Tag: mendeley

The Guo Lab at the Hotchkiss Brain Institute and Alberta Children’s Hospital Research Institute, University of Calgary is seeking candidates for two postdoctoral positions. The long-term goal of the Guo lab is to define fundamental principles governing the functional wiring of the brain. Toward this goal, we are focused on primary cilia, signaling antennae of almost all cells in the brain. Long considered as evolutionary remnants of little significance, primary cilia in the past decade have sparked enormous interest, fueled by the discoveries that mutations in 150+ ciliary genes lead to 30+ human disorders collectively termed “ciliopathies”. The brain is particularly vulnerable to ciliary dysfunction as reflected by the prominent brain anomalies and neurological deficits associated with neurodevelopmental and psychiatric disorders found in ciliopathy patients. Nevertheless, due to the lack of mechanistic insights, how primary cilia can exert such a profound impact on the brain remains a long-standing mystery.
How do primary cilia, only a few m long protrusions from the cell soma, exert such a profound impact on the brain? The Guo lab is incorporating recent technical advances including single cell/nucleus RNAseq and ATACseq, human iPSCs, Serial Block face EM, mouse genetics, biochemistry, cell signaling control, in vivo 2-photon live imaging, and translational pharmacology to peel back the layers of this mystery from gene→cell→circuit→behavior→therapeutics (Guo et al., Developmental Cell 2017; Guo et al., Developmental Cell 2019; Wang et al., Nature Neuroscience 2024). The Guo lab has established a wide range of national and international collaborations. PDFs in the Guo lab have ample opportunities to learn cutting-edge technologies in molecular/cellular/system neuroscience and be co-supervised by Dr. Jeff Biernaskie (scRNAseq/ATACseq, U of C) and Dr. Grant Gordon (in vivo 2-photon imaging, U of C), Dr. Tomas Nowakowski (viral genomic technology to study the human brain, UCSF).

Project summary and responsibilities

• Define the role of primary cilia in glial cells, including astrocytes, oligodendrocytes, and mural cells in development and disease, using both mouse models and human cells.
• Define the role of primary cilia in human brain development, particularly focused on neural progenitors and lineages.
• Analyze data from molecular, genetic, imaging, and behavioral experiments.
• Collaborate with lab members and interdisciplinary teams at U of Calgary and internationally.

Qualifications:

• PhD in neuroscience or a related field.
• (highly desired but not necessary) Experience with molecular biology, scRNAseq/ATACseq, in vivo 2-photon live imaging, and mouse behavior
• Experience with coding is an asset (e.g., R, Python, MATLAB).
• A strong track record with neuroscience research in peer-reviewed journals.
• Ability to work independently and as part of a collaborative team.

Individuals interested in this opportunity should submit the following components in a single PDF document to Dr. Jiami Guo (Jiami.guo@ucalgary.ca).

• Letter of interest (research interests, experience, and goals (<2 pages)
• Curriculum vitae
• Recent publications (links)
• Names and contact information of two or three referees (who will only be contacted if a candidate is shortlisted)

The position is located in Calgary, Alberta. Applications will be accepted until suitable candidates are identified.
Contact information

Dr. Jiami Guo,
jiami.guo@ucalgary.ca

The Chen Lab at the Brain and Mind Research Institute, University of Ottawa is seeking candidates for two postdoctoral positions in molecular/system neuroscience.
The Chen lab is specialized in combining chronic in vivo imaging (two-photon microscopy, fiber photometry, GRIN lens imaging) with genetic and molecular approaches to dissect how cell type- and projection-specific plasticity orchestrate long-lasting structural and functional reorganization of the brain’s circuitry in normal and disease brains (Yin et al., Nature Neuroscience 2021; Lee et al., eLife 2022; Yang et al., Neuron 2022).
https://www.schenlabuottawa.com/

Key Responsibilities:

• Lead a project that identifies the roles of specialized gene expression programs in distinct excitatory and inhibitory neuron subtypes during motor learning.
• Utilize in vivo imaging techniques to monitor neural activity in cortical and/or subcortical regions
• Analyze data from molecular, genetic, and behavioral experiments.
• Collaborate with lab members and interdisciplinary teams within uOttawa’s growing neuroscience community.

Qualifications:

• PhD in neuroscience or a related field.
• Experience with molecular biology, RNAseq, and mouse behavior
• Experience with coding is an asset (e.g., Python, MATLAB).
• A strong track record with neuroscience research in peer-reviewed journals.
• Ability to work independently and as part of a collaborative team.

The researcher will join uOttawa’s Brain and Mind Research Institute (Department of Cellular and Molecular Medicine; Faculty of Medicine). The neuroscience community is fast expanding, highly dynamic and offers a rich array of collaborative opportunities. For more information about the Brain and Mind Research Institute, visit: https://www.uottawa.ca/research-innovation/brain

Ottawa, the capital of Canada, is a green, vibrant, multi-cultural city that offers the highest standard of living in the country and ranks second worldwide for quality of life (Numbeo index, 2015). The city features numerous parks, including the UNESCO World Heritage Rideau Canal and is surrounded by an extensive greenbelt. This bilingual, culturally-rich city lies at the border of Quebec and Ontario and is within driving distance of Montréal and Toronto.
Interested candidates should submit electronically as a single PDF file to Dr. Simon Chen at schen2@uottawa.ca. Applications will be considered until a suitable candidate is found.

Please include:

• A personal statement describing research interests, experience, and goals (<2 pages)
• A complete curriculum vitae
• Names and contact information of three references

Contact information

Dr. Simon Chen
schen2@uottawa.ca

Project Overview

Since 2020, we have collaborated with a patient association with whom we have discovered new genetic variations in a gene that had never before been implicated in neurological diseases. We have access to patient cells and have generated numerous lossof- function models in this gene: KO mouse model, humanized mouse model, conditional KO mouse model, KO zebrafish models, KO cell lines, iPSC-KO… Our recent work has validated the pathogenicity of patient variants and, more broadly, the loss of function of this gene in neurodevelopmental diseases. Over the next few years, we aim to decipher the yet unknown function of this gene during neurodevelopment and central nervous system function. The project will focus on the analysis of neurodevelopment in different conditional KO mouse models. The project will also investigate how perturbations in this gene can affect the function of the central nervous system, particularly causing seizures.

Expertise

We are looking to recruit a passionate post-doctoral fellow with extensive expertise in the study of neurodevelopment in mice and in-depth knowledge of neurogenesis. Expertise in molecular biology analytical techniques applied to mice is required. Expertise in behavioural analysis and EEG recording in mice is a plus. Expertise in bioinformatics data

Why joining?

• All models are already generated
• Working on an entirely new subject with a gene whose function is totally unknown
• Project funded for 3 years
• Participation in one international congress per year to present research data
• A young, dynamic lab autonomy to thrive
• A vast network of collaborators (clinicians, geneticists, researchers)
• Modern premises in the heart of downtown Montreal

Our Lab

Our laboratory is interested in dissecting the molecular mechanisms underlying rare neurological diseases. We take advantage of the ease of use of the zebrafish model, but also combine it with mouse models and human cells.

Find out more about our lab: https://www.samlab.ca/

• Provincial tax exemption with post-doc status at Université de Montréal
• Technical support from more than 19 platforms at the CRCHUM

Contact information Send a cover letter, CV and at least two letters of recommendation to eric.samarut@umontreal.ca

There are no closing dates for applications, and analysis of the files may stop as soon as a candidate has been selected.

Applications are being considered for a new postdoctoral fellow who will work in the laboratories of Drs. Jeff Dong and John Howland at the University of Saskatchewan. The successful applicant will lead two collaborative projects with funding secured from CIHR and the US Department of Defense: 1) the roles of oxidized phosphatidylcholines in brain aging and multiple sclerosis, and 2) the long-term effects of gestational cannabis exposure on offspring brain and behavioural development. The ideal applicant will have experience with single cell and/or spatial transcriptomic analysis as well as proficiency in molecular biology and/or behavioural neuroscience techniques. Applicants are expected to have strong written and oral communication skills, as evidenced by their academic record or previous research experience. We encourage applications from individuals that have been traditionally under-represented in the life sciences. Salary will be commensurate with past experience and external scholarships/awards.

Please contact Jeff Dong (jeff.dong@usask.ca) and John Howland (john.howland@usask.ca) with:

1) a brief statement of research interests, and

2) a CV with the names of at least two references.

The review of applications will begin in early fall, 2024.