Author: Julie

UCalgary researchers discover that a group of ancient cells may play a key role in controlling stress

Stress is ubiquitous, and at no time in recent memory has this been more evident than right now — on a global scale. Our survival depends on our ability to continually adjust and respond to ever-evolving challenges in our world.

Interestingly, how we manage stress now has implications for how we will manage stress in the future. It is not necessarily about the actions we take now, but rather whether we feel our actions give us some control over the outcome during a difficult time. Psychologists and neuroscientists have pondered this ‘stress control’ theory for decades, but how the brain intertwines the perception of controllability of one situation into decisions and actions for future situations has not been well understood. Continue reading →

The Public Health Agency of Canada has sent a second call for items and reagents for the public health laboratories

• For loan:
  1. Thermofisher Kingfisher Flex Purification Systems (automated nucleic acid purification) with the 96- Deep Well head
  2. Associated plastic consumables (96-well plate blocks) would also be of interest

2. For use:
   1. Laboratory grade Guanidine thiocyanate

As with ‘Round 1” please forward any items to:

Rita Finley (rita.finley@canada.ca)

We have been made aware by some of our members that the Public Health Agency of Canada (PHAC) has sent out an urgent request for reagents, specifically RNA extraction reagents for COVID19 testing.  If you have such reagents in your laboratory that you could donate (view list below) please consider doing so. If the laboratories have materials that we could use and are not included in the list, feel free to let us know and we will share with the National Microbiology Laboratory and asses their current requirements.
The contact person at the PHAC is Rita Finley (rita.finley@canada.ca).  As this is a time-sensitive request please let her know directly what you have available. Continue reading →

Read a new article by Université Laval news on a discovery by Martin Lévesque’s team

Cellular cogs of hyperactivity uncovered – Study clarifies the role of dopaminergic neurons in hyperactivity and suggests a mechanism of action for Ritalin

The cellular mechanism uncovered by the researchers could explain the mode of action of Ritalin in humans. The drug is believed to block the reuptake of dopamine by neurons, thereby prolonging the effects of this neurotransmitter.

Although about one in 10 people will suffer from attention deficit hyperactivity disorder (ADHD) in their lifetime, the cellular causes of this health problem are still very poorly understood. A study published in Cell Reports by a team from Laval University’s CERVO Research Centre now sheds some light on the subject. The researchers were able to determine which type of neurons are involved in the development of hyperactivity in mice and the cellular mechanisms involved. This breakthrough suggests a plausible mode of action for Ritalin, a drug widely prescribed for ADHD, but whose mechanism of action is unknown. Continue reading →

Discovery brings hope for novel pain treatment

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs.

The study, published in Cell, is the first to show that TACAN, a highly conserved protein among vertebrates whose function remained unclear, is in fact involved in detecting mechanical pain by converting mechanical pressures into electric signals. Continue reading →

Pain hypersensitivity and many other diseases could be associated with a protein that acts as an ion pump in neurons.

The research team led by  Yves De Koninck, at Université Laval’s Faculté de médecine and the CERVO Brain Research Centre had already targeted a protein called KCC2 as a key player in the mechanism leading to pain hypersensitivity.  A new study published in Nature Communications confirms confirms this lead and reinforces the idea that this protein could be a target of choice for the creation of a new class of analgesics to treat this problem that medicine is often powerless to address. Continue reading →