| Abstract No.: | C-C3081 |
| Country: | Canada |
| | |
| Title: | PASSIVE IMMUNIZATION USING MONOCLONAL ANTIBODY SPECIFIC FOR MUTANT SOD1 DELAYED MORTALITY IN ALS G93A MUTANT SOD1 MICE |
| | |
| Authors/Affiliations: | 1 Francois Gros-Louis*; 1 Jean-Pierre Julien;
1 CHUL Research Centre, Ste-Foy, QC, Canada
|
| | |
| Content: | Amyotrophic lateral sclerosis (ALS) is a fatal, yet untreatable, neurodegenerative disorder leading to motor neuron degenerartion, muscle atrophy, limb paralysis and death. There is emerging evidence for the existence of secretory pathways for superoxide dismutase (SOD1) mutants-linked ALS and for neurotoxicity of extracellular mutant SOD1. Active immunization paradigm has illustrated the potential to delay disease onset and mortality ALS mice models. However, we believe that passive immunization approaches would be safer in future human ALS clinical tests. Thus, we tested a passive immunization approach through intraventricular infusion with miniosmotic pump, using conformation-specific antibodies against misfolded SOD1 mutant that we generated. The data show that it was also effective in alleviating disease symptoms and delaying mortality of ALS mice. From these results, we propose that immunization strategies, especially passive immunization, should be considered as potential avenues for treatment of familial ALS caused by SOD1 mutations. |
| | |
| Back |
|
