A Postdoctoral Researcher position funded by the Canadian Institutes of Health Research is available in the laboratory of Dr. Beverley Orser (www.orserlab.com). The lab is located in the Department of Physiology at the downtown campus of the University of Toronto.
The goal of the research is to understand physiologic and pathological processes underlying learning and memory, and to identify the mechanisms that contribute to a decline in brain function after anesthesia and surgery. Studies will focus on neurons and glia in the hippocampus and cortex. The long-term goal is to develop novel treatments that target subtypes of inhibitory receptors for cognitive disorders after anesthesia and surgery, as well as for inflammation-induced cognitive dysfunction and mood disorders.
Qualifications:
We are looking for a highly motivated and enthusiastic scientist with the following skills and experience:
- Ph.D. in Chemistry/Biochemistry/Biophysics/Molecular Cell Biology.
- Strong background in molecular biology, protein chemistry, and biochemistry.
- Highly experienced in DNA, RNA and protein handling and analysis techniques.
- Technical proficiency in the areas of protein biochemistry, including: protein expression, purification and characterization using SDS-PAGE, HPLC/FPLC; characterizing protein-ligand and protein-protein interactions using affinity chromatography.
- Ability to work independently with strong problem-solving skills.
- Must demonstrate a good understanding of scientific principles, experimental design, and proper laboratory techniques.
Desirable experience and skills:
- Carry out assays such as Bradford, ELISA’s and cell-based assays.
- Knowledge in protein biophysical analysis.
- Basic knowledge in structural biology (X-ray crystallography/Cryo-EM/NMR spectroscopy).
- Basic knowledge of bioinformatics tools and site-directed mutagenesis.
- Knowledge in basic tissues culture techniques is a plus.
- Prior experiences with animal behavioral assays, electrophysiology, and optogenetics are assets.
- Design and execute experiments to support research activities and projects in the lab.
The laboratory provides an excellent training environment and we are strongly committed to training high-quality researchers who are interested in advancing translational neuroscience. The laboratory is also strongly committed to diversity within the communities and especially welcomes applications from racialized persons/persons of color, women, indigenous/Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas. All qualified candidates are encouraged to apply; however, Canadian citizens and permanent residents will be given priority.
Contact information
Please send your application (a Cover Letter, a CV and the names of three references) to Dr. Dianshi Wang (dianshi.wang@utoronto.ca).
