Pioneers in migraine research that has led to the development of new treatments awarded world’s top Brain Prize

A group of four neuroscientists from Denmark, Sweden, UK, and USA who discovered a key mechanism that causes migraine that led to revolutionary new treatments receive The Brain Prize, the world’s most valuable prize in neuroscience.

Four decades of research paved the way for the development of entirely new classes of migraine-specific drugs which are now on the market and are already radically improving the lives of sufferers.

The Brain Prize is awarded annually by the Lundbeck Foundation and is worth DKK 10 (approximately £1.1m, $1.5m, €1.3m).

The Brain Prize will be awarded at a ceremony in Copenhagen on 25 October 2021, presided over by His Royal Highness, The Crown Prince of Denmark.

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Four neuroscientists who, 40 years ago, discovered a biological mechanism that triggers a migraine attack that has led to powerful new treatments have been awarded The Brain Prize, the world’s most prestigious award for brain research.

The four winners are internationally renowned neuroscientists, Lars Edvinsson (Sweden), Peter Goadsby (UK/USA), Michael Moskowitz (USA), and Jes Olesen (Denmark).  For their ground-breaking work on migraine, the Lundbeck Foundation will award them the Brain Prize, worth DKK 10 million (approximately £1.1m, $1.5m, €1.3m).

Migraine is much more than a bad headache. It is a serious neurological disease with symptoms that include severe throbbing and recurring head pain, nausea, vomiting, dizziness, extreme sensitivity to sound, light, touch and smell.  Some migraine attacks can last for several days and more than four million people suffer at least 15 migraine attacks per month. For many, migraine severely diminishes the quality of life, including the ability to work, and can lead to depression, anxiety, and sleep disturbances. The economic and societal costs associated with migraine are extremely high – in the tens of billions of dollars worldwide.

Treatments for migraine have been available for some time, but they can have significant side effects and can only help to relieve the symptoms, not prevent migraine. There was, therefore, an urgent need to develop new classes of migraine-specific drugs.

Understanding a fundamental biological mechanism that triggers a migraine has led to the development of entirely new and effective classes of migraine treatments that received FDA approval in the United States in 2018. Patients have remarked that these drugs have “given them their life back”.

The story begins with Michael Moskowitz, an American and a professor of neurology at Harvard Medical School at the Massachusetts General Hospital. In 1979, he proposed that a migraine attack involves an interaction between the trigeminal nerve (which is involved in detecting sensations from the head and face) and the meninges and its associated blood vessels.  (The meninges are thin membranes that surround the brain and are the only structures inside the skull that sense pain.) Moskowitz showed in experimental models that a migraine attack is triggered when trigeminal nerve fibres release neuropeptides that lead to dilated (opened up) blood vessels of the meninges, inflammation and pain, sometimes in response to a signal from underlying brain. He was the first to propose that blocking the action of released neuropeptides could be a new approach to treating migraine.

Following the early discoveries of calcitonin gene-related peptide (CGRP) with a series of basic ground-breaking studies, Lars Edvinsson, professor of internal medicine at Lund University, Sweden, and Peter Goadsby, director of the NIHR-Wellcome Trust King’s clinical research facility at King’s College London, UK, and professor of neurology, University of California, Los Angeles, USA, teamed up and showed that the recently discovered neuropeptide, CGRP, was released from the trigeminal nerve during a migraine attack and that it was a particularly potent dilator of blood vessels in the meninges. Based on these findings Edvinsson and Goadsby proposed that CGRP may be of crucial importance in migraine and the key molecule in primary headache disorders.

Jes Olesen, clinical professor in the department of clinical neurology, Rigshospitalet, Denmark, then answered a crucial question: was CGRP release the cause or a consequence of a migraine attack? He showed that when given to migraine patients CGRP could trigger a migraine attack. He then went on to show that drugs which blocked CGRP – antagonists – could help treat migraine. Olesen’s work was not only crucial in showing a causal role for CGRP in triggering migraine, but it also demonstrated that CGRP could be an important new target for developing new treatments for migraine. The first CGRP antagonist drug effective in the acute treatment of migraine attacks were shown in a large trial involving Olesen and his team in 2004.

Edvinsson and Goadsby have, since the early discoveries, worked extensively together on migraine and cluster headache.  In the last decade, the idea of blocking the CGRP pathway took another direction leading directly to the development of new drugs called monoclonal antibodies (MAbs) for the prevention of migraine attacks.

Professor Lars Edvinsson said:

“The Brain Prize is the most prestigious recognition there is with focus on brain/neuroscience. It rewards my successful work from basic research to proving the role of CGRP in headache disorders and the fruition of new medications for numerous migraine sufferers world-wide. Each day there is a mail from grateful patients – this warms my heart and I feel an enormous joy for the positive change of their lives they report.”

 

Professor Peter Goadsby said:

“It is an enormous privilege to receive the Brain Prize; really a prize for all the people who have suffered for so long with headache disorders, and for all the excellent scientists who have made an important contribution to this field.  It is an overdue recognition of the ‘Cinderella’ problem of migraine. Cinderella has arrived at the ball as a welcome guest – and got the glass slipper!  I feel privileged to work in medicine with patients’ headache disorders, and their families, to make some small differences and help the incredibly brave patients I see do just a little better.”

 

Professor Michael Moskowitz said:

“When I heard the news, I was surprised and humbled.  The 2021 Brain Prize is very special. It comes with the recognition that years of research have paid off with new knowledge, new mechanisms and with that, new treatments for hundreds of millions of people.  I’m proud to have been part of this research from its beginning.”   

 

Professor Jes Olesen said:

“I have spent my entire professional life trying to get migraine accepted as a neurological disease. Therefore, it is with great joy that I receive the world’s top Brain Prize. It helps to increase awareness of migraine as a widespread and important disease. Even in the international research community, the field has been neglected and misunderstood. I hope the ongoing focus on migraine and other headache disorders will have an even greater impact, leading to new discoveries, research and development of therapies for the benefit of those affected.”

 

The development of CGRP antagonist drugs has opened a new era in migraine research and therapy. Although they do not cure migraine, they markedly improve the quality of life of many migraineurs. They are also the first drugs to have a duality of mechanism, being active in both the acute treatment and the prevention of attacks, and they have paved the way for the study of other potential targets.

The Brain Prize is the world’s largest prize for brain research and is awarded each year by the Lundbeck Foundation, one of the largest commercial foundations in Denmark. The award is worth 10 million DKK (approx. €1.3 million) and is given to one or more neuroscientists who have had a ground-breaking impact in the field.

 

Professor Richard Morris, chair of the prize’s selection committee, explains the reasoning behind the award:

“Migraine is one of the most common and disabling neurological conditions affecting humans. The work of the four recipients contributed to the clinically effective classification of the various types of this disorder, and then to unravelling the key mechanisms that cause it. This understanding led to the development of a novel therapy and has opened windows into future ones. Their work on migraine is a remarkable example of bedside-to-bench-to-bedside research that has yielded tangible clinical benefit.”

END

For further details please contact:

Elaine Snell, Snell Communications, London, UK

Email: elaine@snell-communications.net tel: +44 (0)7973 953794 or +44 (0)20 7738 0424

Jesper Sloth Møller, Head of Media relations, the Lundbeck Foundation

Email: jsm@lundbeckfonden.com tel. +45 2233 8601

Martin Meyer, Director of The Brain Prize at the Lundbeck Foundation,

Email: mm@lundbeckfonden.com  tel. +45 2033 5228

 

Notes to Editors

About this year’s prize winners                      

Lars Edvinsson is Swedish and a Professor of Internal Medicine at Lund University, Sweden. He is also President of the International Headache Society and Professor in Clinical Pharmacology at Copenhagen University. He trained at Lund University Medical Faculty and graduated as MD with PhD in 1980. He became a full professor at Lund University and senior consultant at the University Hospital in Lund in 2002. He is also the founder of the Glostrup Research Institute and has been its leader for the last 15 years. He is a leading expert in the field of cerebral circulation and migraine.

 

Peter Goadsby is Australian/British. He is Director of the NIHR-Wellcome Trust King’s Clinical Research Facility at King’s College London in the United Kingdom and is Professor of Neurology at the University of California, Los Angeles, USA. He is also Honorary Consultant Neurologist at King’s College Hospital and the Hospital for Sick Children, Great Ormond St, London. He obtained his medical degree at the University of New South Wales (UNSW), Australia. After post-doctoral work in New York, Paris, and post-graduate neurology training in London he returned to UNSW, and the Prince of Wales Hospital, Sydney as a consultant neurologist and became an Associate Professor of Neurology.

Michael Moskowitz is American and a Professor of Neurology at Harvard Medical School at the Massachusetts General Hospital, USA.  Professor Moskowitz received his undergraduate and medical degrees from Johns Hopkins University and Tufts University School of Medicine.  After becoming certified by the American Boards in both internal medicine and neurology, he did a post-doctoral fellowship at the Massachusetts Institute of Technology and remained on its faculty for 6 years in full time research.  His research focuses on translational mechanisms underlying migraine and stroke and is credited with foundational discoveries that ushered in modern day migraine therapeutics.

Jes Olesen is Danish and is a Professor of Neurology in the Department of Clinical Neurology, at the University of Copenhagen, Rigshospitalet, Denmark. He studied at the University of Copenhagen. His neurological education included a residency at Cornell Medical School, New York, and a volunteer period at the National Hospital Queen Square, London, UK. He is the father of the International Headache Classification and has identified several signaling mechanisms in migraine leading to new drug targets and registered drugs. He founded and for many years led the Danish Headache Center where he is still an attending physician.

Full biographies and autobiographies are in the accompanying information pack/, available on request.

About The Brain Prize

The Brain Prize is the world’s largest prize for brain research and is awarded each year by the Lundbeck Foundation. The award is worth 10 million DKK (approx. €1.3 million) and is given to one or more neuroscientists who have had a ground-breaking impact in the field.

The Brain Prize is awarded at a ceremony in Copenhagen, presided over by His Royal Highness, The Crown Prince of Denmark. This year it will take place on 25 October.

The Brain Prize recognises highly original and influential advances in any area of brain research, from basic neuroscience to applied clinical research. Winners may be of any nationality and work in any country around the globe. The Brain Prize was first awarded in 2011 and has so far honoured 34 scientists from 9 different countries.

The Prize and associated activities are a celebration of outstanding achievements in neuroscience and are at the forefront of the Lundbeck Foundation’s ambitions to make Denmark a world leading neuroscience nation.

 

Press release by the Lundbeck Foundation

Postdoctoral position in computational neuroscience | CAMH, University of Toronto

We will study cortical processing in health and depression in pre-clinical animal models using large-scale simulations of rat cortical microcircuits (in collaboration with the Blue Brain Project). The position is for 2 years, with anticipated start time in June 2021.

Interested applicants with publications and experience in computational neuroscience, who have completed their PhD in the last 5 years, are invited to send their CV to Dr. Etay Hay (etay.hay@camh.ca). In support of diversity, women are particularly encouraged to apply.

Hay lab for brain microcircuit modelling is located at Krembil Centre for Neuroinformatics, within the Centre for Addiction and Mental Health (camh). We are fully affiliated with the University of Toronto, and situated at the main campus, downtown Toronto.

Contact information:

Dr. Etay Hay (etay.hay@camh.ca)

CAN submission to Department of Finance pre-budget consultations

On January 25, 2021the Deputy Prime Minister and Finance Minister, the Honourable Chrystia Freeland, and the Minister of Middle Class Prosperity and Associate Minister of Finance, the Honourable Mona Fortier, launched pre-budget consultations. These discussions allow the government to hear the best ideas from Canadians and experts across the country about how Budget 2021 can support Canadians through the pandemic and help us build back better.

When COVID-19 is under control and Canada’s economy is ready to rebound, the government has a plan to make smart, targeted investments to jumpstart the country’s economic recovery and begin to repair the damage done by the pandemic. These pre-budget consultations are an opportunity for Canadians from across the country to share their ideas and priorities for how the government can best invest to create jobs, strengthen the middle class, and build a greener, more competitive, more inclusive, and more resilient economy.

Read the full press release here:

https://www.canada.ca/en/department-finance/news/2021/01/government-launches-budget-consultations-to-hear-from-canadians.html

and visit the consultation website here: https://letstalkbudget2021.ca/

https://letstalkbudget2021.ca/pre_budget_consultations

Read the Canadian Association for Neuroscience’s submission here

pre-budget-CAN-ACN.pdf

Research Technologist position in neurophysiology at The Hospital for Sick Children

About SickKids

Dedicated exclusively to children and their families, The Hospital for Sick Children (SickKids) is one of the largest and most respected paediatric healthcare centres in the world. As innovators in child health, we lead and partner to improve the health of children through the integration of healthcare, leading-edge research and education. Our reputation would not have been built – nor could it be maintained – without the skills, knowledge and experience of the extraordinary people who come to work here every day. SickKids is committed to ongoing learning and development, and features a caring and supportive work environment that combines exceptionally high standards of practice.

When you join SickKids, you become part of our community. We share a commitment and determination to fulfill our vision of Healthier Children. A Better World.

Don’t miss out on the opportunity to work alongside the world’s best in paediatric healthcare.

Position Description

Under the supervision of the Investigator, the technologist will assist with neurobehavioural research. Specifically, our lab focuses on understanding the molecular and synaptic mechanisms underlying social memory using mouse and zebrafish models.

Here’s What You’ll Get To Do:

  • Performing electrophysiology, molecular biology, imaging and behavioural experiments
  • Maintaining animal colonies
  • Collecting experimental data, verifying results, performing analysis and passing on findings
  • Working in collaboration with team of researchers and trainees

Here’s What You’ll Need:

  • Recent Masters or Bachelor’s Degree in Physiology, Neuroscience, Molecular Genetics, Cell Biology or equivalent degree
  • Minimum 2 years relevant experience preferably in a basic neuroscience research laboratory setting
  • Experience working with mice and/or zebrafish is preferred
  • Electrophysiology experience is considered an asset
  • Minimum one (1) year of experience with molecular biology techniques (e.g. cloning, PCR, western blotting, preparation of buffers and standard solutions), genetic methods (e.g. the design and execution of genetic crosses), and microscopy techniques, including preparation of specimens for immunofluorescence microscopy
  • Demonstrated experience interpreting experimental results, troubleshooting experiments, and managing priorities and deadlines
  • Experience with computer software tools (e.g. Microsoft Office, R/SPSS, and Adobe Photoshop/Illustrator)
  • Coding experience preferably Python is an asset
  • Experience with online molecular biology analysis tools (e.g. BLAST and primer design tools)
  • Strong oral and written communication skills, ability to exercise initiative and deal effectively with other lab members

Employment Type:

Full-time 15 Month Contract with a possibility of extension, 1.0 FTE

A complete application should include a statement of interest, a CV, and the names of 2 references. Once the suitable candidate is identified, the position will commence immediately upon completion of the necessary paperwork. The position will remain open until filled.

Our Commitment to Diversity

The children and families we care for are diverse, and so are our employees. All are welcome to join our unique organizational culture and be part of our inclusive team.

If requested, SickKids is proud to make available accommodations to support applicants with disabilities during the interview and assessment process. Information received relating to accommodation will be addressed confidentially. SickKids is also committed to providing services in both official languages and our preference is to hire employees who are fluent in both English and French whenever possible.

Thank you for your interest in joining SickKids. Only those applicants selected for an interview will be contacted. In accordance with our Hospital policy, employment at SickKids is conditional upon the Hospital’s receipt of all necessary documentation.

How to Apply

Please use the following link to view the complete posting and to apply.

https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=13581&PostingSeq=1

Tip: Combine your cover letter and resume into ONE document of 20 pages or less as you cannot upload multiple documents as part of your application.

If you are still experiencing technical difficulties please email ask.hr@sickkids.ca to send us a short description of the issues you are experiencing. Please note that we will not accept resumes sent to this inbox but we are happy to respond to requests for technical assistance.

 

Contact information

Apply through the Hospital for Sick Children Career Board:

Please use the following link to view the complete posting and to apply.

https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=13581&PostingSeq=1

 

Posting end date

2021/02/10

 

Neuroscience – Tier 1 Canada Research Chair – University of Ottawa

Location : Ontario

Posting date : 2021-01-25

Posting end date : 2021-02-25

The University of Ottawa invites applications for a Tier 1 Canada Research Chair (CRC) in Neuroscience. The successful candidate will hold a tenure-track position in the Faculty of Medicine’s Department of Cellular and Molecular Medicine and will be an integral member of the University of Ottawa Brain and Mind Research Institute (uOBMRI). The uOBMRI is a University-wide initiative dedicated to understanding fundamental nervous system and neuromuscular processes as well as mechanisms underlying dysfunction with an emphasis on multi-disciplinarity, innovation and translational research. The successful candidate will become part of a dynamic research-intensive environment with access to a broad network of collaborators across the city of Ottawa, as well as state-of-the-art facilities.

We are interested in established researchers who are internationally recognized leaders in neuroscience with a proven track record of independence and with strong mentorship skills. The selected candidate will have a demonstrated track record of innovative thinking, of scientific leadership, such as via the procurement of large- scale grants, and of assembling effective, multidisciplinary partnerships dedicated to the pursuit of basic science and/or translational work.

Applicants will be expected to have strong evidence of research quality and productivity in one of the areas of strategic priorities at the uOBRMI including, but not limited to:

  • Neuroinflammation, for example as applies to the development and/or progression of neurodegenerative diseases, primary microbial illnesses of the nervous system, and post-infectious changes in the central and peripheral nervous system;
  • Neuroimmunology, for example as related to demyelinating diseases of the nervous system triggered by a systemic disease process, and their treatment via modulation of the host’s immune system;
  • Neurooncology, where novel strategies, including gene therapy approaches, focus on harnessing the immune system to target primary or secondary tumors of the brain;
  • Neuroanatomy, such as related to the glymphatic system, related immune surveillance and the exchange of cerebral metabolites during normal and pathological states of Cerebrovascular disease, including a better understanding of the complex pathogenesis of dementia syndromes at the crossroads of microangiopathy, protein misfolding and inflammation.

Tier 1 Chairs, tenable for seven years and renewable once, are for outstanding researchers acknowledged by their peers as world leaders in their fields. For each Tier 1 Chair, the institution receives $200,000 annually for seven years. Nominees for Tier 1 Chair positions must be full professors or associate professors who are expected to be promoted to the full professor level within one or two years of the nomination. Alternatively, if they come from outside the academic sector, nominees must possess the necessary qualifications to be appointed at these levels. New CRC nominees are also eligible for infrastructure support from the Canada Foundation for Innovation (CFI) to help acquire state-of-the-art equipment essential to their work.

Preferential Hiring: The University of Ottawa is committed to ensuring equity, diversity and inclusion in the scholarly and leadership environments of our students, staff, and faculty. Accordingly, we strongly encourage applications from members of the four designated groups such as Indigenous peoples, visible minorities, persons with disabilities, and women, as defined in the Employment Equity Act, as well as from all qualified candidates with the skills and knowledge to productively engage with equitable, diverse and inclusive communities. As part of this preferential hiring process, applications from members of the four designated groups will be prioritized and assessed first for the vacancy. Candidates who wish to qualify for preferential consideration are asked to fill the following self-identification form: https://research.uottawa.ca/sites/research.uottawa.ca/files/crc_self-identification_questionnaire_ovpr.pdf. The purpose of this measure is to increase the representation of members of the four designated groups in the allocation of Canada Research Chair positions.

Required Qualifications: A PhD and/or MD in a relevant field, superior research achievements in the CRC’s identified area as exemplified by a solid publication record, proof of interdisciplinary collaborations, an exceptional profile with respect to teaching and training of students at the graduate level, a strong record of external research funding, and excellent communication skills in either English or French. A passive knowledge of the other official language would be an asset.

Rank and salary: Regular tenure-track academic appointment in the Faculty of Medicine, with a rank and salary consistent with the expertise of the candidate and the collective agreement between the University of Ottawa and the Association of Professors of the University of Ottawa.

Posting No.: 21007-CRC

Application Package:

  • A cover letter;
  • An up-to-date curriculum vitae (include career interruptions that might have affected research
  • productivity);
  • A research plan (2 to 3 pages);
  • A statement of teaching interests (1 to 2 pages);
  • A statement on equity, diversity, and inclusion philosophy and practice (1 page);
  • The names of three people who may be contacted by the University for letters of reference which will follow the Canada Research Chairs guidelines (i.e. all must be arm’s length and one must be from a referee not residing in the country where the nominee is currently working), and
  • Self-identification form (see Preferential Hiring section above).

Deadline: February 25th, 2021

The selection process will begin immediately after the closing date and will continue until the position is filled.

Only candidates selected for an interview will be contacted. Please send the application package to the following address or by email to:

Dr. Sylvain Charbonneau, Vice President, Research

University of Ottawa

550 Cumberland St., room 246

Ottawa, ON Canada KIN 6N5

If you are invited to continue the selection process, please notify us of any particular adaptive measures you might require by contacting the Office of the Vice-Provost, Faculty Relations at 613-562-5958. The Canada Research Chairs Program imposes no restrictions on nominees with regard to nationality or country of residence. Procedures to allow non-Canadian chairholders to work in Canada have been established by Employment and Social Development Canada and Immigration, Refugees and Citizenship Canada.

The University of Ottawa is justly proud of its 160-year tradition of bilingualism. Through its Official Languages and Bilingualism Institute, the University provides training to staff members and their spouses in their second official language. At the time of tenure, professors are expected to be able to function in a bilingual setting. In certain cases, professors must have the ability to teach in both official languages to be granted tenure.

Notice of Collection of Personal Information

In accordance with the Freedom of Information and Protection of Privacy Act (Ontario) and with University Policy 90, your personal information is collected under the authority of the University of Ottawa Act, 1965 and is intended to be used for the purpose of and those consistent with your employment application and the administration of your employment relationship, if established. If you have any questions regarding this collection of personal information, please contact Office of the Vice-Provost, Faculty Relations at (613) 562- 5958 or by email at vra.affairesprofessorales@uottawa.ca.

IBRO – MBL and CSHL Fellowships

The IBRO (International Brain Research Organization) US-Canada Regional Committee (USCRC) is pleased to announce our 2021 fellowships program that will cover the cost for PhD students and postdoctoral fellows training in neuroscience in Canada to attend advanced neuroscience courses or meetings at the Marine Biological Laboratories (MBL) at Woods Hole, MA., and Cold Spring Harbor Laboratory (CSHL), NY.

For MBL, all trainees are welcomed to apply but preference will be given to trainees belonging to minority groups (Indigenous communities in Canada, visible minorities, persons with disabilities, women, and other minorities) as
well as those in non-U15 Universities (http://u15.ca/). The MBL awards will cover the cost of tuition, room, and board. Fellowships are worth up to $11,000 per trainee depending on the course taken.

For CSHL, reduced registration fees for virtual meetings are available for trainees from non-U15 Universities (http://u15.ca/). If in-person courses resume in the second half of 2021, partial tuition support of up to $8,000 per trainee will be available.

The aim of this program is to increase diversity in neuroscience in Canada, by providing such trainees with access to cutting-edge research training in contemporary neuroscience.

Interested trainees should submit applications directly to the course of interest (see link below). Evaluation of applications and offers of admission to courses are made by the course leaders. Accepted candidates with the backgrounds mentioned above will be automatically considered for IBRO fellowship.

Eligible MBL courses: Neural Systems and Behavior, Neurobiology: Mechanisms & Advanced Approaches, Methods in Computational Neuroscience, Biology of the Inner Ear: Experimental and Analytical Approaches, Brains, Minds and Mechanisms, Physiology: Modern Cell Biology Using Microscopic, Biochemical and Computational Approaches, and Frontiers in Stem Cells and Regeneration.

Eligible CSHL courses: see link below.

MBL: http://www.mbl.edu/education/courses/
CSHL: https://meetings.cshl.edu/meetingshome.aspx

Please inform us when applying or if you have questions about eligibility.

Contact: sam.david@mcgill.ca

Post-doctoral Research Fellow position in clinical neurophysiology at The Hospital for Sick Children

Post-doctoral Research Fellow position in clinical neurophysiology

Neurological Outcome of Glycemia in Neonatal Encephalopathy

The Neurosciences & Mental Health Program at the Hospital for Sick Children Research Institute is seeking an enthusiastic postdoc researcher to work in close collaboration with neurologists, neurophysiologists, and neuroradiologists in analysing pre-existing continuous glucose, EEG, and clinical data.

With the direction of principal supervisors Drs. Emily Tam and Cecil Hahn, you will work closely with affiliated staff and students who form a group that use neuroimaging and neurophysiology to study newborn brain disorders.

Despite therapeutic hypothermia for hypoxic-ischemic encephalopathy (HIE), rates of death and major disability continue to be high. Using continuous glucose monitoring, we have found that hyperglycemia occurs in more than 50% of HIE, associated with brain injury and possibly long-term outcomes. This study uses continuous glucose data paired with continuous electroencephalography (cEEG) and detailed clinical data to determine the temporal relationships between abnormal glycemia and brain function.

This is part of an ongoing project that is funded by the Canadian Institutes of Health Research (CIHR) and the National Institutes of Health (NIH).

A substantial amount of data already exists for this project and the motivated researcher will be able to jump straight into analysis.

Requirements

  • PhD in a relevant area (engineering or computer sciences) required.
  • Must have experience with EEG analyses
  • Well developed skills in data science is required.
  • Computer programming (Matlab, Python, or R) and/or signal processing/time series analyses.
  • Proven experience in research commensurate with your level of experience post-PhD.
  • Experience in analysis of neurophysiological data is preferred.
  • Experience in clinical research would be an asset.
  • Excellent communication skills (oral and written).
  • Be able to work independently and meet deadlines.

We offer

  • Initial contract will be for a period of 1 year, with the possibility of extension for a second year.
  • We offer a competitive salary based on qualifications and experience.
  • In addition, we offer an attractive benefits package, that includes extended health and dental coverage.
  • Toronto is a world-class rated in the top ten cities worldwide for livability that has a large and rich neuroscience community.
  • The Research Institute offers many opportunities for career development and additional training as part of the Research Training Centre.

Additional information

The post is available from 4th January 2021.

Contact Dr. Emily Tam via emily.tam@sickkids.ca for more information.
If you wish to apply directly, please send a CV, a cover letter with research statement/interests, and the names of two references.

Please use the following direct link to the job posting to apply to the position via the SickKids website:

https://career.sickkids.ca:8001/psc/CRPRD/CAREER/HRMS/c/HRS_HRAM_FL.HRS_CG_SEARCH_FL.GBL?Page=HRS_APP_JBPST_FL&Action=U&FOCUS=Applicant&SiteId=1&JobOpeningId=13321&PostingSeq=1&

Tenure-Track Assistant Professor in Biomechanics of Human Movement, University of British Columbia

THE UNIVERSITY OF BRITISH COLUMBIA
Faculty of Education – School of Kinesiology – Vancouver Campus

The School of Kinesiology, Faculty of Education at The University of British Columbia (UBC) invites applications for a full-time tenure-track Assistant Professor position in the area of Biomechanics of human movement. The successful candidate will contribute basic and applied research that supports the areas of neuromechanical and systems biology. In addition to basic research into the biomechanical and aspects of human movement, the successful candidate will be able to contribute to teaching in areas that require expertise and advanced knowledge in applied biomechanics (e.g. occupational, sport performance, injury biomechanics, robotics and human factors). The appointment is expected to begin on July 1, 2021 or as negotiated with the successful candidate.

The candidate must hold a PhD at the time of application in biomechanics or a closely related discipline. Post-doctoral training would be an asset. The candidate must have a record of research dissemination, in terms of peer-reviewed articles in recognized academic journals in the field, and evidence of presentations at national and international scholarly conferences. Demonstrated ability to participate in scholarly activity and to secure competitive research funding (e.g. tri-council and partnership grants) in biomechanics is required.

The successful candidate must have advanced knowledge and a demonstrated history of publications using biomechanical approaches in 3-Dimensional kinematics and dynamics. Demonstrated research experience in electromyography, tissue mechanics, mechanical energy, modelling, as well as evidence of using these biomechanical techniques in applied settings would be preferred.

The candidate will have demonstrated capability to provide effective instruction at introductory and advanced levels of biomechanics. The candidate will be expected to teach three courses, including a core undergraduate course in biomechanics as well as develop and teach a new advanced undergraduate/graduate course in a) injury biomechanics and b) applied biomechanics (e.g. occupational, sport, robotics and human factors).

The successful candidate will be encouraged to collaborate across the diverse research areas in the School and, more broadly, the University. The successful candidate will complement the School of Kinesiology’s strategic plans for interdisciplinary research excellence within the School and across Faculties at UBC and play a key role in generating and disseminating knowledge on the role of physical activity and health in diverse populations. The successful candidate is expected to establish a program of original, externally funded research (e.g. tri-council and partnership grants) and teach undergraduate courses in the School, and contribute to the growth of the School through supervision of graduate students, participation in service activities within the University and in the broader scholarly community, and collaboration with scientists within the School and across Faculties at UBC.

The School of Kinesiology currently has 24 full-time tenure stream faculty members, 1350 full-time undergraduate students, and 160 graduate students. We offer a Bachelor of Kinesiology degree with specializations in Neuromechanical and Physiological Sciences, Social and Behavioural Sciences, and Multi-disciplinary Science. The graduate program includes M.A., M.Sc., Master of Kinesiology (non-thesis), Master of High Performance Coaching & Technical Leadership, and Ph.D. degrees. For further details about the School of Kinesiology and its research, please visit the School’s website at http://kin.educ.ubc.ca/.

The UBC Faculty of Education is one of the leading faculties of its kind in the world, advancing educational research and understanding of teaching and learning in a way that celebrates diversity, equity and innovation, and welcomes international collaboration in an increasingly borderless globe. We provide a comprehensive set of programmatic offerings at the baccalaureate, magisterial, and doctoral levels. For further details about the Faculty of Education and its research and teaching programs, please visit www.educ.ubc.ca.

The UBC Vancouver campus is located on the traditional ancestral and unceded territory of the Musqueam people in Vancouver, currently a multicultural, multilingual city ranked as one of the best places to live in the world. The University is a global centre for teaching, learning and research, consistently ranked among the top 20 public universities in the world and recently recognized as North America’s most international university.

The School of Kinesiology, Faculty of Education, and UBC are dedicated to the goal of building a diverse and inclusive academic community. We strongly encourage applications from candidates who can demonstrate through their teaching, research experience and service that they can contribute to this goal. Familiarity with, and experience using pedagogical methods and designing research that enable students across Indigenous, racial, ethnic, sexual and gender identity and socio-economic groups to reach their maximum potential will be considered an asset. Candidates should have a strong commitment to fostering inclusivity and teaching in a welcoming and politically astute environment.

This is a tenure-track position in the Professoriate Stream. The successful candidate will be reviewed for reappointment, tenure and promotion in subsequent years, in accordance with the Collective Agreement. For a detailed description of the Assistant Professor rank and criteria for reappointment and promotion, please visit, https://hr.ubc.ca/sites/default/files/2020-09/Faculty-CA2019-2021.pdf. The position is subject to final budgetary approval. Starting salary is determined both by the candidate’s qualifications and experience and by their placement on the career progress scale within the UBC Faculty of Education.

Interested applicants are invited to send:
(i) a cover letter,
(ii) curriculum vitae,
(iii) a five year research plan,
(iv) a summary of teaching interests and philosophy,
(v) evidence of teaching excellence (such as course outlines and student evaluations if available),
(vi) three papers that are the most significant and relevant to their research interests, and
(vii) a Diversity Statement. Diversity is an important part of the School of Kinesiology/Faculty of Education/UBC mission. Please provide a Diversity Statement (max 1 page) that describes and documents how diversity figures into your past and present experience of teaching, research, and your lived experience. Going forward, how would you imagine incorporating attention to creating/advancing a culture of equity and inclusion?

The complete application file must be submitted in the format of one bookmarked PDF file, addressed to Dr. Robert Boushel, Director School of Kinesiology, and sent electronically to kin.hr@ubc.ca by the application review start date (below). Please indicated in subject heading: Biomechanics of Human Movement. Following the submission of the application, the applicant will receive an Equity Survey link via email. Completion of the anonymous Equity Survey is strongly encouraged as part of the application process.

Applicants should also arrange to have three letters of reference sent directly to kin.hr@ubc.ca by the application review start date (below).

While applications will be received until the position is filled, interested parties are encouraged to submit by February 15, 2021, to ensure optimal consideration.
Questions regarding the position should be directed to Dr. Robert Boushel, Director School of Kinesiology at kin.hr@ubc.ca.

Equity and diversity are essential to academic excellence. An open and diverse community fosters the inclusion of voices that have been underrepresented or discouraged. We encourage applications from members of groups that have been marginalized on any grounds enumerated under the B.C. Human Rights Code, including sex, sexual orientation, gender identity or expression, racialization, disability, political belief, religion, marital or family status, age, and/or status as a First Nation, Metis, Inuit, or Indigenous person.

All qualified persons are encouraged to apply; however, Canadians and permanent residents will be given priority.

Postdoctoral position in cellular/computational Neuroscience: Katalin Tóth, uOttawa Brain and Mind Institute

Applications are invited for a postdoctoral fellowship starting immediately at the University of Ottawa to investigate features of synaptic signal integration and microcircuit function using experimental and computational approaches. The researcher will join a collaborative group with expertise in cellular electrophysiology, two-photon imaging, and advanced computational modelling and statistical processing (Drs Katalin Toth and Richard Naud). Expertise in cellular electrophysiology and/or in two-photon cellular imaging is required. This fully funded position with attractive conditions is available immediately. The candidate is expected to be competitive for external fellowships.

The researcher will join uOttawa’s Brain and Mind Research Institute’s Center for Neural Dynamics (Department of Cellular and Molecular Medicine; Faculty of Medicine). uOttawa’s Neuroscience community is fast expanding, highly dynamic and offers a rich array of collaborative opportunities. Ottawa, the capital of Canada, is a green, multi-cultural city that offers the highest standard of living in the country and is second worldwide for quality of life (Numbeo index, 2015). The city has many parks including the Unesco World Heritage Rideau Canal and is surrounded by an extensive greenbelt. This bilingual, culturally-rich city lies along the border between the province of Quebec and Ontario and is within driving distance to Montréal and Toronto.

Employer Profile:

The University of Ottawa is a bilingual research university in Ottawa, Ontario, Canada. The university offers a wide variety of academic programs, administered by ten faculties. It is a member of the U15, a group of research-intensive universities in Canada. In the Maclean’s 2015 Canadian University rankings, the University of Ottawa ranked 2nd for Medical/Science Grants, 2nd for Scholarships & Bursaries and 1st for Student Services in the Medical/Doctoral University category.

Please send CV, statement of research interest and names of three references to: Katalin Toth (ktoth@uottawa.ca).