The Yuzwa lab in the Department of Laboratory Medicine and Pathobiology at the University of Toronto is seeking to hire a Post-doctoral Fellow. Work in our lab aims to understand how cell genesis occurs in the developing and mature brain under conditions of healthy physiology and disease. To do so, we are currently studying the role of cell signaling inhibition and developing/applying tools to probe lineage and spatial relationships in the brain. Such studies typically involve the use of traditional neurobiological approaches (immunostaining, primary culture, transgenics, etc.) and tools from systems-biology (single-cell genomics and spatially-resolved transcriptomic approaches).
The successful applicant, working independently with consultation from the Principal Investigator (PI), will apply and advance the aforementioned systems-biology tools to characterize neural stem cell biology and the impacts of disease on these cells. The applicant will also be required to validate and test predictions resulting from these data using biochemical, primary neural culture, small animal surgery or transgenic based approaches.
Primary responsibilities will largely include carrying out an independent research project as described above. However, the applicant may be required (as directed by the PI) to 1) work with and train graduate/undergraduate students; 2) help ensure the smooth functioning of the lab (such as maintaining supplies and equipment) and; 3) collaborate with internal/external research groups.
Education: Applicant must hold a PhD or equivalent degree (within 3 years of being awarded) by the agreed upon start date in neuroscience, molecular biology, molecular genetics, cell biology, biochemistry or a related discipline.
Experience: Applicant must demonstrate a strong record of research achievement as evidenced by the ability to prepare and publish scientific manuscripts in major journals and present research findings at scientific meetings. Familiarity with any one or more of the following: neurobiology, synthetic biology, bioinformatics or single-cell genomics would be an asset.
Skills: Prior training in cell culture and molecular biological techniques is required (at minimum). In addition, the successful applicant must possess a number of the following skills: experience with transcriptomics/next-generation sequencing; experience with experimental design and trouble-shooting; ability to adapt and learn new techniques; strong communicator (both oral and written); excellent analytical and problem-resolution skills; good time management and organization skills with the ability to work on multiple competing tasks. Ability to complete University of Toronto certification in chemical, biosafety and animal care, procedures will be required.
Please forward a cover letter, CV and names and contact information for three references to:
Dr. Scott Yuzwa
Department of Laboratory Medicine & Pathobiology
University of Toronto
Medical Sciences Building, 1 King’s College Circle,
Toronto, ON M5S 1A8
Posting end date 2021/04/26
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