Multiplexing through dendritic gap junctions

Stuart Trenholm
Stuart Trenholm

How neurons communicate with each other is central to our understanding of the nervous system. Since the times of Golgi and Cajal, the roles of electrical vs. chemical forms of transmission have been much debated. While it is now well established that both electrical and chemical forms of transmission co-exist throughout the mammalian nervous system, gap junction-mediated electrical signals are found to be extremely weak compared to their chemical counterparts Continue reading

Fragile X study offers hope of new autism treatment

Nahum Sonenberg
Dr. Nahum Sonenberg

People affected by a common inherited form of autism could be helped by a drug that is being tested as a treatment for cancer, according to researchers from the University of Edinburgh and McGill University.

Fragile X Syndrome is the most common genetic cause of autism spectrum disorders. It affects around 1 in 4,000 boys and 1 in 6,000 girls. Currently, there is no cure. Continue reading

Finding “lost” languages in the brain

Denise Klein
Denise Klein

Study has far-reaching implications for unconscious role of infant experiences on adult development
An infant’s mother tongue creates neural patterns that the unconscious brain retains years later even if the child totally stops using the language, (as can happen in cases of international adoption) according to a new joint study by scientists at the Montreal Neurological Institute and Hospital – The Neuro and McGill University’s Department of Psychology. The study offers the first neural evidence that traces of the “lost” language remain in the brain. Continue reading

Total recall: the science behind it

Keith Murai
Keith Murai

MUHC-led study identifies new player in brain function and memory

Is it possible to change the amount of information the brain can store? Maybe, according to a new international study led by the Research Institute of the McGill University Health Centre (RI-MUHC). Their research has identified a molecule that puts a brake on brain processing and when removed, brain function and memory recall is improved. Published in the latest issue of Cell Reports Continue reading

Diversity among vesicles supports multilingualism in axons

Evstratova, Tóth, Chamberland
Evstratova, Tóth, Chamberland

Information is transferred from one neuron to another via synapses. This communication is mediated by neurotransmitters packaged into vesicles. These structures seem identical on electron microscopic images. However, recordings of electrical activity between neurons show that synapses operate under multiple modes of neurotransmitter release depending on the level of activity. Continue reading

Communication pathway discovered between brain neurons and immune cells

Lasse Dissing-Olesen - MacVicar Lab
Lasse Dissing-Olesen, MacVicar Lab

Findings contribute to baseline knowledge of minute-to-minute healthy brain activity.

Examining the brain when it is healthy is essential in order to understand how and why things go wrong when they do. Interested in the brain in its healthy state, Vancouver Coastal Health Research Institute investigators from the Djavad Mowafaghian Centre for Brain Health’s (DMCBH) Dr. Brian MacVicar Lab asked novel research questions about communication between the brain’s neurons and microglia, its immune cells. Continue reading

Impact of neurological conditions in Canada

impact of neurological disorders in Canada

Impact of neurological conditions in Canada

A report by the Neurological Health Charities of Canada NHCC

Mapping Connections: An understanding of neurological conditions in Canada

The National Population Health Study of Neurological Conditions

A partnership between Neurological Health Charities Canada, The Public Health Agency of Canada, Health Canada and The Canadian Institutes of Health Research.

Read the full report on the Public health agency of Canada website.