| Abstract No.: | A-A1009 |
| Country: | Canada |
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| Title: | ROLE OF NEUROTRANSMITTERS IN THE MIGRATORY BEHAVIOUR OF NEURONAL PRECURSORS IN ADULT BRAIN |
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| Authors/Affiliations: | 1 Morgane Lemasson*; 1 Armen Saghatelyan;
1 Centre de recherche Universite Laval Robert-Giffard, Quebec, QC, Canada
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| Content: | The adult olfactory bulb (OB) has a remarkable capacity to renew its interneuronal population along the entire life-span of the animal. The adult subventricular zone (SVZ) – olfactory bulb (OB) pathway is a unique region of the brain where massive neuronal migration occurs. Neuroblasts, born in the SVZ, travel tangentially in the rostral migratory stream (RMS) to reach the OB and then migrate radially into the different bulbar layers. Despite the molecular and cellular changes taking place throughout this long migration path, it is commonly acknowledged that the migration of neuroblasts is a unique phenomenon. To better understand the mechanisms of neuronal migration in adult forebrain we have established a time-lapse videomicroscopy in the acute slices of adult mouse brain and compare the migratory behaviour of neuronal precursors in the SVZ-OB pathway (ventral and dorsal part of the SVZ, vertical and horizontal limb of the RMS and rostral end of the RMS of OB). We observed that migration of neuronal precursors is saltatory throughout the migratory stream with active phases of neuronal displacement interspersed amongst the resting periods. However, the migration parameters (duration of the resting and migratory periods, number of migrating cells, speed of migration and distance travelled) differ depending on the region analyzed. Since the expression of neurotransmitters and their receptors change along the SVZ-OB pathway, we investigated the involvement of neurotransmitters signalling in the migratory behaviour of neuroblasts. Throughout our work we are able to suggest the existence of heterogeneity in the migration processes of adult neuronal precursors along the SVZ-OB pathway. |
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