Category: News

Researchers from the McGill Group for Suicide Studies, based at the Douglas Mental Health University Institute and McGill University’s Department of Psychiatry, have just published research in the American Journal of Psychiatry that suggests that the long-lasting effects of traumatic childhood experiences, like severe abuse, may be due to an impaired structure and functioning of cells in the anterior cingulate cortex. This is a part of the brain which plays an important role in the regulation of emotions and mood. Continue reading →

New research from the Djavad Mowafaghian Centre for Brain Health asks: Can “good” cholesterol protect against age-related cognitive decline? A trio of papers from researchers in Dr. Cheryl Wellington’s lab illustrate new context for the role of high-density lipoproteins (HDL) – commonly described as good cholesterol – in protecting the brain against disease. Continue reading →

Major depression affects the expression of genes in the brains of women and men differently

Major depression presents itself quite differently in women and men, and this dimorphism would have genomic foundations, suggests a study that has just been published in Nature Medicine. According to the first author of this study, Benoit Labonté of the CERVO Brain Research Centre at Université Laval, these differences are such that the search for new antidepressants would benefit from targeting mechanisms specific to each sex. Continue reading →

Abnormalities shown to first appear in brain networks involved in sensory processing

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Promising finding suggests odour identification tests may help scientists track the evolution of the disease in persons at risk

By the time you start losing your memory, it’s almost too late. That’s because the damage to your brain associated with Alzheimer’s disease (AD) may already have been going on for as long as twenty years. Which is why there is so much scientific interest in finding ways to detect the presence of the disease early on. Scientists now believe that simple odour identification tests may help track the progression of the disease before symptoms actually appear, particularly among those at risk. Continue reading →

Scientists at The Hospital for Sick Children (SickKids) have used the gene-editing tool CRISPR to correct a disease-causing mutation in mice with a form of congenital muscular dystrophy, MDC1A. The findings, published in the July 17 online edition of Nature Medicine, show significant improvement in muscle strength and function among the mice treated with CRISPR, with no remaining signs of paralysis.

MDC1A is a rare neuromuscular disease affecting one in 150,000 worldwide. It is caused by a mutation in a gene called laminin alpha 2 and is characterized at birth by muscle weakness and low muscle tone, as well as brain abnormalities. Babies born with this condition eventually lose all muscle function and live an average of 30 years. Continue reading →

Researchers train brains to use different regions for same task

Practice might not always make perfect, but it’s essential for learning a sport or a musical instrument. It’s also the basis of brain training, an approach that holds potential as a non-invasive therapy to overcome disabilities caused by neurological disease or trauma.

Research at the Montreal Neurological Institute and Hospital of McGill University (The Neuro) has shown just how adaptive the brain can be, knowledge that could one day be applied to recovery from conditions such as stroke. Continue reading →

When trying to memorize information, it is better to relate it to something meaningful rather than repeat it again and again to make it stick, according to a recent Baycrest study published in NeuroImage.

“When we are learning new information, our brain has two different ways to remember the material for a short period of time, either by mentally rehearsing the sounds of the words or thinking about the meaning of the words,” says Dr. Jed Meltzer Continue reading →

Non-dependent users also experience dopamine release in response to drug cues

Even among non-dependent cocaine users, cues associated with consumption of the drug lead to dopamine release in an area of the brain thought to promote compulsive use, according to researchers at McGill University.

The findings, published in Scientific Reports, suggest that people who consider themselves recreational users could be further along the road to addiction than they might have realized. Continue reading →

A Canadian clinical trial led by researchers at the University of Calgary’s Hotchkiss Brain Institute (HBI), at the Cumming School of Medicine (CSM), shows that minocycline, a common acne medication, can slow the progress of relapsing-remitting multiple sclerosis (MS) in people who have recently experienced their first symptoms.

In addition to being an unexpected discovery — an acne drug benefitting a neurological disorder — the discovery is significant as it offers a safe and affordable treatment option for those with early onset MS. This discovery could impact thousands of newly diagnosed MS patients around the world. Continue reading →