CAN2023 Meeting – Hotel Bonaventure Montréal
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Saturday, May 27, 2023
CAN public lectures – Diet, Obesity and the Brain
Date: May 27, 2023, 2PM-3:30PM
Location: Auditorium – Grande Bibliothèque, 475 Boul. de Maisonneuve E, Montréal, QC H2L 5C4
- Patricia Pelufo-Silveira, MD, MSc, PhD: Early environment, food preferences and life-long health
- Stephanie Fulton, PhD: Dietary and metabolic threats to anxiety and depression prevalence
- Alain Dagher, MD: Obesity and the Brain (presentation in French, but speaker will answer questions in French and English)
Day 1: Sunday, May 28
| 9:00 AM – 4:00 PM |
CAN Satellite symposia
|
| 5:00 – 5:15 PM |
Welcome and Opening Remarks by
Keith Murai, President of the Canadian Association for Neuroscience |
| 5:15 – 6:15 |
Presidential Lecture
Modeling human brain development with stem cells and organoids: past, present, and future
Flora Vaccarino, Yale School of Medicine |
| 6:15 – 8:00 |
Opening Reception |
Day 2: Monday, May 29
| 8:30 – 10:15 AM |
Plenary symposium 1
Gut feelings: Peripheral and central regulation of motivational and affective states by gut signals
Chair: Alfonso Abizaid | Carleton University
Speakers:
- Keith Sharkey | University of Calgary
How the gut changes behaviour in intestinal inflammation
- Jane Foster | McMaster University
Microbes and Mental Health: Translating preclinical findings to the clinic
- Alfonso Abizaid | Carleton University
Ghrelin-endocannabinoid system interactions in the VTA in the regulation of food reward
|
| 10:15 – 10:30 |
CIHR-INMHA Update
Sam Weiss |
| 10:30 – 10:45 |
Coffee break
Posters/exhibits |
| 10:45 – 11:45 |
Featured Plenary speaker
Dana Small | Yale University
The wisdom of the body |
| 11:45 – 12:00 |
Brain Star Award winner Sébastien Tremblay |
| 12:00 – 1:30 |
Advocacy lunch, organized by the CAN Advocacy committee
Stronger together – building capacity for a Brain Moonshot in Canada |
| 1:30 – 3:00 |
Parallel Symposium 1:
White Matter matters: the role of myelin in cognition
Chair: Meira Machado | Western University
Speakers
- Jérémie Lefebvre | University of Ottawa
Learning to be on time: How white matter plasticity shapes brain dynamics and function
- Kendra Furber | University of Northern British Columbia
Myelination in the aging mouse brain
- Olamide Adebiyi | Robarts Research Institute
Remyelinating potentials of stigmasterol in vanadium-induced neurotoxicity and cognitive impairments
- Elizabeth Dao | University of British Columbia
Myelin in aging and cognitive impairment
Parallel Symposium 2:
Neural mechanisms of skilled motor control across species, circuits, and behaviors
Chair: J. Andrew Pruszynski | Western University
Speakers:
- Ariel Levine | National Institutes of Health
Cell Types and Networks for Spinal Motor Control
- Andrew Pruszynski | Western University
Somatosensory predictions are directly embedded in neural activity that controls movement
- Chethan Pandarinath | Emory University and Georgia Tech
Dynamical mechanisms of flexible pattern generation in spinal neural populations
- Alice Mosberger | Columbia University
Learning and refining skilled actions in the basal ganglia forelimb circuitry
Parallel Symposium 3:
New approaches for human stem cell models of neurological disorders reveal mechanisms and therapeutic strategies
Chair: Gary Bassell | Emory University
- Karun Singh | University of Toronto
Investigating neural circuitry abnormalities at cellular resolution in human 3D organoid models of brain development disorders
- Nisha Raj | Emory University
Altered proteostasis in fragile X syndrome and other neuropsychiatric disorders
- Ryan Purcell | Emory University
Identifying the neurodevelopmental impact of the 3q29 deletion through single-cell sequencing
- Anne Bang | Sanford Burnham, CA
Drug Screens of Human Induced Pluripotent Stem Cell (hiPSC) Derived Neuronal Networks On Multi-Electrode Arrays
Parallel symposium 4:
Form dictates function: crosstalk between channels, scaffolds, and the cytoskeleton with implications for nervous system development and disease
Co-Chairs:
Leigh Anne Swayne | University of Victoria & R Anne McKinney | McGill University
Speakers
- Kota Mizumoto | The University of British Columbia
UNC-9/Innexin locally inhibits chemical synapse formation independent of its channel activity in C. elegans
- Andrew K. J. Boyce | University of Calgary
Cytoskeletal rearrangement promotes neuroprotection following excitotoxicity at peripheral dendrites
- R Anne McKinney | McGill University
Synaptopodin, an actin-associated protein, is required for long-term depression
- Leigh Anne Swayne | University of Victoria
Pannexin 1 regulates spine stabilization by sequestering spine cytoskeletal regulators
|
| 3:00 – 5:00PM |
Coffee break (3:00 – 3:30PM)
Poster session 1 / exhibits |
| 5:00 – 5:30 |
New investigator award lecture 1 |
| 5:30 – 6:00 |
New investigator award lecture 2 |
| 6:00 – 7:00 |
Brain Prize lecture:
Ole Kiehn, University of Copenhagen
Brainstem circuits for locomotion in the healthy and diseased brain |
| 7:30 – 9:30 |
CAN Student Social |
Day 3: Tuesday, May 30
| 8:30 – 10:15 AM |
Plenary symposium 2
Neuroimmune interactions: when the immune system shapes the Central Nervous System
Chair: Nathalie Arbour | Université de Montréal
Speakers:
-
Nader Ghasemlou | Queen’s University
Rhythms of neuroinflammation and chronic pain in EAE: what’s time got to do with it?
-
Catherine Larochelle | Université de Montréal
Molecular mechanisms underlying T cell-oligodendrocytes direct interactions
-
Veronique Miron | University of Toronto
Glial interactions regulating myelin health
|
| 10:15 – 10:25 |
Towards a Canadian Brain Initiative
Jennie Young | Canadian Brain Research Strategy |
| 10:25 – 10:45 |
Coffee break
Posters/exhibits |
| 10:45 – 11:45 |
Featured Plenary speaker 2
Maja Jagodic | Karolinska Institutet
Deciphering mechanisms of Multiple Sclerosis development and progression |
| 11:45 – 12:00 |
Brain Star Award winner Lauren Seabrook |
| 12:00 – 1:00 |
Lunch on own |
| 1:00 – 2:30 |
Parallel Symposium 5
Interactions between diet and cognition
Chair: Léa Décarie-Spain | University of Southern California
Co-sponsored the Société des Neurosciences and the Canadian Association for Neuroscience
Speakers:
- Léa Décarie-Spain | University of Southern California
Trapping a meal engram in the hippocampus
- Guillaume Ferreira | Université de Bordeaux
Obesogenic diet induces circuit-specific memory deficits
- Vivien Chevaleyre | Institute of Psychiatry and Neuroscience of Paris
How an obesogenic high-fat diet disrupts oxytocinergic signaling in hippocampal area CA2 and social memory formation
- Stephanie Borgland | University of Calgary
Time dependent changes in the orbitofrontal cortex with exposure to an obesogenic diet.
Parallel Symposium 6
Synaptic, molecular and ultrastructural dynamics during learning
Co-Chairs : Flavie Lavoie-Cardinal | Université Laval
Jean-Claude Béïque | University of Ottawa
Speakers :
- Flavie Lavoie-Cardinal | Université Laval
Machine learning-assisted super-resolution microscopy at synapses
- Jean-Claude Béïque | University of Ottawa
Nature and dynamics of synaptic eligibility traces in cortex
- Aparna Suvrathan| McGill University
Heterogeneity in information processing by cerebellar synapses
- Shernaz Bamji | University of British Columbia
Role of posttranslational palmitoylation in synaptic plasticity
Parallel Symposium 7
Adolescent Stress Sensitivity and Modulation of Behaviour Across the Lifespan
Chair: Maithe Arruda Carvalho | University of Toronto Scarborough
Speakers:
- Maithe Arruda-Carvalho | University of Toronto Scarborough
Synaptic maturation of affective learning circuits
- Deena Walker | Oregon Health and Science University
Adolescent social isolation disrupts sex-specific developmental profiles of GABA- and glutamatergic gene expression throughout the reward circuitry
- Tamara Franklin | Dalhousie University
The long-term and intergenerational effects of adolescent stress
- Heidi Meyer | Boston University
Developmental age and sex interact to scale the effects of stress on fear regulation
Parallel Symposium 8
Protein Synthesis in Brain Health and Disease
Chair: Jesper Sjöström | McGill University
Presenters:
- Hovy Ho-Wai Wong | McGill University
Local protein synthesis in axons sustains synapse-specific neurotransmission
- Cyril Hanus | University of Paris
Impact of dendritic processing on synaptic receptor glycosylation and function
- Ning Cheng | University of Calgary
Targeting ERK signaling to treat Fragile X Syndrome and autism
- Barbara Bardoni | Université Côte d’Azur
RNA metabolism and pathophysiology of brain developmental disorders: Fragile X Messenger Ribonucleoprotein (FMRP) as a paradigmatic factor
|
| 2:30 – 4:30 |
2:30 – 3:00 Coffee break in Poster Hall
2:30 – 4:30 Poster session 2 & Exhibits |
| 4:30 – 4:45 |
CAN Honor of Karim Nader, introduced by Wayne Sossin
Presented by Shernaz Bamji, Keith Murai and Adriana Di Polo and |
| 4:45– 5:45 |
Keynote Lecture
Sheena Josselyn, SickKids Hospital
Making memories in mice |
| 5:45 – 6:45 |
Life and Neuroscience
Panel discussion with Sheena Josselyn, Ole Kiehn, Flora Vaccarino, Maja Jagodic, Hugo Bellen, Dana Small |
Day 4: Wednesday, May 31
| 8:30 – 10:15 A.M. |
Plenary symposium 3
Emerging molecular mechanisms of neurodegeneration
Chair: Maria Ioannou
Speakers:
- Heidi McBride | McGill University
Immune signaling in Parkinson’s Disease: perspectives of a mitochondria
- Karl Fernandes | Université de Sherbrooke
Fatty acid desaturation: an unexpected role in the pathophysiology of Alzheimer’s disease
- Maria Ioannou | University of Alberta
Protecting neurons from degeneration by autolysosomal exocytosis
|
| 10:15 – 10:30 |
Overview of BrightFocus Foundation opportunities
Diane Bovenkamp, PhD
Vice President, Scientific Affairs, BrightFocus Foundation |
| 10:30 – 10:45 |
Posters/exhibits
Coffee break |
| 10:45 – 11:45 |
Featured Plenary speaker
Hugo Bellen – Baylor College of Medicine
Lipid droplets in Alzheimer’s Disease |
| 11:45 – 12:00 PM |
Brain Star Award winner Shannon Tansley |
| 12:00 – 1:30 PM |
- CAN-ACN Annual General Meeting of members
- Career Networking event
- Lunch on own
|
| 1:30 – 3:30 |
Poster session 3 & Exhibits |
| 3:30 – 5:00 |
Parallel Symposium 9
Cross-disciplinary neuroscience perspectives on autism spectrum disorder
Chair: Argel Aguilar Valles | Carleton University
Speakers
- Emma Duerden | Western University
Amygdala subnuclei maturation and the association with anxiety in children and youth with autism spectrum disorder
- Melissa Perreault | University of Guelph
Sex considerations in translational ASD research
- Tabrez Siddiqui | University of Manitoba
Molecular logic of circuit organization by autism-associated synaptic adhesion proteins
- Eric Klann | New York University
Autism-related mutations in EEF1A2 alter translation and actin bundling
Parallel Symposium 10
Cannabinoids, Endocannabinoids and Microglia
Chairs: Haley Vecchiarelli | University of Victoria & Marie-Ève Tremblay | University of Victoria
Speakers:
- Mallar Chakravarty | McGill University
The impact of prenatal delta-9-tetrahydrocannabinol on the brain and behaviour development across the lifespan
- Haley Vecchiarelli | University of Victoria
Effect of acute vapourized cannabis on microglia
- Tuan Trang | University of Calgary
Central actions of cannabis in neuropathic pain
- Cecilia Hillard | Medical College of Wisconsin
Role of microglial CB2 receptors in the locomotor effects of cocaine
Parallel Symposium 11
Cerebellar wiring and vulnerability in health and disease
Chair: Julie Lefebvre | The Hospital for Sick Children
Speakers:
- Julie L Lefebvre | The Hospital for Sick Children
Regulation of inhibitory interneuron wiring in the cerebellum by an atypical Cadherin
- James P Fawcett | Dalhousie University
Fundamental mechanism in interneuron synaptic organization and function
- Sophie Tremblay | Université de Montréal
Modulation of microglia responses to prevent cerebellar injury and function
- Jeehye Park | The Hospital for Sick Children
Investigation of cerebellar pathology in MATR3 S85C knock-in mouse model of ALS
Parallel Symposia 12
Brain wide network mapping in mice and its applications
Chair: Anne Wheeler | The Hospital for Sick Children
Speakers:
- Timothy Murphy | University of British Columbia
Wide field single photon cortical imaging in combination with sub-cortical or cerebellar neuropixel or fiber photometry
- Sophie Pezet | ESPCI Paris
Identification of specific cerebral networks functionally altered during neuropathic pain in awake mice, using ultrafast ultrasound imaging
- Gisella Vetere | École Supérieure de Physique et de Chimie Industrielles de la Ville de Paris
Memory networks in mice
- Anne Wheeler | The Hospital for Sick Children
Disruption of white matter maturation and its impact on brain-wide networks and behaviour
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