Two CIHR-funded positions are available immediately for enthusiastic graduate students/postdoctoral fellows with a keen interest in using electrophysiology and imaging techniques to study ligand-gated ion-channels and their role in neuronal circuit behavior.
The first project will focus on an ongoing theme to understand the structure-function properties of ionotropic glutamate receptors. The successful applicant will use single-channel and macroscopic patch clamp techniques to tease apart the mechanism of channel activation in wildtype and mutant receptors. This work will be part of a multilab collaboration with researchers using computational chemistry and structural biology.
The second project will examine the signaling defects associated with Fragile X syndrome, a prominent neurodevelopmental disorder. The successful applicant will study neuronal circuit connectivity using single and multi-electrode recordings from acutely isolated brain tissue. Imaging and functional experiments will be collected simultaneously using a multiphoton microscope equipped with an electrophysiology rig.
Dawe et al (2016) Distinct structural pathways coordinate the activation of AMPA receptor-auxiliary subunit complexes. Neuron.
Accardi et al (2014) Mitochondrial reactive oxygen species regulate the strength of inhibitory GABA-mediated synaptic transmission. Nat Commun.
*Student stipends will be based on the policy recommendations of individual McGill Graduate Programs. Postdoctoral salaries will be based on CIHR recommendations and level of experience*
Applicants should send a cover letter, cv and the names of 2-3 referees to:
Dr. Derek Bowie,
Department of Pharmacology & Therapeutics
McGill University, Faculty of Medicine
3649 Promenade Sir-William Osler, Rm 164
Montreal, QC, Canada, H3G 0B1
Tele: 514-398-1581 Email: firstname.lastname@example.org
Connect on LinkedIn: https://www.linkedin.com/in/derek-bowie-177a7855/
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