A Research Associate position is available in the laboratory of Dr. Pierre Marquet at Université Laval in Quebec, within the framework of the Canada Excellence Research Chair (CERC) in Neurophotonics (http://www.cerc.gc.ca/chairholders-titulaires/marquet-eng.aspx). The research theme of Marquet lab is to identify new biomarkers/endophenotpyes of major psychiatric disorders including schizophrenia, bipolar disorders and major depression disorder. By using human pluripotent stem cells made from different kinds of patient cells, our research aims for a better understanding of the pathophysiology of these major affective and non-affective psychoses. The Research Associate will be responsible of the stem cell research axis of the CERC-N and will also collaborate with other organizations such as the Brain Canada platform.
We focus on (i) the establishment of disease-specific human induced pluripotent stem cells (hiPSCs) and (ii) the development of hiPSC-based in-vitro differentiation to identify new neurodevelopmental biomarkers of these major psychiatric disorders. The identification of these biomarkers will be performed using cutting edge multimodal high-resolution optical imaging techniques, having the capacity to monitor multiple dynamic cellular processes concurrently as well as their modulations as a function of the transcriptome and metabolome in particular.
Furthermore, in addition to these multimodal imaging techniques, we have been using a combination of multidisciplinary techniques in our research, including stem cell reprogramming, electrophysiology/patch-clamp recording, molecular/cell biology, biochemistry, pharmacology, microarray and RNA-sequencing techniques. We are looking for individuals who are interested in working on differentiation of human pluripotent stem cells to neural cells or tissues, and application of stem cell technologies to the development of in vitro models including brain organoids aiming at obtaining a better understanding of the neurodevelopmental component of major psychiatric disorders. Candidates should have a good publication record and Ph.D. in neurobiology, developmental neuroscience, stem cell biology or related fields. Experience with electrophysiology, culture and neural differentiation of human pluripotent stem cells are desired. Candidates should also demonstrate excellent communication skills and have a strong passion and commitment to science. Interested candidates should submit their CV including names and contact information of three references and a brief description of their research experience and career goals to Anne-Sophie Poulin-Girard, Scientific coordinator (firstname.lastname@example.org).
Posted June 2016