Cerebral cavernous malformations (CCM) is a rare disease that causes anomalies in tiny capillaries that transport blood throughout the brain. The disease manifests as irregularities that resemble raspberries, most often in the brain, that can lead to hemorrhage, stroke and seizures in afflicted individuals. The disease involves defects in one of three CCM genes (CCM1, CCM2, or CCM3) and affects nearly one in six thousand people. Currently, there is no clinically approved therapy to treat this disease; patients rely on invasive brain surgery for treatment, but some extreme forms cannot be treated surgically. Continue reading
Québec siblings with rare orphan disease lead to discovery of rare genetic diseases
Mutations in a gene involved in brain development have led to the discovery of two new neurodevelopmental diseases by an international team led by researchers at McGill University and CHU Sainte-Justine Research Center.
The first clues about the rare disorder arose after doctors were unable to diagnose why two siblings from Québec City were experiencing seizures and neurodevelopmental deficits. Desperate, the children’s family turned to Carl Ernst at the Douglas Mental Health University Institute in Montreal for answers. Continue reading
Published on Eurekalert, April 15, 2019
The Scientific Program Committee, chaired by Paul Frankland and co-chair Ruth Slack, along with local chair Julie Lefebvre, have put together an exciting roster of scientific presentations, community building events and opportunities for networking and career development.
Scientific highlights of the 2019 meeting include plenary lectures by Michelle Monje, Jeffrey Mogil, Florian Engert, Robert Malenka and Guo-Li Ming. As usual, plenary symposia featuring prominent Canadian and international speakers, and the always diverse parallel symposia proposed by our members complete the CAN scientific program.
We warmly congratulate this year’s Young Investigator laureate, Dr. Blake Richards, from the University of Toronto at Scarsborough. Dr. Richards’ research explores the neural basis of deep learning. The goal of this work is to better understand the neurobiological basis of animal and human intelligence and provide new insights to help guide AI development. His laboratory has made several important contributions to mathematical models of learning and memory in the brain. Don’t miss the CAN Young Investigator award lecture to learn more about these exciting discoveries, on May 24th, 2019 at 5:30PM. https:/
Dr. Richards will also host the CAN public lecture, on May 21 at 6:30PM which this year features a Canadian expert in Artificial Intelligence, Dr. Geoffrey Hinton, from the University of Toronto. This event will explore the use of artificial intelligence to understand how the brain computes. (https:/
For news media only:
Press passes are available for accredited journalist to attend the Canadian Neuroscience Meeting. Please inquire on location at the registration desk.
Public lecture, May 21 sith Geoffrey Hinton:
Congratulations to Geoffrey Hinton (University of Toronto), Joshua Bengio (Université de Montréal) and Yann LeCun (Boston University) who have won the 2019 Turing award for their work to understand neural networks using artificial intelligence and deep learning. The Turing Award is an annual prize given by the Association for Computing Machinery (ACM) to an individual selected for contributions “of lasting and major technical importance to the computer field”. The award is accompanied by a $1 million USD prize, to be shared by the three winners.
Read more on the Association for Computing Machinery website
Fathers of the Deep Learning Revolution Receive ACM A.M. Turing Award
Bengio, Hinton and LeCun Ushered in Major Breakthroughs in Artificial Intelligence
Geoffrey Hinton will be present at the CAN meeting on May 21, 2019, where he will present the CAN annual public lecture, which will be hosted by Blake Richards, from the University of Toronto. More here.
New therapeutic molecules developed at Toronto’s Centre for Addiction and Mental Health (CAMH) show promise in reversing the memory loss linked to depression and aging.
These molecules not only rapidly improve symptoms, but remarkably, also appear to renew the underlying brain impairments causing memory loss in preclinical models. These findings were presented at the American Association for the Advancement of Science (AAAS) Annual Meeting in Washington DC.
“Currently there are no medications to treat cognitive symptoms such as memory loss that occur in depression, other mental illnesses and aging,” says Dr. Etienne Sibille, Deputy Director of the Campbell Family Mental Health Research Institute at CAMH and lead scientist on the study. Continue reading
The Brain Prize 2019: French neuroscientists honoured for outstanding research into small vessel strokes in the brain
Aiming for treatment they have spent more than 30 years describing, understanding and diagnosing the most common hereditary form of stroke, CADASIL. For this, the four French neuroscientists are now receiving the world’s most valuable prize for brain research – the Lundbeck Foundation Brain Prize, worth 1 million euros. Continue reading
Jean-Pierre Julien’s team recently published an article in the high impact journal, the Journal of Clinical Investigations, about a new experimental therapy for ALS and frontotemporal dementia based on the use of antibodies that target the abnormal accumulation of a protein called TDP-43 in degenerating neurons. The formation of TDP-43 aggregates is associated with ALS development. Continue reading
We often think of our brains as the centre of complex motor function and control, but how ‘smart’ is your spinal cord? Turns out, it is smarter than we think.
Circuits which travel down the length of our spine control things like the pain reflex in humans and some motor-control functions in animals. Now, new research from Western has shown that the spinal cord is also able to process and control more complex functions, like the positioning of your hand in external space. Continue reading
Researchers at Western have developed an objective way to monitor female athletes’ concussion injury, by using brain scans to study their brains over time.
By using a technique that combines both structural and functional MRI information, Western University researchers were able to identify three unique signatures – one that shows acute brain changes after an athlete has suffered a concussion, another that can identify persistent brain changes six months after the concussion and a third that shows evidence of concussion history. Continue reading
Queen’s University researcher discovers potential new treatment for Alzheimer’s disease.
Queen’s University researcher Fernanda De Felice (Psychiatry), along with co-authors from the Federal University of Rio de Janeiro, have identified an exercise-linked hormone that could slow the progression of Alzheimer’s disease. This research was recently published in the high-profile publication, Nature Medicine. Continue reading