| Abstract No.: | C-C3123 |
| Country: | Morocco |
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| Title: | EVALUATION OF THE ANALGESIC EFFECT OF ALKALOID EXTRACT OF PEGANUM HARMALA L: POSSIBLE MECHANISMS INVOLVED |
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| Authors/Affiliations: | 2 Loubna Farouk*; 3 Amine Laroubi; 4 Rachida Aboufatima; 1 Ahmed Benharref ; 5 Abderrahman Chait;
1 Laboratoire de Chimie des substances naturelles, Faculté des Sciences Semlalia, Université Cadi Ayyad, Marrakech Morocco; 2 Laboratory of pharmacology and behavior, Faculty of Sciences Semlalia ,Université Cadi Ayyad, Marrakech, Morocco; 3 Laboratory of pharmacology and behavior, Faculty of Sciences Semlalia, ,Université Cadi Ayyad, Marrakech, Morocco; 4 Laboratory of pharmacology and behavior, Faculty of Sciences Semlalia, ,Université Cadi Ayyad,Marrakech, Morocco; 5 Laboratory of pharmacology and behavior, Faculty of Sciences Semlalia,Université Cadi Ayyad, Marrakech, Morocco;
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| Content: | The seeds of Peganum harmala L. (Pgh) (Zygophyllaceae) have been used in Moroccan traditional medicine for treatment of a various diseases and to relieve dolorous process. The major objective of this paper was to investigate the mechanism of the analgesia induced by alkaloid extract of Peganum harmala. In the present work, the antinociceptive action was assayed in several experimental models in mice: writhing, formalin, and hot plate tests. The alkaloid extract and in a dose-dependent manner significantly reduced the nociception by acetic acid intraperitoneal injection. In the formalin test, the extract also significantly reduced the painful stimulus in both phases of the test. Treatment with the extract when given by (i.p. or i.c.v) or with morphine produced a significant increase of the reaction time in hot plate test. These result showed that the alkaloid extract of Pgh contains active analgesic principles acting both centrally and peripherally. Furthermore, this antinociceptive effect has been avoided by naloxone in the first phase of formalin and hot plate tests indicating that this extract act partly through an opioid-mediated mechanism. In conclusion, our results demonstrated that Peaganum harmala had both central and peripheral antinociceptive activities that may be mediated by opioid receptors.
Keywords: Peganum harmala; Rats and mice; Antinociceptive activity; Opioid system
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