Post-Doc and/or Graduate Student Positions, Takahashi lab, IRCM/Université de Montréal

Position available: One Post-doc and/or one graduate student (Master or PhD)

Recruit Information:

Hideto Takahashi
Research Unit Director
Institut de recherches cliniques de Montréal (IRCM)
Department of Medicine, Université de Montréal
Montreal, Quebec, Canada

Project Description:

Our laboratory aims to reveal the molecular and cellular mechanisms underlying the development and plasticity of chemical synapses in the brain using combined approaches of cell biology, molecular biology, fluorescent imaging, biochemistry, proteomics, mouse genetics and electrophysiology. In particular, we are focusing on studying neuronal cell adhesion molecules that have a biological activity to induce synapse formation. The project for this position is either 1) to characterize the functions of a novel synapse-inducing cell-adhesion molecule in synapse development and plasticity or 2) to elucidate the roles of synapse-inducing cell-adhesion complexes on synapse loss and preservation in Alzheimer’s disease. The projects are funded by CIHR, ASRP and NSERC.

Available: Immediately
Deadline: Until the position is filled.

Qualification:

  • B.Sc or/and M.Sc in biomedical sciences with an excellent GPA (for a student position)
  • at least one publication with the first authorship (for a post-doc position)
  • appropriate knowledge and experience in molecular biology, cell biology, biochemistry and/or neuroscience (for both positions)
  • highly motivated candidates who will pursue a career in research (for both positions)
  • excellent written and oral communication skills (for both positions)
  • should register at Université de Montréal for the Molecular biology program in Department of Medicine or the Neuroscience program in Department of Neuroscience (for a student position)

Please send a letter of motivation, curriculum vitae and the contact information for two academic referees by email to Dr. Hideto Takahashi, Hideto.Takahashi@ircm.qc.ca . To apply for a student position, send also a copy of official transcripts. Only those selected for an interview will be contacted.

Publications:

  • Naito Y, Tanabe Y, Lee AK, Hamel E and Takahashi H. (2017). Amyloid-β Oligomers Interact with Neurexin and Diminish Neurexin-mediated Excitatory Presynaptic Organization. Scientific Reports. 13: 42548.
  • Ammendrup-Johnsen I, Naito Y, Craig AM, Takahashi H. (2015). Neurotrophin-3 Enhances the Synaptic Organizing Function of TrkC-PTPσ in Rat Hippocampal Neurons. Journal of Neuroscience. 35(36): 12425-12431.
  • Takahashi H, and Craig A M. (2013) Protein tyrosine phosphatases PTPσ, PTPδ and LAR: presynaptic hubs for synapse organization. Trends in Neuroscience, 36(9):522-34.
  • Takahashi H, Katayama K, Sohya K, Miyamoto H, Prasad T, Matsumoto Y, Ota M, Yasuda H, Tsumoto T, Aruga J, and Craig A M. (2012) Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction. Nature Neuroscience, 15(3): 389-398.
  • Takahashi H, Arstikaitis P, Parasad T, Bartlett T, Wang YT, Murphy TH, Craig AM. (2011) Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex. Neuron, 69(2): 287-303.

Contact information:

Hideto Takahashi, MD, PhD
Synapse Development and Plasticity research unit
Institut de recherches cliniques de Montréal (IRCM)
110, Avenue des Pins Ouest Montreal, QC, Canada, H2W 1R7
E-mail: Hideto.Takahashi@ircm.qc.ca
Web site: www.ircm.qc.ca/takahashi