| Abstract No.: | A-A1002 |
| Country: | Canada |
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| Title: | THE SLITRK FAMILY DURING THE DEVELOPMENT OF THE NERVOUS SYSTEM |
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| Authors/Affiliations: | 1 François Beaubien*; 1 Jean-François Cloutier;
1 MNI, McGill; Montreal, QC, Canada
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| Content: | The regulation of axonal growth and steering is critical for proper wiring of the brain. The Slitrk family of transmembrane proteins is composed of six members that are highly expressed in the nervous system. Recently, mutations in one of these molecules, SLITRK-1, were identified in patients afflicted with the complex mental disorder Tourette syndrome. To date, the function of the Slitrks during the development of the nervous system has yet to be defined. The high homology between the extracellular region of Slitrks and the repulsive axon guidance molecules Slits suggest that Slitrks may regulate axon growth during development. To begin to evaluate their role during development, we have studied their patterns of expression during embryogenesis, and have attempted to identify Slitrks binding partners using proteomics approaches. |
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