The Clark Lab at the University at Buffalo is looking to build a team to investigate a second-generation preclinical model of Progressive Supranuclear Palsy (PSP). PSP is a devastating neurodegenerative disease, which shares attributes with Alzheimer’s Disease; tau protein aggregates, cognitive and motor deficits. Our goal is to identify neurons that are perturbed early in the disease process and that contribute to key aspects of the behavioral deficits and underlying pathology. This knowledge will allow for improved diagnosis and the initiation of pharmacotherapeutic discovery programs. Current research employs surgical manipulation in rats followed by behavioral, biochemical, histological and MRI analysis. We are seeking a Post-Doctoral Fellow to push forward our efforts into proteomic and transcriptomic analyses.
https://pubmed.ncbi.nlm.nih.gov/34668254/
If interested, please contact Dr. Stewart Clark directly (stewartc@buffalo.edu)
