The Macauley lab is accepting applications for a Postdoctoral fellow or Research Associate in the area of neuroimmunology. Research in the lab focuses on the role of Siglec family of immunomodulatory glycan-binding receptors in human health and disease. The lab is located in the Gunning/Lemieux Chemistry center at University of Alberta and is part of the Neuroscience and Mental Health Institute (NHMI) and Alberta Glycomics Institute (GIA). Additionally, we are strongly connected to the Canadian Glycomics Network (GlycoNet), and strong collaboration with experts in studying microglia (Drs. Plemel, Voronova, Sipione), biochemistry of brain in health disease (Drs. Julien, Sim), and animal behavior (Dr. Tan).
Working within a highly interdisciplinary environment, the fellow will lead projects related to the role of an Alzheimer’s disease susceptibility factor, CD33, in disease pathogenesis, as well as development of novel CD33-based therapeutics in this context (PMID:35940942). Transgenic models (PMID:33766097, PMID:31815204, PMID: 38802940), as well as cell models combined with biochemical tools (PMID:34517042) are readily available in our laboratory for working on this exciting project that is closely connected to human disease. Funding through multiple sources – National, Societal, and Industry-sponsorship – is in place to advance our goal of understanding the cellular and molecular mechanisms by which Siglecs impact the function of microglia in the brain.
The position requires a Ph.D. in one of the following disciplines: neurobiology, immunology, chemical biology, biochemistry, or other related fields. Candidates should have a record of completed graduate research that can be directly applied to the field of interest described above. Prior experience with transgenic mouse models of neurodegeneration, including genetics/genotyping, handling, cell culture, microscopy (including immunohistochemical techniques) and biochemical techniques are highly desirable. The ideal candidate must demonstrate excellent laboratory skills, independence, and resourcefulness. Candidates must possess strong communication and organizational skills manifested with proven track records including peer-reviewed publications. The position will be appointed at the level that is commensurate with the education and experience of the individual candidate and is for a period of one year with the possibility of renewal.
We are committed to an equitable, diverse, and inclusive workforce, and therefore welcome applications from all qualified persons. Please email your CV and a brief cover letter to Dr. Macauley (macauley@ualberta) along with the names of 3 potential references.
Contact information
Matthew Macauley (macauley@ualberta.ca )
Posting end date 2025/03/15
