| Abstract No.: | B-C2105 |
| Country: | Canada |
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| Title: | CYTOKINES MEDIATE COGNITIVE FUNCTION IN EUTHYMIC INDIVIDUALS WITH BIPOLAR DISORDER |
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| Authors/Affiliations: | 1 Joanna Soczynska*; 1 Roger McIntyre; 1 Sidney Kennedy;
1 University of Toronto, ON, Canada
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| Content: | Objective: To explore the association between inflammatory mediators and cognitive function in euthymic individuals with bipolar disorder (BD).
Hypothesis: It is hypothesized that pro-inflammatory cytokines mediate cognitive deficits, notably verbal learning and memory, in euthymic individuals with BD.
Method: Prospectively verified euthymic individuals (currently sample: N=24; target enrollment N=50, age 18-55) with DSM-IV-TR-defined BD-I/II have been enrolled. Cognitive performance was measured with the California Verbal Learning Test (CVLT) and Process Dissociation Task. All subjects provided a morning blood sample after an overnight fast. Pro-inflammatory and anti-inflammatory cytokines (IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-13, TNFα, INFα, INFγ) were measured with the Mutliplex Bead ImmunoAssay. Cognitive deficits were operationalized as a one standard deviation below the norm (i.e. impaired vs. not impaired). Spearman correlations were used to test the associations between cytokines concentrations and cognitive performance. Simple linear regressions were used to evaluate which cytokines are significant predictors of cognitive deficits. Significance indicates a p-value of <0.05.
Results: Preliminary evidence indicates that individuals with BD manifest cognitive deficits on short-delay and long-delay free recall (30.6% and 25.7%, respectively). A significant correlation (r=0.456, p=0.043) was found between TNFα and total number of intrusions on the CVLT. Similarly a significant correlation (r=0.458, p=0.042) was found between IL-8 and total number of repetitions on the CVLT. Recollection deficits on the Process Dissociation Task were negatively associated with INFγ (r=-0.466, p=0.044). No significant differences were found between cognitively impaired and not impaired individuals on pro-and-anti- inflammatory cytokines.
Conclusion: These preliminary results indicate that cognitive deficits in BD persist into euthymia and may be subserved by inflammatory response systems.
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