The Macauley lab is accepting applications for a Postdoctoral fellow in the area of neuroimmunology. Research in the lab focuses on the role of Siglec family of immunomodulatory glycan-binding receptors in human health and disease. The lab is located in the Gunning/Lemieux Chemistry center at University of Alberta and is part of the Neuroscience and Mental Health Institute (NHMI) and Alberta Glycomics Institute (GIA). Additionally, we are strongly connected to the Canadian Glycomics Network (GlycoNet), and collaborate closely with several other UAlberta investigators studying microglia (e.g. Drs. Plemel, Voronova, Sipione)
Working within a highly interdisciplinary environment, the fellow will lead projects related to the role of an Alzheimer’s disease susceptibility factor, CD33, in disease pathogenesis, as well as development of novel CD33-based therapeutics in this context (PMID:35940942). Genetic models (PMID:33766097 and PMID:31815204) and biochemical tools (PMID:34517042) are readily available in our laboratory for working on this exciting project that is closely connected to human disease. Funding through multiple sources (CIHR, Alzheimer Society of Canada, Weston Brain Institute, GlycoNet, and NIH) are in place to advance our goal of understanding the cellular and molecular mechanisms by which Siglecs impact the function of microglia in the brain.
The position requires a Ph.D. in one of the following disciplines: neurobiology, immunology, chemical biology, biochemistry, or other related fields. Candidates should have a record of completed graduate research that can be directly applied to the field of interest described above. Prior experience with transgenic models of neurodegeneration, cell culture, microscopy (including immunohistochemical techniques) and biochemical techniques are highly desirable. The ideal candidate must demonstrate excellent laboratory skills, independence, and resourcefulness. Candidates must possess strong communication and organizational skills manifested with proven track records including peer-reviewed publications.
Please email a cover letter, CV, and the name of 3 potential references to Dr. Macauley.
Matthew Macauley
macauley@ualberta.ca
Posting end date: 2022/12/31
