Category: Research Staff

Postdoctoral Associate, Neuroscience – Joy lab at Jackson Laboratory

Posted on | by Julie
Jackson Laboratory logo

The Joy lab is looking for a motivated postdoctoral candidate interested in studying circuit repair and motor behavior after stroke with the goal of identifying translatable therapies for stroke recovery.

The focus of the lab is to determine how brain circuits reorganize after a stroke, contributions of these reorganizational process to motor function, molecular signatures that drive recovery and therapeutic targets for stroke. We use a host of techniques including but not limited to large-scale mesoscopic calcium imaging, optogenetics, gene targeting with viral vectors or transgenics, transcriptomics and ethological measurements of behavior.

The ideal candidate will have a PhD in Biological Sciences or nearing completion, experience in one or more of the above techniques, a strong background in neuroscience and optionally molecular biology and data science. We are looking for a candidate that is driven, can leverage the lab’s existing expertise and build upon this and does not shy away from new ideas/approaches and challenges. Additionally, the candidate will have access to JAX’s unique postdoctoral training program that offers support and substantial guidance for building an independent career in science through applications to postdoctoral and transition awards.

This is also a unique opportunity to explore the beautiful outdoors and the coastline of Bar Harbor, ME , be it a day at the Acadia National park, a walk through the carriage roads, sailing in the Atlantic , snow sports or being part of the exuberant festivities over the Summer.

Interested applicants are encouraged to submit a 1-page cover letter briefing your training, current and future interests, CV and contact information for 2-3 references.

The Joy lab supports postdocs that have either academic or non-academic long-term career goals, international candidates, women and candidates from all backgrounds. We truly believe in equal opportunity for all.

JAX Salary
Year 0 – 1 $65,589
Year 1 – 2 $67,318
Year 2 – 3 $69,095
Year 3 – 4 $70,521
Year 4 – 5 $72,877
Year 5 – 6 $75,569

#CA-NF7

About JAX:

The Jackson Laboratory is an independent, nonprofit biomedical research institution with a National Cancer Institute-designated Cancer Center and nearly 3,000 employees in locations across the United States (Maine, Connecticut, California), Japan and China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.

Founded in 1929, JAX applies over nine decades of expertise in genetics to increase understanding of human disease, advancing treatments and cures for cancer, neurological and immune disorders, diabetes, aging and heart disease. It models and interprets genomic complexity, integrates basic research with clinical application, educates current and future scientists, and provides critical data, tools and services to the global biomedical community. For more information, please visit www.jax.org​​​​​​​.

EEO Statement:

The Jackson Laboratory provides equal employment opportunities to all employees and applicants for employment in all job classifications without regard to race, color, religion, age, mental disability, physical disability, medical condition, gender, sexual orientation, genetic information, ancestry, marital status, national origin, veteran status, and other classifications protected by applicable state and local non-discrimination laws.

Contact information:

Nicole Fraser, Talent Acquisition Partner
Nicole.Fraser@jax.org

Please apply here: https://thejacksonlaboratory.wd1.myworkdayjobs.com/External_JAX/job/Bar-Harbor-Maine/Postdoctoral-Associate—Neuroscience—Joy-Lab_JR004213

Scientist / Senior Scientist – Hospital for Sick Children, University of Toronto

Posted on | by Julie

SCIENTIST/SENIOR SCIENTIST

Research Institute

The Hospital for Sick Children

University of Toronto

The Research Institute at The Hospital for Sick Children (SickKids) is accepting applications for a Scientist/Senior Scientist focused on the neuroscience of child and youth mental health. The position is permanent full-time and will include an accompanying appointment in a relevant department at The University of Toronto (UofT), including but not limited to Psychology, Psychiatry, or Medical Biophysics. The SickKids Research Institute is Canada’s largest, hospital-based child health research institute. Our commitment is to improve the health of children, here in Canada and in the global community.

Applicants must have a Ph.D. in a relevant discipline, as well as significant research experience (i.e., at least 3 years postdoctoral) and a record of outstanding scientific accomplishment and innovation in neuroimaging science related to child and youth mental health. Applicants are expected to demonstrate evidence of: successful research funding (peer-reviewed grants, fellowships, etc.), publications in leading journals, presentations at significant conferences, and increasing leadership experience in a research team. Applicants should have a strong track record of productivity and innovation in research focused on using neuro-imaging to understand child and youth mental health, as well as an established record of collaboration and interdisciplinary research.

The successful candidate will engage in an original, competitive, and independently funded research program of international caliber that will use neuroimaging to understand the bio-psychological underpinnings of clinical symptoms, neuropsychological function, and behaviour across children and youth with a variety of mental health challenges. The successful candidate will be appointed as a Scientist/Senior Scientist in the SickKids Research Institute and expected to qualify for an academic cross-appointment in an appropriate department at the University of Toronto enabling: (a) direct supervision of students, postdoctoral fellows, and research associates; and (b) work with students/post-docs to prepare scientific manuscripts, grant applications, and/or drafts of patent applications. Salary will be commensurate with qualifications and experience. A competitive benefits package is being offered along with support for relocation expenses. Exceptional, appropriately qualified candidates may be nominated for a Canada Research Chair. For further information see: http://www.chairs-chaires.gc.ca/home-accueil-eng.aspx Wherein a practicing MD, the successful candidate will have obtained an appropriate Certificate of Registration from the College of Physicians and Surgeons of Ontario (license to practice), and appropriate VISA, if applicable.

The successful applicant’s research program will be housed at the SickKids Research Institute in the state-of-the-art Peter Gilgan Centre for Research & Learning (686 Bay Street, Toronto, Canada), located in the Discovery District in the heart of downtown Toronto. SickKids is fully affiliated with the UofT – Canada’s largest and top-ranked university, and our researchers benefit from the extensive research facilities at the UofT and other affiliated institutions. The position offers a unique environment for medical science discoveries, with nine teaching and research hospitals in close proximity. The position offers the opportunity to conduct research, teach, and live in one of the most vibrant, safe and diverse cities of the world.

The Hospital for Sick Children recognizes that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances to allow for a fair assessment of their application.

Our Commitment to Diversity

SickKids is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, 2SLGBTQIA+ persons, and others who may contribute to the further diversification of ideas. If requested, SickKids is proud to make available accommodations to support applicants with disabilities during the interview and assessment process. Informed by the Accessibility for Ontarians with Disabilities Act (AODA), the Ontario Human Rights Code, and our Access and Accommodation Policy, we will accommodate the needs of applicants. Please email faculty.office@sickkids.ca of your accessibility needs during the recruitment process. Information received relating to accommodation will be addressed confidentially.

Application Process Interested applicants should email their application (curriculum vitae, description of past research, research plan [3-5 pages], Equity Diversity and Inclusion Statement, three reference letters and copies of three representative publications) preferably in a single PDF file, to Dr. Donald Mabbott, Program Head Neurosciences & Mental Health Research Program at nmh.search@sickkids.ca by the close of the search on April 30, 2024. The search committee will interview applicants beginning in May of 2024 until the position is filled, with a potential start date in the next academic calendar year (2024/2025).

SickKids believes that diversity positively impacts science and is essential to sustain our vibrant world-leading research community. As part of the application process you will be asked to complete a brief voluntary diversity survey. Any information directly related to you is confidential and cannot be accessed by either the search committee or human resources staff. Results will be aggregated for institutional planning purposes. The self-identification information is collected, used, disclosed, retained and disposed of in accordance with the Privacy Act and the Access to Information Act.

All qualified applicants are encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority

Contact information nmh.search@sickkids.ca

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Senior Scientific Assistant for Electron and Light Microscopy – University of Victoria, Department of Biology

Posted on | by Julie

Job posting and application: https://uvic.mua.hrdepartment.com/hr/ats/Posting/view/10364

Department Summary

The Biology Department Electron Microscope (EM) Facility functions as a research and teaching platform and general resource for electron and light microscopy and imaging for the Biology Department. The EM Facility allows for sample preparation and basic histology for microscope work, and is equipped with two Transmission Electron Microscopes, light microscopes, ultramicrotomes, and ancillary equipment. It also houses a FIB/SEM system owned by the Division of Medial Sciences. Individual research labs also host several confocal and widefield microscopes.

Position Summary

The Senior Scientific Assistant is responsible to maintain the facility, including maintaining and trouble-shooting microscopes and other equipment belonging to Biology Department. They train graduate students and other researchers research labs in Biology in electron and light microscopy techniques. The Senior Scientific Assistant carries out research projects in collaboration with faculty and other researchers and advises them on technical approaches. They are expected to support undergraduate courses and labs, and work with faculty to obtain funding for upgrades and new equipment. The Senior Scientific Assistant works collaboratively with other units on campus who may also use the facility.

Key Responsibilities

  • Maintain, diagnose, and repair TEM, light microscopes, and ancillary equipment (25%)
  • Process and image biological samples for TEM, SEM, and light microscopy (25%)
  • Train new users on TEM and ancillary equipment, as well as the department’s widefield and confocal microscopes (25%)
  • Assist EM facility users with trouble-shooting for both hardware and software (10%)
  • Liaise with repair service engineers and other microscope facilities on campus (5%)
  • Maintain chemical and consumables inventory for the EM facility (5%)
  • Compile user records for billing and charge-backs. (5%)

Summary of Qualifications:

– A MSc in Biology or a related discipline with a minimum of 5 years’ experience in operating light and electron microscopes.

– Experience in sample preparation methods (fixation, dehydration, embedding, and sectioning) for brightfield, fluorescence and electron microscopy and with techniques such as immunolabeling, histochemistry and image analysis.

– Demonstrated desire to learn new technologies, stay up-to-date in the field, and to promote new techniques to facility users and the Department.

– Experience in maintenance, calibration, and minor repairs for both light and electron microscopes.

Posting Close Date: 21 November 2023

Research Associate – Western University

Posted on | by Julie

Classification & Regular Hours

Hours per Week: 37.5

Salary Grade: R2

Please note, this is a wholly grant funded position.

About Western

With an international reputation for success, Western ranks as one of Canada’s top research-intensive universities. Our research excellence expands knowledge and drives discovery with real-world application. Western also provides an exceptional employment experience, offering competitive salaries, a wide range of employment opportunities and one of Canada’s most beautiful campuses.

About Us

Western’s Schulich School of Medicine & Dentistry is a leading Canadian centre of outstanding education and research shaping health care for the next generation and is the largest and most complex faculty on campus. The Department of Anatomy and Cell Biology has a long-standing tradition of distinction in research and teaching. The success of Anatomy and Cell biology is predicated on its people, dedicated Faculty, Staff and Trainees who support our mission: excellence in research and scholarship in anatomy, cell biology, neuroscience and education.

The mission of Dr. Khokhar’s research is to disentangle the complex relationship between substance use and serious mental illness. The lab uses a variety of cutting-edge behavioural, neuroimaging and circuit manipulation tools to answer translationally relevant questions related to this chicken-or-egg question with the ultimate goal of improving treatment options for these patients.

Responsibilities

The Research Associate will apply their expertise and knowledge to a research project under the direction of a Principal Investigator and will carry out and oversee original and independent research to assist the PI in achieving their research outcomes regarding the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The position will play a lead role in training staff, graduate students, undergraduate students and post-doctoral fellows, and in resolving issues that arise in the research environment. The Research Associate will support and operationalize new and innovative research opportunities as requested, participate in the development of research and project plans, and design, build and run experiments. The role will plan, implement, and coordinate aspects of data collection, perform data analysis, evaluate and interpret experiment al results, develop models or correlations, and prepare reports and other written material for presentations and/or submissions to various stakeholders as required.

Qualifications

  • Education:
  • Master’s Degree in Neuroscience or Pharmacology
  • PhD Degree in Neuroscience or Pharmacology is preferred.

Experience:

  • 3 years of experience in a related academic research environment with behavioural paradigms including withdrawal, conditioned place preference, self-administration/free-access intake, fear conditioning, prepulse inhibition, and latent inhibition
  • Experience with LC/MS or HPLC methods
  • Experience coding with behavioural control software (such as Med Associates), using behavioural assessment software (such as Noldus Ethovision), and with statistical analysis software packages (such as SPSS or R)
  • Experience with in vivo electrophysiology would be an asset

Knowledge, Skills & Abilities:

  • Familiarity with regulations and guidelines governing research ethics in an academic environment and with best practices for reviewing and writing grant proposals
  • In depth knowledge with methods for research design, implementation, and analysis with ability in methodology, procedures, equipment and standards to produce required research data
  • Proficiency in summarizing research findings, reviewing, appraising and interpreting published literature
  • Familiarity with techniques for updating, managing and extracting data from a research database
  • Ability to collaborate across internal and external boundaries to meet common objectives, improve outcomes and support work beyond one’s own unit
  • Communication skills to describe technical concepts effectively to both novice and sophisticated users, with an ability to complete detailed analytics and reports
  • Ability to work in a manner that mo dels best practices in confidentiality standards
  • Ability to provide solutions and ideas for improvement by using imaginative approaches where constructive thinking and innovation are required
  • Detail-oriented with an ability to function and process information with high levels of accuracy
  • Ability to work within a flexible schedule to accommodate the research group’s events and activities
  • Results-oriented with the ability to motivate and coach students to meet high performance standards, while working effectively as a member of the leadership team
  • Ability to investigate defined issues, solicit input, and suggest remedies and alternative approaches that meet the needs of the situation
  • Proven ability and natural inclination to develop relationships by interacting with people in a professional, respectful and diplomatic manner
  • Advanced skills in software and applications used to produce and analyze research outcomes< br />- Demonstrated ability to research/investigate issues and resolve problems

Background Checks

Please note, successful applicants may be required to produce a current police information record check(s) from a police service prior to commencing employment.

Western Values Diversity

The University invites applications from all qualified individuals. Western is committed to employment equity and diversity in the workplace and welcomes applications from women, members of racialized groups/visible minorities, Indigenous persons, persons with disabilities, persons of any sexual orientation, and persons of any gender identity or gender expression.

Accommodations are available for applicants with disabilities throughout the recruitment process. If you require accommodations for interviews or other meetings, please contact Human Resources at hrhelp@uwo.ca or phone 519-661-2194.

Please Note:

We thank all applicants for their interest; however, only those chosen for an interview will be contacted.

Contact information

Interested applicants are asked to visit https://recruit.uwo.ca for further information and to apply online referencing job #32815 by midnight on October 31st, 2023.

Posting end date: 2023/10/31

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Chief Research and Program Officer – Brain Canada Foundation

Posted on | by Julie

Brain Canada logoPosition: Chief Research and Program Officer

Status: Permanent, full-time

Location: Flexible-work remote position

SUMMARY OF THE POSITION

The Chief Research and Program Officer (CRPO) is a key member of the Executive Leadership Team, and a strategic member of the Management Team. Reporting directly to the President and CEO, the CRPO contributes actively to the organization’s strategic plan by providing leadership and expertise for the development of long-term strategic research and program priorities and goals.

Overseeing a team of dedicated research and program staff, the CRPO leads and directs the development, design, conception and implementation of all Brain Canada’s research activities and funding programs. They engage regularly with the Canadian brain research community and assist with managing relationships at the scientific level with key stakeholders including Brain Canada’s Board of Directors, the Government of Canada, partners and research funders, universities, private or philanthropic donors, and the international brain research community. They act as a key spokesperson and an ambassador for Brain Canada on the national and international stage.

They work in close collaboration with the Evaluation and Special Projects Team on evaluation, impact assessment and other initiatives.

RESPONSIBILITIES:

Positions reporting directly to this role:

  • Program Operational Lead
  • Senior Program Manager, Knowledge Mobilization
  • Research and Program Analyst

Key Accountabilities:

Leadership and Relationship Management:

  • As a key mission ambassador for Brain Canada, lead and inspire Brain Canada’s team in championing and advocating the organization’s ambitious future directions.
  • Develop, grow, and broaden relationships with the federal government and key stakeholders to identify and achieve exciting and transformational research priorities and goals, and promote funding opportunities.
  • Liaise and oversee the presentation of information to the federal government at a strategic level.
  • Develop and maintain active participation and strong relationships with the brain research community and key institutional and organizational research partners, such as universities, partner organizations, research centers and hospitals, researchers, philanthropic donors, etc.
  • Present regularly at Brain Canada Board meetings and represent the Research and Program Team on the Research Committee.
  • Align Brain Canada’s Research and Program activities with the Research Committee recommendations.
  • Participate in the development and stewarding of key donor relationships, assist the President and CEO and the National Director of Philanthropy with discussions, presentations, and meetings with prospective donors and funding partners to develop and implement new agreements which will be mutually beneficial and meet both research and philanthropic objectives.
  • Target and develop new strategic partnerships: initiate discussions with new strategic partners, develop agreements and terms of initial contracts, allocate funds to a specific research domain, etc.

Strategic Planning and Business Management:

  • Lead the Research and Program Team in the development of the organization’s strategic and operational plans (aligned with Brain Canada’s long-term strategic plan). This includes:
    • Overseeing the development, design and conception of all research activities and funding programs, including the peer review process.
    • Preparing and overseeing the execution of the annual budget of the Research and Program Team.
    • Reporting KPIs related to Research and Program to the Board of Directors.
    • Overseeing the selection and implementation of IT systems to increase the Research and Program Team efficiency.
    • Working closely with the CFO and Director of Legal Affairs and Governance to ensure compliance with the federal government’s contribution agreement.
  • Lead the implementation of the long-term strategic plan through annually-developed business plans (with aligned resources, identified reporting, and accountability).
  • Contribute and participate as a member of the executive team supporting the President and CEO to ensure the effective management of the organization including the integration of evidence-based research in the Mission and Vision, Research, Fund Development, and Marketing/Communications plans.
  • Support the Evaluation and Special Projects team to set priorities for evaluation initiatives (e.g., program evaluation, bibliometric analysis).
  • Collaborate closely with the Evaluation and Special Projects Lead on special projects such as strategic planning and stakeholder engagement for Indigenous initiatives and developing concept papers to support program development and philanthropy.

Human Resource Management:

  • Lead, inspire, and engage a highly effective Research and Program Team, ensuring high standards of delivery, competence, performance, and values are maintained and that staff is well supported in fulfilling their duties, developing their skills, and achieving their career potential. Specifically:
  • Ensure a clear understanding of organizational goals and priorities; ensure optimal deployment of resources to achieve business goals.
  • Establish team contribution plan; manage a strong team and develop effective lateral relationships cross-functionally.
  • Establish contribution plans and objectives and review on an ongoing basis.
  • Onboard and integrate direct reports, provide coaching and feedback, assess their contribution, nurture talent, and support their growth to help them realize their potential and engagement.
  • As required, recruit skilled talent in support of current and future needs.
  • Be familiar and comply with Brain Canada policies.
  • Provide coaching and development to team members and implement initiatives that effectively inspire loyalty and philanthropy amongst our supporters.
  • Be a visible leader in living the values throughout the organization.

Policy development:

  • In close collaboration with the Research Committee and Director, Legal Affairs and Governance, develop and update Brain Canada policies that relate to conflict of interest, research integrity, ethical conduct of research, privacy & security, data protection, publication, data access and sharing, intellectual property, and other aspects of the research process.

Other duties:

  • As assigned.

QUALIFICATIONS:

  • Graduate degree in neuroscience or a related discipline; Ph.D is a plus.
  • Proven success as a strategic transformational leader in a mission-driven health care, research or science organization (8-10 years leadership experience).
  • Extensive knowledge in the design, implementation, and delivery of scientific funding competitions, as well as best practices in the management of funded projects, research, and training programs through experience working in a research-funding organization or in an administrative capacity in a research-performing organization.
  • A demonstrated understanding or a desire/ability to acquire knowledge of the scientific and research issues associated with the brain; experience in inspiring, connecting, and engaging with researchers.
  • Excellent relationship-building skills with a proven ability to engage others and establish strong partnerships.
  • Success in advocacy, policy, and program development, working with government officials, research partners, volunteers, and internal teams.
  • Demonstrated ability to communicate and inspire audiences with varying levels of knowledge regarding brain research.
  • Success in rallying a talented staff around a shared vision and plan, delivering planned results.
  • Evidence of strong strategy development and implementation success.
  • Experience in leading change with and through others.
  • Passion for the cause: demonstrated ability to gain partners and donors and raise funds for a cause.

TALENTS:

  • Inspiring and Engaging leadership – inspires, motivates, develops, and manages a high-performing service-oriented team.
  • Excellent relationship-building skills, with people at all levels of organization (internally and externally); a passionate champion and ambassador.
  • Healthy self-confidence, authenticity, and humility.
  • Political savvy/acuity.
  • Superb negotiation, mediation, and persuasive abilities.
  • Ability to work under pressure, balance multiple tasks and projects at once, considering priorities appropriately, meet tight deadlines and cope with rapidly changing scenarios.
  • Excellent written and verbal communications and writing skills in English. Fluency in French is a plus.
  • Available for travel across Canada on a regular basis, and internationally on an occasional basis.
  • Comfort and ease in dealing with volunteers, donors, being visible internally and externally.
  • Agile and flexible leadership style and approach; comfort in leading in a matrix leadership model.
  • Commitment to Equity, Diversity and Inclusion.

Work environment:

Brain Canada Foundation is committed to providing an excellent work environment for team members. We offer:

  • A competitive compensation package including a complete benefits plan.
  • A flexibility to work from home, in accordance with our Work-from-Home Policy.
  • A healthy, flexible, and dynamic work environment that values teamwork, creativity, innovation and work-life balance.
  • Access to professional development and training as available.

About Brain Canada

Brain Canada Foundation (Brain Canada) is a national registered charity headquartered in Montréal, Quebec. We play a unique and invaluable role as a national convenor of those who support and advance brain research. A greater understanding of how the brain works contributes to the prevention, diagnosis, treatment, and cure of disorders of the brain, ultimately improving the health outcomes of people in Canada and around the world.

Our Commitment to equity, diversity, and inclusion (EDI)

Brain Canada is committed to improving and expanding brain science to benefit all people, including groups historically under-researched and underrepresented. We know that increasing the diversity of the research workforce and integrating sex and gender in brain research leads to innovation and greater impact.

Our commitment to EDI is reflected in actions we are taking to diversify our workforce and to foster inclusive environments through our advertising, interviewing, hiring, training, mentoring, and performance review practices. We actively welcome members of underrepresented groups such as women, Indigenous Peoples, persons with disabilities, visible minorities, immigrants, and LGBTQ2+ communities.

Territorial acknowledgement

The offices of Brain Canada Foundation are located on the traditional, ancestral territory of the Kanien’kehá:ka Peoples, a place which has long served as a site of meeting and exchange amongst nations.

In our work, we focus our efforts on the Truth and Reconciliation Commission’s Calls to Action, particularly those that pertain to improving health for Indigenous Peoples and that focus on advancing our own learning on Indigenous issues (Calls to Action numbers 19 to 24)

 

To apply:

careers@braincanada.ca

Senior Bioinformatics Analyst – University Health Network, Toronto

Posted on | by Julie

Source: University Health Network

Job Title: Senior Bioinformatics Analyst

Job Number: CAAR919696

Job Location: Toronto, Ontario, Canada

Posted: 16 May 2023

Job Description:

Job Posting #: 919696

Union: Non-Union

Site: Toronto Western Hospital (TWH) – Krembil Discovery Tower

Department: Donald K. Johnson Eye Institute, Krembil Research Institute

Reports to: Co-Director and Senior Scientist

Hours: 37.5 per week

Salary: $36.88 to $46.10 per hour commensurate with experience and consistent with UHN per hour commensurate with experience and consistent with UHN compensation policy

Status: Permanent Full-Time

Shifts: Days

Posted Date: May 17, 2023

Closing Date: Until filled

The University Health Network, where “above all else the needs of patients come first”, encompasses Toronto General Hospital, Toronto Western Hospital, Princess Margaret Cancer Centre, Toronto Rehabilitation Institute and the Michener Institute of Education. The breadth of research, the complexity of the cases treated, and the magnitude of its educational enterprise has made UHN a national and international resource for patient care, research and education. With a long tradition of ground breaking firsts and a purpose of “Transforming lives and communities through excellence in care, discovery and learning”, the University Health Network (UHN), Canada’s largest research teaching hospital, brings together over 16,000 employees, more than 1,200 physicians, 8,000+ students, and many volunteers. UHN is a caring, creative place where amazing people are amazing the world.

Position Summary

University Health Network (UHN) is looking for an experienced professional to fill the key role of Senior Bioinformatics Analyst in our Donald K. Johnson Eye Institute.

We are looking for a bioinformatician with demonstrated experience single-cell RNA sequencing analysis. The anticipation is that this qualified person will be able to work with scRNAseq and spatial Seq datasets and be able to incorporate the latest multiomic analysis tools.

This is an opportunity to work with state-of-the-art data in the context of novel stem cell and disease models of eye and congenital brain disorders. There will also be opportunities for collaborative work in adult onset neurodegeneration.

The successful applicant will be expected to bring novel ideas and approaches to the research program and contribute to the scientific development of the analysis plan and manuscript preparation.

A competitive compensation package will be offered based on demonstrated experience.

Duties

  • Establish NGS data analysis pipelines for read alignment, targeted sequencing, mapping, annotation, variant calling, cell clustering and differential gene expression analyses.
  • Identify areas for improvement in NGS data processing/interpretation and propose and implement solutions.
  • Explore public biological databases and open source bioinformatics tools, suggest integration approaches and build prototype models.
  • Work closely with researchers to provide technical support for scientific discoveries and model developments.
  • Has solid grasp of the fundamentals and jargon of the domain-specific material.
  • Work with research groups to plan, implement and coordinate all aspects of data collection and/or analysis.
  • Participates partially or fully in initial project design, selection and development of procedures.
  • Participates directly in mid-level data analysis, including application of statistical analysis techniques using standard software.
  • Performs complex data manipulations without assistance.
  • Performs data conversions (as required) without assistance or existing tools.
  • Participates directly in mid-level complexity software or data analysis/visualization method development and implementation.
  • Assists in interpretation of results and preparation of material for presentation, publication, and/or grants.
  • Assesses literature in the field of study.

Qualifications

  • Completion of MSc/PhD/M.D. degree, in relevant field of study.
  • Published experience in scRNAseq data analysis.
  • Interest in neuroscience and willingness to learn about retinal disease.
  • Ability to advise/mentor fellow institute members in bioinformatics analysis strategies.
  • Ability to work independently from home and on-site, and also function as part of a team.
  • Ability to work well under pressure and use good judgment in assessing difficult situations.
  • Attention to detail, excellent organizational and time management skills.
  • Excellent verbal and written communication skills.
  • Problem-solving initiative.

Why join UHN?

In addition to working alongside some of the most talented and inspiring healthcare professionals in the world, UHN offers a wide range of benefits, programs and perks. It is the comprehensiveness of these offerings that makes it a differentiating factor, allowing you to find value where it matters most to you, now and throughout your career at UHN.

  • Competitive offer packages
  • Government organization and a member of the Healthcare of Ontario Pension Plan (HOOPP https://hoopp.com/)
  • Close access to Transit and UHN shuttle service
  • A flexible work environment
  • Opportunities for development and promotions within a large organization
  • Additional perks (multiple corporate discounts including: travel, restaurants, parking, phone plans, auto insurance discounts, on-site gyms, etc.)

Current UHN employees must have successfully completed their probationary period, have a good employee record along with satisfactory attendance in accordance with UHN’s attendance management program, to be eligible for consideration.

Vaccines (COVID and others) are a requirement of the job unless you have an exemption on a medical ground pursuant to the Ontario Human Rights Code.

UHN is a respectful, caring, and inclusive workplace. We are committed to championing accessibility, diversity and equal opportunity. Requests for accommodation can be made at any stage of the recruitment process. Applicants need to make their requirements known in advance. Any information received related to an accommodation will be addressed confidentially.

University Health Network thanks all applicants, however, only those selected for an interview will be contacted.

You will be asked to submit one letter of motivation, a brief one page statement of research interests, up-to-date CV with publications and two references.

 

To apply to this job, please click on the link, fill out and submit the application form. Click to apply here:

 

https://recruitment.hrsoft.com/cb/Apply/application.htm?ujn=CAAR919696&source=Direct%20Contact&Is=1&At=11&JobRandKey=966920378

PDF version of this advertisement:

https://can-acn.org/wp-content/uploads/formidable/7/Senior-Bioinformatics-Analyst-University-Health-Network-1.pdf

Research Technician – Hazrati lab, McGill University

Posted on | by Julie

About the Role:

We are seeking an enthusiastic, organized, and experienced research lab technician to help run the Hazrati research lab at McGill University. Our lab studies the pathology and pathophysiology of mild traumatic brain injury using human brains, animal models, and cell culture experiments. In particular, we focus on cellular senescence and seek to explore the early molecular underpinnings of brain dysfunction associated with trauma. This lab has recently been relocated, and so part of this job will be setting up a new research lab space.

Responsibilities:

  • Optimize and develop molecular assays for assessing human tissue, mouse tissue, and cell culture experiments
  • Statistically analyze data and use critical thinking to interpret results
  • Keep track of inventory and ordering reagents and supplies for the lab
  • Support graduate students by running assays and helping with data analysis
  • Manage electronic lab notebook for the lab
  • Manage brain bank research IDs
  • Present lab updates regularly at weekly lab meetings
  • Lab safety management
  • Management of regulatory paperwork (Health Canada exemptions, animal use protocols, SOPs, REBs and legal paperwork within the institution)

Requirements:

  • Minimum MSc in a relevant biological science field (neuroscience background is preferred)
  • Experience with nucleic acid and protein isolation protocols
  • Experience with protein assays (Western Blots. ELISA, etc.), qPCR, and immunoassays
  • Experience with microscopy (brightfield, confocal)
  • Experience with mammalian cell culture is an asset
  • Previous experience working with mice  and surgical and behavioral testing skills are an asset
  • Preferably experience with tissue cutting using microtome and/or cryostat
  • Bioinformatics experience is an asset (bulk or single cell RNAseq, for example)
  • R or Python programming language experience is an asset

Employment type: Full-time, 1-year contract

Contact: lili-naz.hazrati@McGill.ca

Research professional – CERVO Brain Research Centre, Quebec city

Posted on | by Julie

The research team at The CERVO Brain Research Center in Quebec City is looking for a research professional in the laboratory of Dr. Chantelle Sephton: https://cervo.ulaval.ca/en/chantelle-f-sephton

Research area: The main research objective of the lab is to determine how RNA processing is impaired in neurodegenerative diseases. We will achieve this by studying the RNA-binding proteins that are mutated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). We will use our mouse models and cell culture models of ALS to study the function of RNA-binding proteins and the effectiveness of therapeutic drug treatments. The results of these studies will provide insight into how impaired RNA regulation can cause ALS and we will use this information to develop targeted therapeutic treatments to treat the disease.

Research project: The current project in the Sephton laboratory requires a research professional to conduct preclinical testing of drugs in ALS mouse models as a proof of concept for the therapeutic treatment of ALS.

Main responsibilities

Under the supervision of Dr. Chantelle Sephton, the research professional’s main responsibilities are to:

  • Co-ordinate, conduct and analyze the results pertaining to the ongoing research program;
  • Work under minimal supervision for many tasks;
  • Supervise the people under his responsibility and ensure the quality and relevance of the results;
  • Ensure the coordination of research activities in close collaboration with students (ethical authorizations, purchases, communication with partners);
  • Participate in data collection (administration of tests, laboratory measurements), data entry and analysis;
  • Contribute to the dissemination of research results (scientific articles, presentations, and knowledge transfer);
  • Conduct scientific literature reviews to support project development.

Note: Responsibilities could be modulated according to the experience of the candidate

Required profile

Candidates should have some experience in animal handling (mice or rats) and experience in animal handling (e.g. i.p. injection and behavioral testing) as well as experience in molecular biology (PCR, purification DNA) and in biochemistry (Western blot, protein determination)

  • Must hold a Bachelor of Science in one of the following fields: biochemistry, neuroscience, genetics or molecular biology (candidates holding a master’s or doctoral degree are also invited to apply);
  • Sense of organization, initiative, rigour, flexibility and autonomy;
  • Excellent interpersonal and teamwork skills;
  • Ease in the use of various computer software;
  • Language proficiency (English-intermediate and French-advanced)

Additional information

  • Type of employment: Initial one-year contract with possibility of renewal.
  • Schedule: Full time, 35 hours per week.
  • Salary: According to qualifications and experience.

Advantages :

  • Contribution to the Government and Public Employees Retirement Plan (RREGOP);
  • Group insurance (after three months of work) and paid at 50% by the employer;
  • 5 paid sick days per year;
  • 13 paid statutory holidays per year.

Contact information

TO APPLY
Interested persons are invited to send a cover letter and their Curriculum vitae at the following address: chantelle.sephton.1@ulaval.ca
Posting end date 2023/03/31

Imaging Specialist Position at University of Manitoba

Posted on | by Julie

Position Title: Imaging Specialist

Employer: University of Manitoba, Department of Pharmacology & Therapeutics

Salary: $60,000-70,000; salary will be commensurate with qualifications and experience.

Expected Start: December 1st, 2022 or earliest availability.

 

Job Description

The Live-Cell Imaging Facility (LCIF) is a Rady Faculty of Health Sciences (RFHS) supported core platform located within the Neuroscience Research Program on the 4th floor of the Kleysen Institute for Advanced Medicine. The LCIF includes state-of-the-art facilities for intravital multiphoton imaging from behaving small animals, in vitro multiphoton imaging, imaging with laser-capture/microdissection, confocal and super-resolution imaging. LCIF facilities are routinely accessed for day-to-day research activities of highly successful and established RFHS members probing the molecular, genetic and cellular basis of disease.

The LCIF seeks to hire a full-time Research Associate with a strong background in advanced optical microscopy who will oversee day-to-day operations of the LCIF and provide expert-level technical expertise and user support.

Responsibilities:

  • Facilitate facility access and promote increased adoption of advanced imaging and analysis techniques.
  • Offer in depth training, assistance with experimental design and advanced analysis procedures.
  • Consolidate and share collective expertise and best practices among our user base by organizing instructional seminars, tutorials and workshops.
  • Assist in the development of post-processing algorithms and software tools, including commercially available and in-house software.
  • Promote open access to imaging expertise and tools locally, nationally and internationally by networking with other facilities, curating content hosted on the LCIF website, and by further promoting discoveries and capabilities (e.g. via social media).
  • Ensure optimal operation and longevity of imaging facilities by troubleshooting system problems, undertaking routine maintenance and liaising with system manufacturers for scheduled maintenance or repairs.
  • Manage bookings, track and report system usage (number of users and hours logged), assist in billing based on usage and maintain training records (number of new users and hours of training provided).

Qualifications, skills and abilities:

  • Doctoral degree or equivalent qualifications and experience.
  • Experience with advanced optical microscopy (e.g. widefield, confocal or multiphoton imaging) including experimental design, sample preparation, image processing and analysis.
  • Experience in training and supervising trainees and staff.
  • Ability to troubleshoot and resolve technical problems with imaging equipment or software.
  • Ability and willingness to learn new techniques and skills, and to keep abreast of developments in the areas of expertise.
  • Effective communication skills, both written and verbal, and enthusiasm for sharing knowledge and expertise with others.
  • Demonstrated organizational skills and ability to prioritize tasks to meet objectives.
  • Ability to work both independently and as a member of a team is essential.

Interested Candidates should send their CV and cover letter, including a summary of their experience and qualifications for the position described, as well as the names and contact information for academic/research references, to Dr. Michael Jackson (michael.jackson@umanitoba.ca).

Additional information:

The University of Manitoba is committed to the principles of equity, diversity & inclusion and to promoting opportunities in hiring, promotion and tenure (where applicable) for systemically marginalized groups who have been excluded from full participation at the University and the larger community including Indigenous Peoples, women, racialized persons, persons with disabilities and those who identify as 2SLGBTQIA+ (Two Spirit, lesbian, gay, bisexual, trans, questioning, intersex, asexual and other diverse sexual identities). All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.

If you require accommodation supports during the recruitment process, please contact UM.Accommodation@umanitoba.ca or 204-474-7195. Please note this contact information is for accommodation reasons only.

An inclusive, open and diverse community is essential to excellence and fosters voices that have been ignored or discouraged. To address the Rady Faculty of Health Sciences commitment to equity, diversity and inclusion, and in recognition of the underrepresentation of members of historically and currently excluded groups, we take proactive measures including implicit bias training for all hiring panels. We strive for diversity and cultural safety throughout the hiring process (hiring panels, short-list of candidates, interviews). We encourage you to self-identify any aspect of diversity in your cover letter.

Application materials, including letters of reference, will be handled in accordance with the protection of privacy provision of The Freedom of Information and Protection of Privacy Act (Manitoba). Please note that curriculum vitae may be provided to participating members of the search process.

Contact information

Dr. Michael Jackson

LCIF Director

Associate Professor, Department of Pharmacology & Therapeutics

University of Manitoba

michael.jackson@umanitoba.ca

Research Associate 1 – University of Guelph – Khokhar lab

Posted on | by Julie

Position Title:                 Research Associate 1, (Grant & Trust Professional)
Employer:                         University of Guelph (Biomedical Sciences, Ontario Veterinary College)
Term:                                  Temporary full time (15 month contract to start as soon as possible)
Hours:                               Full-time (35 Hours/Week)
Number of Positions:  1
Hiring Ref. Number:   2022-0604

N.B.:    Please read the Application Instructions before applying: https://www.uoguelph.ca/hr/careers-guelph/how-apply

The Khokhar Lab researches the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The Research Associate is responsible for the following main duties:

  • conducts behavioural experiments assessing the effects of cannabinoids in a variety of animal models of addiction (e.g., withdrawal, conditioned place preference and self-administration/free-access intake) and serious mental illness (e.g., prepulse inhibition, latent inhibition);
  • provides input with respect to appropriate methodology, procedures, equipment and standards to produce required research data;
  • applies specialized knowledge and principles to review, appraise and interpret published literature, summarize research findings, and draft scientific/technical reports, manuscripts, grant proposals;
  • establishes and maintains effective relationships with external partners, which may include coordinating of project plans, presenting research findings (may include presenting findings at conferences).

Education, Skills, Work Experience and other Requirements:

  • Master’s degree in relevant discipline combined with at least 3-5 years of relevant research experience with behavioural paradigms including: withdrawal, conditioned place preference, self-administration/free-access intake, prepulse inhibition, latent inhibition;
  • Experience coding with behavioural control software (e.g., Med Associates or equivalent), and using behavioural assessment software (e.g., Noldus Ethovision or equivalent) and statistical analysis software packages (e.g., SPSS or R);
  • Proven ability in methodology, procedures, equipment and standards to produce required research data;
  • Proficiency in summarizing research findings, reviewing, appraising and interpreting published literature;
  • Strong attention to detail;
  • Self-motivated and able to work collaboratively within a team environment;
  • Experience with in vivo electrophysiology is considered an asset.

Salary: $54,107 – $62,168

Vacation Pay: accrual rate of 1.25-1.83 days/month

Benefits: Extended Health, Basic Life Insurance (up to specified maximums), Dental coverage subject to minimum employment contract and minimum workload thresholds being met and Long Term Disability subject to minimum employment contract and minimum workload thresholds being met (payable to a maximum of 5 years).

Location of Employer: 50 Stone Road, Guelph, ON N1G2W1

Location of Work: Guelph, ON                    

Language of Work: English

All Canadian citizens or permanent residents who qualify are invited to apply by sending their Cover Letter and CV (including list of publications demonstrating relevant experience), quoting hiring number 2022-0604, by email to careers@uoguelph.ca or by mail to the following address: 50 Stone Rd E, Guelph ON N1G 2W1 (Attention: Human Resources).

At the University of Guelph, fostering a culture of inclusion is an institutional imperative. The University invites and encourages applications from all qualified individuals, including from groups that are traditionally underrepresented in employment, who may contribute to further diversification of our Institution.