Katalin Toth - Alyson Fournier new CAN executives Tuan Trang and Mike Sapieha - CAN Young Investigator winners for 2017 Canadian Neuroscience Research luncheon in Parliament impact of neurological disorders in Canada

 

CAN-ACN news

For Neil who is living with dystonia, fundamental research offers hope and partial relief.

Neil Merovitch is an impressive and resilient young man who has very personal reasons to believe in the importance of fundamental research.  At a young age, he was diagnosed with dystonia, a devastating disease in which normal movement is impaired due to neurological dysfunction. Individuals with this condition deal with sustained or repetitive, and often painful, muscle contractions.

Yet from the moment you meet Neil, his passion for fundamental research is clear. “I’ve always been interested in research,” he says. “It’s fascinating for me to explore the link between brain and behaviour each and every day.”  And dystonia does not prevent him from pursuing his goal, which is to obtain a PhD in neuroscience and physiology from the University of Toronto.

Sick Kids Researchers Have Found An Unexpected Twist in How Our Brains Develop

One example of the latter recently came from the joint laboratory of Freda Miller and David Kaplan, at the Hospital for Sick Children in Toronto. They found that a type of cell known for transmitting information between nerve cells also plays another vital role. It instructs stem cells that build the brain to make another type of cell called an oligodendrocyte. This cell is crucial for making sure communication and information transmission in the brain happen at the right time in the right place. The results were published in the journal, Neuron, http://www.cell.com/neuron/fulltext/S0896-6273(17)30344-6.

McGill Researchers Have Found A Possible Path For Treatment of Fragile X Syndrome

There is no denying autism spectrum disorders, commonly known as ASD, have become some of the world’s greatest health concerns. But what most people do not know is the incredible complexity of these conditions. As researchers have found, the problems are not singular in nature. Rather, they are a consequence of several changes in the way the cells of the brain function. This reality has forced ASD researchers to head deep into the molecular level of the brain in the hope of understanding what is happening in those affected.

Neuroscience news

Muscle function regained in CRISPR-treated mice with congenital muscular dystrophy, SickKids study finds

Ronald Cohn

Ronald Cohn

Scientists at The Hospital for Sick Children (SickKids) have used the gene-editing tool CRISPR to correct a disease-causing mutation in mice with a form of congenital muscular dystrophy, MDC1A. The findings, published in the July 17 online edition of Nature Medicine, show significant improvement in muscle strength and function among the mice treated with CRISPR, with no remaining signs of paralysis.

MDC1A is a rare neuromuscular disease affecting one in 150,000 worldwide. It is caused by a mutation in a gene called laminin alpha 2 and is characterized at birth by muscle weakness and low muscle tone, as well as brain abnormalities. Babies born with this condition eventually lose all muscle function and live an average of 30 years.

Brains are more plastic than we thought

Chris Pack

Chris Pack

Researchers train brains to use different regions for same task

Practice might not always make perfect, but it’s essential for learning a sport or a musical instrument. It’s also the basis of brain training, an approach that holds potential as a non-invasive therapy to overcome disabilities caused by neurological disease or trauma.

Research at the Montreal Neurological Institute and Hospital of McGill University (The Neuro) has shown just how adaptive the brain can be, knowledge that could one day be applied to recovery from conditions such as stroke.

Making information meaningful leads to better memory

Jed Meltzer

Jed Meltzer

When trying to memorize information, it is better to relate it to something meaningful rather than repeat it again and again to make it stick, according to a recent Baycrest study published in NeuroImage.

“When we are learning new information, our brain has two different ways to remember the material for a short period of time, either by mentally rehearsing the sounds of the words or thinking about the meaning of the words,” says Dr. Jed Meltzer

Brain area involved in addiction activated earlier than previously thought in recreational cocaine users

Marco Leyton

Marco Leyton

Non-dependent users also experience dopamine release in response to drug cues

Even among non-dependent cocaine users, cues associated with consumption of the drug lead to dopamine release in an area of the brain thought to promote compulsive use, according to researchers at McGill University.

The findings, published in Scientific Reports, suggest that people who consider themselves recreational users could be further along the road to addiction than they might have realized.