Stopping tumours in their path

Dr. Stephano Stifani
Dr. Stephano Stifani

New study sheds light on most common and deadly form of brain cancer

Glioblastoma (GBM) is the most common and deadly form of primary malignant brain cancer accounting for approximately 15% of all brain tumours and occurring mostly in adults between the ages of 45 and 70. The aggressive recurrent nature of this cancer is only temporarily contained by combined surgery, chemotherapy and radiation treatment. The recurrence of GBM is usually fatal, resulting in an average patient survival time of less than two years. A new study from the Montreal Neurological Institute and Hospital – The Neuro – at McGill University, published in Nature Communications, identifies two specific key players in the growth of GBM. Continue reading

Quality control of mitochondria as a defense against disease

Edward Fon
Dr. Edward Fon

Scientists from the Montreal Neurological Institute and Hospital in Canada have discovered that two genes linked to hereditary Parkinson’s disease are involved in the early-stage quality control of mitochondria. The protective mechanism, which is reported in The EMBO Journal, removes damaged proteins that arise from oxidative stress from mitochondria.  Continue reading

Preterm babies with slower brain growth more likely to have slower cognitive, language and motor development as toddlers

Steven Miller
Dr. Steven Miller

New research shows that preterm babies with slower brain development as they reach their due dates are more likely to have delayed cognitive, language and motor development at 18 months of age. The researchers also found that preterm babies with significant injury to the brain’s white matter were more likely to have slower motor development as toddlers. Continue reading

Boosting the immune system to treat brain cancer

Dr. V. Wee Yong
Dr. V. Wee Yong

Researchers identify mechanism implicated in brain cancer and a drug that decreases brain tumour growth

Researchers at the University of Calgary’s Hotchkiss Brain Institute (HBI) have made a discovery that could lead to better treatment for patients suffering from brain cancer.

Despite current treatment strategies, the median survival for patients with the most aggressive brain cancer – called glioblastoma, is 15 months. Less than five per cent of patients survive beyond five years. Continue reading

IRCM researchers discover a protein’s critical role in the brain

Nabil Seidah
Nabil Seidah

A team of Montréal researchers at the IRCM led by Dr. Nabil G. Seidah, in collaboration with Dr. William C. Wetsel’s team at Duke University in the United States, discovered that the protein PC7 plays a critical role in the brain by affecting certain types of cognitive performance such as anxiety, learning and emotional memory. Their results, recently published in the scientific journals Proceedings of the National Academy of Sciences (PNAS) and Nature, could have a significant impact on regulating behaviour related to anxiety disorders and trauma. Continue reading

Discovery of the gene defective in a rare developmental disorder of the brain

Dr. Jacques Michaud
Dr. Jacques Michaud

In April 2009, a Quebec family experienced the worst tragedy for parents: before the age of one, one of their sons died of a rare genetic disease causing congenital microcephaly, intellectual disability, cerebral atrophy, and refractory seizures. The event was even more tragic because it was the third infant to die in this family from the same disease.

This tragedy led Dr. Jacques Michaud, professor in the Faculty of Medecine of Université de Montréal and Doctor at CHU Ste-Justine Hospital, to discover the genetic abnormality responsible for this developmental disorder. Continue reading

Scientists find brain region that helps you make up your mind

Stan Floresco and Colin Stopper
Stan Floresco and Colin Stopper

One of the smallest parts of the brain is getting a second look after new research suggests it plays a crucial role in decision making.

A University of British Columbia study published today in Nature Neuroscience says the lateral habenula, a region of the brain linked to depression and avoidance behaviours, has been largely misunderstood and may be integral in cost-benefit decisions. Continue reading

Monocytes to the rescue

Dr. Serge Rivest
Dr. Serge Rivest

Researchers show that these immune cells attack one of the main manifestations of Alzheimer’s disease

An article published in the journal Cell Reports by researchers from Université Laval reveals the existence of a natural mechanism to prevent one of the manifestations of Alzheimer’s in the brain. Using medical imaging techniques to view live events that occur in living mice with Alzheimer’s, researchers have discovered that a type of white blood cells – patrolling monocytes – selectively attack amyloid aggregates attached to the inner lining of blood vessels in the brain. Continue reading

Disturbing the fetal brain during pregnancy impacts neural stem cell growth of offspring into adulthood

Freda Miller
Dr. Freda Miller

It is well known that there are events that happen in utero that can impact the child’s health as an adult. Changes in the maternal environment can have lasting effects for the child decades later. A new study led by The Hospital for Sick Children (SickKids) is the first to demonstrate how disturbances (like infections) during pregnancy can result in a surge of brain stem cells in offspring. The study, published in the November 7 online edition of Cell Stem Cell, shows what occurs in the brain when the fetal environment is disturbed. Continue reading

Scientists reduce behaviours associated with problem gambling in rats

Dr. Catherine Winstanley
Dr. Catherine Winstanley

With the help of a rat casino, University of British Columbia brain researchers have successfully reduced behaviours in rats that are commonly associated with compulsive gambling in humans.

The study, which featured the first successful modeling of slot machine-style gambling with rats in North America, is the first to show that problem gambling behaviours can be treated with drugs that block dopamine D4 receptors. The findings have been published in Biological Psychiatry journal. Continue reading