welcome applications from members of racialized minorities, Indigenous peoples, persons with disabilities, persons of minority sexual orientations and gender identities, and others with the skills and knowledge to productively engage with diverse communities.

CHEO Research Institute does not use artificial intelligence during the selection and recruitment process.

Worksite, unless otherwise indicated will be at 401 Smyth Road, Ottawa, Ontario K1H 8L1. Applications will only be considered from those that are eligible to work in Canada

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Postdoctoral Associate, Neuroscience – Joy lab at Jackson Laboratory

Posted on | by Julie
Jackson Laboratory logo

The Joy lab is looking for a motivated postdoctoral candidate interested in studying circuit repair and motor behavior after stroke with the goal of identifying translatable therapies for stroke recovery.

The focus of the lab is to determine how brain circuits reorganize after a stroke, contributions of these reorganizational process to motor function, molecular signatures that drive recovery and therapeutic targets for stroke. We use a host of techniques including but not limited to large-scale mesoscopic calcium imaging, optogenetics, gene targeting with viral vectors or transgenics, transcriptomics and ethological measurements of behavior.

The ideal candidate will have a PhD in Biological Sciences or nearing completion, experience in one or more of the above techniques, a strong background in neuroscience and optionally molecular biology and data science. We are looking for a candidate that is driven, can leverage the lab’s existing expertise and build upon this and does not shy away from new ideas/approaches and challenges. Additionally, the candidate will have access to JAX’s unique postdoctoral training program that offers support and substantial guidance for building an independent career in science through applications to postdoctoral and transition awards.

This is also a unique opportunity to explore the beautiful outdoors and the coastline of Bar Harbor, ME , be it a day at the Acadia National park, a walk through the carriage roads, sailing in the Atlantic , snow sports or being part of the exuberant festivities over the Summer.

Interested applicants are encouraged to submit a 1-page cover letter briefing your training, current and future interests, CV and contact information for 2-3 references.

The Joy lab supports postdocs that have either academic or non-academic long-term career goals, international candidates, women and candidates from all backgrounds. We truly believe in equal opportunity for all.

JAX Salary
Year 0 – 1 $65,589
Year 1 – 2 $67,318
Year 2 – 3 $69,095
Year 3 – 4 $70,521
Year 4 – 5 $72,877
Year 5 – 6 $75,569

#CA-NF7

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org​​​​​​​.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Contact information:

Nicole Fraser, Talent Acquisition Partner
Nicole.Fraser@jax.org

Please apply here: https://thejacksonlaboratory.wd1.myworkdayjobs.com/External_JAX/job/Bar-Harbor-Maine/Postdoctoral-Associate—Neuroscience—Joy-Lab_JR004213

Scientist / Senior Scientist – Hospital for Sick Children, University of Toronto

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SCIENTIST/SENIOR SCIENTIST

Research Institute

The Hospital for Sick Children

University of Toronto

The Research Institute at The Hospital for Sick Children (SickKids) is accepting applications for a Scientist/Senior Scientist focused on the neuroscience of child and youth mental health. The position is permanent full-time and will include an accompanying appointment in a relevant department at The University of Toronto (UofT), including but not limited to Psychology, Psychiatry, or Medical Biophysics. The SickKids Research Institute is Canada’s largest, hospital-based child health research institute. Our commitment is to improve the health of children, here in Canada and in the global community.

Applicants must have a Ph.D. in a relevant discipline, as well as significant research experience (i.e., at least 3 years postdoctoral) and a record of outstanding scientific accomplishment and innovation in neuroimaging science related to child and youth mental health. Applicants are expected to demonstrate evidence of: successful research funding (peer-reviewed grants, fellowships, etc.), publications in leading journals, presentations at significant conferences, and increasing leadership experience in a research team. Applicants should have a strong track record of productivity and innovation in research focused on using neuro-imaging to understand child and youth mental health, as well as an established record of collaboration and interdisciplinary research.

The successful candidate will engage in an original, competitive, and independently funded research program of international caliber that will use neuroimaging to understand the bio-psychological underpinnings of clinical symptoms, neuropsychological function, and behaviour across children and youth with a variety of mental health challenges. The successful candidate will be appointed as a Scientist/Senior Scientist in the SickKids Research Institute and expected to qualify for an academic cross-appointment in an appropriate department at the University of Toronto enabling: (a) direct supervision of students, postdoctoral fellows, and research associates; and (b) work with students/post-docs to prepare scientific manuscripts, grant applications, and/or drafts of patent applications. Salary will be commensurate with qualifications and experience. A competitive benefits package is being offered along with support for relocation expenses. Exceptional, appropriately qualified candidates may be nominated for a Canada Research Chair. For further information see: http://www.chairs-chaires.gc.ca/home-accueil-eng.aspx Wherein a practicing MD, the successful candidate will have obtained an appropriate Certificate of Registration from the College of Physicians and Surgeons of Ontario (license to practice), and appropriate VISA, if applicable.

The successful applicant’s research program will be housed at the SickKids Research Institute in the state-of-the-art Peter Gilgan Centre for Research & Learning (686 Bay Street, Toronto, Canada), located in the Discovery District in the heart of downtown Toronto. SickKids is fully affiliated with the UofT – Canada’s largest and top-ranked university, and our researchers benefit from the extensive research facilities at the UofT and other affiliated institutions. The position offers a unique environment for medical science discoveries, with nine teaching and research hospitals in close proximity. The position offers the opportunity to conduct research, teach, and live in one of the most vibrant, safe and diverse cities of the world.

The Hospital for Sick Children recognizes that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances to allow for a fair assessment of their application.

Our Commitment to Diversity

SickKids is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, 2SLGBTQIA+ persons, and others who may contribute to the further diversification of ideas. If requested, SickKids is proud to make available accommodations to support applicants with disabilities during the interview and assessment process. Informed by the Accessibility for Ontarians with Disabilities Act (AODA), the Ontario Human Rights Code, and our Access and Accommodation Policy, we will accommodate the needs of applicants. Please email faculty.office@sickkids.ca of your accessibility needs during the recruitment process. Information received relating to accommodation will be addressed confidentially.

Application Process Interested applicants should email their application (curriculum vitae, description of past research, research plan [3-5 pages], Equity Diversity and Inclusion Statement, three reference letters and copies of three representative publications) preferably in a single PDF file, to Dr. Donald Mabbott, Program Head Neurosciences & Mental Health Research Program at nmh.search@sickkids.ca by the close of the search on April 30, 2024. The search committee will interview applicants beginning in May of 2024 until the position is filled, with a potential start date in the next academic calendar year (2024/2025).

SickKids believes that diversity positively impacts science and is essential to sustain our vibrant world-leading research community. As part of the application process you will be asked to complete a brief voluntary diversity survey. Any information directly related to you is confidential and cannot be accessed by either the search committee or human resources staff. Results will be aggregated for institutional planning purposes. The self-identification information is collected, used, disclosed, retained and disposed of in accordance with the Privacy Act and the Access to Information Act.

All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority

Contact information nmh.search@sickkids.ca

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Senior Scientific Assistant for Electron and Light Microscopy – University of Victoria, Department of Biology

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Job posting and application: https://uvic.mua.hrdepartment.com/hr/ats/Posting/view/10364

Department Summary

The Biology Department Electron Microscope (EM) Facility functions as a research and teaching platform and general resource for electron and light microscopy and imaging for the Biology Department. The EM Facility allows for sample preparation and basic histology for microscope work, and is equipped with two Transmission Electron Microscopes, light microscopes, ultramicrotomes, and ancillary equipment. It also houses a FIB/SEM system owned by the Division of Medial Sciences. Individual research labs also host several confocal and widefield microscopes.

Position Summary

The Senior Scientific Assistant is responsible to maintain the facility, including maintaining and trouble-shooting microscopes and other equipment belonging to Biology Department. They train graduate students and other researchers research labs in Biology in electron and light microscopy techniques. The Senior Scientific Assistant carries out research projects in collaboration with faculty and other researchers and advises them on technical approaches. They are expected to support undergraduate courses and labs, and work with faculty to obtain funding for upgrades and new equipment. The Senior Scientific Assistant works collaboratively with other units on campus who may also use the facility.

Key Responsibilities

  • Maintain, diagnose, and repair TEM, light microscopes, and ancillary equipment (25%)
  • Process and image biological samples for TEM, SEM, and light microscopy (25%)
  • Train new users on TEM and ancillary equipment, as well as the department’s widefield and confocal microscopes (25%)
  • Assist EM facility users with trouble-shooting for both hardware and software (10%)
  • Liaise with repair service engineers and other microscope facilities on campus (5%)
  • Maintain chemical and consumables inventory for the EM facility (5%)
  • Compile user records for billing and charge-backs. (5%)

Summary of Qualifications:

– A MSc in Biology or a related discipline with a minimum of 5 years’ experience in operating light and electron microscopes.

– Experience in sample preparation methods (fixation, dehydration, embedding, and sectioning) for brightfield, fluorescence and electron microscopy and with techniques such as immunolabeling, histochemistry and image analysis.

– Demonstrated desire to learn new technologies, stay up-to-date in the field, and to promote new techniques to facility users and the Department.

– Experience in maintenance, calibration, and minor repairs for both light and electron microscopes.

Posting Close Date: 21 November 2023

Research Associate – Western University

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Classification & Regular Hours

Hours per Week: 37.5

Salary Grade: R2

Please note, this is a wholly grant funded position.

About Western

With an international reputation for success, Western ranks as one of Canada’s top research-intensive universities. Our research excellence expands knowledge and drives discovery with real-world application. Western also provides an exceptional employment experience, offering competitive salaries, a wide range of employment opportunities and one of Canada’s most beautiful campuses.

About Us

Western’s Schulich School of Medicine & Dentistry is a leading Canadian centre of outstanding education and research shaping health care for the next generation and is the largest and most complex faculty on campus. The Department of Anatomy and Cell Biology has a long-standing tradition of distinction in research and teaching. The success of Anatomy and Cell biology is predicated on its people, dedicated Faculty, Staff and Trainees who support our mission: excellence in research and scholarship in anatomy, cell biology, neuroscience and education.

The mission of Dr. Khokhar’s research is to disentangle the complex relationship between substance use and serious mental illness. The lab uses a variety of cutting-edge behavioural, neuroimaging and circuit manipulation tools to answer translationally relevant questions related to this chicken-or-egg question with the ultimate goal of improving treatment options for these patients.

Responsibilities

The Research Associate will apply their expertise and knowledge to a research project under the direction of a Principal Investigator and will carry out and oversee original and independent research to assist the PI in achieving their research outcomes regarding the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The position will play a lead role in training staff, graduate students, undergraduate students and post-doctoral fellows, and in resolving issues that arise in the research environment. The Research Associate will support and operationalize new and innovative research opportunities as requested, participate in the development of research and project plans, and design, build and run experiments. The role will plan, implement, and coordinate aspects of data collection, perform data analysis, evaluate and interpret experiment al results, develop models or correlations, and prepare reports and other written material for presentations and/or submissions to various stakeholders as required.

Qualifications

  • Education:
  • Master’s Degree in Neuroscience or Pharmacology
  • PhD Degree in Neuroscience or Pharmacology is preferred.

Experience:

  • 3 years of experience in a related academic research environment with behavioural paradigms including withdrawal, conditioned place preference, self-administration/free-access intake, fear conditioning, prepulse inhibition, and latent inhibition
  • Experience with LC/MS or HPLC methods
  • Experience coding with behavioural control software (such as Med Associates), using behavioural assessment software (such as Noldus Ethovision), and with statistical analysis software packages (such as SPSS or R)
  • Experience with in vivo electrophysiology would be an asset

Knowledge, Skills & Abilities:

  • Familiarity with regulations and guidelines governing research ethics in an academic environment and with best practices for reviewing and writing grant proposals
  • In depth knowledge with methods for research design, implementation, and analysis with ability in methodology, procedures, equipment and standards to produce required research data
  • Proficiency in summarizing research findings, reviewing, appraising and interpreting published literature
  • Familiarity with techniques for updating, managing and extracting data from a research database
  • Ability to collaborate across internal and external boundaries to meet common objectives, improve outcomes and support work beyond one’s own unit
  • Communication skills to describe technical concepts effectively to both novice and sophisticated users, with an ability to complete detailed analytics and reports
  • Ability to work in a manner that mo dels best practices in confidentiality standards
  • Ability to provide solutions and ideas for improvement by using imaginative approaches where constructive thinking and innovation are required
  • Detail-oriented with an ability to function and process information with high levels of accuracy
  • Ability to work within a flexible schedule to accommodate the research group’s events and activities
  • Results-oriented with the ability to motivate and coach students to meet high performance standards, while working effectively as a member of the leadership team
  • Ability to investigate defined issues, solicit input, and suggest remedies and alternative approaches that meet the needs of the situation
  • Proven ability and natural inclination to develop relationships by interacting with people in a professional, respectful and diplomatic manner
  • Advanced skills in software and applications used to produce and analyze research outcomes< br />- Demonstrated ability to research/investigate issues and resolve problems

Background Checks

Please note, successful applicants may be required to produce a current police information record check(s) from a police service prior to commencing employment.

Western Values Diversity

The University invites applications from all qualified individuals. Western is committed to employment equity and diversity in the workplace and welcomes applications from women, members of racialized groups/visible minorities, Indigenous persons, persons with disabilities, persons of any sexual orientation, and persons of any gender identity or gender expression.

Accommodations are available for applicants with disabilities throughout the recruitment process. If you require accommodations for interviews or other meetings, please contact Human Resources at hrhelp@uwo.ca or phone 519-661-2194.

Please Note:

We thank all applicants for their interest; however, only those chosen for an interview will be contacted.

Contact information

Interested applicants are asked to visit https://recruit.uwo.ca for further information and to apply online referencing job #32815 by midnight on October 31st, 2023.

Posting end date: 2023/10/31

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Chief Research and Program Officer – Brain Canada Foundation

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Brain Canada logoPosition: Chief Research and Program Officer

Status: Permanent, full-time

Location: Flexible-work remote position

SUMMARY OF THE POSITION

The Chief Research and Program Officer (CRPO) is a key member of the Executive Leadership Team, and a strategic member of the Management Team. Reporting directly to the President and CEO, the CRPO contributes actively to the organization’s strategic plan by providing leadership and expertise for the development of long-term strategic research and program priorities and goals.

Overseeing a team of dedicated research and program staff, the CRPO leads and directs the development, design, conception and implementation of all Brain Canada’s research activities and funding programs. They engage regularly with the Canadian brain research community and assist with managing relationships at the scientific level with key stakeholders including Brain Canada’s Board of Directors, the Government of Canada, partners and research funders, universities, private or philanthropic donors, and the international brain research community. They act as a key spokesperson and an ambassador for Brain Canada on the national and international stage.

They work in close collaboration with the Evaluation and Special Projects Team on evaluation, impact assessment and other initiatives.

RESPONSIBILITIES:

Positions reporting directly to this role:

  • Program Operational Lead
  • Senior Program Manager, Knowledge Mobilization
  • Research and Program Analyst

Key Accountabilities:

Leadership and Relationship Management:

  • As a key mission ambassador for Brain Canada, lead and inspire Brain Canada’s team in championing and advocating the organization’s ambitious future directions.
  • Develop, grow, and broaden relationships with the federal government and key stakeholders to identify and achieve exciting and transformational research priorities and goals, and promote funding opportunities.
  • Liaise and oversee the presentation of information to the federal government at a strategic level.
  • Develop and maintain active participation and strong relationships with the brain research community and key institutional and organizational research partners, such as universities, partner organizations, research centers and hospitals, researchers, philanthropic donors, etc.
  • Present regularly at Brain Canada Board meetings and represent the Research and Program Team on the Research Committee.
  • Align Brain Canada’s Research and Program activities with the Research Committee recommendations.
  • Participate in the development and stewarding of key donor relationships, assist the President and CEO and the National Director of Philanthropy with discussions, presentations, and meetings with prospective donors and funding partners to develop and implement new agreements which will be mutually beneficial and meet both research and philanthropic objectives.
  • Target and develop new strategic partnerships: initiate discussions with new strategic partners, develop agreements and terms of initial contracts, allocate funds to a specific research domain, etc.

Strategic Planning and Business Management:

  • Lead the Research and Program Team in the development of the organization’s strategic and operational plans (aligned with Brain Canada’s long-term strategic plan). This includes:
    • Overseeing the development, design and conception of all research activities and funding programs, including the peer review process.
    • Preparing and overseeing the execution of the annual budget of the Research and Program Team.
    • Reporting KPIs related to Research and Program to the Board of Directors.
    • Overseeing the selection and implementation of IT systems to increase the Research and Program Team efficiency.
    • Working closely with the CFO and Director of Legal Affairs and Governance to ensure compliance with the federal government’s contribution agreement.
  • Lead the implementation of the long-term strategic plan through annually-developed business plans (with aligned resources, identified reporting, and accountability).
  • Contribute and participate as a member of the executive team supporting the President and CEO to ensure the effective management of the organization including the integration of evidence-based research in the Mission and Vision, Research, Fund Development, and Marketing/Communications plans.
  • Support the Evaluation and Special Projects team to set priorities for evaluation initiatives (e.g., program evaluation, bibliometric analysis).
  • Collaborate closely with the Evaluation and Special Projects Lead on special projects such as strategic planning and stakeholder engagement for Indigenous initiatives and developing concept papers to support program development and philanthropy.

Human Resource Management:

  • Lead, inspire, and engage a highly effective Research and Program Team, ensuring high standards of delivery, competence, performance, and values are maintained and that staff is well supported in fulfilling their duties, developing their skills, and achieving their career potential. Specifically:
  • Ensure a clear understanding of organizational goals and priorities; ensure optimal deployment of resources to achieve business goals.
  • Establish team contribution plan; manage a strong team and develop effective lateral relationships cross-functionally.
  • Establish contribution plans and objectives and review on an ongoing basis.
  • Onboard and integrate direct reports, provide coaching and feedback, assess their contribution, nurture talent, and support their growth to help them realize their potential and engagement.
  • As required, recruit skilled talent in support of current and future needs.
  • Be familiar and comply with Brain Canada policies.
  • Provide coaching and development to team members and implement initiatives that effectively inspire loyalty and philanthropy amongst our supporters.
  • Be a visible leader in living the values throughout the organization.

Policy development:

  • In close collaboration with the Research Committee and Director, Legal Affairs and Governance, develop and update Brain Canada policies that relate to conflict of interest, research integrity, ethical conduct of research, privacy & security, data protection, publication, data access and sharing, intellectual property, and other aspects of the research process.

Other duties:

  • As assigned.

QUALIFICATIONS:

  • Graduate degree in neuroscience or a related discipline; Ph.D is a plus.
  • Proven success as a strategic transformational leader in a mission-driven health care, research or science organization (8-10 years leadership experience).
  • Extensive knowledge in the design, implementation, and delivery of scientific funding competitions, as well as best practices in the management of funded projects, research, and training programs through experience working in a research-funding organization or in an administrative capacity in a research-performing organization.
  • A demonstrated understanding or a desire/ability to acquire knowledge of the scientific and research issues associated with the brain; experience in inspiring, connecting, and engaging with researchers.
  • Excellent relationship-building skills with a proven ability to engage others and establish strong partnerships.
  • Success in advocacy, policy, and program development, working with government officials, research partners, volunteers, and internal teams.
  • Demonstrated ability to communicate and inspire audiences with varying levels of knowledge regarding brain research.
  • Success in rallying a talented staff around a shared vision and plan, delivering planned results.
  • Evidence of strong strategy development and implementation success.
  • Experience in leading change with and through others.
  • Passion for the cause: demonstrated ability to gain partners and donors and raise funds for a cause.

TALENTS:

  • Inspiring and Engaging leadership – inspires, motivates, develops, and manages a high-performing service-oriented team.
  • Excellent relationship-building skills, with people at all levels of organization (internally and externally); a passionate champion and ambassador.
  • Healthy self-confidence, authenticity, and humility.
  • Political savvy/acuity.
  • Superb negotiation, mediation, and persuasive abilities.
  • Ability to work under pressure, balance multiple tasks and projects at once, considering priorities appropriately, meet tight deadlines and cope with rapidly changing scenarios.
  • Excellent written and verbal communications and writing skills in English. Fluency in French is a plus.
  • Available for travel across Canada on a regular basis, and internationally on an occasional basis.
  • Comfort and ease in dealing with volunteers, donors, being visible internally and externally.
  • Agile and flexible leadership style and approach; comfort in leading in a matrix leadership model.
  • Commitment to Equity, Diversity and Inclusion.

Work environment:

Brain Canada Foundation is committed to providing an excellent work environment for team members. We offer:

  • A competitive compensation package including a complete benefits plan.
  • A flexibility to work from home, in accordance with our Work-from-Home Policy.
  • A healthy, flexible, and dynamic work environment that values teamwork, creativity, innovation and work-life balance.
  • Access to professional development and training as available.

About Brain Canada

Brain Canada Foundation (Brain Canada) is a national registered charity headquartered in Montréal, Quebec. We play a unique and invaluable role as a national convenor of those who support and advance brain research. A greater understanding of how the brain works contributes to the prevention, diagnosis, treatment, and cure of disorders of the brain, ultimately improving the health outcomes of people in Canada and around the world.

Our Commitment to equity, diversity, and inclusion (EDI)

Brain Canada is committed to improving and expanding brain science to benefit all people, including groups historically under-researched and underrepresented. We know that increasing the diversity of the research workforce and integrating sex and gender in brain research leads to innovation and greater impact.

Our commitment to EDI is reflected in actions we are taking to diversify our workforce and to foster inclusive environments through our advertising, interviewing, hiring, training, mentoring, and performance review practices. We actively welcome members of underrepresented groups such as women, Indigenous Peoples, persons with disabilities, visible minorities, immigrants, and LGBTQ2+ communities.

Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien’kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues (Calls to Action numbers 19 to 24)

 

To apply:

careers@braincanada.ca

Senior Bioinformatics Analyst – University Health Network, Toronto

Posted on | by Julie

Source: University Health Network

Job Title: Senior Bioinformatics Analyst

Job Number: CAAR919696

Job Location: Toronto, Ontario, Canada

Posted: 16 May 2023

Job Description:

Job Posting #: 919696

Union: Non-Union

Site: Toronto Western Hospital (TWH) – Krembil Discovery Tower

Department: Donald K. Johnson Eye Institute, Krembil Research Institute

Reports to: Co-Director and Senior Scientist

Hours: 37.5 per week

Salary: $36.88 to $46.10 per hour commensurate with experience and consistent with UHN per hour commensurate with experience and consistent with UHN compensation policy

Status: Permanent Full-Time

Shifts: Days

Posted Date: May 17, 2023

Closing Date: Until filled

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

Position Summary

University Health Network (UHN) is looking for an experienced professional to fill the key role of Senior Bioinformatics Analyst in our Donald K. Johnson Eye Institute.

We are looking for a bioinformatician with demonstrated experience single-cell RNA sequencing analysis. The anticipation is that this qualified person will be able to work with scRNAseq and spatial Seq datasets and be able to incorporate the latest multiomic analysis tools.

This is an opportunity to work with state-of-the-art data in the context of novel stem cell and disease models of eye and congenital brain disorders. There will also be opportunities for collaborative work in adult onset neurodegeneration.

The successful applicant will be expected to bring novel ideas and approaches to the research program and contribute to the scientific development of the analysis plan and manuscript preparation.

A competitive compensation package will be offered based on demonstrated experience.

Duties

  • Establish NGS data analysis pipelines for read alignment, targeted sequencing, mapping, annotation, variant calling, cell clustering and differential gene expression analyses.
  • Identify areas for improvement in NGS data processing/interpretation and propose and implement solutions.
  • Explore public biological databases and open source bioinformatics tools, suggest integration approaches and build prototype models.
  • Work closely with researchers to provide technical support for scientific discoveries and model developments.
  • Has solid grasp of the fundamentals and jargon of the domain-specific material.
  • Work with research groups to plan, implement and coordinate all aspects of data collection and/or analysis.
  • Participates partially or fully in initial project design, selection and development of procedures.
  • Participates directly in mid-level data analysis, including application of statistical analysis techniques using standard software.
  • Performs complex data manipulations without assistance.
  • Performs data conversions (as required) without assistance or existing tools.
  • Participates directly in mid-level complexity software or data analysis/visualization method development and implementation.
  • Assists in interpretation of results and preparation of material for presentation, publication, and/or grants.
  • Assesses literature in the field of study.

Qualifications

  • Completion of MSc/PhD/M.D. degree, in relevant field of study.
  • Published experience in scRNAseq data analysis.
  • Interest in neuroscience and willingness to learn about retinal disease.
  • Ability to advise/mentor fellow institute members in bioinformatics analysis strategies.
  • Ability to work independently from home and on-site, and also function as part of a team.
  • Ability to work well under pressure and use good judgment in assessing difficult situations.
  • Attention to detail, excellent organizational and time management skills.
  • Excellent verbal and written communication skills.
  • Problem-solving initiative.

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

  • Competitive offer packages
  • Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
  • Close access to Transit and UHN shuttle service
  • A flexible work environment
  • Opportunities for development and promotions within a large organization
  • Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN’s attendance management program, to be eligible for consideration.

Vaccines (COVID and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known in advance. Any information received related to an accommodation will be addressed confidentially.

University Health Network thanks all applicants, however, only those selected for an interview will be contacted.

You will be asked to submit one letter of motivation, a brief one page statement of research interests, up-to-date CV with publications and two references.

 

To apply to this job, please click on the link, fill out and submit the application form. Click to apply here:

 

https://recruitment.hrsoft.com/cb/Apply/application.htm?ujn=CAAR919696&source=Direct%20Contact&Is=1&At=11&JobRandKey=966920378

PDF version of this advertisement:

https://can-acn.org/wp-content/uploads/formidable/7/Senior-Bioinformatics-Analyst-University-Health-Network-1.pdf

Research Technician – Hazrati lab, McGill University

Posted on | by Julie

About the Role:

We are seeking an enthusiastic, organized, and experienced research lab technician to help run the Hazrati research lab at McGill University. Our lab studies the pathology and pathophysiology of mild traumatic brain injury using human brains, animal models, and cell culture experiments. In particular, we focus on cellular senescence and seek to explore the early molecular underpinnings of brain dysfunction associated with trauma. This lab has recently been relocated, and so part of this job will be setting up a new research lab space.

Responsibilities:

  • Optimize and develop molecular assays for assessing human tissue, mouse tissue, and cell culture experiments
  • Statistically analyze data and use critical thinking to interpret results
  • Keep track of inventory and ordering reagents and supplies for the lab
  • Support graduate students by running assays and helping with data analysis
  • Manage electronic lab notebook for the lab
  • Manage brain bank research IDs
  • Present lab updates regularly at weekly lab meetings
  • Lab safety management
  • Management of regulatory paperwork (Health Canada exemptions, animal use protocols, SOPs, REBs and legal paperwork within the institution)

Requirements:

  • Minimum MSc in a relevant biological science field (neuroscience background is preferred)
  • Experience with nucleic acid and protein isolation protocols
  • Experience with protein assays (Western Blots. ELISA, etc.), qPCR, and immunoassays
  • Experience with microscopy (brightfield, confocal)
  • Experience with mammalian cell culture is an asset
  • Previous experience working with mice  and surgical and behavioral testing skills are an asset
  • Preferably experience with tissue cutting using microtome and/or cryostat
  • Bioinformatics experience is an asset (bulk or single cell RNAseq, for example)
  • R or Python programming language experience is an asset

Employment type: Full-time, 1-year contract

Contact: lili-naz.hazrati@McGill.ca

Research professional – CERVO Brain Research Centre, Quebec city

Posted on | by Julie

The research team at The CERVO Brain Research Center in Quebec City is looking for a research professional in the laboratory of Dr. Chantelle Sephton: https://cervo.ulaval.ca/en/chantelle-f-sephton

Research area: The main research objective of the lab is to determine how RNA processing is impaired in neurodegenerative diseases. We will achieve this by studying the RNA-binding proteins that are mutated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). We will use our mouse models and cell culture models of ALS to study the function of RNA-binding proteins and the effectiveness of therapeutic drug treatments. The results of these studies will provide insight into how impaired RNA regulation can cause ALS and we will use this information to develop targeted therapeutic treatments to treat the disease.

Research project: The current project in the Sephton laboratory requires a research professional to conduct preclinical testing of drugs in ALS mouse models as a proof of concept for the therapeutic treatment of ALS.

Main responsibilities

Under the supervision of Dr. Chantelle Sephton, the research professional’s main responsibilities are to:

  • Co-ordinate, conduct and analyze the results pertaining to the ongoing research program;
  • Work under minimal supervision for many tasks;
  • Supervise the people under his responsibility and ensure the quality and relevance of the results;
  • Ensure the coordination of research activities in close collaboration with students (ethical authorizations, purchases, communication with partners);
  • Participate in data collection (administration of tests, laboratory measurements), data entry and analysis;
  • Contribute to the dissemination of research results (scientific articles, presentations, and knowledge transfer);
  • Conduct scientific literature reviews to support project development.

Note: Responsibilities could be modulated according to the experience of the candidate

Required profile

Candidates should have some experience in animal handling (mice or rats) and experience in animal handling (e.g. i.p. injection and behavioral testing) as well as experience in molecular biology (PCR, purification DNA) and in biochemistry (Western blot, protein determination)

  • Must hold a Bachelor of Science in one of the following fields: biochemistry, neuroscience, genetics or molecular biology (candidates holding a master’s or doctoral degree are also invited to apply);
  • Sense of organization, initiative, rigour, flexibility and autonomy;
  • Excellent interpersonal and teamwork skills;
  • Ease in the use of various computer software;
  • Language proficiency (English-intermediate and French-advanced)

Additional information

  • Type of employment: Initial one-year contract with possibility of renewal.
  • Schedule: Full time, 35 hours per week.
  • Salary: According to qualifications and experience.

Advantages :

  • Contribution to the Government and Public Employees Retirement Plan (RREGOP);
  • Group insurance (after three months of work) and paid at 50% by the employer;
  • 5 paid sick days per year;
  • 13 paid statutory holidays per year.

Contact information

TO APPLY
Interested persons are invited to send a cover letter and their Curriculum vitae at the following address: chantelle.sephton.1@ulaval.ca
Posting end date 2023/03/31