Scientists discover gene behind rare disorders

Dr. Eric Shoubridge

International study with researchers at The Neuro reveals links with other neurodegenerative diseases

Scientists at the Montreal Neurological Institute and Hospital – The Neuro,  McGill University working with a team at Oxford University have uncovered the genetic defect underlying a group of rare genetic disorders.  

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How genetics shape our addictions

Alain Dagher
Dr. Alain Dagher
Genes predict the brain’s reaction to smoking

Have you ever wondered why some people find it so much easier to stop smoking than others? New research shows that vulnerability to smoking addiction is shaped by our genes. A study from the Montreal Neurological Institute and Hospital – The Neuro, McGill University shows that people with genetically fast nicotine metabolism have a significantly greater brain response to smoking cues than those with slow nicotine metabolism. Continue reading

Kurt Haas discovers master regulator of brain plasticity

Dr Kurt Haas
Dr. Kurt Haas

Synaptic plasticity, or the ability of neurons to form, strengthen, or weaken connections with each other, has long been studied as the basis for learning and memory. While the cellular processes and biological mechanisms involved are complex, much progress has been made at the Brain Research Centre and other research institutes around the world towards understanding this dynamic brain process.

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Maternal depression affects language development in babies

Dr. Janet Werker
Dr. Janet Werker
Maternal depression and a common class of antidepressants can alter a crucial period of language development in babies, according to a new study by researchers at the University of British Columbia, Harvard University and the Child & Family Research Institute (CFRI) at BC Children’s Hospital.

Published today in the Proceedings of the National Academy of Sciences, the study finds that treatment of maternal depression with serotonin reuptake inhibitors(SRIs) can accelerate babies’ ability to attune to the sounds and sights of their native language, while untreated maternal depression can prolong the period of tuning. Continue reading

Researchers link genetic mutation to psychiatric disease and obesity

Dr. Carl Ernst
Dr. Carl Ernst
McGill researchers have identified a small region in the genome that conclusively plays a role in the development of psychiatric disease and obesity. The key lies in the genomic deletion of brain-derived neurotrophic factor, or BDNF, a nervous system growth factor that plays a critical role in brain development.

To determine the role of BDNF in humans, Carl Ernst, PhD, from McGill’s Department of Psychiatry, Faculty of Medicine, screened over 35,000 people referred for genetic screening at clinics and over 30,000 control subjects in Canada, the U.S., and Europe. Continue reading

A Memorable Protein

Paul De Koninck, Mado Lemieux
Lemieux, De Koninck

Researchers demonstrate the key role played by a protein in learning and memory

Learning and remembering are based on molecular mechanisms that are still poorly understood. According to some experts, information is stored in the brain and reactivated as required by strengthening synapses that link neurons together. The strength of these links depends on the abundance of neurotransmitters, receptors, and of all other molecules involved in chemical transmission of information. Continue reading

Eye test helps diagnose neurological disorders

Douglas Munoz
Dr. Douglas Munoz

A new test that measures eye movement while watching television helps detect neurological disorders earlier including Parkinson’s disease, fetal alcohol spectrum disorder, autism and attention deficit hyperactivity disorder.

The low-cost test, developed at Queen’s University and the University of Southern California, provides new insight into how specific disorders affect attention.

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Astrocytes: The superheroes of brain cells

Brian MacVicar
Dr. Brian MacVicar

Eight years ago, Brian MacVicar discovered that astrocytes—cells that surround nerve cells and all blood vessels in the brain—have a primary role in regulating blood flow within the brain, which provided a new target for potential therapies for stroke, migraine, and vascular dementia. Now he and Hyun Beom Choi, a research associate in his lab, have uncovered a new role for this heroic brain cell: detecting problems in the brain and delivering nutrients to keep brain cells healthy in times of critical need. Continue reading

“Using your Brain” video receives honorable mention from SfN

Using your brain

The Brain Awareness Video Contest is organized by SfN to provide videos to the public on various topics related to the brain and nervous system. This year, the honorable mention place winner is Kenneth Dyson who made his video with help from his two sons (6 and 12 year-old Taj and Deszmo). Kenneth is a postdoctoral fellow at Université de Montréal. His video, Using Your Brain, can be viewed here. Vote for his video for the Brain Awareness Week People’s choice award!

LDI researcher develops promising model for schizophrenia

Dr. Hyman Schipper
Dr. Hyman Schipper, a neurologist and researcher at the Lady Davis Institute at the Jewish General Hospital and Professor of Neurology and Medicine at McGill University, has discovered a new pathway that holds promise for unlocking some of the mysteries of schizophrenia, a serious mental illness afflicting about one in every hundred persons and characterized by varying degrees of abnormal thought and mood, and dissociation from reality. Its causes are unknown and, though treatable, it remains incurable. Continue reading