Published in Nature Communications, their study shows that small conductance calcium-activated potassium (SK) channels regulate and optimize sensory neural responses to natural stimuli. Changes in SK channel conductance disrupted neural tuning, which in turn compromised optimality of coding and behavioral responses. These results thus reveal an elegant computation by which the brain can adapt to changes in natural stimulus statistics, which is critical for understanding brain function at large.
Original research article:
Huang CG, Zhang ZD, Chacron MJ. Temporal decorrelation by SK channels enables efficient neural coding and perception of natural stimuli. Nat Commun. 2016 Apr 18;7:11353. doi: 10.1038/ncomms11353. (OPEN)