Researchers link genetic mutation to psychiatric disease and obesity

Dr. Carl Ernst
Dr. Carl Ernst
McGill researchers have identified a small region in the genome that conclusively plays a role in the development of psychiatric disease and obesity. The key lies in the genomic deletion of brain-derived neurotrophic factor, or BDNF, a nervous system growth factor that plays a critical role in brain development.

To determine the role of BDNF in humans, Carl Ernst, PhD, from McGill’s Department of Psychiatry, Faculty of Medicine, screened over 35,000 people referred for genetic screening at clinics and over 30,000 control subjects in Canada, the U.S., and Europe. Continue reading

A Memorable Protein

Paul De Koninck, Mado Lemieux
Lemieux, De Koninck

Researchers demonstrate the key role played by a protein in learning and memory

Learning and remembering are based on molecular mechanisms that are still poorly understood. According to some experts, information is stored in the brain and reactivated as required by strengthening synapses that link neurons together. The strength of these links depends on the abundance of neurotransmitters, receptors, and of all other molecules involved in chemical transmission of information. Continue reading

Eye test helps diagnose neurological disorders

Douglas Munoz
Dr. Douglas Munoz

A new test that measures eye movement while watching television helps detect neurological disorders earlier including Parkinson’s disease, fetal alcohol spectrum disorder, autism and attention deficit hyperactivity disorder.

The low-cost test, developed at Queen’s University and the University of Southern California, provides new insight into how specific disorders affect attention.

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Astrocytes: The superheroes of brain cells

Brian MacVicar
Dr. Brian MacVicar

Eight years ago, Brian MacVicar discovered that astrocytes—cells that surround nerve cells and all blood vessels in the brain—have a primary role in regulating blood flow within the brain, which provided a new target for potential therapies for stroke, migraine, and vascular dementia. Now he and Hyun Beom Choi, a research associate in his lab, have uncovered a new role for this heroic brain cell: detecting problems in the brain and delivering nutrients to keep brain cells healthy in times of critical need. Continue reading

“Using your Brain” video receives honorable mention from SfN

Using your brain

The Brain Awareness Video Contest is organized by SfN to provide videos to the public on various topics related to the brain and nervous system. This year, the honorable mention place winner is Kenneth Dyson who made his video with help from his two sons (6 and 12 year-old Taj and Deszmo). Kenneth is a postdoctoral fellow at Université de Montréal. His video, Using Your Brain, can be viewed here. Vote for his video for the Brain Awareness Week People’s choice award!

LDI researcher develops promising model for schizophrenia

Dr. Hyman Schipper
Dr. Hyman Schipper, a neurologist and researcher at the Lady Davis Institute at the Jewish General Hospital and Professor of Neurology and Medicine at McGill University, has discovered a new pathway that holds promise for unlocking some of the mysteries of schizophrenia, a serious mental illness afflicting about one in every hundred persons and characterized by varying degrees of abnormal thought and mood, and dissociation from reality. Its causes are unknown and, though treatable, it remains incurable. Continue reading

Caffeine may ease Parkinson’s symptoms

Dr. Ronald Postuma
Caffeine, which is widely consumed around the world in coffee, tea and soft drinks, may help control movement in people suffering from Parkinson’s. This is the finding of a study conducted at the Research Institute of the McGill University Health Centre (RI MUHC) that was recently published in Neurology®, the official journal of the American Academy of Neurology. The study opens the door to new treatment options for Parkinson’s disease that affects approximately 100 000 Canadians. Continue reading

Finding may suggest new treatments for sleep disorders

John Peever Two powerful brain chemical systems work together to paralyze skeletal muscles during rapid eye movement (REM) sleep, according to new research in the July 18 issue of The Journal of Neuroscience. The finding may help scientists better understand and treat sleep disorders, including narcolepsy, tooth grinding, and REM sleep behavior disorder.

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Widely prescribed MS treatment may not slow progression of disease: Vancouver Coastal Health and UBC Research

Dr Helen Tremlett
Dr. Helen Tremlett

Researchers with the UBC Hospital MS Clinic and Brain Research Centre at Vancouver Coastal Health and the University of British Columbia have published important data in the Journal of the American Medical Association (JAMA) about the impact of a common drug therapy on the progression of multiple sclerosis for people with the relapsing-remitting form of the disease.

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Brain scans detect early signs of autism

Dr. Alan Evans

A new study shows significant differences in brain development in high-risk infants who develop autism starting as early as age 6 months. The findings published in the American Journal of Psychiatry reveal that this abnormal brain development may be detected before the appearance of autism symptoms in an infant’s first year of life. Autism is typically diagnosed around the age of 2 or 3. Continue reading