source: chusj.org
Source : CHU Sainte-Justine Research Centre
MONTREAL, February 16, 2023– Results of a new study led by Roberto Araya, a neuroscientist, biophysicist and researcher at the CHU Sainte-Justine Research Centre, show that in Fragile X syndrome (FXS), the most common cause of autism, sensory signals from the outside world are integrated differently, causing them to be underrepresented by cortical pyramidal neurons in the brain. Continue reading
A new study published in Current Biology reveals the nanostructure of brain cells at an unprecedented level of resolution
Brain cells are among the most anatomically complex cells in the human body. They create an intricate web of connections that enables the brain to detect, process, encode and respond to diverse information. Importantly, communication breakdown between brain cells leads to disorders and diseases such as dementia and Alzheimer’s disease that affects an estimated 50 million people worldwide. Continue reading
CAN made the following recommendations to the recent consultations on budget 2023 by the Minister of Finances:
The Canadian Association for Neuroscience recommends the following:
Recommendation 1: That the government of Canada increase investments in the Canadian Institutes of Health Research (CIHR), the Natural Sciences and Engineering Research Council (NSERC) and the Social Sciences and Humanities Research Council (SSHRC) for the benefit of all Canadians. We urge the government to adopt a four-year plan to double the budgets of the three main federal funding agencies (CIHR, NSERC, SSHRC) starting with a 25% increase in the next budget. This recommendation aims to bring Canadian investment in scientific research to a level commensurate to that of other G7 countries.
Recommendation 2: That the government of Canada increase its support for graduate students and postdoctoral fellows by 50% for graduate scholarships and postdoctoral fellowships to increase both value and number awarded in the next budget. In conjunction with recommendation 1, this recommendation will ensure our next generation of scientists have the means to participate fully in Canada’s knowledge economy.
Recommendation 3: That the government of Canada make research on the Brain and Mental Health a national priority by investing in research to understand the brain through well-established and trusted organizations in the field.
About the position:
Position: Postdoctoral researcher for a two year term, with the possibility of extension
Field of Specialization: Spinal cord nociceptive processing; translational pain models
Academic Group: Hildebrand Pain Lab, Department of Neuroscience, Carleton University
Sources of Funds: 2023-2028 CIHR Project Grant, potential future industrial R&D fellowship
Start Date: May 1, 2023 (or earlier/later depending on applicant’s availability)
Closing Date: March 30, 2023
The Hildebrand Pain Lab (HildebrandPainLab.com) at Carleton University (and affiliated with the Ottawa Hospital Research Institute) invites applications for a postdoctoral research position investigating spinal mechanisms of nociceptive processing in rodent and human tissue models. This translational project involves combining cutting-edge high density multi-electrode array (MEA) recordings with the Hildebrand lab’s unique ability to collect highly viable tissue from human organ donors. Using this powerful combination, the applicant will investigate how molecular and cellular mechanisms of spinal excitability and pain processing are conserved and/or diverge across sex and species. Beyond these physiological questions, the applicant will test how targeting specific molecular players with current and potential future therapeutic compounds impacts excitability in spinal nociceptive circuits of both rodents and humans.
The skills, networks, and mentorship gained through this translational pain project will equip the candidate for potential careers in academic, industrial, and/or healthcare-related fields. Along with direct supervision and mentorship by Dr. Hildebrand, the applicant will be working alongside a neurosurgeon/clinical research scientist collaborator at the Ottawa Hospital, Dr. Eve Tsai (https://www.ohri.ca/profile/etsai), with the opportunity to participate in the surgical collection of spinal cord tissue from neurologic determination of death organ donors. Because of the high translational value of these rodent-to-human spinal cord physiology and pharmacology experiments, the applicant will also have the opportunity to work with and be mentored by pharmaceutical researchers that have ongoing collaborative research partnerships with the Hildebrand Pain Lab.
Qualifications:
Candidates must have a Ph.D. in a relevant field, with neuroscience-related research experience including performing electrophysiological, pharmacological, and/or biochemical experiments on ex vivo nervous system tissue. Expertise in analysis of large datasets and coding is also an asset. The position is full time, and salary will be commensurate with experience. The postdoc will be considered unionized, as a member of PSAC Local 77000. Information on this bargaining unit can be found here: https://psac77000.ca/. Optional extended health and dental benefit plans are available with this position.
The Hildebrand Pain Lab and Carleton University are strongly committed to fostering diversity within their communities as a source of excellence, cultural enrichment, and social strength. We welcome those who would contribute to the further diversification of our team, including, but not limited to: women; visible minorities; First Nations, Inuit and Métis peoples; persons with disabilities; and persons of any sexual orientation or gender identity and expressions. We understand that career paths vary. Legitimate career interruptions will in no way prejudice the assessment process and their impact will be taken into careful consideration.
Application instructions:
Completed applications should be sent as one single PDF document to Dr. Hildebrand (mike.hildebrand@carleton.ca) and should include a cover letter highlighting relevant research experiences and how this position fits with your career goals, as well as a curriculum vitae that includes the names and contact information of three referees familiar with your past work and experiences. Please indicate in your application if you are a Canadian citizen or permanent resident of Canada.
About Carleton University:
The Neuroscience department (https://carleton.ca/neuroscience/) is a dynamic and growing academic/research unit at Carleton University that includes a diverse range of research interests, outreach activities, and networking/mentorship opportunities. To learn more about our University and the City of Ottawa, please visit https://carleton.ca/provost/reports/.
Contact information
Michael Hildebrand, mike.hildebrand@carleton.ca
Associate Professor and Graduate Chair, Carleton University
Affiliate Investigator, Ottawa Hospital Research Institute
1125 Colonel By Drive
6310 Health Sciences Building
Ottawa, ON K1S 5B6 CANADA
Posting end date
2023/06/01
Nature of the Work:
The Faculty of Science has been catalyzing change and inspiring discovery, creativity, and innovation for over 50 years. Our strategic direction integrates current and emerging strengths with areas targeted for future growth and investment. Our strategic priorities, goals, and values guide our mission to advance research, scholarship, and innovation, create authentic learning experiences, and inspire careers of the future. We fuel transformational change, and build a strong community through teaching, learning, research, scholarship, and collaborative partnerships. We do this work to generate curiosity-drive discovery and contribute solutions to society’s grand challenges. For more information, visit science.ucalgary.ca.
We thrive in the dynamic context of the University of Calgary, one of Canada’s most youthful and innovative universities. We are a bold and ambitious research university, grounded in innovative learning and teaching, fully engaged in Calgary’s entrepreneurial spirit.
This is a full-time fixed term appointment, part of the AUPE Bargaining Unit.
Primary Purpose of the Position:
The postdoctoral researcher is responsible for performing experimental research on detecting ultra-weak photon emission from biological samples. The candidate will plan, perform and analyze experiments on biological samples using single-photon detection systems. The candidate’s tasks will be based at the National Research Council of Canada in Ottawa with occasional research visits to U. Calgary. These two sites are home to teams with expertise in biophoton detection/theory and neuroscience applications, who will jointly mentor and supervise the candidate. The candidate is expected to support the development of funding and attracting graduate students to ensure continued growth in the area of quantum biology. The incumbent will be expected to also present research accomplishments and findings in internal and external meetings, conferences, reports and publications.
Qualifications/Expertise Required:
Accountabilities/Tasks and Duties:
Technical:
The candidate will primarily be responsible for operation of an experimental setup designed to detect single photons (biophotons) from biological samples. Biological samples to be investigated will include living tadpoles and various neuron culture assemblies. Biophoton emission will be investigated using pharmacological and possibly electrophysiological approaches. The incumbent will also be responsible for the analysis and interpretation of the data, working with the teams at U. Calgary and the NRC. The incumbent will design, implement, and consult with the Principal Investigator on projects and programs. The candidate will be expected to identify and pursue new research opportunities aligned with the overall vision of the lab.
Mentorship/Coaching:
The candidate will provide training of undergraduate and graduate students in experimental and theoretical research techniques, as well as presentation skills(written and oral).
Publishing/Presenting Research:
Occupational Health& Safety:
Position posting at UCalgary
Read the latest edition of our newsletter: CAN Connection January 2023
View the table of contents:
The research team at The CERVO Brain Research Center in Quebec City is looking for a research professional in the laboratory of Dr. Chantelle Sephton: https://cervo.ulaval.ca/en/chantelle-f-sephton
Research area: The main research objective of the lab is to determine how RNA processing is impaired in neurodegenerative diseases. We will achieve this by studying the RNA-binding proteins that are mutated in the motor neuron disease, amyotrophic lateral sclerosis (ALS). We will use our mouse models and cell culture models of ALS to study the function of RNA-binding proteins and the effectiveness of therapeutic drug treatments. The results of these studies will provide insight into how impaired RNA regulation can cause ALS and we will use this information to develop targeted therapeutic treatments to treat the disease.
Research project: The current project in the Sephton laboratory requires a research professional to conduct preclinical testing of drugs in ALS mouse models as a proof of concept for the therapeutic treatment of ALS.
Under the supervision of Dr. Chantelle Sephton, the research professional’s main responsibilities are to:
Note: Responsibilities could be modulated according to the experience of the candidate
Candidates should have some experience in animal handling (mice or rats) and experience in animal handling (e.g. i.p. injection and behavioral testing) as well as experience in molecular biology (PCR, purification DNA) and in biochemistry (Western blot, protein determination)
TO APPLY
Interested persons are invited to send a cover letter and their Curriculum vitae at the following address: chantelle.sephton.1@ulaval.ca
Posting end date 2023/03/31
Multiple graduate student positions (M.Sc., Ph.D.) are available in the laboratory of Dr. Tabrez Siddiqui at the University of Manitoba. The Siddiqui lab’s multidisciplinary research program encompasses the molecular, systems and behavioural branches of neuroscience to investigate neuronal circuit organization, plasticity and network integration. Our goals are to generate transformative knowledge on the molecular mechanisms of synapse development and function in both the developing and mature brain, provide conceptual advances in understanding the mechanisms governing enduring changes in synaptic properties (plasticity) that underlie cognitive function and associative learning, and determine how synapses are specified in the mammalian brain to provide the framework for understanding the molecular logic of circuit organization and associated behaviours. The Siddiqui lab is also actively pursuing translational goals in uncovering synaptic regulatory mechanisms and targets in neurodevelopmental and psychiatric disorders such as autism and schizophrenia.
Eligibility Requirements
The positions are fully funded with standard stipends commensurate with the University of Manitoba guidelines and Departmental bylaws. Successful students will be admitted to the Physiology graduate program, but may be considered for the Biomedical Engineering program.
This search will close on January 20, 2023.
Please send the following the documents to Dr. Siddiqui by email
We thank all applicants for their interest. However, however only those candidates selected for interviews will be contacted.
Rady Faculty of Health Sciences
Max Rady College of Medicine
Department of Physiology and Pathophysiology
Neuroscience Research Program
Kleysen Institute for Advanced Medicine
Health Sciences Centre
SR422-710 William Avenue
Winnipeg, MB R3E 0Z3
Phone: 1.204.318.2564
Email: tabrez.siddiqui@umanitoba.ca
Siddiqui Lab Publications can be accessed here.
https://pubmed.ncbi.nlm.nih.gov/?term=Tabrez+j+siddiqui&sort=date
Some of our recent published studies are listed below
Tabrez J. Siddiqui, PhD
Associate Professor of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba.
Principal Investigator, Children’s Hospital Research Institute of Manitoba.
Principal Investigator, Neuroscience Research Program,
Kleysen Institute for Advanced Medicine, Health Sciences Centre.
SR422-710 William Avenue, Winnipeg R3E 0Z3, Manitoba, Canada.
Phone: 1. 204.318.2564
https://umanitoba.ca/medicine/faculty-staff/tabrez-siddiqui
Twitter: @siddiquilab
The University of Manitoba campuses are located on original lands of Anishinaabeg, Cree, Oji-Cree, Dakota and Dene peoples, and on the homeland of the Métis Nation. We respect the Treaties that were made on these territories, we acknowledge the harms and mistakes of the past, and we dedicate ourselves to move forward in partnership with Indigenous communities in a spirit of reconciliation and collaboration.
The Khokhar Lab (www.khokharlab.com) researches the interactions between substance use and serious mental illness, with an eye toward treatment of these disorders using a variety of behavioural and circuit-interrogation methods. The Post-doctoral Fellow will conduct brain imaging and behavioural experiments assessing the effects of alcohol/cannabis use and chemogenetic or pharmacologic manipulation in a rat model of schizophrenia or during development (CRC and CIHR-funded grant).
Previous training and experience with pre-clinical MRI imaging (e.g., fMRI, DTI, MRS) is preferred. In addition, any experience with schizophrenia (e.g., pre-pulse inhibition) and addiction-like behaviours (e.g., self-administration) would be beneficial. The Post-doctoral fellow will also provide input with respect to appropriate methodology, procedures, equipment and standards to produce required research data and apply specialized knowledge and principles to review, appraise and interpret published literature, summarize research findings, and draft scientific/technical reports, manuscripts, grant proposals while establishing and maintaining effective relationships with lab members, and presenting research findings (may include presenting findings at conferences).
Minimum Qualifications: PhD degree in Neuroscience or Medical Biophysics, with related research experience (pre-clinical MRI Imaging and Behavioural methods above).
The successful applicant will be encouraged to apply to extramural funding, but funding is in place for renewal of contract beyond the first year. The expected start date is as soon as possible. The position will remain open until filled. Please indicate in your application if you are a Canadian citizen or a permanent resident of Canada.
How to apply
Please send a cover letter/statement of interest, current CV, and a list of 3 references to Dr. Jibran Khokhar at jkhokha@uwo.ca. We will notify applicants before contacting any references.
Field of Specialization: CIHR Tier 2 CRC in Indigenous, Racialized and/or Vulnerable Populations
Academic Unit: Faculty of Science
Category of Appointment: Preliminary (tenure-track) or tenured
Rank/Position Title: Assistant Professor or Associate Professor
Start Date: July 1, 2023
Closing Date: January 30, 2023
The Faculty of Science invites applications from qualified candidates for a Canadian Institute of Health Research (CIHR) Tier 2 Canada Research Chair (CRC) appointment beginning July 1, 2023.
The Faculty of Science is seeking an emerging scholar in one or more of the following research areas: Indigenous health; health in remote/northern communities; nutrition in isolated/vulnerable populations; and/or substance use health. Applicants with research at the intersection of these areas will be considered. Applicants will preferably possess lived experiences relating to this role.
Tier 2 Chairs are intended for exceptional emerging scholars (e.g., candidates must have been an active researcher in their field for fewer than 10 years at the time of nomination). Applicants who are more than 10 years from having earned their highest degree (and where career breaks exist, such as maternity, parental or extended sick leave, clinical training, etc.) may have their eligibility for a Tier 2 Chair assessed through the program’s Tier 2 justification process.
For more details, please see the Canada Research Chairs Secretariat and the Carleton Office for Research Initiatives and Services.
The successful candidate will work with the Faculty of Science to prepare the application for the Tier 2 CRC Chair. Academic appointment is conditional on the approval of the application by the CRC Program and will be made to an appropriate unit within the Faculty of Science.
To see the full position posting, please visit Carleton University’s Deputy Provost’s website at https://carleton.ca/deputyprovost/jobs/academics/.
The Faculty of Science is a research-intensive unit comprising 12 departments, schools, and institutes serving more than 5000 students. The Faculty includes world-leading researchers in many different areas and has strong and growing interactions with industry partners, government organizations, and other organizations located in Canada’s National Capital region. For more information, visit: https://science.carleton.ca.
Applications must be sent electronically in one single PDF file, which includes the following:
Applicants should provide the names of three individuals to provide letters of recommendation.
Please indicate in your application if you are a legally eligible to work in Canada.
If you’re interested in this opportunity, please contact Katherine Frank (kfrank@kbrs.ca) or Lauren Wright (lwright@kbrs.ca), or submit your application online at https://www.kbrs.ca/Career/16572.
To help Carleton University develop its equity programs, a confidential equity and diversity self-identification survey will be sent to all applicants separately.
Located in Ottawa, Carleton is an innovative teaching and research institution with a tradition of leading change. Internationally recognized academics, staff, and researchers engage more than 31,000 students in over 100 programs of study. Carleton has long been known for promoting research excellence and connectedness and is involved in partnerships around the globe. With strong leadership, it enjoys a healthy financial position and our proximity to government and cultural institutions, media, and a thriving knowledge economy make Carleton and Ottawa a great place to work, learn, and live. Our picturesque campus is fully accessible and, along with award-winning student services, Carleton’s Paul Menton Centre for Students with Disabilities has been heralded as the gold standard for disability support services in Canada. Learn more about our university and the city of Ottawa.
We are strongly committed to equity, diversity, and inclusion in the nomination and appointment process. Carleton University is committed to fostering diversity within its community as a source of excellence, cultural enrichment, and social strength. We welcome those who would contribute to the further diversification of our university including, but not limited to women, visible minorities, First Nations, Inuit and Métis peoples, persons with disabilities, and persons of any sexual orientation, gender identity and/or expression. Furthermore, Carleton understands that career paths vary and interruptions will not prejudice the assessment process. We invite you to review our revitalized Indigenous strategy, Kinàmàgawin and visit our Department of Equity and Inclusive Communities for information about our commitment to leadership in the areas of equity, diversity, and inclusion.
Accessibility is a university strategic priority and applicants selected for an interview who require accommodations are invited to contact the hiring Chair as soon as possible to ensure appropriate arrangements are made.
All qualified candidates are encouraged to apply; however, Canadians and permanent residents will be given priority. All positions are subject to budgetary approval.
