| Abstract No.: | B-C2082 |
| Country: | Canada |
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| Title: | OXYDATIVE STATUS AND CAPACITY OF FUNCTIONING, COGNITIVE FUNCTIONS AND ACTIVES SYMPTOMS OF ILLNESS IN PSYCHOTIC PATIENTS. |
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| Authors/Affiliations: | 1 Patrick Berube*; 1 Mylene Poirier; 1 Joanie Mayette; 1 Sylvain Grignon;
1 University of Sherbrooke, QC, Canada
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| Content: | Objective: Oxidative stress is implicated in the pathophysiology of schizophrenia and may account for poor prognosis, but the way it affect patients is unclear. The authors searched for a correlation between oxidative stress and capacity of functioning, cognitive functions and active symptoms of psychotic illness.
Methods: 19-26 patients with schizophrenia or schizoaffective disorder were included in a transversal study. A semi-structured interview was completed to confirm the DSM-IV diagnosis and assess the functional status with the QLS (Quality of Life Scale), symptomatology with the PANSS (Positive and Negative Syndrome Scale), and cognitive functions with BACS (Brief Assessment of Cognition in Schizophrenia). The oxidative status was assessed by measuring malonedialdehyde (MDA) levels. Simple linear regression analysis was done between MDA results and each scale.
Results: A negative correlation was observed between MDA level and intrapsychic foundation sub-scale of QLS (p=0.0119). There was also a marked trend towards a positive correlation between MDA and the total score of the PANSS (p=0.0119) as well as with negative score of the PANSS (p=0.0253) but not with BACS (p=0.7197).
Conclusion: This study confirms the link between oxidative stress and functional status in patients with a psychotic illness, and suggests it can be a good marker of poor prognosis.
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