New research from the University of British Columbia suggests that following a strict eating schedule can help clear away the protein responsible for Huntington disease in mice.
Huntington disease (HD) is an inherited, progressive disorder that causes involuntary movements and psychiatric problems. Symptoms appear in adulthood and worsen over time. Children born to a parent with HD have a one in two chance of inheriting the disease, which is caused by a buildup of mutant huntingtin protein (mHTT).
Eight years in the making, a discovery by neuroscientists at the CRCHUM highlights the value of long-term, fundamental research and provides important information for future drug targets.
It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), works.
McMaster University Scientists have published 2 studies identifying which gene is responsible for causing brain development disorders when several genes are deleted in an individual’s genome, providing a path forward for developing new therapies.
In Ontario, there are more than 300,000 children and youth affected by a neurodevelopmental disorder such as autism spectrum disorders, attention deficit hyperactivity disorder, and intellectual disability. These disorders typically cause long-term problems and impact the day-to-day life of affected individuals and families. There are no specific treatments, and medications have side-effects that can be severe in children and young adults.
Researchers at Western University have uncovered a unique neurobiological pathway triggered by head trauma which underlies both Chronic Traumatic Encephalopathy (CTE) and amyotrophic lateral sclerosis (also called ALS or Lou Gehrig’s Disease).
CTE is a fatal neurodegenerative disease shown to be a result of repeated head trauma, and is associated with elite athletes involved in contact sports. Previous research has shown that between 4 and 6 per cent of patients with CTE will also simultaneously show clinical features of ALS – that’s 800 fold higher than the prevalence of ALS in the general population.
New research could provide clinicians with insights regarding clinical progression to dementia
Doctors who work with individuals at risk of developing dementia have long suspected that patients who do not realize they experience memory problems are at greater risk of seeing their condition worsen in a short time frame, a suspicion that now has been confirmed by a team of McGill University clinician scientists.
Concussion affects the developing adolescent brain and may delay key cognitive processes, hampering the brain’s ability to change focus and pay attention. New research from Dr. Naznin Virji-Babul’s team, published today in the journal ASN Neuro, shows that concussion changes the way that different neural networks interact, stalling the brain in a state of cognitive inflexibility.
Even at rest, the brain is continuously active, processing and exchanging information. This active interaction between different parts of the brain is necessary for a person to be aware of her surroundings, or to be able to focus on his work or switch between tasks.