Post-doctoral fellow or research assistant in behavioural neuroscience of reward – Samaha laboratory – Université de Montréal

https://pubmed.ncbi.nlm.nih.gov/31953370/

I will hire someone i) whose primary expertise is in the behavioural neuroscience of reward, and ii) who has demonstrated experience with optogenetic manipulations in vivo.

This profile is required. Please only apply if you have it.

Training in complementary techniques such as DREADDs, electrophysiology, voltammetry and in molecular biology assays is also desirable. Being able to speak French is an asset, but not required.

Our lab is dynamic and very collaborative. We are part of several research groups and networks, with many opportunities for collaborations. I will also support you in gaining visibility for your research work and in learning the skills necessary for a career in science.

See also
https://pubmed.ncbi.nlm.nih.gov/?term=samaha+AN+montreal&sort=date

To apply, please send your cover letter, CV, representative publications and contact details for two references to Dr Mike Robinson mike.robinson@umontreal.ca & Dr A Samaha anna.samaha@umontreal.ca

Candidates in Canada or who can easily travel to Canada will be given preference.

Postdoc position in Neuroscience-University of Calgary

A Postdoctoral position in neuroscience is available in the laboratory of Dr. Derya Sargin at the University of Calgary. Work in our lab is focused on understanding how chronic stress disrupts brain function. Two major lines of research ongoing in the lab are investigating the long-term impact of early life stress and chronic social isolation on behavior and brain circuits/networks. We are using transgenic mouse models and a variety of techniques ranging from in-vivo calcium imaging, electrophysiology, optogenetics, emotional and social behaviour, and machine learning-based data analysis. With these tools, we are able to visualize brain activity in real time and investigate how brain function deteriorates in response to developmental and chronic stress. The ultimate goal of our work is to build towards novel treatment strategies for stress related disorders.

We are looking for motivated and enthusiastic candidates, with a PhD degree in neuroscience or a related field, who are eager to work in a collaborative lab environment. Applicants with a strong background in neuroscience and a proven publication record are invited to apply. Experience in any of the techniques including fiber photometry, optogenetics, rodent behavior or patch clamp electrophysiology is advantageous. Our lab, department and university are committed to fostering and enhancing diversity, equity and inclusion. We welcome all applicants of diverse backgrounds. Applications from underrepresented Indigenous, black and minority ethnic populations are particularly encouraged to apply.

Dr. Sargin’s research group is a part of the Department of Psychology, Hotchkiss Brain Institute, Alberta Children’s Hospital Research Institute and the Mathison Centre for Mental Health Research and Education. Our group is in a highly collaborative, interdisciplinary and international research environment that provides opportunities to develop new skills and collaborations.

To apply, please send a cover letter describing research background and interests along with a CV to Dr. Derya Sargin at derya.sargin@ucalgary.ca

Post doctoral and graduate student positions in neuroscience – Thompson laboratory, University of Calgary

Postdoctoral and Graduate Student (PhD) positions in neuroscience

The lab of Dr. Roger Thompson at the University of Calgary, Hotchkiss Brain Institute is seeking applications for 2 postdoctoral fellows in 2-year funded positions. Appointment extension may be possible after successful performance reviews. Highly qualified candidates for graduate studies at the PhD level may also be considered.
The lab focusses on cellular and molecular mechanisms of neuronal death and altered synaptic / cellular function caused by stroke and Alzheimer’s related dementias. Opportunity exists for research studies using state-of-the-art technologies including molecular biology, protein biochemistry, electrophysiology, optogenetics, in vitro and in vivo multiphoton / confocal imaging and rodent behaviour.

Current CIHR funded research projects could be (but are not limited to):

  • Identify cellular and neural circuit pathways of neuronal death and dysfunction.
  • Discovery of molecular / cellular links between stroke and cognitive decline (i.e., Alzheimer’s disease).
  • Characterize novel forms of synaptic plasticity or cellular excitability related to the pannexin-1 ion / metabolite channel
  • Opportunities may also exist for self-directed research projects that fit within the overall mandate of the lab.

The Thompson lab (www.pannexinexus.com) is a dynamic research group, committed to optimizing success in an inclusive, equitable and diverse environment. Successful candidates will be expected to thrive and contribute to our collaborative environment while producing high quality neuroscience research results that accelerate understanding of stroke, dementia and their linkages.

The University of Calgary recognizes that a diverse staff/faculty benefits and enriches the work, learning and research experiences of the entire campus and greater community. We are committed to removing barriers that have been historically encountered by some people in our society. We strive to recruit individuals who will further enhance our diversity and will support their professional success while they are here. We encourage all qualified applicants to apply, however preference will be given to Canadian citizens and permanent residents of Canada.

Review of applications will begin immediately and continue until successful candidates are identified.
Contact information
Dr. Roger Thompson
Professor
Hotchkiss Brain Institute
University of Calgary
rj.thompson@ucalgary.ca

 

Post-doctoral fellowship – Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry – Université Laval

Understanding the impact of chronic stress on the activity of the mPFC excitatory/inhibitory microcircuitry

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the impact of chronic stress on the activity of the medial prefrontal cortical (mPFC) excitatory/inhibitory circuitry in males and females. This project builds on results from our group showing that chronic stress interferes with the inhibitory control of principal cells differently in the mPFC of chronically stressed males and females. The aim of this project is to define how stress impacts the transcriptional programs controlling the activity of the different inhibitory interneuron subclasses in the mPFC and dissect their individual contribution on the disruption of the mPFC excitatory/inhibitory balance required for proper emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either behavioral or computational neuroscience with an established record of productivity in these fields of research. The lab models complex emotional responses to chronic stress through different paradigms including social defeat stress, chronic variable stress and prolonged social isolation. The project involves combining different trans-sectional viral approaches with single-cell RNAseq, patch clamp electrophysiology and single-cell Ca2+ imaging in freely behaving animals during stressful and operant tasks to ultimately dissect and confirm the contribution of cell-type specific gene programs on the maintenance/alteration of the excitatory/inhibitory balance in the mPFC of stressed males and females. Of particular interest, our lab owns unique human molecular profiles which provide highly translational findings relevant to clinical populations. This project is fully funded.

The candidate should have proven expertise with the assessment of mouse behavior and stereotaxic delivery of viral vectors. The candidate should also have a have a strong background with either patch clamp electrophysiology and/or Ca2+ imaging. Previous molecular expertise is a plus and proficiency with Matlab, R and Python coding would be ideal. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. The candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

Post-doctoral fellowship – Deciphering the epigenetics code underlying the expression of major depressive disorder in men and women.

The Labonté lab is opening a postdoctoral position for a highly motivated postdoctoral fellow interested in studying the epigenetic regulation of sex-specific gene networks across brain regions from men and women suffering from Major Depressive Disorder (MDD). This project relies on solid findings published from our lab showing that the transcriptional organization of gene networks across brain regions from men and women with MDD is highly sexually dimorphic and that these sex-specific gene networks control different aspects of emotional stress responses in males and females. The aim of this project is to reveal the epigenetic landscape across brain regions from men and women with MDD and confirm the impact of epigenetic changes on the activity of sex-specific gene networks and their control over emotional responses to chronic stress in males and females.

The successful candidate should possess a PhD degree in either molecular or cellular biology, genetics, neuroscience or any other relevant disciplines with an established record of productivity in the respective fields of research. The project implies combining approaches to screen histone modifications, chromatin confirmation/occupancy and DNA base modifications in post-mortem tissue from men and women with MDD. The relationship between the layers of epigenetic complexity and the transcriptional organization of gene networks in men and women with MDD will be assessed by bioinformatically. In the lab, this will be first performed by delivering epigenetic modulators at regions of interest in human NPS cell lines and ultimately in mouse models using conditional viral approaches in transgenic mouse lines. This is a truly translational project with direct clinical implications in human populations. This project is fully funded and in-house bioinformatics expertise is already established.

The candidate should have proven expertise in basic and advanced molecular techniques related to the study of epigenetic, chromatin or DNA base modifications. The candidate should also have a strong experience with cell line maintenance and manipulation. Experience with animal work and stereotaxic viral delivery would be important assets. Proficiency with R or Python coding is a plus. The successful candidate will be responsible to coordinate and perform the experiments, collaborate with MSc and PhD students in the lab, write manuscripts and present its work at national and international scientific meetings. By joining the group, the candidate will integrate a multidisciplinary team of experts in molecular, cellular and integrative neuroscience located at the CERVO Brain Research Center affiliated with Laval University in Quebec City, Canada.

The CERVO Brain Research Center is a leading multi-disciplinary research and training environment with >40 laboratories and over 250 trainees and staff pursuing basic and clinical neuroscience research. It offers a transdisciplinary environment with state-of-the-art facilities aiming to understand the central nervous system at the molecular, cellular, systems, and clinical levels in normal and pathological states. The CERVO is located in Quebec City, one of the oldest cities in North America and a UNESCO World Heritage travel destination. As a cultural center of North America, Quebec City is also a truly affordable city with a European flair. The city is embedded in a region rich in nature that offers an abundance of outdoor summer and winter activities. The CERVO is a fully bilingual environment and, while several options to learn French are available, the English language is prioritized in the lab.

Applicants are required to send a motivation letter and their scientific CV with three reference contacts at the following email address: benoit.labonte@fmed.ulaval.ca.

Contact information

benoit.labonte@fmed.ulaval.ca

Clinician Scientist Fellowships – University of Alberta

The Neuroscience and Mental Health Institute (NMHI) at the University of Alberta is offering two fellowships to attract outstanding clinician scientists in training to the University of Alberta to conduct postdoctoral research in neurology and neuroscience: The Mildred I. Olsen Neurology Fellowship and The University Hospital Foundation Neurology Fellowship.

To apply:

  • Your supervisor must be a member of the NMHI (applicants must identify and contact a potential NMHI supervisor before applying);
  • You must hold an MD and plan to work in an area that falls within the NMHI research areas;

The value of each fellowship is $70,000 to be used towards salary costs; supervisors are responsible for benefits. The awards are tenable at the University of Alberta.

Deadline for Applications: August 31, 2021

About the NMHI: The NMHI is a multi-faculty, interdisciplinary teaching and research institute located at the University of Alberta. It is home to over 150 scientists and clinicians, spanning across all areas of neuroscience and mental health.

Contact information

nmhicoms@ualberta.ca

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Posting end date

2021/08/31

 

Post-Doctoral Fellowship in Experimental Quantum Neuroscience – University of Waterloo

The Quantum Neuroscience research group at the University of Waterloo, Canada is seeking an outstanding applicant for a Post-Doctoral Fellowship with experience in electrophysiology and molecular neuroscience.

Motivated by growing interest in the possibility that quantum effects may be at play in neuroscience, the University of Waterloo Quantum Neuroscience research group is aiming to find experimental evidence of novel quantum effects across established mammalian models used in experimental neuroscience. Specifically, the project will focus on studying the effects lithium isotopes may have on the electrophysiological activity of rodent-derived brain tissue. The demonstration of a lithium isotope effect in brain activity will be of great interest in helping to shed light on its mode of action. Of particular interest, a lithium isotope effect on animal behaviour was previously reported by Sechzer et al. [DOI:10.1016/0006-3223(86)90308-2] and, more recently, by Ettenberg et al. [DOI:10.1016/j.pbb.2020.172875]. In addition, the Waterloo Team recently obtained experimental evidence for a lithium isotope effect on electrical responses of rodent brain tissue. The post-doctoral fellow will extend this work using electrophysiology and other biochemical and biophysical methods.

The Waterloo Quantum Neuroscience research team consists of four faculty members: Zoya Leonenko, Michel Gingras, John Mielke and Michael Beazely and 12 undergraduate and graduate students. The team adopts an interdisciplinary approach that brings together expertise in theoretical physics, experimental biophysics, molecular pharmacology and neuroscience. The Waterloo team is part of the International Quantum Brain Network and works on this project in collaboration with Matthew Fisher at the University of California at Santa Barbara and four other research laboratories and is funded by an industrial pharmaceutical partner.

As a part of this project, we are seeking a post-doctoral level scientist with the following key characteristics and skills:

  • neuroscience-related, or biophysics doctoral degree
  • demonstrated expertise in the recording of field potentials (ideally, using multi-electrode arrays)
  • demonstrated research excellence in publications and presentations
  • well-developed ability to write in English
  • strong ability to work effectively within an inter-disciplinary team (involving biologists, physicists, and trainees at all levels)
  • detail-oriented with strong organizational skills
  • expertise with statistical tools typically used in biophysics and medical science
  • training in basic molecular biology techniques (such as Western blotting) is a plus

Expected duties and responsibilities:

  1. design and execute experiments
  2. work with team members to identify experimental goals and the research plans needed to reach these targets
  3. use a multi-electrode array (MED64) to perform field recording experiments from tissue slices acutely prepared from rodent brain
  4. analyze and present data, prepare written reports, and manuscript drafts
  5. analyze and present data for regular lab meetings
  6. present results (in poster, or oral form) at scientific meetings
  7. mentor junior trainees
  8. serve as a role model for junior-level trainees by providing constructive feedback and maintaining a friendly disposition

The position is initially for a 12-month appointment, with the possibility of renewal for up to three years, depending on performance. Applications will be considered until a suitable applicant is found. The start date can be as early as May 1, 2021.

To apply, please send a cover letter (2 pages maximum), a CV (including your education, scientific skills, your research experience and list of publications) and contact information for at least three senior researchers familiar with your research credentials and expertise who could provide a letter of reference on your behalf.

Contact information

Please send your application by email to: qneuro.uwaterloo@gmail.com with subject line: PDF Applicant QNeuro; Last name, First name.

Posting end date: 2021-10-01

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Postdoc position in neural stem cell biology – University of Toronto

The Yuzwa lab in the Department of Laboratory Medicine and Pathobiology at the University of Toronto is seeking to hire a Post-doctoral Fellow. Work in our lab aims to understand how cell genesis occurs in the developing and mature brain under conditions of healthy physiology and disease. To do so, we are currently studying the role of cell signaling inhibition and developing/applying tools to probe lineage and spatial relationships in the brain. Such studies typically involve the use of traditional neurobiological approaches (immunostaining, primary culture, transgenics, etc.) and tools from systems-biology (single-cell genomics and spatially-resolved transcriptomic approaches).

The successful applicant, working independently with consultation from the Principal Investigator (PI), will apply and advance the aforementioned systems-biology tools to characterize neural stem cell biology and the impacts of disease on these cells. The applicant will also be required to validate and test predictions resulting from these data using biochemical, primary neural culture, small animal surgery or transgenic based approaches.

Primary responsibilities will largely include carrying out an independent research project as described above. However, the applicant may be required (as directed by the PI) to 1) work with and train graduate/undergraduate students; 2) help ensure the smooth functioning of the lab (such as maintaining supplies and equipment) and; 3) collaborate with internal/external research groups.

Qualifications (Minimum):

Education: Applicant must hold a PhD or equivalent degree (within 3 years of being awarded) by the agreed upon start date in neuroscience, molecular biology, molecular genetics, cell biology, biochemistry or a related discipline.

Experience: Applicant must demonstrate a strong record of research achievement as evidenced by the ability to prepare and publish scientific manuscripts in major journals and present research findings at scientific meetings. Familiarity with any one or more of the following: neurobiology, synthetic biology, bioinformatics or single-cell genomics would be an asset.

Skills: Prior training in cell culture and molecular biological techniques is required (at minimum). In addition, the successful applicant must possess a number of the following skills: experience with transcriptomics/next-generation sequencing; experience with experimental design and trouble-shooting; ability to adapt and learn new techniques; strong communicator (both oral and written); excellent analytical and problem-resolution skills; good time management and organization skills with the ability to work on multiple competing tasks. Ability to complete University of Toronto certification in chemical, biosafety and animal care, procedures will be required.

Contact information

Please forward a cover letter, CV and names and contact information for three references to:

Dr. Scott Yuzwa
Department of Laboratory Medicine & Pathobiology
University of Toronto
Medical Sciences Building, 1 King’s College Circle,
Toronto, ON M5S 1A8
yuzwalab.ca
Email: scott.yuzwa@utoronto.ca

Posting end date 2021/04/26

Download a PDF version of this advertisement: Yuzwa_PostDoc_Posting_Mar2021_FINAL.pdf

Two Postdoc positions are available to study the role of primary cilia in neurodevelopment – University of Calgary

Two postdoctoral fellow positions in the field of Neuroscience are immediately available in the research group of Dr. Jiami Guo, Calgary University, Alberta, Canada. The research team focuses on the function of primary cilia, under-appreciated cellular antenna, in brain development and function and how disrupted cilia contribute to neurological disorders such as intellectual disabilities, autism spectrum disorders, and glioblastoma.
Interested applicants must have a Ph.D. and/or M.D. degree in a field related to Neuroscience or Biomedical sciences.

For position 1, previous research experience with neurodevelopment, human/mouse genetics, iPSC, biochemistry, molecular cloning, organoids, single-cell RNAseq, next-generation RNAseq will be considered a plus;

For position 2, 2-photon live imaging, in vitro and in vivo electrophysiology, optogenetic/chemogenetic neural circuit manipulations, rodent behavioral assays, neural surgeries and viral delivery of genes will be considered a strong plus. This position will be co-supervised by another PI who is a leading expert in these techniques.

Successful applicants will be highly motivated and energetic individuals with good communication skills, interest and experience in neuroscience/cell biology /developmental biology /genetics, and will have a proven publication record and the ability to work independently.

The research group of Dr. Jiami Guo is part of the Department of Cell Biology and Anatomy. Dr. Guo is a New York Stem Cell Foundation Robertson Investigator, a member of the Alberta Children’s Hospital Research Institute and Hotchkiss Brain Institute. These institutes provide an international, dynamic and collaborative research environment and stimulate innovative basic and biomedical research.

To apply, please send a cover letter describing research background and interests, plus Curriculum Vitae with a complete list of all your journal publications and the contact information of 3 professional references to Dr. Jiami Guo (email: jiami.guo@ucalgary.ca)