McMaster study debunks controversial MS theory

Dr. Ian Rodger
Dr. Ian Rodger

There is no evidence that impaired blood flow or blockage in the veins of the neck or head is involved in multiple sclerosis, says a McMaster University study.

The research, published online by PLOS ONE Wednesday, found no evidence of abnormalities in the internal jugular or vertebral veins or in the deep cerebral veins of any of 100 patients with multiple sclerosis (MS) compared with 100 people who had no history of any neurological condition. Continue reading

A new role for sodium in the brain

Dr. Derek Bowie
Dr. Derek Bowie

Findings identify a novel pharmaco-logical target for drug development

Researchers at McGill University have found that sodium – the main chemical component in table salt – is a unique “on/off” switch for a major neurotransmitter receptor in the brain. This receptor, known as the kainate receptor, is fundamental for normal brain function and is implicated in numerous diseases, such as epilepsy and neuropathic pain. Continue reading

A revolutionary new 3D digital brain atlas

Dr. Alan Evans
Dr. Alan Evans

Imagine being able to zoom into the brain to see various cells the way we zoom into Google maps of the world and can see houses on a street. And keep in mind that the brain is considered the most complex structure in the universe with 86 billion neurons. Zooming in is now possible thanks to a new brain atlas with unprecedented resolution. BigBrain is the first 3D microstructural model of the entire human brain, and is free and publicly available to researchers world-wide. Continue reading

Study points to role of nervous system in arthritis

Dr. Alfredo Ribeiro-da-Silva
Dr. Alfredo Ribeiro-da-Silva

Reducing levels of nerve-growth factor may be a key to developing better pain treatments

Arthritis is a debilitating disorder affecting one in 10 Canadians, with pain caused by inflammation and damage to joints. Yet the condition is poorly managed in most patients, since adequate treatments are lacking – and the therapies that do exist to ease arthritis pain often cause serious side effects, particularly when used long-term. Any hope for developing more-effective treatments for arthritis relies on understanding the processes driving this condition. Continue reading

New imaging technique holds promise for speeding MS research

Dr. Alexander Rauscher
Dr. Alexander Rauscher

Researchers at the University of British Columbia have developed a new magnetic resonance imaging (MRI) technique that detects the telltale signs of multiple sclerosis in finer detail than ever before – providing a more powerful tool for evaluating new treatments.

The technique analyzes the frequency of electro-magnetic waves collected by an MRI scanner, instead of the size of those waves. Although analyzing the number of waves per second had long been considered a more sensitive way of detecting changes in tissue structure, the math needed to create usable images had proved daunting. Continue reading