Scientists have known for years that blood vessel loss in the brain impacts cognitive decline as people age. New research from the University of Victoria has provided an explanation for why we lose blood vessels—vital knowledge that could lead to better preventive and protective strategies for maintaining brain health.
UVic neuroscientist Craig Brown and PhD student Patrick Reeson have been researching the phenomenon of clogged capillaries, the brain’s smallest blood vessels. These tiny capillaries routinely get “stuck,” clogged by cells, fat and debris in the blood. Most clear within seconds to minutes, however some can remain stuck for much longer, but what ultimately happens to these lingering clogs has remained a mystery.
Invitation to participate in a research study on vulnerability in mental health research ethics
National study on vulnerability in mental health and psychiatric research
Does a mental health condition prevent someone from being able to participate to research?
What are acceptable conditions for ethical mental health and psychiatric research?
New research from the University of British Columbia suggests that following a strict eating schedule can help clear away the protein responsible for Huntington disease in mice.
Huntington disease (HD) is an inherited, progressive disorder that causes involuntary movements and psychiatric problems. Symptoms appear in adulthood and worsen over time. Children born to a parent with HD have a one in two chance of inheriting the disease, which is caused by a buildup of mutant huntingtin protein (mHTT).
Eight years in the making, a discovery by neuroscientists at the CRCHUM highlights the value of long-term, fundamental research and provides important information for future drug targets.
It took eight long years of research, but now an international team led by neuroscientists at Université de Montréal has discovered a basic molecular mechanism that better helps understand how Lou Gehrig’s disease, or amyotrophic lateral sclerosis (ALS), works.
McMaster University Scientists have published 2 studies identifying which gene is responsible for causing brain development disorders when several genes are deleted in an individual’s genome, providing a path forward for developing new therapies.
In Ontario, there are more than 300,000 children and youth affected by a neurodevelopmental disorder such as autism spectrum disorders, attention deficit hyperactivity disorder, and intellectual disability. These disorders typically cause long-term problems and impact the day-to-day life of affected individuals and families. There are no specific treatments, and medications have side-effects that can be severe in children and young adults.
Researchers at Western University have uncovered a unique neurobiological pathway triggered by head trauma which underlies both Chronic Traumatic Encephalopathy (CTE) and amyotrophic lateral sclerosis (also called ALS or Lou Gehrig’s Disease).
CTE is a fatal neurodegenerative disease shown to be a result of repeated head trauma, and is associated with elite athletes involved in contact sports. Previous research has shown that between 4 and 6 per cent of patients with CTE will also simultaneously show clinical features of ALS – that’s 800 fold higher than the prevalence of ALS in the general population.