Sleep behaviour disorder linked to brain disease

Dr. John Peever
John Peever

Researchers at the University of Toronto say a sleep disorder that causes people to act out their dreams is the best current predictor of brain diseases like Parkinson’s and many other forms of dementia.

“Rapid-eye-movement sleep behaviour disorder (RBD) is not just a precursor but also a critical warning sign of neurodegeneration that can lead to brain disease,” says associate professor and lead author Dr. John Peever. In fact, as many as 80 to 90 per cent of people with RBD will develop a brain disease.” Continue reading

Researchers uncover ways to help cells survive after a stroke

Ruth Slack
Ruth Slack

Researchers from the uOttawa Brain and Mind Research Institute have made an important discovery in stroke research that could significantly advance recovery for patients. Their findings were published in the prestigious journal Nature Communications on April 1, 2014.

When a person suffers a stroke, oxygen—a vital component for cell survival in the human brain—is cut off. This loss of oxygen not only causes immediate cell death in the primary stroke area, but also puts the cells in the surrounding areas at risk. If their ability to produce energy is not restored, they will eventually die. With this in mind, researchers worked to understand what happens to cellular energy production in affected cells and what could be done to help salvage them. Continue reading

Scientists discover brain’s anti-distraction system

John McDonald
John McDonald

Two Simon Fraser University psychologists have discovered that our brains have an active suppression mechanism that helps us avoid distraction when we want to focus on a particular item or task.

Their study is the first to identify this mechanism, which they say could revolutionize doctors’ perception and treatment of attention-deficit disorders. Continue reading

Pain curbs sex drive in female mice, but not in males

Jeffrey Mogil
Jeffrey Mogil

Findings could help scientists study pain-inhibited sexual desire in humans

“Not tonight, dear, I have a headache.” Generally speaking, that line is attributed to the wife in a couple, implying that women’s sexual desire is more affected by pain than men’s.

Now, researchers from McGill University and Concordia University in Montreal have investigated, possibly for the first time in any species, the direct impact of pain on sexual behaviour in mice. Their study, published in the April 23 issue of The Journal of Neuroscience, found that pain from inflammation greatly reduced sexual motivation in female mice in heat — but had no such effect on male mice. Continue reading

Noisy brain signals: How the schizophrenic brain misinterprets the world

Christopher Pack
Christopher Pack

People with schizophrenia often misinterpret what they see and experience in the world. New research provides insight into the brain mechanisms that might be responsible for this misinterpretation. The study from the Montreal Neurological Institute and Hospital – The Neuro – at McGill University and McGill University Health Centre, reveals that certain errors in visual perception in people with schizophrenia are consistent with interference or ‘noise’ in a brain signal known as a corollary discharge. Continue reading

Parkinson’s disease: Quickly identifying patients at risk of dementia

Dr. Oury Monchi
Dr. Oury Monchi

It may now be possible to identify the first-stage Parkinson’s patients who will go on to develop dementia, according to a study conducted at the Institut universitaire de gériatrie de Montréal by Dr. Oury Monchi, PhD, and his postdoctoral student, Dr. Alexandru Hanganu, MD, PhD, both of whom are affiliated with Université de Montréal. These findings were published in the journal Brain. Continue reading

Scientists catch brain damage in the act

Brian MacVicar
Brian MacVicar

Scientists have uncovered how inflammation and lack of oxygen conspire to cause brain damage in conditions such as stroke and Alzheimer’s disease.

The discovery, published today in Neuron, brings researchers a step closer to finding potential targets to treat neurodegenerative disorders. Continue reading

Learning new ideas alters brain cells

Shernaz Bamji
Shernaz Bamji

A new University of British Columbia study identifies an important molecular change that occurs in the brain when we learn and remember.

Published this month in Nature Neuroscience, the research shows that learning stimulates our brain cells in a manner that causes a small fatty acid to attach to delta-catenin, a protein in the brain. This biochemical modification is essential in producing the changes in brain cell connectivity associated with learning, the study finds. Continue reading