Program 2022

This is a preliminary program, subject to change and updates.

Wednesday, May 11

CAN public lectures:

Starting at 5 PM

Focused ultrasound to transiently open the blood brain barrier for therapeutics

Presenters:

Isabelle Aubert, Sunnybrook Research Institute
Kullervo Hynynen, Sunnybrook Research Institute
Nir Lipsman, Sunnybrook Research Institute

Virtual event – get your ticket here

Day 1 : Thursday, May 12

In person at the Sheraton Toronto Centre

9:00 AM – 4:00 PM	CAN Satellite symposia Symposium on Graduate Neuroscience Education in Canada Neural stem cells: from function to dysfunction GABAergic inhibitory circuits in health and disease Canadian Neurophotonics Platform Satellite meeting
5:00 – 5:15 PM	Welcome and Opening Remarks by Shernaz Bamji, President of the Canadian Association for Neuroscience
5:15 – 6:15	Presidential Lecture Making up your mind: the intimate dependence and remarkable precision of cortical interneurons Gordon Fishell, Harvard Medical School
6:15 – 8:00	Opening Reception

Day 2: Friday, May 13

In person at the Sheraton Toronto Centre

8:30 – 10:15 AM	Plenary symposium 1 Mitochondrial function and dysfunction in Parkinson’s disease: insights from native and model cells Chair: Louis-Eric Trudeau, Université de Montréal Speakers : Mechanisms of metabolic dysfunction in synucleinopathies Scott Ryan, University of Guelph Mitochondrial dysfunction in idiopathic Parkinson’s disease, what can patient-derived induced neurons tell us? Janelle Drouin-Ouellet, Université de Montréal Mitochondrial dysfunction in dopamine neurons in Parkinson’s disease: at the interface of cell-autonomous and non-cell autonomous mechanisms Louis-Eric Trudeau, Université de Montréal
10:15 – 10:30	CIHR-INMHA Update Sam Weiss
10:30 – 10:45	Coffee break Posters/exhibits
10:45 – 11:45	Featured Plenary speaker 1 Decoding Parkinson’s disease Valina Dawson, Johns Hopkins
11:45 – 12:00	Brain Star Award presentation 1 Xuming Yin \| University of Ottawa Delayed motor learning in a 16p11.2 deletion mouse model of autism is rescued by locus coeruleus activation
12:00 – 1:30	Advocacy lunch (pre-registration required) Science Advocacy – Why it matters, and how you can participate
1:30 – 3:00	Parallel symposia PS1 Novel Sources of neurogenesis in vivo and in response to neurological injury Chair: Jing Wang \| Ottawa Hospital Research Institute Speakers: Direct neuronal reprogramming by temporal identity factors Michel Cayouette \| Montreal Clinical Research Institute Recruiting quiescent neural stem cells in the injured spinal cord Karl Fernandes \| University of Sherbrooke Direct lineage reprogramming strategies for CNS repair Maryam Faiz \| University of Toronto Ischemic injury induces reprogramming and local neural regeneration in the adult brain Jing Wang \| Ottawa Hospital Research Institute PS2 The amygdala and the response to reward cues Sponsored by CERVO Brain Research Centre Chair: Anna Samaha \| Université de Montréal Speakers: Acetylcholine Dynamics in the BLA During Reward Learning Marina Picciotto \| Yale School of Medicine Approach behaviours and instrumental pursuit triggered by appetitive cues: role of the basolateral amygdala Anne-Noel Samaha \| Université de Montréal Optogenetic excitation of central amygdala amplifies ‘wanting’ but not ‘liking’ for sucrose reward Shelley Warlow \| University of California San Diego Amygdala mechanisms distinguishing addiction vulnerability phenotypes Donna Calu \| University of Maryland School of Medicine PS3 The diverse roles of glia in stress and metabolic disorders Sponsored by the Brain Repair and Integrative Neuroscience Program (BRaIN) Program at the RI-MUHC Chair: Thierry Alquier \| University of Montreal Speakers: Astroglial endozepines in the hypothalamic control of energy homeostasis Thierry Alquier \| University of Montreal The role of astrocytes in stress-induced cognitive dysfunction Ciaran Murphy-Royal \| University of Montreal Role of the leptin receptor expressing pericyte in energy balance and beyond Maia Kokoeva \| McGill University Glia-Neuronal interaction in Health and Salt-induced Hypertension Masha Prager-Khoutorsky \| McGill University PS4 Neuronal dynamics underlying memory in the input and output structures of the hippocampus. Chair: Adrien Peyrache \| McGill University Speakers: Not just a compass: the role of the head-direction system in learning and memory during sleep. Adrien Peyrache \| McGill University Network-level contribution of adult-born neurons to hippocampal population dynamics David Dupret \| University of Oxford Prefrontal neuronal dynamics supporting memory integration and transformation. Kaori Takehara-Nishiuchi \| University of Toronto
3:00 – 3:30	Coffee break
3:30 – 5:30PM	Poster session 1 & Exhibits
5:30 – 7:00	Presentation: Martin Meyer – Scientific Programme Director – The Brain Prize Brain Prize lecture: From CADASIL to other cerebral small vessel diseases. How genetics can inform pathophysiological pathways Elisabeth Tournier-Lasserve, Université Paris Diderot
7:30 – 9:30	CAN Student Social Sponsored by the Hotchkiss Brain Institute The Pint Public House – 277 Front St. West, Toronto, On, M5V 2X4 – wear your meeting badge to get in

Day 3: Saturday, May 14

In person at the Sheraton Toronto Centre

8:30 – 10:15 AM	Plenary symposium 2 Neurovascular coupling in health and disease: what we know and what we need to know Chair: Adriana Di Polo, Université de Montréal Speakers Optical dissection of brain pericytes and capillary function during aging Andy Shih, Seattle Children’s Hospital Neurovascular coupling and functional connectivity in Alzheimer’s disease mice: Effects of pharmacotherapy. Edith Hamel, McGill University Inter-pericyte tunneling nanotubes: at the heart of neurovascular dysfunction in optic neuropathies Adriana Di Polo, Université de Montréal
10:15 – 10:20	Brief update Viviane Poupon, President and CEO, Brain Canada
10:20 – 10:45	Coffee break Posters/exhibits
10:45 – 11:45	Featured Plenary speaker 2 Rescuing cerebral blood flow deficits in small vessel disease Mark Nelson, University of Vermont
11:45 – 12:00	Brain Star Award presentation 2 Yash Patel \| University of Toronto, NIH Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders
12:00 – 12:30
12:30 – 1:30	Equity, Diversity and Inclusion committee event: Picture A Scientist Panel Discussion
1:30 – 3:00	Parallel symposia PS5 Alternative splicing in the health and disease of the mammalian brain Chair: Derek Bowie \| McGill University Speakers: Cell-specific epigenetic control of calcium ion channel splicing and function E. Javier Lopez Soto \| North Carolina State University Gain control of LTP and learning by alternative splicing of the GluN1 subunit of NMDA receptors Ameet Sengar \| Hospital for Sick Children Alternative splicing of AMPA receptor signalling complexes Amanda Perozzo \| McGill University A splicing code reveals an expanded landscape of brain microexons with direct genetic links to autism Benjamin Blencowe \| University of Toronto PS6 Understanding dynamic neural circuit activity during defensive behavior with optical recording methods Sponsored by CERVO Brain Research Centre Chair: Robert Rozeske \| University of Toronto Speakers: Serotonergic modulation of ventral hippocampus underlies sex-related differences in anxiety Bénédicte Amilhon \| Université de Montréal Sex differences in neural representation of threat in ventral hippocampal and prefrontal cortical projections to nucleus accumbens Jessie Muir \| McGill University Synaptic transmission at the lateral habenula neural outputs in normal and pathological conditions Christophe Proulx \| Université Laval Dorsal hippocampus neuronal activity during context fear discrimination Robert Rozeske \| University of Toronto PS7 Cueing Factors in Addiction Sponsored by the Djavad Mowafaghian Centre for Brain Health Chair: Jennifer Murray \| University of Guelph Speakers: Morphine learned as an interoceptive stimulus causes sex- and task-dependent alterations in subsequent morphine reinforcement and reward in rats. Jennifer Murray \| University of Guelph Interoceptive correlates of acute alcohol administration and future clinical avenues Mateo Leganes-Fonteneau \| Rutgers University Differences in alcohol cue reactivity based on the social context Samuel Acuff \| The University of Memphis Contribution of Cues to Concurrent Decision-Making Justin Strickland \| Johns Hopkins University PS8 Balancing Tensions between Proprietary Research, Open Neuroscience, and Human Rights Sponsored by Vision: Science to Applications (VISTA) York University Chair: Judy Illes \| University of British Columbia Speakers: Primer on patenting of neurotechnologies from the Canadian perspective Zelma Kiss \| University of Calgary Insights from the DMCBH Open Science Initiative: an open science buy-in project in action Jeffrey LeDue \| University of British Columbia Neuromodulation Patents: a landscape analysis from 2016 through 2020 Ari Rotenberg \| University of British Columbia Perspectives on Intellectual Property Protections and Open Neuroscience Ashley Lawson \| University of British Columbia
3:00 – 3:30	Coffee break
3:30 – 5:30	Posters session 2 and Exhibits
5:30 – 6:00	New investigator award lecture Sponsored by Neuroscience and Mental Health Institute Boris Bernhardt, McGill University
6:00 – 7:00	Keynote Lecture Sponsored by SickKids Neurosciences & Mental Health Research Program AND the SickKids Garry Hurvitz Centre for Brain & Mental Health Mechanisms of Axon Growth and Regeneration Frank Bradke, German Center for neurodegenerative diseases

Day 4: Sunday, May 15

8:30 – 10:15 A.M.	Plenary symposium 3 Cannabinoids and endocannabinoids in the context of neurological and psychiatric disorders Chair: Matthew Hill, University of Calgary Speakers: Synaptic dysfunction and altered plasticity in Huntington disease: Role of endocannabinoids Lynn Raymond, University of British Columbia Endocannabinoids, Astrocytes and the Social Transmission of Stress Jaideep Bains, University of Calgary Endocannabinoids, the Amygdala and the Regulation of Stress and Anxiety Matthew Hill, University of Calgary
10:15 – 10:20	Brief update Jennie Young, Executive Director, Canadian Brain Research Strategy
10:20 – 10:45	Posters/exhibits Coffee break
10:45 – 11:45	Featured Plenary speaker 3 Surprising Origins of Sex Differences in the Brain Margaret (Peg) McCarthy, University of Maryland Baltimore
11:45 – 12:00 PM	Brain Star Award presentation 3 Archana Gengatharan \| Université Laval – Marlene Reimer Brain Star of the year award winner Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics
12:00 – 1:30 PM	CAN-ACN Annual General Meeting of members Career Networking event Lunch on own
1:30 – 3:30	Poster session 3 & Exhibits
3:30 – 5:00	Parallel symposia PS9 Systemic Inflammation and the Brain: Interactions with Glia and Neurons Sponsored by the Djavad Mowafaghian Centre for Brain Health Chairs: Alexander Lohman \| University of Calgary & Jo Anne Stratton \| Montreal Neurological Institute Speakers: The danger of brain infections: Microglia cell death is required for optimal immunity to Toxoplasma gondii in the CNS Tajie Harris \| University of Virginia The potential contribution of systemic inflammation in neuropathic pain Ji Zhang \| McGill University The role of ependymal cells in regulating CNS inflammation Jo Anne Stratton \| Montreal Neurological Institute (MNI) Versican as a potential inhibitor of remyelination: proposed mechanisms through impeding oligodendrocytes and promoting Th17 cytotoxic neuroinflammation Samira Ghorbanigazar \| University of Calgary PS10 Sleep perturbations in Alzheimer’s disease patients and animal models Co-Chairs : Valérie Mongrain \| Université de Montréal & Jonathan Brouillette \| Université de Montréal Speakers: Cognitive, Histological, and Transcriptional Correlates of Sleep Fragmentation in Older Adults Andrew Lim \| University of Toronto Ambulatory EEG sleep monitoring in Alzheimer disease: A Pilot Study Brianne Kent \| Simon Fraser University Potential Role of Orexin Receptor Antagonists in the Treatment of Sleep Disorders Associated with Alzheimer’s Disease Margaret Moline \| Eisai Alterations in wakefulness and sleep quality in animal models of amyloid-beta derived neurodegeneration Jonathan Brouillette \| Université de Montréal PS11 Canadian Cannabis and Psychosis Research Team (CCPRT): Multi-disciplinary investigations of the underlying neurobiology of the link between cannabis and psychosis Chair: Jeremy Watts \| CHU Sainte-Justine/Universite de Montreal Speakers: Impact of cannabis use on brain maturation in a Canadian longitudinal cohort Jeremy Watts \| CHU Sainte-Justine/Universite de Montreal Sexually dimorphic effects of THC in adolescence: from dysregulation of dopamine guidance cues to changes in cognitive control Giovanni Hernandez \| Mcgill University Anxiety Mediates the Relationship Between Cannabis Use Frequency and Psychotic-Like Experiences in Emerging Adult Females Haley Bernusky & Phil Tibbo \| Dalhousie University PS12 Arousal related brain circuits and their role in sensory processing and behaviour. Sponsored by CERVO Brain Research Centre Chair: Jesse Jackson \| University of Alberta Speakers: Spatiotemporal dynamics and targeted functions of locus coeruleus norepinephrine Vincent Breton-Provencher \| University of Laval The role of hypocretin/orexin neurons in social behaviour Derya Sargin \| University of Calgary Interneuron contributions to state-dependent sensory processing Katie Ferguson \| Yale University Investigating the role of the claustrum in the control of behavioral state Jesse Jackson \| University of Alberta