Scientists at the Research Institute of the McGill University Health Centre (RI-MUHC) and Duke University have made a breakthrough that advances our understanding of how the brain detects and prevents dehydration.
They have identified the structure of a key protein located in the brain, which is involved in body hydration and that could control temperature.
New research conducted in the laboratory of Louis-Éric Trudeau at the Université de Montréal helps explain why some neurons in the brain are specifically affected and die in Parkinson’s disease. His team found that the death of neurons affected by Parkinson’s, including some found in regions called the substantia nigra (literally “the black substance”), the locus ceruleus and the dorsal nucleus of the vagus nerve, may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating movement.
A new study by Karl Fernandes, a researcher at the CRCHUM and a professor at Université de Montréal linking abnormal fast deposits in the brain and the development of Alzheimer’s disease. “We found fatty acid deposits in the brain of patients who died from the disease and in mice that were genetically modified to develop Alzheimer’s disease. Our experiments suggest that these abnormal fat deposits could be a trigger for the disease”, said Karl Fernandes.
“Our study shows the importance of understanding environmental influences on the developing brain in early life” says Dr Tomas Paus, of the University of Toronto’s department of psychiatry. “Given the solid epidemiologic evidence supporting a link between cannabis exposure during adolescence and schizophrenia, we investigated whether the use of cannabis during early adolescence (by 16 years of age) is associated with variations in brain maturation as a function of genetic risk for schizophrenia,”
Cerebral palsy (CP) is the most common cause of physical disability in children. Every year 140 children are diagnosed with cerebral palsy in Quebec.
It has historically been considered to be caused by factors such as birth asphyxia, stroke and infections in the developing brain of babies. In a new game-changing Canadian study, a research team from The Hospital for Sick Children (SickKids) and the Research Institute of the McGill University Health Centre (RI-MUHC) has uncovered strong evidence for genetic causes of cerebral palsy that turns experts’ understanding of the condition on its head.
A brief period of postnatal visual deprivation, when early in life, drives a rewiring of the brain areas involved in visual processing, even if the visual restoration is completed well before the baby reaches one year of age, researchers at the University of Trento, McMaster University, and the University of Montreal revealed today in Current Biology.