Identification of two brain signal features that guide surgery in drug-resistant epilepsy
Epilepsy is one of the most common neurological conditions, affecting individuals across all age groups, social classes, and geographical locations. For patients whose seizures remain uncontrolled despite optimal medical therapy, epilepsy surgery represents the most effective treatment option and offers the highest chance of long-term seizure freedom. Surgical success, however, critically depends on the accurate identification of the seizure generating (epileptogenic) tissue, as its complete removal is a major determinant of postoperative outcome.
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Abdallah C, Thomas J, Aron O, Avigdor T, Jaber K, Doležalová I, Mansilla D, Nevalainen P, Parikh P, Singh J, Beniczky S, Kahane P, Minotti L, Chabardes S, Colnat-Coulbois S, Maillard L, Hall J, Dubeau F, Gotman J, Grova C, Frauscher B. Visual Features in Stereo-Electroencephalography to Predict Surgical Outcome: A Multicenter Study. Ann Neurol. 2025 Sep;98(3):547-560. doi: 10.1002/ana.27278. Epub 2025 Jun 16. PMID: 40519108; PMCID: PMC12392059.
