Slowing the progression of multiple sclerosis

Alexandre Prat  CREDIT: BONESSO-DUMAS
Alexandre Prat
CREDIT: BONESSO-DUMAS

By identifying a molecule that delays the progression of MS, CRCHUM researchers pave the way for new therapies for the nearly 77,000 Canadians living with the disease.

Over 77,000 Canadians are living with multiple sclerosis, a disease whose causes still remain unknown. Presently, they have no hope for a cure. In a study published in Science Translational Medicine, researchers at the University of Montreal Hospital Research Centre (CRCHUM) identify a molecule named ALCAM which, once blocked, delays the progression of the disease. Their results, obtained from in vitro human and in vivo mouse studies, could lead to the development of a new generation of therapies to treat this autoimmune disease. Continue reading

Cellular origins of pediatric brain tumors identified

Dr Claudia KleinmanSource: MUHC and Lady Davis Institute

A research team led by Dr. Claudia Kleinman, an investigator at the Lady Davis Institute at the Jewish General Hospital, together with  Dr. Nada Jabado, of the Research Institute of the McGill University Health Centre (RI-MUHC), and Dr. Michael Taylor, of The Hospital for Sick Children (SickKids), discovered that several types of highly aggressive and, ultimately, fatal pediatric brain tumors originate during brain development. The genetic event that triggers the disease happens in the very earliest phases of cellular development, most likely prenatal. The findings represent a significant advance in understanding these diseases, and are published in Nature Genetics. Continue reading

Activation of opioid receptor uncovered

Louis Gendron - Université de SherbrookeIn conjunction with Chinese, Belgian, German and American academic colleagues, the team of researchers from the Université de Sherbrooke (UdeS), led by the Director of the Department of Pharmacology-Physiology, Professor Louis Gendron, participated in the discovery of the binding mechanism of an important opioid receptor. The results should facilitate the development of new active substances. Opioids used today to treat severe pain can be addictive and often have significant side effects, such as nausea. The results are published in the renowned journal Science Advances. Continue reading

2020 Fellowship announcement IBRO US-Canada Regional Fellowships

IBRO logo
The US-Canada Regional Committee of IBRO (International Brain Research Organization) is pleased to announce our 2020 fellowships program that will cover the cost for PhD students and postdoctoral fellows training in neuroscience in Canada to attend advanced neuroscience courses. Preference will be given to trainees belonging to minority groups (First Nations and other Indigenous communities in Canada, visible minorities, women, persons with disabilities, and other minorities) as well as those in non-U15 Universities (http://u15.ca/). Fellowships will be awarded to support trainees to take neuroscience or related courses at the Marine Biological Laboratories (MBL) at Woods Hole, MA, and at Cold Spring Harbor Labs (CSHL; see links below) in 2020. Both laboratories offer a variety of excellent courses, and in addition are outstanding venues for trainees to network with leaders in the field. They also provide collaboration and mentoring opportunities that will be invaluable for future career development.

We are looking for talented trainees who have a keen desire to pursue careers in research. The aim of this program is to increase diversity in neuroscience in Canada, by providing such trainees with access to cutting-edge research approaches in contemporary neuroscience.

Interested trainees should submit applications directly to the courses of interest (see below for list of eligible courses). Evaluation of applications and offers of admission to courses are made by the course leaders. Accepted candidates with the backgrounds mentioned above will be automatically considered for an IBRO fellowship. The IBRO fellowship will cover the cost of tuition, room and board for 4 Canadian students (2 at MBL and 2 at CSHL). Fellowships are worth up to $11,000 per trainee at MBL and up to $8,000 per trainee at CSHL depending on the courses taken.

Eligible MBL courses: Neural Systems and Behavior, Neurobiology: Mechanisms & Advanced Approaches, Methods in Computational Neuroscience, Biology of the Inner Ear: Experimental and Analytical Approaches, Brains, Minds and Mechanisms, Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches,  and Frontiers in Stem Cells and Regeneration.

Eligible CSHL courses: Ion Channels in Synaptic and Neural Circuit Physiology, Vision: A Platform for Linking Circuits, Perception and Behavior, Advanced Techniques in Molecular Neuroscience, Drosophila Neurobiology: Genes, Circuits & Behavior, Imaging Structure & Function in the Nervous System, Workshop on Autism Spectrum Disorders, Neuroscience of Addiction.

Note that the deadlines for applications range from February – June.
Check these links for details.

MBL: http://www.mbl.edu/education/courses/
CSHL: https://meetings.cshl.edu/courseshome.aspx

When applying for courses, also inform us by sending e-mail to sam.david@mcgill.ca
Questions about fellowship eligibility may be addressed to:
sam.david@mcgill.ca

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell regulation and function, Lindsey Lab at the Rady Faculty of Health Sciences, University of Manitoba

Description of the position:

Our research focuses on uncovering the function and regulation of neural stem cell populations during brain development, behaviour, and following neurotrauma. The overarching goal of our lab is to define conserved themes in vertebrate neural stem cell regulation at the molecular and cellular levels. To address this goal, our lab takes advantage of the lifelong proliferative, neurogenic, and regenerative capacity of the zebrafish model. We currently use a number of transgenic zebrafish lines to study the response of neural stem cells to brain and spinal cord injury, stem cell niche maturation, and animal behaviour. A variety of models of neurotrauma are used in the lab along with contemporary molecular, cellular, imaging, and behavioral techniques, including primary cell culture, 2-D and 3-D imaging, correlative EM, RNA-sequencing approaches, fluorescence in situ hybridization, immunohistochemistry, etc.

Eligibility Requirements:

  • Experience in Imaging (2-D/3-D, confocal, EM, clearing methods)
  • Experience in Molecular Biology (cloning, PCR, CRISPR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry)
  • Experience using animal models of study
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

Benjamin.lindsey@umanitoba.ca
Dr. Benjamin Lindsey, Ph.D.
Assistant Professor,

Department of Human Anatomy & Cell Science

Rady Faculty of Health Sciences

University of Manitoba

 

130 Basic Medical Science Building

745 Bannatyne Avenue,

Winnipeg, Manitoba, R3E 0J9, CANADA

A post-doc position in the field of neural stem cell reprogramming and differentiation, Wang lab, Ottawa Hospital Research Institute

Description of the position:

Our research focuses on delineating molecular mechanisms that regulate neural stem cell reprogramming and differentiation, with the ultimate goal of the development of stem cell- based therapy to promote neural repair in the context of various neurological disorders. The individual filling this position is particularly involved in the ongoing project in the lab that is to develop integration-free methodology to reprogram non-neuronal cells into neural cells and to optimize stem cell-based therapies for post-stroke neurovascular regeneration and functional recovery. A variety of molecular, cellular, and behavioral techniques are used in the laboratory, including transgenic mouse models, neurosphere culture, rodent and human reprogramming cell culture and stereotaxic surgery, various neurological degeneration disease models, etc.

Eligibility Requirements:

  • Experience in rat stroke models, stereotaxic surgery, Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry) and in vivo animal study.
  • Excellence in research with strong publication records
  • Excellent written and oral communication skills
  • Self-motivated and strong desire to learn
  • Experience with Human primary cell culture is an asset

Deadline: Until the position is filled.

Individuals who are interested in the position should submit curriculum vitae, a copy of official transcripts, statement of research interest and names of three references to:

jiwang@ohri.ca
Dr. Jing Wang, Ph.D.
Senior Scientist, Sprott Centre for Stem Cell Research
Ottawa Hospital Research Institute
Assistant Professor Department of Cellular & Molecular Medicine

University of Ottawa
Ottawa Hospital, 501 Smyth Rd, Box 511
Ottawa, ON K1H 8L6 CANADA

Seeking Graduate Students (MS.c./Ph.D.) in the field of neural stem cell reprogramming and differentiation, Wang lab at Ottawa Hospital Research Institute

Description of the position:

Our research focuses on delineating molecular mechanisms that regulate neural stem cell reprograming and differentiation, with the ultimate goal of defining ways to recruit the stem cells that are resident in the brains or are derived from non-neuronal cells, and to thereby potentially promote neural repair. We are currently using stroke, Alzheimer’s disease, multiple sclerosis and autism as brain disease models to explore underlying molecular mechanisms. A variety of molecular, cellular, biochemical and behavioral techniques are used in the laboratory, including transgenic mouse models, in vivo neurodegenerative disease model, primary cell culture, co-IP and ChIP, and RNA-seq approaches and etc.

Eligibility Requirements:

  • Experience in Molecular Biology (cloning, mutagenesis, PCR), Cell Biology (cell line or primary cell culture, immunohistochemistry and immunocytochemistry) or in vivo animal model study.
  • Excellence at the academic level and in research
  • Excellent written and oral communication skills

Deadline: Until the position is filled.

Contact information

jiwang@ohri.ca
Dr. Jing Wang, Ph.D.
Senior Scientist, Sprott Centre for Stem Cell Research
Ottawa Hospital Research Institute
Assistant Professor Department of Cellular & Molecular Medicine

University of Ottawa
Ottawa Hospital, 501 Smyth Rd, Box 511
Ottawa, ON K1H 8L6 CANADA

Postdoctoral Researcher in Computational Neuroscience – Lefebvre lab at UOttawa

The Lefebvre lab at uOttawa is recruiting two postdoctoral fellows for the Winter 2020. Candidates interested in computational neuroscience, brain imaging and applied mathematics are encouraged to apply.

Selected candidates will be involved in the following projects:

  1. In collaboration with the Griffiths Lab at the CAMH Krembil Center for Neuroinformatics (KCNI) and University of Toronto, the goal of the project is to develop, analyse and explore computational models of non-invasive brain stimulation (e.g. TMS, TES) and their impact on multi-scale neural activity. Specifically, we seek to better understand network-based mechanisms of neural control, oscillatory entrainment and/or stimulation-induced brain plasticity. This project involves a combination of computational and mathematical modelling, has strong potential for knowledge translation, and aims to help inspire new non-invasive treatments for Major Depressive Disorder (MDD).
  2. In collaboration with the Hospital for Sick Children (SickKids) in Toronto, the goal of this project is to better understand mechanisms of white matter plasticity, neuron-glia interactions, myelination and its impact on brain function. Using a combination of modelling and simulations, interfacing rodent and human data, the role of the fellow will be to examine the influence of white matter plasticity on neural synchrony and memory. This project involves a combination of computational and mathematical modelling, and strong interactions with experimentalists.

The research will take place in the Department of Biology, the Brain and Mind Institute and the Center for Neural Dynamics of the University of Ottawa, a vivid interdisciplinary research cluster set in the bilingual capital of Canada. Both projects are deployed in the Ottawa-Toronto axis, through close collaborations between uOttawa, uToronto, CAMH KCNI, The University Health Network and The Krembil Research Institute. Based on the research needs and resources, candidates will be required to travel between both cities often. Throughout, candidates will interact closely with clinicians, experimentalists and scholars in neuroimaging.

Requisites:

Candidates should have completed their PhD in physics, mathematics, neuroscience or related disciplines, and have an excellent publication track record. Expertise in programming is a necessity, as well as independence in research. Experience in brain imaging, signal processing and dynamical systems are considered strong assets. Contracts are for one year, with possibility of extension subject to sufficient progress. of one additional year. While the positions are fully funded, candidates are nonetheless expected to apply for external/competitive funding throughout their training.

To apply, please send 1) a letter of interest, 2) a full CV and 3) two(2) letters of reference to jeremie.lefebvre at hotmail dot com. Selected candidates will be contacted for an interview! Job open until filled!

Tenure-track Assistant or Associate Professor in Neurobiology of Aging and Dementia – Queen’s University

Tenure-track Assistant or Associate Professor in Neurobiology of Aging and Dementia
Department of Biomedical & Molecular Sciences and Department of Psychiatry
Centre for Neuroscience Studies
Queen’s University, Kingston, Ontario CANADA

The Departments of Biomedical & Molecular Sciences and Psychiatry in the Faculty of Health Sciences and the Centre for Neuroscience Studies at Queen’s University are seeking an outstanding early to mid-career scientist and educator with passion, energy, and a strong vision for innovative research in the area of neurobiology of aging and dementia. The research strengths of the preferred candidate need to complement at least one of the existing fields of neuroscience specialization within the faculty, which include: (i) cellular/molecular neuroscience, (ii) systems neuroscience, (iii) cognitive/behavioural neuroscience, and (iv) clinical neuroscience. More specifically, areas of particular interest include conditions associated with aging and neurological disease progression, such as but not limited to Alzheimer’s disease/dementia, Parkinson’s disease, mood disorders/depression, and autism spectrum disorders. The preferred candidate will need to demonstrate that they are an emerging leader in innovative, translational research approaches and methodologies, including proven experience with pre-clinical rodent or non-human primate research models in neuroscience (including aging-related conditions) that could foster collaborations locally, nationally and internationally.

Thus, the preferred candidate must have a distinguished track record of discovery and innovative research, and an ability to collaborate with colleagues in the Departments of Biomedical and Molecular Sciences, the Department of Psychiatry, Providence Care Hospital, the Centre for Neuroscience Studies, as well as with other scientists and clinical researchers at Queen’s University. Evidence that the candidate has the capacity to develop and deliver educational content in the area of neuropharmacology to both undergraduate and graduate programs will be an important selection criterion as well.

Appointments will be either tenure-track or with tenure, at the rank of Assistant or Associate Professor, depending upon the level of experience of the successful candidate. The preferred starting date is July 1, 2020. Candidates must have a PhD or equivalent degree completed at the start date of the appointment. As part of the submitted application, the successful candidate will: (i) provide evidence of high-quality scholarly output that demonstrates potential for independent research leading to peer-assessed publications and an externally-funded world-class research program; and (ii) demonstrate strong potential to make outstanding teaching contributions at both the undergraduate and graduate levels and an ongoing commitment to academic and pedagogical excellence in support of the Departments’ programs. Applicants will be expected to provide evidence of an ability to work collaboratively in an interdisciplinary and student-centred environment. The successful candidate will make contributions through service to the Departments, the Faculty, the University, and/or the broader community. Salary will be commensurate with qualifications and experience. This position is subject to final budgetary approval by the University.

Queen’s University is host to numerous research centres and research groups, housing scientists with research interests that will complement the successful applicant. These include the Centre for Neuroscience Studies (CNS); the Human Mobility Research Centre (HMRC Queen’s Chronic Pain Clinic at Hotel-Dieu Hospital); the Cardiac, Circulatory and Respiratory Research Group and Queen’s Cardiopulmonary Unit (QCPU); the Group for Research in Reproductive and Developmental Origins of Health, Disability and Disease; the Infection, Immunity and Inflammation Research Group; and the Queen’s Cancer Research Institute (QCRI). These groups and units maintain extensive collaborations with researchers locally, nationally, and internationally. They deploy an array of platforms to support transdisciplinary research teams interested in developing clinical tools for early diagnosis of disease, assessing prognosis and progression, and for predicting therapeutic response. Additionally, the Centre for Advanced Computing at Queen’s delivers a world-class high-performance computing environment and storage resources.

The University invites applications from all qualified individuals. Queen’s is committed to employment equity and diversity in the workplace and welcomes applications from women, visible minorities, Aboriginal peoples, persons with disabilities, and LGBTQ persons. All qualified candidates are encouraged to apply; however, in accordance with Canadian Immigration requirements, Canadian citizens and permanent residents of Canada will be given priority. To comply with Federal laws, the University is obliged to gather statistical information about how many applicants for each job vacancy are Canadian citizens / permanent residents of Canada. Applicants need not identify their country of origin or citizenship, however, all applications must include one of the following statements: “I am a Canadian citizen / permanent resident of Canada”; OR, “I am not a Canadian citizen / permanent resident of Canada”. Applications that do not include this information will be deemed incomplete.
A complete application consists of:

  • a cover letter (including one of the two statements regarding Canadian citizenship / permanent resident status specified in the previous paragraph);
  • a current curriculum vitae (including a comprehensive list of publications, awards, and grants received);
  • a statement of current and prospective research interests and experience;
  • a statement of teaching experience and interests together with a teaching portfolio (including teaching outlines and evaluations if available);
  • the names and contact information of a minimum of three referees, one of whom must be at arm’s length.

The deadline for applications is February 3, 2020. Applications will continue to be reviewed until a suitable candidate is found. Applicants are asked to send all documents in their application packages electronically as PDFs to the attention of Dr. Claudio Soares, Professor and Head, Department of Psychiatry, and to Dr. Lynne-Marie Postovit, Professor and Head, Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, K7L 3N6. Please email to the attention of Ms. Jackie Moore in the Department of Biomedical and Molecular Sciences at dbmsrecruit@queensu.ca.

The University will provide support in its recruitment processes to applicants with disabilities, including accommodation that takes into account an applicant’s accessibility needs. If you require accommodation during the interview process, please contact: Jackie Moore in the Department of Biomedical and Molecular Sciences at dbmsrecruit@queensu.ca.

Academic staff at Queen’s University are governed by a Collective Agreement between the University and the Queen’s University Faculty Association (QUFA), which is posted at http://queensu.ca/facultyrelations/faculty-librarians-and-archivists/collective-agreement and at http://qufa.ca.

Contact information

Applicants are asked to send all documents in their application packages electronically as PDFs to the attention of Dr. Claudio Soares, Professor and Head, Department of Psychiatry, and to Dr. Lynne-Marie Postovit, Professor and Head, Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, Ontario, K7L 3N6. Please email to the attention of Ms. Jackie Moore in the Department of Biomedical and Molecular Sciences at dbmsrecruit@queensu.ca.

Download a PDF version of this advertisement: Neurobiology-of-Aging-Advert-FINAL

2 Post-doc positions in clinical and cognitive neuroimaging MRI/DTI and EEG/MEG – SickKids Hospital

Neurophysiological and structural imaging in PTSD and mild traumatic brain injury

Two postdoctoral research fellow positions at the Hospital for Sick Children (SickKids) are available with immediate start. The positions are initially available for a 1-year period with the possibility of extension.

This project examines functional (MEG, fMRI) and structural (MRI, DTI) brain circuits in posttraumatic stress disorder and mild traumatic brain injury (concussion) in adults. Currently, there are no known imaging markers for psychiatric disease or ‘mild’ brain injuries. This project aims to define signatures for use in a machine learning framework to classify individual cases and identify future targets for neurostimulation in treatment-resistant cases of PTSD and those with lingering symptoms of a concussion.

This is part of an ongoing project that is funded by the Canadian Department of National Defence and Innovation for Defence, Excellence and Security (IDEaS) Program.

A substantial amount of data already exists for this project and the motivated researcher will be able to jump straight into analysis.

 

Your profile

We are seeking two enthusiastic postdoc researchers to work in close collaboration with engineers and research associates in analysing pre-existing and new MEG, MRI & DTI data. Ideally, one researcher will focus on MRI and DTI data, and the other one MEG data, the latter collected during resting state and a task of memory function. Given the initial short-time frame of this position, imaging experience is necessary.

As a postdoc in this position you will be expected to:

  • hold a PhD in a relevant area (cognitive neuroscience, neuroimaging, engineering, computer sciences);
  • have experience with EEG/MEG and/or MRI/DTI analyses;
  • have a knowledge of neuropsychiatric disease that would be advantageous;
  • hold a track record in research commensurate with your level of experience post-PhD;
  • have experience with computer programming (Matlab, Python, or R) and/or signal processing/time series analyses;
  • have excellent communication skills (oral and written);
  • be able to work independently and meet deadlines.

 

Your work environment

The principal investigator on this project is Dr. Ben Dunkley.

The candidate will be based in the Neurosciences & Mental Health Program, the Hospital for Sick Children Research Institute. You will work closely with affiliated staff and students who form a group that use neuroimaging to study a variety of brain disorders.

We offer

Salary Scale: $CAD 55,000 to 65,000 gross annual (depending on qualifications and experience).

In addition, we offer an attractive benefits package, that includes partial coverage for dental, drug and medical.

The temporary employment will be for a period of 1 year initially, with a possibility of extension.

Toronto is a world-class rated in the top ten cities worldwide for livability that has a large and rich neuroscience community.

The institute offers many opportunities for career development and additional training as part of the Research Training Centre.

 

Additional information

The post is available from 1st January 2020.

Contact Dr. Ben Dunkley via ben.dunkley@sickkids.ca for more information.

If you wish to apply directly, please send a CV, a cover letter with research statement/interests, and the names of two references.