Senior Bioinformatics Analyst – University Health Network, Toronto

Source: University Health Network

Job Title: Senior Bioinformatics Analyst

Job Number: CAAR919696

Job Location: Toronto, Ontario, Canada

Posted: 16 May 2023

Job Description:

Job Posting #: 919696

Union: Non-Union

Site: Toronto Western Hospital (TWH) – Krembil Discovery Tower

Department: Donald K. Johnson Eye Institute, Krembil Research Institute

Reports to: Co-Director and Senior Scientist

Hours: 37.5 per week

Salary: $36.88 to $46.10 per hour commensurate with experience and consistent with UHN per hour commensurate with experience and consistent with UHN compensation policy

Status: Permanent Full-Time

Shifts: Days

Posted Date: May 17, 2023

Closing Date: Until filled

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

Position Summary

University Health Network (UHN) is looking for an experienced professional to fill the key role of Senior Bioinformatics Analyst in our Donald K. Johnson Eye Institute.

We are looking for a bioinformatician with demonstrated experience single-cell RNA sequencing analysis. The anticipation is that this qualified person will be able to work with scRNAseq and spatial Seq datasets and be able to incorporate the latest multiomic analysis tools.

This is an opportunity to work with state-of-the-art data in the context of novel stem cell and disease models of eye and congenital brain disorders. There will also be opportunities for collaborative work in adult onset neurodegeneration.

The successful applicant will be expected to bring novel ideas and approaches to the research program and contribute to the scientific development of the analysis plan and manuscript preparation.

A competitive compensation package will be offered based on demonstrated experience.

Duties

  • Establish NGS data analysis pipelines for read alignment, targeted sequencing, mapping, annotation, variant calling, cell clustering and differential gene expression analyses.
  • Identify areas for improvement in NGS data processing/interpretation and propose and implement solutions.
  • Explore public biological databases and open source bioinformatics tools, suggest integration approaches and build prototype models.
  • Work closely with researchers to provide technical support for scientific discoveries and model developments.
  • Has solid grasp of the fundamentals and jargon of the domain-specific material.
  • Work with research groups to plan, implement and coordinate all aspects of data collection and/or analysis.
  • Participates partially or fully in initial project design, selection and development of procedures.
  • Participates directly in mid-level data analysis, including application of statistical analysis techniques using standard software.
  • Performs complex data manipulations without assistance.
  • Performs data conversions (as required) without assistance or existing tools.
  • Participates directly in mid-level complexity software or data analysis/visualization method development and implementation.
  • Assists in interpretation of results and preparation of material for presentation, publication, and/or grants.
  • Assesses literature in the field of study.

Qualifications

  • Completion of MSc/PhD/M.D. degree, in relevant field of study.
  • Published experience in scRNAseq data analysis.
  • Interest in neuroscience and willingness to learn about retinal disease.
  • Ability to advise/mentor fellow institute members in bioinformatics analysis strategies.
  • Ability to work independently from home and on-site, and also function as part of a team.
  • Ability to work well under pressure and use good judgment in assessing difficult situations.
  • Attention to detail, excellent organizational and time management skills.
  • Excellent verbal and written communication skills.
  • Problem-solving initiative.

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

  • Competitive offer packages
  • Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
  • Close access to Transit and UHN shuttle service
  • A flexible work environment
  • Opportunities for development and promotions within a large organization
  • Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN’s attendance management program, to be eligible for consideration.

Vaccines (COVID and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known in advance. Any information received related to an accommodation will be addressed confidentially.

University Health Network thanks all applicants, however, only those selected for an interview will be contacted.

You will be asked to submit one letter of motivation, a brief one page statement of research interests, up-to-date CV with publications and two references.

 

To apply to this job, please click on the link, fill out and submit the application form. Click to apply here:

 

https://recruitment.hrsoft.com/cb/Apply/application.htm?ujn=CAAR919696&source=Direct%20Contact&Is=1&At=11&JobRandKey=966920378

PDF version of this advertisement:

https://can-acn.org/wp-content/uploads/formidable/7/Senior-Bioinformatics-Analyst-University-Health-Network-1.pdf

Congratulations to the winners of the 2022 CAN- CIHR-INMHA Brain Star Awards!

The Canadian Association for Neuroscience (CAN) and the Canadian Institutes of Health’s Institute of Neurosciences, Mental Health and Addiction (CIHR-INMHA) are proud to announce the winners of the 2022 Brain Star Awards.

The CIHR-INMHA Brain Star awards, administered by the Canadian Association for Neuroscience, are awarded to students and trainees who have published high impact discoveries in all fields and disciplines covered by CIHR’s Institute of Neurosciences, Mental Health and Addiction in the 2022 calendar year.

The top 3 Brain Star Award winners of the year have been invited to make a presentation at the CAN meeting in May.

Learn more about the Brain Star Award winners of 2022

Spring 2023 election results

We are happy to announce the results of the Spring 2023 elections!

We want to thank all candidates who showed interest in serving the community and all those who took the time to vote.

The following members were elected and will take office on June 1, 2023 Continue reading

Postdoctoral Position in Systems Neuroscience at the University of Toronto Scarborough

The Developmental Systems Neuroscience lab (https://devsneurolab.com/) is looking for a highly motivated postdoc to lead a fully funded project intersecting neuronal activity-tagging (engrams), synaptic transmission and behaviour. Our group uses a combination of slice electrophysiology, chemo/optogenetics, fiber photometry and behavior to investigate the neural basis of emotional learning and affective behaviour. Come to our diverse and beautiful campus, and join a supportive, collaborative and mentorship-focused lab!

Contact information Please send a CV, list of references and statement of interests to:
Maithe Arruda-Carvalho
m.arrudacarvalho@utoronto.ca
https://devsneurolab.com

Postdoc positions in visual neuroscience at Université de Montréal

The Neurophotonics lab of the School of Optometry of the University of Montreal is looking for postdocs. Our projects focus on the plasticity of cortical maps and functional connectivity in different models of blindness and stroke affecting visual functions. We are also interested in the spatial coding of information in the context of Brain/Machine interfaces and the development of neuroprosthesis to restore vision.
We use a platform for measuring and manipulating brain functions in mice performing visual cognitive tasks in combination with neurophotonic approaches such as calcium imaging (macroscopic or multi-photon) or optogenetics.
We are also interested in the development of technologies applied to neuroscience, in collaboration with companies.
The support of the lab (CIHR, NSERC) will guarantee a scholarship for trainees who do not yet have the support of funding organizations.

To apply:

  • You must have experience in the field of neurophotonics (such as: calcium imaging, in vivo multiphoton microscopy, optogenetics, etc.)
  • You will also need to have experience in data analysis (with Matlab or Python ideally)
  • Qualifications in the field of rodent behavioral measurements, computational neuroscience or biomedical engineering (3D design/printing, electronics, etc.) could be an important asset

Lab website: https://www.opto.umontreal.ca/cortex/
Contact information Send your CV and cover letter (and any other documents you think could be relevant: transcript, achievement, etc.) to Matthieu Vanni: matthieu.vanni@umontreal.ca

Master’s and PhD positions available in visual neuroscience at Université de Montréal.

The Neurophotonics lab of the School of Optometry of the University of Montreal is looking for students interested to start a MSc or a PhD in Vision Sciences, Neuroscience or Biomedical Engineering. Our projects focus on the plasticity of cortical maps and functional connectivity in different models of blindness and stroke affecting visual functions. We are also interested in the spatial coding of information in the context of Brain/Machine interfaces and the development of neuroprosthesis to restore vision.
We use a platform for measuring and manipulating brain functions in mice performing visual cognitive tasks in combination with neurophotonic approaches such as calcium imaging (macroscopic or multi-photon) or optogenetics.
We are also interested in the development of technologies applied to neuroscience, in collaboration with companies.

The support of the lab (CIHR, NSERC) will guarantee a scholarship for students who do not yet have the support of funding organizations.

To apply:

  1. You will need to have training or lab experience in at least one of the disciplines below:
    – Neurophysiology (including calcium imaging, electrophysiology, …)
    – Computational Neuroscience
    – Behavioral measurement in animals
    – Biomedical Engineering
  2. You must have a preliminary experience in data analysis (with Matlab or Python ideally)

Contact information Send your CV and cover letter (and any other documents you think could be relevant: transcript, achievement, etc.) to Matthieu Vanni: matthieu.vanni@umontreal.ca

Drs. Arkady Khoutorsky and Bratislav Misic win 2023 CAN New Investigator Awards

The Canadian Association for Neuroscience is very proud to present Dr. Arkady Khoutorsky, Associate Professor in the Department of Anesthesia and Faculty of Dental Medicine and Oral Health Sciences at McGill University, and Dr. Bratislav Misic, leader of the Network Neuroscience Lab at the Montreal Neurological Institute 2023 CAN New Investigator awards.

Dr. Arkady Khoutorsky is making disruptive contributions in two key areas of neuroscience: translational control in neurological disorders and chronic pain, and his work in both areas is bringing forward new concepts for developing novel types of therapeutic interventions. Read his full profile here: Arkady Khoutorsky wins a 2023 CAN New Investigator award for pioneering research on chronic pain and neurological disorders.

Dr. Bratislav Misic studies how cognition and behaviour emerge from the links and interactions among brain areas. His innovative work, integrating in vivo neuroimaging, statistical learning and network science, is profoundly transforming the field’s understanding of multi-scale structure-function relationships in the brain. Read his full profile here: Bratislav Misic wins a CAN 2023 New Investigator Award for ground-breaking work on brain networks

Tier 2 Canada Research Chair in Non-human Primate Models of Health and Disease – Queen’s University

The Faculty of Health Sciences (FHS) at Queen’s University invites applications from exceptional scholars performing research on non-human primate (NHP) models of health and disease. This appointment is open only to qualified individuals who self-identify as members of one or more of the Four Designated Groups under the Canada Research Chair program (view note 1) : women, Indigenous/Aboriginal peoples, persons with disabilities and racialized persons/visible minorities.

The successful candidate will be appointed at the rank of Assistant Professor (tenure-track) or Associate Professor (tenured), depending upon level of experience, in the Department of Biomedical and Molecular Sciences with an anticipated start date of September 1, 2023. They will be expected to submit an external nomination for a five-year term position as a Tier 2 Canada Research Chair (CRC), eligible for renewal once, to a maximum of two five-year terms as a Tier 2 CRC in NHP models of Health and Disease.

The incumbent will hold an advanced degree (i.e., PhD or MD or MD/PhD) and post-doctoral training to position them as an emerging leader in the field using NHP Models of Health and Disease. They will have a distinguished innovative record of accomplishment and possess expertise in innovative experimental approaches using NHPs to understand healthy sensorimotor and/or cognitive functions, and/or develop models of disease. They will establish an innovative, independent research program and will be expected to secure external funding from diverse sources, including national agencies such as the Natural Science and Engineering Research Council of Canada, and Canadian Institutes of Health Research. They will supervise, mentor, and train students and other highly qualified personnel.

Our top priority is to provide opportunities for emerging scholars to develop an internationally recognized research profile within a dynamic environment wherein all faculty can thrive. A key criterion is to enhance existing strengths at Queen’s University in systems neuroscience that explore NHPs to study neural circuits supporting sensory, motor and cognitive processes and models of neurological diseases/injury. Queen’s boasts a large, modern non-human primate research facility including over a dozen behavioural assessment labs, surgical suites, and an adjacent and easily-accessible MRI facility that houses a state-of-the-art Siemens Prisma system.

Prior to May 1, 2022, the University required all students, faculty, staff, and visitors (including contractors) to declare their COVID-19 vaccination status and provide proof that they were fully vaccinated or had an approved accommodation to engage in in-person University activities. These requirements were suspended effective May 1, 2022, but the University may reinstate them at any point.

Canada Research Chairs were established as part of a national strategy to foster research excellence (www.chairs-chaires.gc.ca). The successful candidate must submit an external application to the Tri-agency Institutional Program Secretariat that meets the requirements for the successful nomination of Tier 2 Chair as defined by the Canada Research Chairs Program:

  • be an excellent emerging world-class researcher who has demonstrated particular research creativity;
  • have demonstrated the potential to achieve international recognition in their field in the next five to ten years;
  • have the potential to attract, develop and retain excellent trainees, students and future researchers; and
  • be proposing an original, innovative research program of high

 

Candidates more than 10 years from their highest degree at the time of nomination may have their eligibility for a Tier 2 Chair assessed through the program’s Tier 2 justification process. Acceptable justifications are generally limited to breaks in the candidate’s research career due to maternity or parental leave, extended sick leave, clinical training, and family care. Please contact research@queensu.ca if you desire more information on the Tier 2 justification process. In addition, the impact of certain circumstances (including but not limited to parental leave, family responsibilities, illness, disability, research in emerging fields, limited access to resources) that may legitimately affect a nominee’s record of research achievement will be given careful consideration when assessing the nominee’s research productivity. Candidates are encouraged to provide any relevant information about their experience and/or career interruptions to allow for a fair assessment of their application.

People from across Canada and around the world come to learn, teach and carry out research at Queen’s University. Faculty and their dependents are eligible for an extensive benefits package including prescription drug coverage, vision care, dental care, long term disability insurance, life insurance and access to the Employee and Family Assistance Program. You will also participate in a pension plan. Tuition assistance is available for qualifying employees, their spouses, and dependent children. Queen’s values families and is pleased to provide a ‘top up’ to government parental leave benefits for eligible employees on maternity/parental leave. In addition, Queen’s provides partial reimbursement for eligible daycare expenses for employees with dependent children in daycare. Details are set out in the Queen’s-QUFA Collective Agreement. For more information on employee benefits, see Queen’s Human Resources.

Additional information about Queen’s University can be found on the Faculty Recruitment and Support website. The University is situated on the traditional territories of the Haudenosaunee and Anishinaabe, in historic Kingston on the shores of Lake Ontario. Kingston’s residents enjoy an outstanding quality of life with a wide range of cultural, recreational, and creative opportunities. Visit Inclusive Queen’s for information on equity, diversity and inclusion resources and initiatives.

Queen’s Commitment to Equity, Diversity and Inclusion: Queen’s is committed to excellence in research and research training for the benefit of Canadians and to achieving a more equitable, diverse and inclusive Canadian research enterprise.

Queen’s University is committed to diversity and inclusion and has an employment equity program that meets the goals of the Canada Research Chairs program and the requirements of our collective agreement with the Faculty Association. As mentioned above, this appointment is open only to qualified individuals who self-identify as members of one or more of the Four Designated Groups under the Canada Research Chair program: women, Indigenous/Aboriginal peoples, persons with disabilities and racialized persons/visible minorities. All above-defined eligible applicants for this position will be invited to self-identify once they have applied. Self- identification information will be held in confidence by the Human Rights and Equity Office and one specially trained member of the selection committee. Shortlisted candidates who self- identify as Indigenous will be asked to verify their identity in accordance with the Hiring of Indigenous Specific Positions – Interim Policy prior to being invited to interview. All qualified candidates are encouraged to apply; however, in accordance with Canadian Immigration requirements, Canadian citizens and Permanent Residents of Canada will be given priority.

To comply with federal laws, the University is obliged to gather statistical information as to how many applicants for each job vacancy are Canadian citizens / permanent residents of Canada. Applicants need not identify their country of origin or citizenship; however, all applications must include one of the following statements: “I am a Canadian citizen / permanent resident of Canada”; OR, “I am not a Canadian citizen / permanent resident of Canada”. Applications that do not include this information will be deemed incomplete.

Candidates should submit a complete application comprising:

  • a cover letter (including one of the two statements regarding Canadian citizenship / permanent resident status specified in the previous paragraph);
  • a current Curriculum Vitae that includes a comprehensive list of publications, awards, and grants received;
  • a statement of current and prospective research interests and experience;
  • a statement of teaching experience and interests together with a teaching portfolio;
  • a statement of equity, diversity, and inclusion: candidates should identify their strengths and experiences with respect to increasing equity, diversity, and inclusion;
  • the names and contact information of a minimum of three referees, one of whom must be at arm’s length.

Review of applications will commence on May 24, 2023 and continue until a suitable candidate is found. Applicants are asked to send all documents in their application packages electronically as PDFs to:

Dr. Stephen Scott

Vice-Dean Research, Queen’s Health Sciences Queen’s University

Kingston, Ontario, K7L 3N6 QHS_Research@queensu.ca

 

The University will provide support in its recruitment processes to applicants with disabilities, including accommodation that takes into account an applicant’s accessibility needs. If you require accommodation during the interview process, please contact Megan Coleman in the Vice-Dean Research Office at QHS_Research@queensu.ca.

Academic staff at Queen’s University are governed by a Collective Agreement between the University and the Queen’s University Faculty Association (QUFA).

Appointments are subject to review and final approval by the Provost. Only nominees external to Queen’s University will be considered. (Please note that, for the purposes of this competition, Queen’s Term Adjuncts and Adjunct-1s will be considered as external nominees).

Note 1:

The CRC Program currently employs the categories of the four federally designated groups (FDG)

  • Women, Indigenous Peoples, Persons with Disabilities, and Members of Visible Minorities – to monitor progress towards meeting equity Queen’s has an under-representation across the FDG’s among Canada Research Chairholders. The Tri-Agency Institutional Programs Secretariat (TIPS) has established targets for CRC representation, with staggered deadlines for meeting targets between the period of 2020 to 2029.

CAN-ACN’s response to the 2023 budget

Response to the budget tabled March 28, 2023

The Canadian Association for Neuroscience joins its voice to the rest of the scientific community in expressing disappointment in the lack of support for science, research, and students in Budget 2023.

There are some questions left unanswered following this budget:

How can the government fail to recognize that fundamental research drives innovation and economic growth?

Continue reading

Two Members of Parliament visit the Trudeau lab at Université de Montréal

Dr. Louis-Eric Trudeau, neuroscientist at the Université de Montréal and his research team hosted on April 4 two federal MPs, M. Yves-François Blanchet, leader of the Bloc Québécois, and M. Maxime Joncas-Blanchette MP for the Rimouski region and in charge of science issues at the Bloc. The goal was to discuss the funding of neuroscience and biomedical research in Quebec and in Canada and also the challenges of sharing research discoveries in French. Both expressed strong support for increased federal funding for research.

Lab visits are a great way to engage with elected officials and promote science in Canada – Congratulations Dr. Trudeau!