Eight years in the making, a discovery by neuroscientists at the CRCHUM highlights the value of long-term, fundamental research and provides important information for future drug targets.
It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), works. Continue reading
McMaster University Scientists have published 2 studies identifying which gene is responsible for causing brain development disorders when several genes are deleted in an individual’s genome, providing a path forward for developing new therapies.
In Ontario, there are more than 300,000 children and youth affected by a neurodevelopmental disorder such as autism spectrum disorders, attention deficit hyperactivity disorder, and intellectual disability. These disorders typically cause long-term problems and impact the day-to-day life of affected individuals and families. There are no specific treatments, and medications have side-effects that can be severe in children and young adults. Continue reading
Researchers at Western University have uncovered a unique neurobiological pathway triggered by head trauma which underlies both Chronic Traumatic Encephalopathy (CTE) and amyotrophic lateral sclerosis (also called ALS or Lou Gehrig’s Disease).
CTE is a fatal neurodegenerative disease shown to be a result of repeated head trauma, and is associated with elite athletes involved in contact sports. Previous research has shown that between 4 and 6 per cent of patients with CTE will also simultaneously show clinical features of ALS – that’s 800 fold higher than the prevalence of ALS in the general population. Continue reading
New research could provide clinicians with insights regarding clinical progression to dementia
Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition worsen in a short time frame, a suspicion that now has been confirmed by a team of McGill University clinician scientists. Continue reading
Concussion affects the developing adolescent brain and may delay key cognitive processes, hampering the brain’s ability to change focus and pay attention. New research from Dr. Naznin Virji-Babul’s team, published today in the journal ASN Neuro, shows that concussion changes the way that different neural networks interact, stalling the brain in a state of cognitive inflexibility.
Even at rest, the brain is continuously active, processing and exchanging information. This active interaction between different parts of the brain is necessary for a person to be aware of her surroundings, or to be able to focus on his work or switch between tasks. Continue reading
For the past three years, Dr. Terrance Snutch and research associate Dr. John Tyson have been working with Oxford Nanopore Technologies (ONT) to develop a novel deoxyribonucleic acid (DNA) sequencing tool with promising implications for personalized medicine. About the size of a mobile phone, the MinION device is a USB-powered DNA sequencer capable of mapping complex genomic structures; with it, researchers were recently able to assemble a complete human genome using reads hundreds of times larger than has previously been possible with conventional methods. Continue reading
Research from the IRCM contributes to our understanding of how our brain locates painful stimuli
When you experience a painful sensation such as touching a hot stove with your hand, the pain is restricted to your hand, allowing you to remove it quickly from the source of heat. How does the brain know that the pain is indeed coming from your hand and not from anywhere else on your body? Work recently published by Montreal Clinical Research Institute (IRCM) researchers help clarifying this question. Continue reading
University of Calgary research study benefits people with severe essential tremor
Elias Pharaon is 85 years old and can sign his name for the first time in five years thanks to a new way to do brain surgery. Performed by a team of University of Calgary physicians and researchers with the Hotchkiss Brain Institute, magnetic resonance guided focused ultrasound (MRgFUS) is a new technology that allows surgeons to access the brain without cutting the skin or drilling into the skull. Continue reading
Pimozide, known for treating certain psychiatric conditions, may stabilize progression of the disease. The University of Calgary’s Lawrence Korngut is leading a clinical trial with nine hospital centres across Canada to recruit patients for further study.
If you took part in the ALS Ice Bucket Challenge, you may have wondered where the money raised by the millions of people who poured buckets of ice water over their heads went. Some of those funds are being invested in a University of Calgary research study investigating a potential drug treatment for amyotrophic lateral sclerosis (ALS) patients. Continue reading