Lost in translation: how gene expression diverges between humans and macaque model systems
Among all model organisms studied in neuroscience, the macaque is genetically closest to humans. Genetic similarity is paramount because genes exert powerful influences on brain organization, function, and dysfunction. But the potential for research to find applications in the clinic, that is its translational value, rests on the untested assumption that gene expression in the macaque follows the same organisation as human genes. Work by Andrea Luppi, working in the laboratory of Bratislav Misic at the Montreal Neurological Institute, provides the first systematic benchmarking of macaque gene expression in the cerebral cortex to investigate how similar, or different, brain expression is in the two species.
Continued – read the full story here: https://can-acn.org/brain-star-award-winner-andrea-luppi-2/
Read the original research article:
Andrea I. Luppi, Zhen-Qi Liu, Justine Y. Hansen, Rodrigo Cofre, Meiqi Niu, Elena Kuzmin Seán Froudist-Walsh, Nicola Palomero-Gallagher, and Bratislav Misic. Benchmarking macaque brain gene expression for horizontal and vertical translation. Science Advances, 11(9), eads6967 (2025). DOI: 10.1126/sciadv.ads6967
