Concussions loosen insulation around brain cells

Alex Rauscher
Alex Rauscher

Researchers say the findings provide a convincing reason to keep concussed athletes on the bench even if they no longer exhibit any symptoms.

Detailed scans of concussed University of British Columbia hockey players found that the protective fatty tissue surrounding brain cell fibres was loosened two weeks after the injury—even though the athletes felt fine and were deemed ready to return to the ice. Continue reading

Research Assistant – Quandt lab – University of British Columbia

We have a position in our laboratory for a research assistant with funding for up to three years. The UBC posting can be found at: www.staffcareers.ubc.ca/31013

Interested applicants are invited to review our website for more information.

www.quandtlab.com

Training & expectations: Major areas of focus will include inflammatory mediators, oxidative stress, environmental stressors, immune populations, neurodegeneration and repair. The successful candidate will have a solid understanding and demonstrated proficiency in several of the following and others will be provided on the job:

  • Cell culture and aseptic technique, preferably involving both isolation and maintenance of rodent primary cultures as well as cell lines.
  • Aseptic technique and experience with human blood handling for the isolation of PBMC and subsequent culture/assay
  • Ability to perform and troubleshoot a wide variety of molecular and cellular biology techniques, including many of the following:
    RNA/DNA isolation, quantitative PCR, transfection, siRNA knockdown and cDNA construct knockin, flow cytometry, immunohisto- and cytochemistry on cells as well as frozen and formalin-fixed, paraffin embedded tissues, fluorescence and light microscopy – conventional and/or confocal; ELISA, protein isolation and western blotting;
  • Willingness to work with small rodents is essential. Able to carry out and oversee procedures involving small rodents including immunization/injections, necropsy, blood sampling, and minor surgical procedures involved in animal surgery; applicants with experience in pre-clinical models of neurodegenerative diseases including MS are especially encouraged to apply.
  • Maintenance/monitoring of colonies of transgenic animals, including colony breeding, screening and management.
  • Excellent verbal and written communication
  • Understanding of experimental design and assay optimization is important along with ability to work well with others and to work independently.

The link between obesity, the brain, and genetics

Alain Dagher
Dr. Alain Dagher

When it comes to weight gain, the problem may be mostly in our heads, and our genes

Clinicians should consider how the way we think can make us vulnerable to obesity, and how obesity is genetically intertwined with brain structure and mental performance, according to new research.

The study, led by researchers at the Montreal Neurological Institute and Hospital (The Neuro) and published in the Proceedings of the National Academy of Sciences on Aug. 28, 2018, was an examination of magnetic resonance imaging (MRI) and cognitive test data from 1,200 individuals, supplied as part of the Human Connectome Project. Continue reading

Congratulations to newly elected fellows of the Royal Society of Canada, and to the incoming class of the college of new scientists

The Royal Society of Canada has recently announced new Fellows in the Academies of Arts and Humanities, Social Sciences, and Science.  They have been elected by their peers for their outstanding scholarly, scientific and artistic achievement. Recognition by the RSC is the highest honour an individual can achieve in the Arts, Social Sciences and Sciences.

The RSC also welcomed new Members of the College of New Scholars, Artists and Scientists, that include top mid-career leaders in Canada. The College provides the RSC with a multigenerational capacity to help Canada and the world address major challenges and seize new opportunities including those identified in emerging fields. Continue reading

Genetic model offers elegant tool for testing Parkinson’s disease therapies

Matthew Farrer
Matthew Farrer

For the past decade, Parkinson’s disease researchers have relied on the experimental equivalent of using a sledgehammer to tune a guitar to test new therapies for the disease. This may be a reason clinical trials of promising neuroprotective drugs fail. But, in new research published today in Nature Parkinson’s Disease, researchers at the Djavad Mowafaghian Centre for Brain Health (DMCBH) may have found the ideal tool for the job.

“We believe we’ve found an approach that is most relevant to humans, in that our models of gene dysfunction mimic the etiology of Parkinson’s disease rather than its pathology— meaning its beginning rather than its end,” says Dr. Matthew Farrer, the study’s lead investigator and a researcher at the Centre for Applied Neurogenetics at DMCBH. “This means we’re looking at the disease before it becomes symptomatic, before it begins affecting an individual’s motor skills or cognition.” Continue reading

Scientist denied visas to attend next SfN meeting

Individual members of the Canadian Association for Neuroscience (CAN) have alerted us to the fact that a number of scientists across Canada are being denied visas to enter the United States to attend the next annual Society for Neuroscience meeting in San Diego. Many are students and postdoctoral fellows who have left their home countries to dedicate their energy and talents to research into devastating brain and mental health conditions that afflict millions worldwide. CAN takes the position that the exchange of ideas cannot be limited by political boundaries. To do so severely compromises the ability of the scientific enterprise to develop new ideas and advance humanity. Scientists must have the ability to travel freely to discuss their work and interact with colleagues across the globe. Continue reading

Field Scientist: Neuroscience Specialist – Mightex Systems – Toronto

Overview

Mightex Systems, is a market leader in developing and producing photonic systems for life science research. Our most recent innovation, the OASIS Implant, is an all-optical system for cellular resolution optogenetics and calcium imaging in freely-behaving animals, a ground-breaking tool that will enable neuroscientists to make new discoveries about how the brain works.

The successful candidate will be responsible for providing post-sales support to our customers using the OASIS Implant. The type of support provided will include biological and surgical guidance, overall experimental design, technical training and troubleshooting, as well as data analysis. The candidate will be required to provide support both remotely and in person by periodically travelling to customer sites. They will also be required to contribute their expertise during the pre-sales stages to help customers determine how to apply Mightex solutions to their research goals. If you are a self-motivated neuroscientist who is interested in cutting-edge technology and in contributing to the advancement of neuroscience and brain research, this is an exciting opportunity for you.

Responsibilities

  • Provide hands-on scientific and technical support for neuroscience labs with Mightex equipment from experimental preparation to implementation
  • Organize and conduct training sessions
  • Assist with drafting new scientific and technical support resources that are provided to customers
  • Track progress of assigned customer cases
  • Report customer challenges and new experimental requirements to the Product Development team
  • Support sales team members when scientific expertise is required for a customer case.
  • Flexibility to be able to handle some new incoming sales inquiries when required.
  • Participate in international trade shows, seminars, and roadshows.

Qualifications & Skills:

  • Ph.D. in Neuroscience
  • Previous experience with in vivo calcium imaging and optogenetics in rodents. Expertise with viral transfections (e.g., GCaMP) and GRIN lens implantation is a must
  • Previous experience with head-mounted miniature microscopes is an asset
  • Strong analytical and hands-on skills are essential to provide accurate and quality customer training and guidance
  • Excellent teamwork skills and able to collaborate effectively across multiple departments
  • Delivers a positive customer experience; listens to and understands the customer’s needs and recommends solutions
  • Demonstrates sound professional judgment in analysing, responding to, and resolving enquiries
  • Excellent written and oral communication skills
  • Ability to travel domestically or internationally to customer sites
  • Legally able and cleared to work in Canada

How to Apply

Please send your resume to hr1@mightex.com.

The power of multidisciplinary collaboration: A sculptor’s exploration of the brain

Read about a multidisciplinary collaboration between neuroscientists and artists, developed through The Convergence Initiative.  Founded in 2016 by neuroscientist and graphic designer Dr. Cristian Zaelzer, the Convergence – Perceptions of Neuroscience initiative is a partnership with the Brain Repair and Integrative Neuroscience Program (BRaIN) of the Research Institute of the McGill University Health Centre (RI-MUHC), the Faculty of Fine Arts of Concordia University (FoFA), and the Canadian Association for Neuroscience (CAN/ACN). This partnership has been continuously supported by the RI-MUHC, the Montreal General Hospital Foundation, McGill University Integrative Program in Neurosciences (IPN), and the Visual Voice Gallery.

Dr. Keith Murai, BRaIN program director, thinks the science vs. humanities dichotomy is a false one. Continue reading